TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.459 | Formula: C20H26N6O3
H donors: 2 H acceptors: 4 LogP: 0.95 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)N1CCC(CC1)Nc1ncc2c(n1)c1n(C)cc(c1CC2)C(=O)N
InChi: 1S/C20H26N6O3/c1-3-29-20(28)26-8-6-13(7-9-26)23-19-22-10-12-4-5-14-15(18(21)27)11-25(2)17(14)16(12)24-19/h10-11,13H,3-9H2,1-2H3,(H2,21,27)(H,22,23,24)
InChiKey: OKCKMDCMHXPONP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin A1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Onchocerca volvulus		Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Giardia lamblia	G2/mitotic-specific cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania infantum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei gambiense	cyclin 6,mitotic cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin A, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Entamoeba histolytica	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium hominis	mitotic cyclin-CYC2	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania infantum	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium parvum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ecdysone induced protein 78C	0.0237	0.7819	0.8594
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0051	0.0811	0.7767
Schistosoma mansoni	nuclear receptor	0.0112	0.3089	0.2939
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0078	0.182	0.1816
Echinococcus granulosus	nuclear receptor nhr 48	0.0112	0.3089	0.325
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0237	0.7819	0.7771
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0125	0.3595	0.3457
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Loa Loa (eye worm)	nuclear hormone receptor	0.0112	0.3089	0.3408
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0883	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0883	0.0974
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0036	0.0212	0.5
Schistosoma mansoni	coup transcription factor	0.0237	0.7819	0.7771
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0237	0.7819	0.8594
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0125	0.3595	0.3457
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0036	0.0212	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0237	0.7819	0.8594
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0237	0.7819	0.8594
Mycobacterium leprae	Conserved hypothetical protein	0.0036	0.0212	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0112	0.3089	0.325
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0237	0.7819	0.8594
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0125	0.3595	0.3822
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0036	0.0212	0.5
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3595	0.3967
Trichomonas vaginalis	cyclins, putative	0.0051	0.0811	0.0751
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0237	0.7819	0.7771
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0269	0.9063	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0237	0.7819	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0473	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3595	0.3967
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0237	0.7819	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0112	0.3089	0.325
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0237	0.7819	0.8594
Treponema pallidum	cyclic nucleotide binding protein	0.0036	0.0212	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0237	0.7819	0.8594
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0053	0.0883	0.0758
Leishmania major	cyclin	0.0051	0.0811	0.7767
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0036	0.0212	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0237	0.7819	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3595	0.3967
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0112	0.3089	0.325
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Brugia malayi	nuclear hormone receptor	0.0237	0.7819	0.8594
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0811	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0112	0.3089	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0811	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Brugia malayi	hypothetical protein	0.0112	0.3089	0.325
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0053	0.0883	0.0686
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0125	0.3595	0.3822
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0053	0.0883	0.0686
Brugia malayi	nuclear receptor NHR-88	0.0237	0.7819	0.8594
Treponema pallidum	cyclic nucleotide binding protein	0.0036	0.0212	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0056	0.0984	0.1085
Onchocerca volvulus		0.0112	0.3089	0.3782
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0112	0.3089	0.2939
Brugia malayi	tailless protein	0.0112	0.3089	0.325
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0053	0.0883	0.0974
Schistosoma mansoni	thyroid hormone receptor	0.0237	0.7819	0.7771
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0053	0.0883	0.0686
Trypanosoma cruzi	cyclin 6, putative	0.0051	0.0811	0.7767
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0036	0.0212	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0112	0.3089	0.325
Echinococcus granulosus	FTZ F1 alpha	0.0237	0.7819	0.8594
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0237	0.7819	0.8594
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0112	0.3089	0.325
Loa Loa (eye worm)	hypothetical protein	0.0234	0.7716	0.8514
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0125	0.3595	0.3967
Trypanosoma cruzi	cytochrome P450, putative	0.0056	0.0984	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0237	0.7819	0.8627
Echinococcus granulosus	cyclin B	0.0051	0.0811	0.0677
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0036	0.0212	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0237	0.7819	0.8594
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0252	0.8392	1
Brugia malayi	ecdysteroid receptor	0.0237	0.7819	0.8594
Brugia malayi	Cytochrome P450 family protein	0.0056	0.0984	0.0872
Trichomonas vaginalis	cyclins, putative	0.0051	0.0811	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3595	0.3967
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0237	0.7819	0.8594
Schistosoma mansoni	nuclear hormone receptor	0.0112	0.3089	0.2939
Trichomonas vaginalis	cyclins, putative	0.0051	0.0811	0.0751
Schistosoma mansoni	60S ribosomal protein L21	0.0042	0.0473	0.0267
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0237	0.7819	0.8594
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0269	0.9063	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0078	0.182	0.1816
Schistosoma mansoni	RAR-like nuclear receptor	0.0237	0.7819	0.7771
Trypanosoma cruzi	cyclin, putative	0.0051	0.0811	0.7767
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0112	0.3089	0.325
Brugia malayi	nuclear receptor RXR	0.0112	0.3089	0.325
Plasmodium falciparum	cGMP-dependent protein kinase	0.0036	0.0212	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0237	0.7819	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3595	0.3967
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0112	0.3089	0.3782
Echinococcus multilocularis	FTZ F1 alpha	0.0237	0.7819	0.8594
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0237	0.7819	0.7771
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0053	0.0883	0.0686
Onchocerca volvulus	Protein ultraspiracle homolog	0.0237	0.7819	1
Entamoeba histolytica	cyclin, putative	0.0051	0.0811	0.5
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0237	0.7819	0.8594
Brugia malayi	Steroid receptor seven-up type 2	0.0237	0.7819	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0036	0.0212	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0056	0.0984	0.1085
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0811	0.0751
Giardia lamblia	G2/mitotic-specific cyclin B	0.0051	0.0811	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0112	0.3089	0.3782
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0237	0.7819	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0078	0.182	0.2008
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0036	0.0212	0.5
Trichomonas vaginalis	cyclins, putative	0.0051	0.0811	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Loa Loa (eye worm)	CYP4Cod1	0.0056	0.0984	0.1085
Brugia malayi	nuclear hormone receptor family member odr-7	0.0112	0.3089	0.325
Trypanosoma brucei	mitotic cyclin 6	0.0051	0.0811	0.7767
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0036	0.0212	0.002
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0212	0.002
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0112	0.3089	0.325
Brugia malayi	photoreceptor-specific nuclear receptor	0.0237	0.7819	0.8594
Onchocerca volvulus		0.0237	0.7819	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0811	0.0895
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0237	0.7819	0.8594
Brugia malayi	nuclear receptor NHR-67	0.0112	0.3089	0.325
Schistosoma mansoni	nuclear hormone receptor	0.0112	0.3089	0.2939
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0036	0.0212	0.5
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0053	0.0883	0.0686
Schistosoma mansoni	nuclear hormone receptor	0.0237	0.7819	0.7771
Brugia malayi	nuclear hormone receptor	0.0112	0.3089	0.325
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0053	0.0883	0.0758
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0036	0.0212	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0237	0.7819	1
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0036	0.0212	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0125	0.3595	0.3822
Loa Loa (eye worm)	steroid hormone receptor	0.0237	0.7819	0.8627
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0053	0.0883	0.0758
Brugia malayi	orphan nuclear receptor NR2E1	0.0112	0.3089	0.325
Echinococcus multilocularis	nuclear receptor nhr 48	0.0112	0.3089	0.325
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0036	0.0212	0.5
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Schistosoma mansoni	nuclear receptor	0.0112	0.3089	0.2939
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0112	0.3089	0.3408
Loa Loa (eye worm)	DR-78	0.0112	0.3089	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0053	0.0883	0.0758
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0036	0.0212	0.5
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0212	0.0234
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0212	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0237	0.7819	0.8594
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0036	0.0212	0.5
Brugia malayi	hypothetical protein	0.0112	0.3089	0.325
Treponema pallidum	catabolite gene activator (Crp)	0.0036	0.0212	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0294	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0112	0.3089	0.325
Trypanosoma cruzi	cyclin, putative	0.0051	0.0811	0.7767
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0053	0.0883	0.0758
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0237	0.7819	0.8594
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0237	0.7819	0.8627
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0078	0.182	0.1816
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0112	0.3089	0.2939
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0237	0.7819	0.8627
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0053	0.0883	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0212	0.002
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0112	0.3089	0.325
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0036	0.0212	0.5
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0811	0.0751
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0056	0.0984	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0112	0.3089	0.325
Brugia malayi	hypothetical protein	0.0125	0.3595	0.3822
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0212	0.0234
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0237	0.7819	0.8627
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0053	0.0883	0.0758
Brugia malayi	Cytochrome P450 family protein	0.0056	0.0984	0.0872
Brugia malayi	conserved hypotetical protein	0.0112	0.3089	0.325
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0053	0.0883	0.0758
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0237	0.7819	0.7771
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0237	0.7819	0.7771
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0112	0.3089	0.325
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0212	0.002
Echinococcus multilocularis	voltage gated potassium channel	0.0078	0.182	0.1816
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0051	0.0811	0.0677
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0237	0.7819	0.8594
Echinococcus multilocularis	cyclin B	0.0051	0.0811	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7819	0.8627
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0036	0.0212	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0237	0.7819	0.8594
Schistosoma mansoni	voltage-gated potassium channel	0.0078	0.182	0.1643
Schistosoma mansoni	cyclin B	0.0051	0.0811	0.0612
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0237	0.7819	0.8594
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0051	0.0811	0.0677
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0237	0.7819	0.8594
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0036	0.0212	0.002
Brugia malayi	hypothetical protein	0.0125	0.3595	0.3822
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0036	0.0212	0.0234
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0237	0.7819	0.8594
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0252	0.8392	1
Onchocerca volvulus		0.0112	0.3089	0.3782
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0053	0.0883	0.0758
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0883	0.0838
Brugia malayi	nuclear receptor NHR-88	0.0112	0.3089	0.325
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0237	0.7819	0.7771
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0237	0.7819	0.7771
Echinococcus granulosus	hyperpolarization activated cyclic	0.0053	0.0883	0.0758
Trypanosoma brucei	cytochrome P450, putative	0.0056	0.0984	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0053	0.0883	0.0758
Leishmania major	cytochrome p450-like protein	0.0056	0.0984	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0237	0.7819	0.8594
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0053	0.0883	0.0758
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0237	0.7819	0.8594
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0269	0.9063	1
Brugia malayi	ecdysone receptor	0.0112	0.3089	0.325
Schistosoma mansoni	voltage-gated potassium channel	0.0053	0.0883	0.0686
Schistosoma mansoni	voltage-gated potassium channel	0.0078	0.182	0.1643
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0053	0.0883	0.0974
Echinococcus multilocularis	ecdysone induced protein 78C	0.0237	0.7819	0.8594
Trypanosoma cruzi	cytochrome P450, putative	0.0056	0.0984	1
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0036	0.0212	0.0234
Brugia malayi	nuclear receptor RXR	0.0125	0.3595	0.3822
Echinococcus granulosus	thyroid hormone receptor alpha	0.0112	0.3089	0.325
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0237	0.7819	0.8594
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0811	0.0751
Brugia malayi	Cytochrome P450 family protein	0.0134	0.3937	0.4208
Trichomonas vaginalis	cyclin A, putative	0.0051	0.0811	0.0751
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0112	0.3089	0.325
Onchocerca volvulus		0.0051	0.0811	0.0788
Treponema pallidum	catabolite gene activator	0.0036	0.0212	0.5
Brugia malayi	steroid hormone receptor	0.0237	0.7819	0.8594
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0269	0.9063	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0237	0.7819	0.8627
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0237	0.7819	0.8627
Echinococcus granulosus	voltage gated potassium channel	0.0078	0.182	0.1816
Schistosoma mansoni	retinoic acid receptor RXR	0.0237	0.7819	0.7771
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0237	0.7819	0.8627
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0051	0.0811	0.7767
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Schistosoma mansoni	nuclear receptor nhr-48	0.0112	0.3089	0.2939
Schistosoma mansoni	zinc finger protein	0.0112	0.3089	0.2939
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408
Brugia malayi	Nuclear hormone receptor E75	0.0112	0.3089	0.325
Schistosoma mansoni	thyroid hormone receptor	0.0237	0.7819	0.7771
Loa Loa (eye worm)	cytochrome P450 family protein	0.0134	0.3937	0.4344
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0237	0.7819	0.8594
Brugia malayi	Nuclear hormone receptor-like 1	0.0125	0.3595	0.3822
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0237	0.7819	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3089	0.3408

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9	Inhibition of CDK2/cyclin A	ChEMBL.	20869873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1270713

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1246197