Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase | 0.0073 | 0.3933 | 0.3933 |
Leishmania major | CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 | 0.0073 | 0.3933 | 0.5 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M48 containing protein | 0.0073 | 0.3933 | 0.2026 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0767 | 0.0767 |
Mycobacterium ulcerans | hypothetical protein | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | heat shock protein HtpX | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 1 | 1 |
Brugia malayi | Peptidase family M48 containing protein | 0.0073 | 0.3933 | 0.2026 |
Mycobacterium leprae | CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | caax prenyl protease 1 | 0.0073 | 0.3933 | 0.2026 |
Trypanosoma brucei | metallo- peptidase, Clan M- Family M48 | 0.0073 | 0.3933 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan M- Family M48 | 0.0073 | 0.3933 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0767 | 0.0767 |
Toxoplasma gondii | CAAX metallo endopeptidase | 0.0073 | 0.3933 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0167 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase | 0.0073 | 0.3933 | 0.3933 |
Mycobacterium leprae | PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0167 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | TPR repeat-containing Zn-dependent protease | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 1, putative | 0.0073 | 0.3933 | 0.5 |
Schistosoma mansoni | farnesylated-protein converting enzyme 1 (M48 family) | 0.0073 | 0.3933 | 0.2026 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0167 | 1 | 1 |
Mycobacterium ulcerans | peptidase M48 like-protein | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease transmembrane protein heat shock protein HtpX | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | caax prenyl protease 1 | 0.0073 | 0.3933 | 0.2026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Antifungal activity against FLCZ-susceptible Candida albicans ATCC 90028 assessed as concentration required to 80% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | ChEMBL. | 20875745 |
MIC (functional) | = 1 ug ml-1 | Antifungal activity against FLCZ-resistant Candida albicans ATCC MYA-573 assessed as concentration required to 80% growth inhibition using alamar blue staining after 18 to 72 hrs by microdilution method | ChEMBL. | 20875745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.