Detailed information for compound 1247453

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.531 | Formula: C25H30N4O2
  • H donors: 2 H acceptors: 2 LogP: 3.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1ccc2c(c1)NC(=O)/C/2=C(/c1ccccc1)\NC1CCN(CC1)C)C
  • InChi: 1S/C25H30N4O2/c1-4-29(3)25(31)18-10-11-20-21(16-18)27-24(30)22(20)23(17-8-6-5-7-9-17)26-19-12-14-28(2)15-13-19/h5-11,16,19,26H,4,12-15H2,1-3H3,(H,27,30)/b23-22-
  • InChiKey: DVCSUGRKKGJBHN-FCQUAONHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens activin A receptor, type IB Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni protein kinase Get druggable targets OG5_129709 All targets in OG5_129709
Echinococcus multilocularis TGF beta receptor type 1 Get druggable targets OG5_129709 All targets in OG5_129709
Schistosoma japonicum ko:K04674 transforming growth factor, beta receptor I, putative Get druggable targets OG5_129709 All targets in OG5_129709
Echinococcus granulosus TGF beta receptor type 1 Get druggable targets OG5_129709 All targets in OG5_129709
Echinococcus granulosus TGF-beta receptor type-1 Get druggable targets OG5_129709 All targets in OG5_129709
Brugia malayi bone morphogenetic protein type 1 receptor Get druggable targets OG5_129709 All targets in OG5_129709
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase Get druggable targets OG5_129709 All targets in OG5_129709
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1679 0.1679
Trypanosoma brucei unspecified product 0.0014 0.0101 0.1887
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0512 0.6184 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0372 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0176 0.3432
Brugia malayi hypothetical protein 0.0006 0.0008 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0006 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0005
Echinococcus granulosus zinc finger protein 0.0006 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Onchocerca volvulus 0.0006 0.0008 0.0215
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.2674 0.4323
Brugia malayi MH2 domain containing protein 0.0011 0.0065 0.0105
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0008 0.0013
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0497 1
Schistosoma mansoni hypothetical protein 0.0162 0.1911 0.3159
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0008 0.0013
Echinococcus multilocularis zinc finger protein 0.0006 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.0074 0.0834 0.1349
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Echinococcus multilocularis cpg binding protein 0.0031 0.0306 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Echinococcus granulosus expressed protein 0.0006 0.0008 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0075 0.0121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0075 0.0124
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.025 0.5108
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0075 0.0075
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0008 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0065 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Brugia malayi PHD-finger family protein 0.0006 0.0003 0.0005
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0008 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0075 0.0121
Loa Loa (eye worm) TK/ROR protein kinase 0.0006 0.0012 0.002
Schistosoma mansoni transcription factor LCR-F1 0.0219 0.2603 0.4303
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0162 0.1911 0.1911
Loa Loa (eye worm) hypothetical protein 0.0074 0.0831 0.1343
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0021 0.0034
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0006 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0075 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0075 0.0124
Schistosoma mansoni hypothetical protein 0.0219 0.2603 0.4303
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0372 0.7437
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0075 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0372 0.6939
Loa Loa (eye worm) hypothetical protein 0.035 0.4206 0.6802
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0176 0.0291
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0008 0.0013
Brugia malayi beta-lactamase 0.0036 0.0372 0.0601
Schistosoma mansoni bromodomain containing protein 0.0006 0.0003 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0075 0.0075
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0075 0.0124
Brugia malayi MH2 domain containing protein 0.0355 0.4265 0.6898
Echinococcus multilocularis GPCR, family 2 0.0162 0.1911 0.1911
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0372 0.6939
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0532 0.088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0096 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0162 0.1911 0.309
Brugia malayi protein C17H12.11 0.0074 0.0831 0.1343
Onchocerca volvulus 0.0006 0.0008 0.0215
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0008 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0075 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0075 0.0121
Onchocerca volvulus 0.0006 0.0008 0.0215
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0176 0.4614
Schistosoma mansoni Smad4 0.0011 0.0065 0.0107
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0008 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0075 0.2019
Schistosoma mansoni cpg binding protein 0.0031 0.0306 0.0506
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0075 0.0124
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0176 0.3432
Loa Loa (eye worm) hypothetical protein 0.0036 0.0372 0.0601
Schistosoma mansoni hypothetical protein 0.0501 0.6049 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0008 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.025 0.4621
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.025 0.5108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0042 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0372 0.0601
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0075 0.0075
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0008 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0075 0.0121
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0008 0.0013
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0482 0.1827
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0008 0.0013
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0372 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0372 0.6939
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0008 0.0013
Leishmania major DNA polymerase eta, putative 0.0032 0.0329 0.6568
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0372 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0101 0.1887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1679 0.2776
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1679 0.2776
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0008 0.0013
Brugia malayi Smad1 0.0024 0.0228 0.0369
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0008 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0372 0.0764
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0075 0.0124
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0532 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.025 0.4955
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0008 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0065 0.0105
Brugia malayi ecdysteroid receptor 0.0012 0.0075 0.0121
Loa Loa (eye worm) hypothetical protein 0.0046 0.0497 0.0803
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0008 0.0013
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0008 0.0013
Brugia malayi hypothetical protein 0.0017 0.0138 0.0223
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1679 0.2715
Brugia malayi hypothetical protein 0.0219 0.2603 0.4209
Leishmania major DNA polymerase kappa, putative 0.002 0.0176 0.3432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0075 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0372 0.6939
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0021 0.0034
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0008 0.0013
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0176 0.4614
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0176 0.0648
Echinococcus granulosus TGF-beta receptor type-1 0.0191 0.2271 0.3754
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0075 0.0075
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0008 0.0013
Echinococcus granulosus smad 0.0024 0.0228 0.0377
Schistosoma mansoni hypothetical protein 0.0012 0.0075 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0075 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1679 0.2715
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0075 0.0124
Brugia malayi CXXC zinc finger family protein 0.0029 0.0286 0.0462
Brugia malayi beta-lactamase family protein 0.0036 0.0372 0.0601
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0219 0.2603 0.4303
Schistosoma mansoni hypothetical protein 0.0501 0.6049 1
Brugia malayi latrophilin 2 splice variant baaae 0.035 0.4206 0.6802
Schistosoma mansoni hypothetical protein 0.0162 0.1911 0.3159
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0176 0.3432
Brugia malayi MH1 domain containing protein 0.0024 0.0228 0.0369
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0176 0.0291
Schistosoma mansoni Smad4 0.0011 0.0065 0.0107
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0008 0.0013
Loa Loa (eye worm) TK protein kinase 0.0006 0.0012 0.002
Trypanosoma brucei unspecified product 0.0014 0.0101 0.1887
Loa Loa (eye worm) hypothetical protein 0.0036 0.0372 0.0601
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0008 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1679 0.1679
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0006 0.0012 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.025 0.4955
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0075 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0074 0.0834 0.1349
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0162 0.1911 0.309
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0075 0.2019
Brugia malayi follicle stimulating hormone receptor 0.0224 0.2674 0.4323
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0075 0.0121
Loa Loa (eye worm) Smad1 0.0024 0.0228 0.0369
Schistosoma mansoni coup transcription factor 0.0012 0.0075 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0008 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0681 0.1126
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0065 0.0065
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0482 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0372 0.6939
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0075 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0075 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0372 0.7437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0008 0.0013
Onchocerca volvulus 0.0036 0.0372 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0176 0.0285
Echinococcus multilocularis activin receptor type 0.0088 0.101 0.101
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0042
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0008 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0075 0.0121
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0008 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0176 0.3432
Mycobacterium tuberculosis Conserved protein 0.0036 0.0372 0.0764
Onchocerca volvulus 0.0029 0.0286 0.7691
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0075 0.0124
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0041 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0075 0.0121
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0026 0.025 0.4955
Echinococcus granulosus histone acetyltransferase KAT2B 0.0162 0.1913 0.3163
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0228 0.0228
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0372 0.0372
Schistosoma mansoni smad 0.0011 0.0065 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0075 0.0121
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0008 0.0013
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0008 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0162 0.1911 0.3159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0162 0.1911 0.3159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0075 0.0121
Mycobacterium tuberculosis Conserved protein 0.0036 0.0372 0.0764
Schistosoma mansoni bromodomain containing protein 0.0006 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0372 0.0614
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0008 0.0013
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0021 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0176 0.3432
Echinococcus granulosus GPCR family 2 0.0162 0.1911 0.3159
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0286 0.0462
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0228 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0075 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0075 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1679 0.2776
Entamoeba histolytica hypothetical protein 0.0219 0.2603 1
Echinococcus granulosus geminin 0.0501 0.6049 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Schistosoma mansoni smad1 5 8 and 0.0024 0.0228 0.0377
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0372 0.0601
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0075 0.0075
Brugia malayi Bromodomain containing protein 0.0006 0.0003 0.0005
Schistosoma mansoni cpg binding protein 0.0029 0.0286 0.0473
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Brugia malayi G-protein alpha subunit 0.0006 0.0008 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2735 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0372 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0176 0.3538
Leishmania major hypothetical protein, conserved 0.0036 0.0372 0.7437
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0101 0.1887
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1679 0.2776
Echinococcus multilocularis expressed protein 0.0006 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0075 0.0121
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0008 0.0008
Onchocerca volvulus 0.0036 0.0372 1
Schistosoma mansoni hypothetical protein 0.0162 0.1911 0.3159
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0176 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Echinococcus multilocularis Smad4 0.0024 0.0228 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0219 0.2603 0.2603
Brugia malayi steroid hormone receptor 0.0012 0.0075 0.0121
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0008 0.0008
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0008 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1679 0.2776
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0176 0.3432
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0006 0.0003 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0176 0.3432
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0532 0.8144
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.4265 0.6898
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0497 1
Trichomonas vaginalis helicase, putative 0.0007 0.0013 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0075 0.0124
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Brugia malayi hypothetical protein 0.0026 0.025 0.0405
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0006 0.0003 0.0005
Schistosoma mansoni tyrosine kinase 0.0006 0.0012 0.002
Echinococcus granulosus dna polymerase kappa 0.002 0.0176 0.0291
Loa Loa (eye worm) hypothetical protein 0.0512 0.6184 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0482 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0065 0.0065
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0008 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0075 0.0121
Leishmania major DNA polymerase eta, putative 0.0046 0.0497 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0372 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0075 0.0075
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0008 0.0013
Schistosoma mansoni hypothetical protein 0.0162 0.1911 0.3159
Brugia malayi hypothetical protein 0.0074 0.0831 0.1343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0075 0.0121
Onchocerca volvulus Tyrosine kinase homolog 0.0006 0.0012 0.0327
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0094
Mycobacterium tuberculosis Conserved protein 0.0036 0.0372 0.0764
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0008 0.0014
Echinococcus granulosus TGF beta receptor type 1 0.0191 0.2271 0.3754
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Brugia malayi nuclear receptor NHR-88 0.0012 0.0075 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0162 0.1911 0.309
Brugia malayi hypothetical protein 0.0006 0.0008 0.0013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0075 0.0075
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0228 0.0377
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0075 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0094
Schistosoma mansoni protein kinase 0.0088 0.1006 0.1663
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0228 0.0369
Brugia malayi MH1 domain containing protein 0.0024 0.0228 0.0369
Brugia malayi nuclear receptor RXR 0.0006 0.0008 0.0013
Schistosoma mansoni cpg binding protein 0.0031 0.0306 0.0506
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0532 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Echinococcus multilocularis dna polymerase eta 0.0046 0.0497 0.0497
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0372 0.0614
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0176 0.3206
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0075 0.0124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0075 0.0121
Echinococcus granulosus cpg binding protein 0.0031 0.0306 0.0506
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0162 0.1911 0.1911
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0008 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0075 0.0124
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0372 1
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.197 0.3186
Brugia malayi MH1 domain containing protein 0.0013 0.0096 0.0156
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0008 0.0013
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0042 0.0068
Schistosoma mansoni hypothetical protein 0.035 0.4206 0.6954
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0176 0.0291
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0065 0.0107
Loa Loa (eye worm) nuclear factor I 0.0013 0.0096 0.0156
Echinococcus multilocularis geminin 0.0501 0.6049 0.6049
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0532 0.8144
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0329 0.6568
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0176 0.3206
Loa Loa (eye worm) latrophilin receptor protein 2 0.0162 0.1911 0.309
Trypanosoma brucei unspecified product 0.002 0.0176 0.3432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.025 0.3764
Entamoeba histolytica hypothetical protein 0.0219 0.2603 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Echinococcus granulosus Smad4 0.0024 0.0228 0.0377
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0532 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0176 0.3432
Brugia malayi bone morphogenetic protein type 1 receptor 0.0193 0.2288 0.37
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.4265 0.6898
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.025 0.4955
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0228 0.0377
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0075 0.0075
Toxoplasma gondii ABC1 family protein 0.0036 0.0372 0.5649
Mycobacterium ulcerans hypothetical protein 0.0036 0.0372 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0372 0.0601
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0094
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0075 0.2019
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0372 0.0764
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0075 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0075 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0497 0.0803
Echinococcus granulosus activin receptor type 0.0088 0.101 0.1669
Schistosoma mansoni DNA polymerase eta 0.0046 0.0497 0.0821
Schistosoma mansoni zinc finger protein 0.0006 0.0003 0.0005
Echinococcus multilocularis TGF beta receptor type 1 0.0191 0.2271 0.2271
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0065 0.0107
Brugia malayi beta-lactamase family protein 0.0036 0.0372 0.0601
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0372 0.0764
Loa Loa (eye worm) acetyltransferase 0.0167 0.197 0.3186
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.197 0.3257
Onchocerca volvulus 0.0036 0.0372 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0372 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0101 0.1887
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.0094
Echinococcus granulosus dna polymerase eta 0.0046 0.0497 0.0821
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0075 0.0124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0372 0.6937
Echinococcus multilocularis smad 0.0024 0.0228 0.0228
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0074 0.0834 0.1349
Brugia malayi MH2 domain containing protein 0.0024 0.0228 0.0369
Brugia malayi polk-prov protein 0.0006 0.0008 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0512 0.6184 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0228 0.0377
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0372 0.5
Echinococcus multilocularis dna polymerase kappa 0.002 0.0176 0.0176
Schistosoma mansoni smad 0.0024 0.0228 0.0377
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0228 0.0228
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0075 0.0125
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0008 0.0013
Brugia malayi MH2 domain containing protein 0.0024 0.0228 0.0369
Mycobacterium leprae Probable lipase LipE 0.0036 0.0372 0.5
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.197 0.197
Schistosoma mansoni smad1 5 8 and 0.0024 0.0228 0.0377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0105
Brugia malayi MH1 domain containing protein 0.0013 0.0096 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0075 0.0121
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0228 0.0369
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0193 0.2288 0.37
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0075 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0372 0.7437
Onchocerca volvulus 0.0012 0.0075 0.2019
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0086 0.0989 0.0989
Brugia malayi hypothetical protein 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0651 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0372 0.0601
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0075 0.0124
Schistosoma mansoni Smad4 0.0024 0.0228 0.0377
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0065 0.0105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0075 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0075 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0372 0.0764
Loa Loa (eye worm) hypothetical protein 0.0036 0.0372 0.0601
Schistosoma mansoni protein kinase 0.0191 0.2271 0.3754
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0372 0.0601
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0008 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0075 0.0124
Entamoeba histolytica hypothetical protein 0.0219 0.2603 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0176 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0075 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0512 0.6184 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0372 0.0764
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Entamoeba histolytica hypothetical protein 0.0219 0.2603 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0075 0.0075
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0021 0.0021
Trichomonas vaginalis esterase, putative 0.0036 0.0372 0.6939
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0065 0.1747
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0176 0.3432
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0372 0.0764
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0075 0.0124
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0329 0.4989
Brugia malayi nuclear hormone receptor 0.0012 0.0075 0.0121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0075 0.0124

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 10000 nM Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA ChEMBL. 20919678
IC50 (binding) > 5000 nM Inhibition of PDGFRalpha ChEMBL. 20919678
IC50 (binding) > 50000 nM Inhibition of TGFbeta receptor ChEMBL. 20919678

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.