Detailed information for compound 1247800

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.436 | Formula: C22H22N4O
  • H donors: 0 H acceptors: 2 LogP: 4.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1c(nn(c1/N=C/N1CCCCC1)c1ccccc1)c1ccccc1
  • InChi: 1S/C22H22N4O/c27-16-20-21(18-10-4-1-5-11-18)24-26(19-12-6-2-7-13-19)22(20)23-17-25-14-8-3-9-15-25/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2/b23-17+
  • InChiKey: JAUMHQQIXMURTF-HAVVHWLPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 alpha 0.0102 0.0739 0.5128
Mycobacterium leprae Probable lipase LipE 0.0183 0.1441 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0215 0.0884
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.006 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Schistosoma mansoni nuclear hormone receptor 0.002 0.0028 0.0197
Mycobacterium leprae conserved hypothetical protein 0.0183 0.1441 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0028 0.0079
Brugia malayi glutathione reductase 0.0049 0.0277 0.0774
Onchocerca volvulus 0.0183 0.1441 0.3521
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0028 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0261 0.181
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0167
Echinococcus granulosus tar DNA binding protein 0.0064 0.0404 0.1196
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0404 0.2801
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0387 0.2685
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1071 0.4413
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0028 0.0084
Trypanosoma brucei trypanothione reductase 0.0049 0.0277 0.0888
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0261 0.181
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0821 0.5512
Brugia malayi RNA binding protein 0.0064 0.0404 0.1128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1071 0.4253
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0316 0.0883
Toxoplasma gondii thioredoxin reductase 0.0049 0.0277 0.1923
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0028 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0028 0.0079
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0404 0.1128
Trypanosoma brucei hypothetical protein, conserved 0.0183 0.1441 0.582
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0102 0.0739 0.219
Mycobacterium tuberculosis Probable esterase LipL 0.0183 0.1441 0.1435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0316 0.0883
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0169 0.0473
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0183 0.1441 0.1435
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0316 0.0883
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0929 0.0922
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.0278
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0028 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0028 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0387 0.2685
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0929 0.0922
Toxoplasma gondii hypothetical protein 0.0048 0.0268 0.1859
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0028 0.0079
Mycobacterium ulcerans lipase LipD 0.0183 0.1441 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0387 0.2685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0028 0.0079
Onchocerca volvulus 0.002 0.0028 0.0069
Onchocerca volvulus 0.0024 0.006 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0739 0.2065
Loa Loa (eye worm) hypothetical protein 0.0183 0.1441 0.4027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0028 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0261 0.0729
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.2435
Schistosoma mansoni coup transcription factor 0.002 0.0028 0.0197
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2427 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Mycobacterium ulcerans hypothetical protein 0.0024 0.006 0.0365
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0028 0.0197
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2427 1
Brugia malayi beta-lactamase family protein 0.0183 0.1441 0.4027
Onchocerca volvulus 0.0062 0.0387 0.0945
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0404 0.2801
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0028 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0028 0.0079
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0263
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0028 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0028 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0028 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.006 0.0365
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0028 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0028 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0028 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0028 0.0079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0183 0.1441 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0404 0.1128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0261 0.0773
Brugia malayi hypothetical protein 0.0025 0.0067 0.0189
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0404 0.1128
Leishmania major hypothetical protein, conserved 0.0025 0.0067 0.0278
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.002
Toxoplasma gondii ABC1 family protein 0.0183 0.1441 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0028 0.0197
Brugia malayi ecdysteroid receptor 0.002 0.0028 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0261 0.0729
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0007 0.5
Plasmodium vivax glutathione reductase, putative 0.0049 0.0277 0.1923
Loa Loa (eye worm) glutathione reductase 0.0049 0.0277 0.0774
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0028 0.0197
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0167
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Loa Loa (eye worm) beta-lactamase 0.0183 0.1441 0.4027
Leishmania major hypothetical protein, conserved 0.0183 0.1441 0.5936
Schistosoma mansoni hypothetical protein 0.0082 0.0563 0.3908
Echinococcus granulosus beta LACTamase domain containing family member 0.0183 0.1441 0.4271
Onchocerca volvulus 0.049 0.4093 1
Brugia malayi TAR-binding protein 0.0064 0.0404 0.1128
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.006 0.0365
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0277 0.1923
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0277 0.0821
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0051
Plasmodium falciparum glutathione reductase 0.0049 0.0277 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0387 0.2685
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0028 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0183 0.1441 0.1435
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0404 0.2801
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0028 0.0079
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0028 0.0197
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0183 0.1441 0.4027
Brugia malayi nuclear hormone receptor 0.002 0.0028 0.0079
Brugia malayi Thioredoxin reductase 0.0049 0.0277 0.0774
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.006 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0183 0.1441 0.1435
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0821 0.0814
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0387 0.1147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0215 0.0884
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0028 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.002
Mycobacterium ulcerans hypothetical protein 0.0157 0.1209 0.8381
Loa Loa (eye worm) hypothetical protein 0.0183 0.1441 0.4027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.006 0.0365
Echinococcus multilocularis beta LACTamase domain containing family member 0.0183 0.1441 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.0278
Trichomonas vaginalis set domain proteins, putative 0.049 0.4093 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0028 0.0079
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0028 0.0197
Leishmania major trypanothione reductase 0.0049 0.0277 0.1142
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0067 0.0468
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0028 0.0197
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2427 1
Plasmodium vivax SET domain protein, putative 0.0062 0.0387 0.2685
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1071 0.4413
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0404 0.2801
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0821 0.0814
Brugia malayi AMP-binding enzyme family protein 0.0024 0.006 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0028 0.0079
Loa Loa (eye worm) hypothetical protein 0.0183 0.1441 0.4027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0215 0.0884
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0067 0.0468
Loa Loa (eye worm) hypothetical protein 0.0102 0.0739 0.2065
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0277 0.0774
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0028 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0404 0.2801
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.2435
Brugia malayi Pre-SET motif family protein 0.0062 0.0387 0.1081
Onchocerca volvulus 0.0183 0.1441 0.3521
Mycobacterium tuberculosis Probable hydrolase 0.0183 0.1441 0.1435
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0404 0.2801
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0215 0.0624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0028 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.006 0.0246
Mycobacterium tuberculosis Conserved protein 0.0183 0.1441 0.1435
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0028 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0028 0.0197
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.006 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0739 0.2065
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2427 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.006 0.0365
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0102 0.0739 0.5128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0261 0.0773
Mycobacterium tuberculosis Probable reductase 0.0112 0.0821 0.0814
Mycobacterium tuberculosis Conserved protein 0.0183 0.1441 0.1435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0261 0.181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0028 0.0079
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.006 0.5
Mycobacterium ulcerans hypothetical protein 0.0183 0.1441 1
Mycobacterium tuberculosis Probable lipase LipD 0.0183 0.1441 0.1435
Brugia malayi Pre-SET motif family protein 0.043 0.3578 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0028 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0277 0.027
Brugia malayi beta-lactamase 0.0183 0.1441 0.4027
Onchocerca volvulus 0.0183 0.1441 0.3521
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0387 0.2685
Brugia malayi AMP-binding enzyme family protein 0.0024 0.006 0.0167
Plasmodium falciparum thioredoxin reductase 0.0049 0.0277 1
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0277 0.1142
Trypanosoma cruzi hypothetical protein, conserved 0.0183 0.1441 0.5936
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0183 0.1441 0.1435
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0387 0.2685
Plasmodium vivax hypothetical protein, conserved 0.0183 0.1441 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0183 0.1441 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0028 0.0069
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0821 0.0814
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0183 0.1441 0.4027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0387 0.1081
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0821 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0028 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0821 0.0814
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0028 0.0079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0028 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.006 0.0365
Schistosoma mansoni hypothetical protein 0.0037 0.0169 0.1176
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0167
Mycobacterium ulcerans beta-lactamase 0.0183 0.1441 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0028 0.0197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0261 0.181
Loa Loa (eye worm) RNA binding protein 0.0064 0.0404 0.1128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0316 0.0883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0028 0.0079
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0294 0.121
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0929 0.0922
Loa Loa (eye worm) hypothetical protein 0.0183 0.1441 0.4027
Brugia malayi AMP-binding enzyme family protein 0.0024 0.006 0.0167
Brugia malayi steroid hormone receptor 0.002 0.0028 0.0079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0028 0.0069
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0028 0.0197
Brugia malayi beta-lactamase family protein 0.0183 0.1441 0.4027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1209 0.1202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.006 0.0052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0367 0.1089
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0028 0.0079
Mycobacterium ulcerans esterase/lipase LipP 0.0183 0.1441 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.1441 0.4027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.3578 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.1441 0.4027
Trypanosoma cruzi hypothetical protein, conserved 0.0183 0.1441 0.5936
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0102 0.0739 0.5128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0028 0.0197
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0028 0.0084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0929 0.6294
Echinococcus granulosus FTZ F1 alpha 0.0407 0.3374 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0183 0.1441 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.006 0.0365
Schistosoma mansoni thyroid hormone receptor 0.002 0.0028 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0079
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.006 0.0365
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.006 0.5
Mycobacterium tuberculosis Conserved protein 0.0183 0.1441 0.1435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0261 0.181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0028 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0387 0.2685
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0028 0.0197
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0277 0.1923

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 17.7 uM Growth inhibition of human NCI-H661 cells after 72 hrs by MTT assay ChEMBL. 20855206
GI50 (functional) = 29 uM Growth inhibition of human Jurkat cells after 72 hrs by MTT assay ChEMBL. 20855206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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