TDR Targets

Basic information

Technical information

TDR Targets ID: 1247833
Name: 2-(2,4-dichlorophenyl)sulfanyl-N-(4-methylpip erazin-1-yl)acetamide
MW: 334.265 | Formula: C13H17Cl2N3OS
H donors: 1 H acceptors: 1 LogP: 3.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)NC(=O)CSc1ccc(cc1Cl)Cl
InChi: 1S/C13H17Cl2N3OS/c1-17-4-6-18(7-5-17)16-13(19)9-20-12-3-2-10(14)8-11(12)15/h2-3,8H,4-7,9H2,1H3,(H,16,19)
InChiKey: DYAGELMQYPZBOS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(2,4-dichlorophenyl)thio]-N-(4-methyl-1-piperazinyl)acetamide
2-[(2,4-dichlorophenyl)thio]-N-(4-methylpiperazin-1-yl)acetamide
2-(2,4-dichlorophenyl)sulfanyl-N-(4-methylpiperazin-1-yl)ethanamide
T0506-1913
Oprea1_761691
MLS001017413
SMR000353644

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Inositol monophosphatase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma brucei gambiense	inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trichomonas vaginalis	myo inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania infantum	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma congolense	inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	Get druggable targets OG5_126810	All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_126810	All targets in OG5_126810
Trichomonas vaginalis	inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Neospora caninum	hypothetical protein	Get druggable targets OG5_126810	All targets in OG5_126810
Echinococcus granulosus	inositol monophosphatase 1	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania donovani	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Loa Loa (eye worm)	inositol-1	Get druggable targets OG5_126810	All targets in OG5_126810
Entamoeba histolytica	myo-inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Mycobacterium ulcerans	extragenic suppressor protein SuhB	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma japonicum	ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	inositol monophosphatase	Get druggable targets OG5_126810	All targets in OG5_126810
Brugia malayi	Inositol-1	Get druggable targets OG5_126810	All targets in OG5_126810
Schistosoma mansoni	inositol monophosphatase	Get druggable targets OG5_126810	All targets in OG5_126810
Trichomonas vaginalis	myo inositol monophosphatase, putative	Get druggable targets OG5_126810	All targets in OG5_126810
Echinococcus multilocularis	inositol monophosphatase 1	Get druggable targets OG5_126810	All targets in OG5_126810
Leishmania mexicana	myo-inositol-1(or 4)-monophosphatase 1, putative	Get druggable targets OG5_126810	All targets in OG5_126810

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Inositol monophosphatase family protein	Inositol monophosphatase 1	277 aa	238 aa	21.8 %
Trypanosoma congolense	inositol-1(or 4)-monophosphatase, putative	Inositol monophosphatase 1	277 aa	304 aa	28.9 %
Entamoeba histolytica	3(2),5-bisphosphate nucleotidase, putative	Inositol monophosphatase 1	277 aa	287 aa	22.3 %
Onchocerca volvulus	Putative 28S ribosomal protein S10, mitochondrial	Inositol monophosphatase 1	277 aa	271 aa	46.1 %
Schistosoma mansoni	pap-inositol-14-phosphatase	Inositol monophosphatase 1	277 aa	279 aa	22.9 %
Trichomonas vaginalis	inositol monophosphatase, putative	Inositol monophosphatase 1	277 aa	258 aa	21.7 %
Trichomonas vaginalis	diphosphonucleoside phosphohydrolase, putative	Inositol monophosphatase 1	277 aa	263 aa	21.7 %
Onchocerca volvulus		Inositol monophosphatase 1	277 aa	238 aa	22.7 %
Candida albicans	one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt	Inositol monophosphatase 1	277 aa	306 aa	22.5 %
Onchocerca volvulus	Putative trans-2-enoyl-CoA reductase 1, mitochondrial	Inositol monophosphatase 1	277 aa	278 aa	23.0 %
Trypanosoma brucei	inositol-1(or 4)-monophosphatase, putative	Inositol monophosphatase 1	277 aa	304 aa	27.3 %
Candida albicans	one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt	Inositol monophosphatase 1	277 aa	300 aa	22.0 %
Dictyostelium discoideum	3',5'-bisphosphate nucleotidase	Inositol monophosphatase 1	277 aa	230 aa	25.2 %
Trypanosoma cruzi	myo-inositol-1 phosphatase, putative	Inositol monophosphatase 1	277 aa	284 aa	30.6 %
Trichomonas vaginalis	inositol monophosphatase, putative	Inositol monophosphatase 1	277 aa	268 aa	22.4 %
Candida albicans	one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt	Inositol monophosphatase 1	277 aa	307 aa	22.5 %
Trypanosoma cruzi	inositol polyphosphate 1-phosphatase, putative	Inositol monophosphatase 1	277 aa	291 aa	23.7 %
Trichomonas vaginalis	myo inositol monophosphatase, putative	Inositol monophosphatase 1	277 aa	276 aa	21.4 %
Schistosoma japonicum	ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative	Inositol monophosphatase 1	277 aa	275 aa	21.5 %
Entamoeba histolytica	3(2),5-bisphosphate nucleotidase, putative	Inositol monophosphatase 1	277 aa	263 aa	24.0 %
Loa Loa (eye worm)	hypothetical protein	Inositol monophosphatase 1	277 aa	298 aa	23.8 %
Dictyostelium discoideum	3',5'-bisphosphate nucleotidase 1	Inositol monophosphatase 1	277 aa	275 aa	22.2 %
Trypanosoma brucei gambiense	inositol-1(or 4)-monophosphatase, putative	Inositol monophosphatase 1	277 aa	309 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0039	0.0555	0.0959
Trypanosoma brucei	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Brugia malayi	hypothetical protein	0.0123	0.2036	0.2036
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	expressed protein	0.0014	0.0118	0.0205
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2036	0.2036
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0014	0.0118	0.0205
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Leishmania major	ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0014	0.0118	0.0118
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0014	0.0118	0.0118
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0014	0.0118	0.0205
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0184	0.3094	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	hypothetical protein	0.0061	0.0932	0.1613
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0023	0.0023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0336	0.5781	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0012	0.0084	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0023	0.004
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0055	0.0838	0.145
Toxoplasma gondii	hypothetical protein	0.0012	0.0084	0.0411
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0336	0.5781	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Plasmodium vivax	ubiquitin specific protease, putative	0.0012	0.0084	0.0411
Giardia lamblia	Hypothetical protein	0.0012	0.0084	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0061	0.0932	0.1613
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0012	0.0084	0.1291
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0023	0.004
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0014	0.0118	0.0205
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0012	0.0084	0.0145
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0014	0.0118	0.0205
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	G protein alpha subunit, putative	0.0014	0.0118	0.1823
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0023	0.004
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0014	0.0118	0.0118
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0023	0.0023
Echinococcus multilocularis	ubiquitin specific protease 41	0.0012	0.0084	0.0145
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0012	0.0084	0.0145
Entamoeba histolytica	hypothetical protein	0.0012	0.0084	0.1291
Schistosoma mansoni	hypothetical protein	0.0061	0.0932	0.1613
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	tar DNA binding protein	0.0192	0.3242	0.5608
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 47	0.0012	0.0084	0.0145
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.3242	0.5608
Brugia malayi	MH1 domain containing protein	0.0022	0.0246	0.0246
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0119	0.0586
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0084	0.0145
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0119	0.0206
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0023	0.004
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 2, putative	0.0012	0.0084	0.0411
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Brugia malayi	RNA binding protein	0.0192	0.3242	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0118	0.0118
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0045	0.0649	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0014	0.0118	0.0118
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0014	0.0118	0.0118
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 14	0.0012	0.0084	0.0411
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0014	0.0118	0.0205
Schistosoma mansoni	inositol monophosphatase	0.0045	0.0649	0.1122
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0119	0.0206
Brugia malayi	G-protein alpha subunit	0.0014	0.0118	0.0118
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0014	0.0118	0.0205
Onchocerca volvulus		0.0014	0.0118	0.031
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	N-terminal motif family protein	0.0184	0.3094	0.3094
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0119	0.0586
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0119	0.0206
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 24	0.0012	0.0084	0.0145
Plasmodium falciparum	ataxin-2 like protein, putative	0.0123	0.2036	1
Schistosoma mansoni	hypothetical protein	0.0131	0.2172	0.3757
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0119	0.0119
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0018	0.0173	0.0299
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.004	0.0566	1
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase 46	0.0012	0.0084	0.0084
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0014	0.0118	0.0205
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0173	0.0173
Loa Loa (eye worm)	MH1 domain-containing protein	0.0039	0.0555	0.0555
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 36	0.0012	0.0084	0.0145
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0023	0.004
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0012	0.0084	0.0084
Schistosoma mansoni	dishevelled	0.0009	0.0023	0.004
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0014	0.0118	0.0205
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0084	0.0145
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0014	0.0118	0.0205
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0192	0.324	0.324
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0023	0.004
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Echinococcus granulosus	GPCR family 2	0.0061	0.0932	0.1613
Trypanosoma brucei	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0023	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0119	0.0206
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	smad	0.0039	0.0555	0.0959
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0118	0.0118
Schistosoma mansoni	ubiquitin-specific peptidase 30 (C19 family)	0.0012	0.0084	0.0145
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0014	0.0118	0.0118
Brugia malayi	MH2 domain containing protein	0.0039	0.0555	0.0555
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0336	0.5781	0.5781
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0014	0.0118	0.1823
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0014	0.0118	0.1823
Echinococcus multilocularis	ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase	0.0012	0.0084	0.0145
Giardia lamblia	DUB-1	0.0012	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Onchocerca volvulus		0.0012	0.0084	0.0198
Onchocerca volvulus		0.0012	0.0084	0.0198
Brugia malayi	hypothetical protein	0.008	0.1266	0.1266
Echinococcus granulosus	smad	0.0039	0.0555	0.0959
Echinococcus multilocularis	inositol monophosphatase 1	0.0045	0.0649	0.1122
Trypanosoma cruzi	PAB1-binding protein , putative	0.0123	0.2036	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 16	0.0012	0.0084	0.0145
Leishmania major	hypothetical protein, conserved	0.0123	0.2036	1
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.0012	0.0084	0.0145
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 36	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0023	0.0023
Schistosoma mansoni	calpain-7 (C02 family)	0.0012	0.0084	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0246	0.0246
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.3242	0.5608
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0119	0.0119
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0014	0.0118	0.0205
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.0012	0.0084	0.0145
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 47	0.0012	0.0084	0.0145
Trypanosoma cruzi	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0192	0.324	0.324
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 23	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0012	0.0084	0.1291
Toxoplasma gondii	UBA/TS-N domain-containing protein	0.0012	0.0084	0.0411
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 16	0.0012	0.0084	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0118	0.0118
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.1291
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0014	0.0118	0.0205
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0012	0.0084	0.0145
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0084	0.0145
Echinococcus multilocularis	GPCR, family 2	0.0061	0.0932	0.1613
Schistosoma mansoni	ubiquitin-specific peptidase 24 (C19 family)	0.0012	0.0084	0.0145
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0119	0.0586
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 12	0.0012	0.0084	0.0145
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0061	0.0932	0.0932
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase	0.0012	0.0084	0.0145
Brugia malayi	hypothetical protein	0.0009	0.0023	0.0023
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Brugia malayi	MH2 domain containing protein	0.0018	0.0173	0.0173
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0014	0.0118	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.0023
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.0012	0.0084	0.0145
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 12	0.0012	0.0084	0.0145
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0119	0.0119
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0119	0.0206
Plasmodium falciparum	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0012	0.0084	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Schistosoma mansoni	ubiquitin-specific peptidase 48 (C19 family)	0.0012	0.0084	0.0145
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0084	0.0145
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0039	0.0555	0.0959
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0061	0.0932	0.1613
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	Ubiquitin carboxyl terminal hydrolase 48	0.0012	0.0084	0.0145
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0012	0.0084	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 45 (C19 family)	0.0012	0.0084	0.0145
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	hypothetical protein	0.0061	0.0932	0.1613
Schistosoma mansoni	dishevelled	0.0009	0.0023	0.004
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0012	0.0084	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0119	0.0206
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0336	0.5781	1
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0014	0.0118	0.0118
Toxoplasma gondii	LsmAD domain-containing protein	0.0123	0.2036	1
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0014	0.0118	0.0205
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	hypothetical protein	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	hypothetical protein	0.0014	0.0118	0.0118
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0014	0.0118	0.0118
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0023	0.004
Brugia malayi	latrophilin 2 splice variant baaae	0.0131	0.2172	0.2172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Trypanosoma cruzi	Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0014	0.0118	0.0205
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0014	0.0118	0.1823
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Echinococcus multilocularis	Ubiquitin carboxyl terminal hydrolase 48	0.0012	0.0084	0.0145
Schistosoma mansoni	family C19 unassigned peptidase (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	hypothetical protein	0.0061	0.0932	0.1613
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0118	0.0118
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.3242	0.5608
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Brugia malayi	MH1 domain containing protein	0.0022	0.0246	0.0246
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0084	0.0145
Echinococcus granulosus	ubiquitin specific protease 41	0.0012	0.0084	0.0145
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0014	0.0118	0.1823
Schistosoma mansoni	smad1 5 8 and	0.0039	0.0555	0.0959
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	mothers against decapentaplegic 5	0.0039	0.0555	0.0959
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Toxoplasma gondii	ubiquitin-specific protease USP4	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Echinococcus multilocularis	expressed protein	0.0012	0.0084	0.0145
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0045	0.0649	0.3186
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold	0.0012	0.0084	0.0145
Echinococcus granulosus	inositol monophosphatase 1	0.0045	0.0649	0.1122
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Plasmodium falciparum	ubiquitin specific protease, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	calpain-7 (C02 family)	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Schistosoma mansoni	dep domain containing protein	0.0009	0.0023	0.004
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0119	0.0586
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 24	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	Smad4	0.0039	0.0555	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	MH2 domain containing protein	0.0039	0.0555	0.0555
Echinococcus multilocularis	Smad4	0.0039	0.0555	0.0959
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma brucei	PAB1-binding protein , putative	0.0123	0.2036	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0045	0.0649	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Brugia malayi	DIX domain containing protein	0.0009	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0084	0.0145
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0014	0.0118	0.0118
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0649	0.3186
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	MH1 domain containing protein	0.0039	0.0555	0.0555
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.0012	0.0084	0.0145
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0014	0.0118	0.0205
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 20	0.0012	0.0084	0.0145
Echinococcus granulosus	ubiquitin specific peptidase 30 (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0018	0.0173	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0932	0.0932
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	tar DNA binding protein	0.0192	0.3242	0.5608
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 14	0.0012	0.0084	0.0145
Brugia malayi	MH1 domain containing protein	0.0039	0.0555	0.0555
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 2, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0039	0.0555	0.0959
Loa Loa (eye worm)	RNA binding protein	0.0192	0.3242	0.3242
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0119	0.0206
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0061	0.0932	0.1613
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0014	0.0118	0.0205
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0014	0.0118	0.1823
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0336	0.5781	1
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	MH2 domain-containing protein	0.0576	1	1
Schistosoma mansoni	smad	0.0018	0.0173	0.0299
Schistosoma mansoni	ubiquitin-specific peptidase 46 (C19 family)	0.0012	0.0084	0.0145
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 1, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0014	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0119	0.0586
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 14 (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0012	0.0084	0.1291
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0184	0.3094	0.3094
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0119	0.0586
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Brugia malayi	ubiquitin carboxyl-terminal hydrolase 46	0.0012	0.0084	0.0084
Schistosoma mansoni	inositol monophosphatase	0.0045	0.0649	0.1122
Schistosoma mansoni	Smad4	0.0018	0.0173	0.0299
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0023	0.004
Plasmodium falciparum	ubiquitin specific protease, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	Smad4	0.0018	0.0173	0.0299
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.0012	0.0084	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0131	0.2172	0.2172
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Onchocerca volvulus		0.0014	0.0118	0.031
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0014	0.0118	0.0118
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Loa Loa (eye worm)	TAR-binding protein	0.0192	0.3242	0.3242
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	hypothetical protein	0.0012	0.0084	0.0084
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0023	0.004
Plasmodium vivax	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0012	0.0084	0.0411
Echinococcus granulosus	Smad4	0.0039	0.0555	0.0959
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0014	0.0118	0.0118
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0012	0.0084	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0336	0.5781	0.5781
Loa Loa (eye worm)	G protein alpha subunit 3	0.0014	0.0118	0.0118
Echinococcus multilocularis	expressed protein	0.0014	0.0118	0.0205
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase family 2, putative	0.0012	0.0084	0.0411
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0119	0.0586
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.004	0.0566	0.5
Schistosoma mansoni	hypothetical protein	0.0055	0.0838	0.145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Brugia malayi	Smad1	0.0039	0.0555	0.0555
Schistosoma mansoni	ubiquitin-specific peptidase 42 (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase family 2 protein	0.0012	0.0084	0.0411
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0023	0.0023
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0014	0.0118	0.0205
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	smad	0.0039	0.0555	0.0959
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0192	0.324	0.324
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0014	0.0118	0.0118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0336	0.5781	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0045	0.0649	0.5
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0014	0.0118	0.0205
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0061	0.0932	0.1613
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0192	0.324	0.324
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0014	0.0118	0.0205
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0014	0.0118	0.1823
Brugia malayi	Inositol-1	0.0045	0.0649	0.0649
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0336	0.5781	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Brugia malayi	Latrophilin receptor protein 2	0.0061	0.0932	0.0932
Onchocerca volvulus		0.0014	0.0118	0.031
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0119	0.0586
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0649	0.3186
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0012	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0012	0.0084	0.0411
Brugia malayi	mothers against decapentaplegic homolog 3	0.0018	0.0173	0.0173
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	smad1 5 8 and	0.0039	0.0555	0.0959
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0119	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 5	0.0012	0.0084	0.0145
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0039	0.0555	0.0959
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0118	0.0118
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Toxoplasma gondii	ubiquitin specific protease 39 isoform 2, putative	0.0012	0.0084	0.0411
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 14	0.0012	0.0084	0.0145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0336	0.5781	1
Schistosoma mansoni	ubiquitin-specific peptidase 16 (C19 family)	0.0012	0.0084	0.0145
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0649	0.3186
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0045	0.0649	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Brugia malayi	RNA recognition motif domain containing protein	0.0192	0.3242	0.3242
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0018	0.0173	0.0488
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 7 (C19 family)	0.0012	0.0084	0.0145
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0023	0.004
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0012	0.0084	0.0145
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.3242	0.5608
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0084	0.0084
Loa Loa (eye worm)	inositol-1	0.0045	0.0649	0.0649
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0061	0.0932	0.0932
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0649	0.3186
Brugia malayi	ubiquitin specific protease 14	0.0012	0.0084	0.0084
Schistosoma mansoni	peptidase	0.0012	0.0084	0.0145
Loa Loa (eye worm)	transcription factor SMAD2	0.0576	1	1
Schistosoma mansoni	smad1 5 8 and	0.0039	0.0555	0.0959
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 20	0.0012	0.0084	0.0145
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0023	0.004
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0084	0.0411
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin specific peptidase c family	0.0012	0.0084	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trypanosoma cruzi	PAB1-binding protein , putative	0.0123	0.2036	1
Toxoplasma gondii	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0411
Echinococcus granulosus	mothers against decapentaplegic 2	0.0018	0.0173	0.0299
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Toxoplasma gondii	hypothetical protein	0.0009	0.0023	0.0113
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase	0.0012	0.0084	0.0145
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Echinococcus multilocularis	ubiquitin specific peptidase 42 (C19 family)	0.0012	0.0084	0.0145
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0084	0.0145
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0014	0.0118	0.0205
Plasmodium falciparum	ataxin-2 like protein, putative	0.0123	0.2036	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0084	0.0084
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma cruzi	ubiquitin hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0055	0.0838	0.145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0014	0.0118	0.0205
Echinococcus granulosus	mothers against decapentaplegic 6	0.0018	0.0173	0.0299
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0014	0.0118	0.1823
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	inositol monophosphatase, putative	0.0045	0.0649	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	Smad1	0.0039	0.0555	0.0555
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0012	0.0084	0.1291
Loa Loa (eye worm)	nuclear factor I	0.0022	0.0246	0.0246
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Brugia malayi	hypothetical protein	0.0009	0.0023	0.0023
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0014	0.0118	0.0205
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0023	0.004
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0045	0.0649	1
Schistosoma mansoni	ubiquitin-specific peptidase 10 (C19 family)	0.0012	0.0084	0.0145
Echinococcus granulosus	5'partial\|Ubiquitin carboxyl terminal hydrolase 48	0.0012	0.0084	0.0145
Plasmodium vivax	ataxin-2 like protein, putative	0.0123	0.2036	1
Brugia malayi	TAR-binding protein	0.0192	0.3242	0.3242
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0014	0.0118	0.0205
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0014	0.0118	0.1823
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0192	0.3242	0.3242
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.3242	0.5608
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0084	0.0411
Schistosoma mansoni	ubiquitin-specific peptidase 4 (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Schistosoma mansoni	ubiquitin-specific peptidase 22 (C19 family)	0.0012	0.0084	0.0145
Onchocerca volvulus		0.0012	0.0084	0.0198
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0084	0.0084
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0012	0.0084	0.0145
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291
Loa Loa (eye worm)	MH2 domain-containing protein	0.0039	0.0555	0.0555
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0084	0.1291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0084	0.1291

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1321428

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1247833