Detailed information for compound 1248539

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 382.843 | Formula: C20H19ClN4O2
  • H donors: 3 H acceptors: 4 LogP: 2.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNc1ccc(c(n1)C)C(=O)Nc1ccc(c(c1)c1ccccn1)Cl
  • InChi: 1S/C20H19ClN4O2/c1-13-15(6-8-19(24-13)23-10-11-26)20(27)25-14-5-7-17(21)16(12-14)18-4-2-3-9-22-18/h2-9,12,26H,10-11H2,1H3,(H,23,24)(H,25,27)
  • InChiKey: NVWIOXPZVQAFHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.017 0.0443
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0013 0.0013
Onchocerca volvulus 0.0111 0.0574 0.2063
Schistosoma mansoni hypothetical protein 0.0645 0.383 0.9621
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0253 0.0635
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0065
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0465 0.2733 0.6866
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0049 0.1427
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0111 0.0574 0.1498
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0173 0.095 0.248
Echinococcus granulosus tar DNA binding protein 0.0064 0.0288 0.0464
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0056 0.0174
Onchocerca volvulus 0.0025 0.0049 0.0177
Plasmodium vivax glutathione reductase, putative 0.0039 0.0134 0.2155
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0056 0.0767
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0049 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0288 0.0723
Brugia malayi nuclear receptor NHR-88 0.0021 0.0026 0.008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0574 0.1498
Schistosoma mansoni ran 0.0044 0.017 0.0426
Giardia lamblia DNA repair protein RAD52 0.0351 0.2035 1
Trichomonas vaginalis glutaminase, putative 0.0543 0.3208 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0026 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.1437 0.3751
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0056 0.0034
Toxoplasma gondii ABC1 family protein 0.0111 0.0574 0.9012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0435 0.0739
Onchocerca volvulus Alhambra homolog 0.0058 0.0253 0.0909
Echinococcus granulosus biogenic amine 5HT receptor 0.0254 0.1445 0.2328
Onchocerca volvulus 0.0111 0.0574 0.2063
Brugia malayi TATA binding protein associated factor 0.0025 0.0049 0.0153
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0435 0.0739
Echinococcus granulosus peregrin 0.0058 0.0253 0.0407
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0049 0.0582
Loa Loa (eye worm) glutathione reductase 0.0039 0.0134 0.0349
Brugia malayi Thioredoxin reductase 0.0039 0.0134 0.0417
Echinococcus granulosus microtubule associated protein 2 0.067 0.3981 0.6414
Schistosoma mansoni hypothetical protein 0.008 0.0385 0.0967
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0026 0.0092
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.017 0.2517
Trypanosoma brucei trypanothione reductase 0.0039 0.0134 0.2155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0026 0.0041
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0203
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0056 0.0691
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0081 0.0211
Schistosoma mansoni hypothetical protein 0.0058 0.0253 0.0635
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0049 0.0646
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0392 0.0631
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0036
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0111 0.0574 0.1498
Echinococcus granulosus cpg binding protein 0.0032 0.0091 0.0147
Brugia malayi jmjC domain containing protein 0.019 0.1059 0.3301
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0013 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0026 0.0026
Echinococcus granulosus neuropeptide receptor A26 0.0553 0.3268 0.5265
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0465 0.2733 0.2733
Echinococcus multilocularis GPCR, family 2 0.008 0.0385 0.0385
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0574 1
Schistosoma mansoni cpg binding protein 0.0032 0.0091 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0635 0.1596
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0056 0.0767
Mycobacterium ulcerans hypothetical protein 0.0111 0.0574 0.1661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0465 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0026 0.008
Leishmania major importin beta-1 subunit, putative 0.0049 0.0197 0.296
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0026 0.008
Schistosoma mansoni jumonji domain containing protein 0.0151 0.0821 0.2061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0026 0.0067
Brugia malayi TAR-binding protein 0.0064 0.0288 0.0897
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0574 0.0925
Echinococcus multilocularis importin subunit beta 1 0.006 0.0267 0.0267
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0056 0.014
Mycobacterium tuberculosis Conserved protein 0.0111 0.0574 0.1079
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0137 0.0137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0026 0.0064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.0161 0.0881 0.23
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0197 0.3284
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0056 0.0146
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0574 0.1661
Brugia malayi jmjC domain containing protein 0.0072 0.0338 0.1053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0056 0.014
Brugia malayi hypothetical protein 0.0231 0.1307 0.4073
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.017 0.017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0026 0.0026
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.008 0.0385 0.0967
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0265 0.0667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0026 0.008
Echinococcus multilocularis snurportin 1 0.0645 0.383 0.383
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0049 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0574 1
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.004
Schistosoma mansoni hypothetical protein 0.0515 0.3035 0.7623
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0049 0.0079
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0026 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0635 0.1024
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0288 0.0897
Brugia malayi Pre-SET motif family protein 0.0416 0.2432 0.7581
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0635 0.1229
Brugia malayi steroid hormone receptor 0.0021 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.006 0.0267 0.0697
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0049 0.0123
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0435 0.0739
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0574 0.1661
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0034
Trichomonas vaginalis chaperonin, putative 0.0026 0.0056 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0026 0.0067
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.0152 0.0822 0.2146
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0265 0.4056
Entamoeba histolytica Ran family GTPase 0.0044 0.017 0.0606
Loa Loa (eye worm) RNA binding protein 0.0064 0.0288 0.0751
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0338 0.0849
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.017 0.0528
Schistosoma mansoni hypothetical protein 0.0515 0.3035 0.7623
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0049 0.0646
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0574 0.1661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0049 0.0646
Onchocerca volvulus 0.0047 0.0186 0.0668
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0288 0.0723
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0253 0.3855
Brugia malayi RNA, U transporter 1 0.0172 0.0946 0.2948
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0049 0.0646
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0465 0.2733 0.7137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0026 0.0064
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0049 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0385 0.0385
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.1437 0.4477
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0267 0.4526
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0111 0.0574 0.1498
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0049 0.0079
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0026 0.0026
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0197 0.0468
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0265 0.0265
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0338 0.0544
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0574 1
Echinococcus multilocularis serotonin receptor 0.0254 0.1445 0.1445
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0056 0.0056
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0056 0.0691
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0049 0.1427
Schistosoma mansoni glutaminase 0.0543 0.3208 0.806
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0026 0.008
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0026 0.0064
Schistosoma mansoni importin beta-1 0.006 0.0267 0.067
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0049 0.0646
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0495 0.0886
Giardia lamblia PHD finger protein 15 0.0058 0.0253 0.0995
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0013 0.0021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0049 0.0049
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0435 0.0739
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.017 0.2793
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0073 0.0183
Echinococcus granulosus tumor protein p63 0.1035 0.6206 1
Onchocerca volvulus 0.0025 0.0049 0.0177
Brugia malayi glutathione reductase 0.0039 0.0134 0.0417
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0013 0.0032
Echinococcus granulosus phd:f box containing protein 0.0019 0.0013 0.0021
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0574 0.1079
Schistosoma mansoni ran 0.0044 0.017 0.0426
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0049 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.095 0.2961
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0013 0.0013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0049 0.0079
Schistosoma mansoni survival motor neuron protein 0.0047 0.0186 0.0467
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0465 0.0749
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0049 0.0646
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0128
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0026 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0465 0.0465
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0574 0.1442
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0299 0.0751
Schistosoma mansoni biogenic amine (5HT) receptor 0.0254 0.1445 0.3629
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0049 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0152 0.0822 0.2064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0128
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.017 0.617
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0026 0.0041
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0049 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0288 0.0723
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0049 0.0128
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0014 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0026 0.008
Brugia malayi PHD-finger family protein 0.0021 0.0025 0.0077
Toxoplasma gondii thioredoxin reductase 0.0039 0.0134 0.1942
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.017 0.2793
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0128
Brugia malayi AF-10 protein 0.0019 0.0014 0.0045
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0049 0.0646
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.017 0.2793
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0111 0.0574 0.1498
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0197 0.0468
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0026 0.0026
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0574 0.1661
Echinococcus granulosus neuropeptide s receptor 0.0553 0.3268 0.5265
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.019 0.1059 0.1706
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0049 0.0646
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0635 0.1856
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0231 0.1307 0.3412
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0574 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0026 0.008
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0635 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0351 0.2035 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0025 0.0495
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0049 0.0049
Onchocerca volvulus 0.003 0.0081 0.0291
Brugia malayi hypothetical protein 0.0025 0.0049 0.0153
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0137 0.0221
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0267 0.4526
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0049 0.0049
Brugia malayi nuclear hormone receptor 0.0021 0.0026 0.008
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0049 0.0646
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0465 0.1214
Brugia malayi beta-lactamase family protein 0.0111 0.0574 0.1789
Mycobacterium ulcerans glutaminase 0.0543 0.3208 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0288 0.0751
Mycobacterium tuberculosis Conserved protein 0.0111 0.0574 0.1079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0026 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0026 0.0026
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0083 0.026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0574 0.1789
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.019 0.1059 0.1059
Loa Loa (eye worm) hypothetical protein 0.0254 0.1445 0.3772
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0465 0.0749
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0288 0.0723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0635 1
Leishmania major hypothetical protein, conserved 0.0111 0.0574 0.9012
Echinococcus granulosus leukotriene A 4 hydrolase 0.0465 0.2733 0.4404
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0134 0.2155
Leishmania major trypanothione reductase 0.0039 0.0134 0.1942
Onchocerca volvulus 0.0473 0.2782 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0574 0.1079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0465 0.0465
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0574 0.1661
Loa Loa (eye worm) glutaminase 2 0.0543 0.3208 0.8377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0338 0.0849
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0026 0.0092
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0392 0.0392
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0134 0.0349
Brugia malayi beta-lactamase 0.0111 0.0574 0.1789
Brugia malayi Importin beta-1 subunit 0.006 0.0267 0.0832
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.0049 0.0646
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0574 0.1079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0026 0.0026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0465 0.1449
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0574 1
Plasmodium falciparum phd finger protein, putative 0.0058 0.0253 0.9452
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0253 0.066
Trichomonas vaginalis esterase, putative 0.0111 0.0574 0.1661
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0327 0.0327
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.017 0.0574
Loa Loa (eye worm) hypothetical protein 0.0252 0.1437 0.3751
Brugia malayi Pre-SET motif family protein 0.006 0.0265 0.0827
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0025 0.0224
Entamoeba histolytica hypothetical protein 0.0049 0.0197 0.0745
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0026 0.0064
Brugia malayi PHD-finger family protein 0.0058 0.0253 0.0788
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0049 0.0646
Mycobacterium leprae Probable lipase LipE 0.0111 0.0574 1
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0026 0.0092
Plasmodium vivax importin-beta 2, putative 0.006 0.0267 0.4526
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0435 0.0739
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0056 0.1694
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0013 0.0032
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0049 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0026 0.008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.017 0.0273
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0056 0.0021
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0049 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0026 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0026 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0134 0.2155
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0026 0.0064
Brugia malayi beta-lactamase family protein 0.0111 0.0574 0.1789
Loa Loa (eye worm) hypothetical protein 0.01 0.0506 0.1321
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Brugia malayi hypothetical protein 0.0025 0.0049 0.0153
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1307 0.1307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.1437 0.4477
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0574 0.1661
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.0506 0.2303
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0049 0.0153
Schistosoma mansoni hypothetical protein 0.0173 0.095 0.2386
Echinococcus granulosus geminin 0.0515 0.3035 0.489
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0049 0.0646
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0635 0.1596
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0026 0.0026
Echinococcus granulosus aminopeptidase N 0.0025 0.0049 0.0079
Loa Loa (eye worm) hypothetical protein 0.008 0.0385 0.1006
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0254 0.1445 0.3772
Schistosoma mansoni hypothetical protein 0.008 0.0385 0.0967
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0265 0.0428
Echinococcus multilocularis neuropeptide s receptor 0.0553 0.3268 0.3268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0465 0.1168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0265 0.0667
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0338 0.0882
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0635 0.1856
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0056 0.014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0026 0.0041
Brugia malayi hypothetical protein 0.0214 0.1202 0.3746
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0013 0.0021
Echinococcus granulosus importin subunit beta 1 0.006 0.0267 0.043
Schistosoma mansoni hypothetical protein 0.0047 0.0186 0.0467
Echinococcus granulosus GPCR family 2 0.008 0.0385 0.0621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0265 0.0667
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.063 0.1645
Brugia malayi Latrophilin receptor protein 2 0.008 0.0385 0.12
Onchocerca volvulus 0.0021 0.0026 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.067 0.3981 0.3981
Echinococcus multilocularis aminopeptidase N 0.0025 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.01 0.0506 0.2303
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0013 0.0013
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0014 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0026 0.0041
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0049 0.0582
Echinococcus multilocularis serotonin receptor 0.0254 0.1445 0.1445
Echinococcus multilocularis geminin 0.0515 0.3035 0.3035
Brugia malayi CXXC zinc finger family protein 0.003 0.0081 0.0252
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0288 0.0751
Echinococcus multilocularis tumor protein p63 0.1035 0.6206 0.6206
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0034
Loa Loa (eye worm) beta-lactamase 0.0111 0.0574 0.1498
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0574 0.1079
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0026 0.008
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0014 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0574 0.1442
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0465 0.1168
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0253 0.3855
Echinococcus multilocularis peregrin 0.0058 0.0253 0.0253
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0197 0.0468
Mycobacterium tuberculosis Probable reductase 0.0088 0.0435 0.0739
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0258 0.3931
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0253 0.4277
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0385 0.1006
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0026 0.008
Trichomonas vaginalis set domain proteins, putative 0.0473 0.2782 0.8649
Plasmodium vivax SET domain protein, putative 0.006 0.0265 0.45
Echinococcus multilocularis neuropeptide receptor A26 0.0553 0.3268 0.3268
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0023 0.0038
Brugia malayi ecdysteroid receptor 0.0021 0.0026 0.008
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0013 0.0032
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0495 0.0886
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0049 0.0582
Onchocerca volvulus 0.0152 0.0822 0.2954
Mycobacterium ulcerans lipase LipD 0.0111 0.0574 0.1661
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0645 0.383 1
Brugia malayi glutaminase DH11.1 0.0543 0.3208 1
Schistosoma mansoni cpg binding protein 0.0032 0.0091 0.023
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0049 0.0079
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0574 0.0574
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0049 0.0582
Onchocerca volvulus 0.0025 0.0049 0.0177
Onchocerca volvulus 0.0161 0.0881 0.3167
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0026 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0026 0.008
Brugia malayi RNA binding protein 0.0064 0.0288 0.0897
Mycobacterium ulcerans beta-lactamase 0.0111 0.0574 0.1661
Mycobacterium tuberculosis Conserved protein 0.0111 0.0574 0.1079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0708 0.4213 1
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0574 0.1079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0265 0.0667
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0495 0.4317
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0026 0.0067
Schistosoma mansoni coup transcription factor 0.0021 0.0026 0.0064
Trichomonas vaginalis ran, putative 0.0044 0.017 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0026 0.008
Echinococcus multilocularis cpg binding protein 0.0032 0.0091 0.0091
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.006 0.0265 0.0693
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0385 0.0621
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0049 0.0153
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0013 0.0032
Plasmodium falciparum thioredoxin reductase 0.0039 0.0134 0.4761
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0267 0.4079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0026 0.0067
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0056 0.009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0385 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0026 0.0067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.2432 0.6351
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0574 0.1079
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0111 0.0574 0.1498
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0288 0.0288
Schistosoma mansoni microtubule-associated protein tau 0.067 0.3981 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0288 0.0723
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.004
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0056 0.0767
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.004
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1307 0.2106
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.017 0.2793
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0049 0.0582
Onchocerca volvulus 0.0111 0.0574 0.2063
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0049 0.0123
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0049 0.0079
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0186 0.0579
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0495 0.0886
Plasmodium falciparum importin beta, putative 0.006 0.0267 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0385 0.12
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0574 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0049 0.0128
Loa Loa (eye worm) glutaminase 0.0543 0.3208 0.8377
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0253 0.0407
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0635 0.1856
Onchocerca volvulus 0.006 0.0265 0.0954
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0067
Plasmodium falciparum glutathione reductase 0.0039 0.0134 0.4761
Brugia malayi Bromodomain containing protein 0.0058 0.0253 0.0788
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0248 0.04
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0014 0.0026
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0023 0.0023
Echinococcus granulosus snurportin 1 0.0645 0.383 0.6171
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0049 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0026 0.008
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0026 0.0041
Leishmania major GTP-binding protein, putative 0.0044 0.017 0.2517
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0026 0.0041
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0049 0.0646
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0026 0.0064
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0049 0.0079
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0056 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0385 0.0621
Brugia malayi hypothetical protein 0.0161 0.0881 0.2746
Schistosoma mansoni hypothetical protein 0.008 0.0385 0.0967
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0574 0.1661
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0026 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0111 0.0574 0.1498
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
INH (ADMET) > 20 uM Inhibition of CYP2C9 ChEMBL. 20875741
INH (ADMET) > 20 uM Inhibition of CYP3A4 ChEMBL. 20875741

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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