Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2298 | 0.2298 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2324 | 0.2403 |
Onchocerca volvulus | 0.0104 | 0.5291 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2324 | 0.2324 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0154 | 0.8393 | 0.8678 |
Trypanosoma brucei | glucosidase, putative | 0.004 | 0.1374 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.3208 | 0.3208 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.6987 | 0.6987 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.004 | 0.1374 | 0.1374 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3208 | 0.3317 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.3208 | 0.3208 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1234 | 0.1276 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.183 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0179 | 0.9923 | 0.9923 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0179 | 0.9923 | 0.9923 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0179 | 0.9923 | 0.9923 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0179 | 0.9923 | 0.9923 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.6987 | 0.6987 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2298 | 0.2298 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.183 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.004 | 0.1374 | 0.1374 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.9671 | 0.9671 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2324 | 0.2403 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3208 | 0.3317 |
Leishmania major | alpha glucosidase II subunit, putative | 0.004 | 0.1374 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.3208 | 0.3208 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2324 | 0.2324 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.937 | 0.937 |
Schistosoma mansoni | alpha glucosidase | 0.004 | 0.1374 | 0.1421 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.3208 | 0.3208 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.2093 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.2093 | 0.2093 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.6987 | 0.6987 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2298 | 0.2298 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.004 | 0.1374 | 0.1374 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.1374 | 0.5 |
Brugia malayi | RNA binding protein | 0.007 | 0.3208 | 0.3208 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.2093 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3208 | 0.3317 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.9671 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3208 | 0.3317 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3208 | 0.3317 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.2093 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2324 | 0.2324 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.2093 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.004 | 0.1374 | 0.1374 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2324 | 0.2324 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.183 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2298 | 0.2298 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2324 | 0.2403 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.2093 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1234 | 0.1234 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.1374 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2324 | 0.2324 |
Brugia malayi | TAR-binding protein | 0.007 | 0.3208 | 0.3208 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2324 | 0.2324 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.3208 | 0.3208 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0179 | 0.9923 | 0.9923 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.3208 | 0.3208 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.9671 | 0.9671 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.9671 | 0.9671 |
Schistosoma mansoni | alpha-glucosidase | 0.0154 | 0.8393 | 0.8678 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1234 | 0.1234 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 67.554 uM | PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504766, AID504790] | ChEMBL. | No reference |
IC50 (functional) | > 67.554 uM | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): luminescence-based cell-based high throughput dose response assay to identify compounds that interfere with the UAS/Gal4 system and/or luciferase reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504766, AID504790] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (binding) | 17.7828 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.