Detailed information for compound 1248642

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.379 | Formula: C21H19NO5
  • H donors: 3 H acceptors: 5 LogP: 3.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(cc(c1)C)Cn1cc(c2c1cccc2O)C(=O)/C=C(/C(=O)O)\O
  • InChi: 1S/C21H19NO5/c1-12-6-13(2)8-14(7-12)10-22-11-15(18(24)9-19(25)21(26)27)20-16(22)4-3-5-17(20)23/h3-9,11,23,25H,10H2,1-2H3,(H,26,27)/b19-9-
  • InChiKey: XDIIRLSMFBFEGH-OCKHKDLRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Integrase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0194 0.4705 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus multilocularis neuropeptide s receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Brugia malayi Cathepsin L-like precursor 0.0016 0.023 0.0438
Schistosoma mansoni thyroid hormone receptor 0.0132 0.3131 0.3131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0795 1
Onchocerca volvulus 0.0194 0.4705 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis neuropeptide FF receptor 2 0.0194 0.4705 0.4705
Schistosoma mansoni hypothetical protein 0.0027 0.0505 0.0505
Brugia malayi hypothetical protein 0.0194 0.4705 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.045 0.4906
Echinococcus granulosus cathepsin L 0.0008 0.0032 0.0032
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0883 0.6312
Mycobacterium leprae PROBABLE HYDROLASE 0.0031 0.0611 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1035 0.2159
Leishmania major cathepsin L-like protease 0.0062 0.1374 1
Echinococcus multilocularis g-protein coupled receptor 0.0194 0.4705 0.4705
Brugia malayi hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni opsin-like receptor 0.0194 0.4705 0.4705
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0505 0.6198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0068 0.0093
Brugia malayi MH2 domain containing protein 0.0118 0.2793 0.5915
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0032 0.0032
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0094 0.2175 0.2175
Brugia malayi ecdysteroid receptor 0.001 0.0068 0.0093
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.3429 0.3429
Schistosoma mansoni hypothetical protein 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0068 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0194 0.4705 0.4705
Brugia malayi G-protein coupled receptor 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0385 0.077
Brugia malayi hypothetical protein 0.0194 0.4705 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0057 0.1258 0.2565
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0068 0.0093
Schistosoma mansoni hypothetical protein 0.0194 0.4705 0.4705
Brugia malayi Serotonin receptor 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus multilocularis cpg binding protein 0.003 0.0578 0.0578
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.3328 0.3328
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni hypothetical protein 0.0015 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0068 0.0093
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0194 0.4705 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0194 0.4705 0.4705
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0505 0.2402
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi hypothetical protein 0.0194 0.4705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0505 0.2402
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0068 0.0093
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0068 0.0068
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Schistosoma mansoni amine GPCR 0.0194 0.4705 0.4705
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.023 0.023
Brugia malayi Cathepsin L-like precursor 0.0016 0.023 0.0438
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0505 0.6198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0025 0.045 0.1921
Onchocerca volvulus 0.0037 0.074 0.1449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1035 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0194 0.4705 1
Loa Loa (eye worm) G-protein coupled receptor 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi hypothetical protein 0.0037 0.0758 0.1566
Echinococcus granulosus neuropeptide receptor 0.0194 0.4705 0.4705
Echinococcus granulosus cpg binding protein 0.003 0.0578 0.0578
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0068 0.0093
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0883 0.0883
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0206 0.0387
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0068 0.0093
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.2885 0.2885
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.3131 0.3131
Loa Loa (eye worm) melatonin receptor type 1A 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi neuropeptide F receptor 0.0194 0.4705 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0505 0.1613
Echinococcus multilocularis neuropeptides capa receptor 0.0194 0.4705 0.4705
Echinococcus granulosus tachykinin peptides receptor 99D 0.0194 0.4705 0.4705
Brugia malayi Tachykinin-like peptides receptor 99D 0.0194 0.4705 1
Schistosoma mansoni biogenic amine receptor 0.0194 0.4705 0.4705
Entamoeba histolytica hypothetical protein 0.0037 0.0758 0.9514
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Echinococcus multilocularis serotonin receptor 0.0194 0.4705 0.4705
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.023 0.2591
Onchocerca volvulus 0.0011 0.0095 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Echinococcus multilocularis cathepsin L 0.0008 0.0032 0.0032
Echinococcus granulosus g protein coupled receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis neuropeptide receptor 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Trypanosoma brucei RNA helicase, putative 0.0125 0.2962 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0194 0.4705 0.4705
Brugia malayi Hemopexin family protein 0.0037 0.074 0.1528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Mycobacterium ulcerans hydrolase 0.0031 0.0611 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.045 0.5474
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni coup transcription factor 0.001 0.0068 0.0068
Brugia malayi AKH receptor 0.0194 0.4705 1
Brugia malayi GnHR receptor homolog 0.0194 0.4705 1
Loa Loa (eye worm) matrixin family protein 0.0057 0.1258 0.2634
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Onchocerca volvulus Neuropeptide F receptor homolog 0.0194 0.4705 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Echinococcus multilocularis cysteine protease 0.0016 0.023 0.023
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0194 0.4705 1
Schistosoma mansoni histamine h1 receptor 0.0194 0.4705 0.4705
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0025 0.0025
Brugia malayi Matrixin family protein 0.0026 0.047 0.095
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0206 0.0387
Brugia malayi Matrixin family protein 0.0026 0.047 0.095
Brugia malayi follicle stimulating hormone receptor 0.0194 0.4705 1
Schistosoma mansoni smad 0.0008 0.0025 0.0025
Echinococcus granulosus somatostatin receptor 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0206 0.0206
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Brugia malayi Cathepsin L-like precursor 0.0011 0.0095 0.015
Schistosoma mansoni opsin-like receptor 0.0194 0.4705 0.4705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0025
Onchocerca volvulus 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0068 0.0068
Brugia malayi putative neuropeptide receptor NPR1 0.0194 0.4705 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0194 0.4705 0.4705
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0206 0.0387
Loa Loa (eye worm) fibroinase 0.0016 0.023 0.0438
Entamoeba histolytica cysteine protease, putative 0.0016 0.023 0.2591
Brugia malayi Cathepsin L-like precursor 0.0016 0.023 0.0438
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0194 0.4705 0.4705
Brugia malayi Cathepsin L-like precursor 0.0016 0.023 0.0438
Schistosoma mansoni neuropeptide receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0068 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0194 0.4705 0.4705
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1035 0.2159
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0068 0.0068
Loa Loa (eye worm) neuropeptide F receptor 0.0194 0.4705 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.023 0.023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Brugia malayi Cathepsin L-like precursor 0.0016 0.023 0.0438
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0194 0.4705 1
Echinococcus multilocularis neuropeptides capa receptor 0.0194 0.4705 0.4705
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0026 0.047 0.095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0194 0.4705 0.4705
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2793 0.5915
Onchocerca volvulus 0.0194 0.4705 1
Onchocerca volvulus 0.0194 0.4705 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0025 0.0025
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1338 0.1338
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0194 0.4705 0.4705
Brugia malayi Dopamine receptor protein 1 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Onchocerca volvulus 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2793 0.5915
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0537 0.1094
Schistosoma mansoni hypothetical protein 0.0033 0.0651 0.0651
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus granulosus geminin 0.0175 0.4227 0.4227
Schistosoma mansoni hypothetical protein 0.0037 0.0758 0.0758
Echinococcus granulosus 7TM GPCR rhodopsin 0.0194 0.4705 0.4705
Echinococcus multilocularis g protein coupled receptor 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Loa Loa (eye worm) matrixin family protein 0.0062 0.1387 0.2911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0883 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.023 0.0438
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0883 0.6312
Brugia malayi G-protein coupled receptor 0.0194 0.4705 1
Brugia malayi sulfakinin receptor protein 0.0194 0.4705 1
Onchocerca volvulus 0.0194 0.4705 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.023 0.0348
Brugia malayi larval opioid receptor 0.0194 0.4705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.023 0.2322
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi hypothetical protein 0.0194 0.4705 1
Entamoeba histolytica hypothetical protein 0.0037 0.0758 0.9514
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0068 0.0068
Loa Loa (eye worm) cysteine protease 0.0016 0.023 0.0438
Brugia malayi cathepsin L-like precursor 0.0011 0.0095 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Schistosoma mansoni myosin xvIII 0.0194 0.4705 0.4705
Brugia malayi Matrixin family protein 0.0026 0.047 0.095
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0194 0.4705 1
Schistosoma mansoni biogenic amine receptor 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni neuropeptide receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.045 0.5474
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0095 0.015
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0015 0.0206 0.0206
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis neuropeptide receptor 0.0194 0.4705 0.4705
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Onchocerca volvulus 0.0016 0.023 0.0348
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni hypothetical protein 0.0015 0.0206 0.0206
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0194 0.4705 0.4705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0068 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.045 0.311
Echinococcus granulosus hypothetical protein 0.0194 0.4705 0.4705
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0068 0.0068
Plasmodium vivax vivapain-2 0.0016 0.023 0.2322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0194 0.4705 0.4705
Echinococcus granulosus alpha 1A adrenergic receptor 0.0194 0.4705 0.4705
Schistosoma mansoni hypothetical protein 0.0194 0.4705 0.4705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0068 0.0068
Onchocerca volvulus 0.0016 0.023 0.0348
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0505 0.1613
Schistosoma mansoni adenoreceptor 0.0194 0.4705 0.4705
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Echinococcus granulosus smad 0.0008 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni hypothetical protein 0.0122 0.2885 0.2885
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0505 0.352
Onchocerca volvulus 0.0016 0.023 0.0348
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0194 0.4705 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0068 0.0093
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0026 0.047 0.047
Brugia malayi neuropeptide F receptor 0.0194 0.4705 1
Loa Loa (eye worm) TYRA-2 protein 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0651 0.1339
Echinococcus granulosus cysteine protease 0.0008 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0095 0.0824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Echinococcus granulosus FTZ F1 alpha 0.001 0.0068 0.0068
Echinococcus granulosus cathepsin l1 0.0011 0.0095 0.0095
Brugia malayi steroid hormone receptor 0.001 0.0068 0.0093
Onchocerca volvulus 0.0016 0.023 0.0348
Echinococcus granulosus neuropeptide receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.015
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1042 0.7525
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0505 0.5554
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.0028 0.0537 0.0537
Echinococcus multilocularis orexin receptor type 2 0.0194 0.4705 0.4705
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0385 0.077
Entamoeba histolytica hypothetical protein 0.0037 0.0758 0.9514
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0883 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0011 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi hypothetical protein 0.0194 0.4705 1
Echinococcus granulosus GPCR family 2 0.0015 0.0206 0.0206
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0194 0.4705 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.045 0.311
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0068 0.0093
Schistosoma mansoni amine GPCR 0.0194 0.4705 0.4705
Schistosoma mansoni Smad4 0.0008 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0068 0.0093
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi Melatonin receptor type 1A 0.0194 0.4705 1
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0505 0.0505
Schistosoma mansoni hypothetical protein 0.0015 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Schistosoma mansoni opsin-like receptor 0.0194 0.4705 0.4705
Echinococcus granulosus sex peptide receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0031 0.0611 0.1251
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0068 0.0068
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Schistosoma mansoni nuclear hormone receptor 0.001 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0194 0.4705 0.4705
Loa Loa (eye worm) G-protein coupled receptor 0.0194 0.4705 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi hypothetical protein 0.0016 0.0227 0.0433
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0032 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis fmrfamide receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Schistosoma mansoni amine GPCR 0.0194 0.4705 0.4705
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Echinococcus granulosus dro:myosuppressin receptor 0.0194 0.4705 0.4705
Echinococcus granulosus cathepsin l1 0.0016 0.023 0.023
Brugia malayi CXXC zinc finger family protein 0.0028 0.0537 0.1094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0068 0.0093
Echinococcus multilocularis smad 0.0008 0.0025 0.0025
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0505 0.352
Schistosoma mansoni biogenic amine receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) acetyltransferase 0.0144 0.3429 0.7273
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0041 0.0034
Onchocerca volvulus Matrilysin homolog 0.0057 0.1258 0.2565
Onchocerca volvulus 0.0028 0.0537 0.1011
Schistosoma mansoni neuropeptide F-like receptor 0.0194 0.4705 0.4705
Echinococcus granulosus g-protein coupled receptor 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0016 0.023 0.0348
Brugia malayi G protein-coupled receptor 0.0194 0.4705 1
Entamoeba histolytica hypothetical protein 0.0037 0.0758 0.9514
Echinococcus multilocularis neuropeptide Y receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0194 0.4705 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1374 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0068 0.0068
Echinococcus granulosus serotonin receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.023 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0068 0.0093
Onchocerca volvulus 0.0194 0.4705 1
Echinococcus multilocularis G protein coupled receptor 139 0.0194 0.4705 0.4705
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0194 0.4705 0.4705
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.023 0.0438
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0094 0.2175 0.2175
Schistosoma mansoni growth hormone secretagogue receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0025 0.0025
Echinococcus multilocularis sex peptide receptor 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Brugia malayi hypothetical protein 0.0194 0.4705 1
Leishmania major cathepsin L-like protease 0.0062 0.1374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis g protein coupled receptor 0.0194 0.4705 0.4705
Brugia malayi Matrixin family protein 0.0062 0.1387 0.2911
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.023 0.2591
Schistosoma mansoni amine GPCR 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0016 0.023 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0068 0.0093
Echinococcus granulosus G protein coupled receptor 139 0.0194 0.4705 0.4705
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0026 0.047 0.095
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.045 0.2125
Schistosoma mansoni neuropeptide receptor 0.0194 0.4705 0.4705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Onchocerca volvulus 0.0016 0.023 0.0348
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0068 0.0093
Echinococcus granulosus neuropeptides capa receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Brugia malayi ORL1-like opioid receptor 0.0194 0.4705 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0068 0.0093
Onchocerca volvulus Cathepsin F homolog 0.0016 0.023 0.0348
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.023 0.023
Brugia malayi hypothetical protein 0.0194 0.4705 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.124 0.8997
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0068 0.0093
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0032 0.0032
Plasmodium vivax vivapain-2 0.0016 0.023 0.2322
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0068 0.0093
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0505 0.352
Echinococcus granulosus allatostatin A receptor 0.0194 0.4705 0.4705
Onchocerca volvulus Matrilysin homolog 0.0026 0.047 0.0865
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0505 0.0505
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni amine GPCR 0.0194 0.4705 0.4705
Brugia malayi hypothetical protein 0.0025 0.045 0.0908
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0032 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0405 1 1
Echinococcus granulosus g protein coupled receptor 0.0194 0.4705 0.4705
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0026 0.047 0.095
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0068 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.023 0.2322
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.023 0.2591
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0068 0.0068
Brugia malayi putative neuropeptide receptor 0.0194 0.4705 1
Schistosoma mansoni hypothetical protein 0.0037 0.074 0.074
Echinococcus multilocularis G-protein coupled receptor, putative 0.0194 0.4705 0.4705
Schistosoma mansoni hypothetical protein 0.0405 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0194 0.4705 0.4705
Schistosoma mansoni neuropeptide f receptor 76f 0.0194 0.4705 0.4705
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0795 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0883 1
Echinococcus multilocularis fmrfamide receptor 0.0194 0.4705 0.4705
Leishmania major cathepsin L-like protease 0.0062 0.1374 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Brugia malayi Dopamine receptor 0.0194 0.4705 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0031 0.0611 0.1251
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis neuropeptide Y receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis g protein coupled receptor 0.0194 0.4705 0.4705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Echinococcus multilocularis neuropeptide receptor A26 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0016 0.023 0.0438
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0026 0.047 0.0865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0068 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0206 0.0387
Echinococcus multilocularis dro:myosuppressin receptor 0.0194 0.4705 0.4705
Brugia malayi Dopamine receptor protein 2 0.0194 0.4705 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.3429 0.3429
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.023 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0194 0.4705 0.4705
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.023 0.1472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0758 0.0758
Echinococcus multilocularis somatostatin receptor 0.0194 0.4705 0.4705
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0095 0.0739
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0194 0.4705 0.4705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.023 0.2591
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1374 1
Echinococcus multilocularis serotonin receptor 0.0194 0.4705 0.4705
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0068 0.0093
Schistosoma mansoni hypothetical protein 0.0125 0.2962 0.2962
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0194 0.4705 0.4705
Echinococcus granulosus peptide allatostatin:somatostatin 0.0194 0.4705 0.4705
Echinococcus granulosus tm gpcr rhodopsin 0.0194 0.4705 0.4705
Onchocerca volvulus 0.0194 0.4705 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0194 0.4705 1
Loa Loa (eye worm) ctsf protein 0.0016 0.023 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis allatostatin A receptor 0.0194 0.4705 0.4705
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0194 0.4705 0.4705
Schistosoma mansoni biogenic amine (5HT) receptor 0.0194 0.4705 0.4705
Echinococcus granulosus neuropeptide receptor A26 0.0194 0.4705 0.4705
Echinococcus granulosus neuropeptides capa receptor 0.0194 0.4705 0.4705
Brugia malayi Serotonin receptor 0.0194 0.4705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0095 0.0739
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus granulosus tm gpcr rhodopsin 0.0194 0.4705 0.4705
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0068 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0194 0.4705 0.4705
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0194 0.4705 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0068 0.0068
Brugia malayi hypothetical protein 0.0194 0.4705 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.023 0.0438
Echinococcus granulosus orexin receptor type 2 0.0194 0.4705 0.4705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1374 0.4582
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0068 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1374 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0068 0.0093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0758 0.0758
Schistosoma mansoni biogenic amine (5HT) receptor 0.0194 0.4705 0.4705
Echinococcus granulosus tm gpcr rhodopsin 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0025 0.045 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0068 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0175 0.4227 0.4227
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0068 0.0093
Onchocerca volvulus 0.0194 0.4705 1
Loa Loa (eye worm) matrix metalloproteinase 0.0026 0.047 0.095
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0758 0.0758
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0795 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.023 0.023
Echinococcus multilocularis cysteine protease 0.0016 0.023 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.023 0.2322
Brugia malayi hypothetical protein 0.0194 0.4705 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1035 0.2159
Echinococcus granulosus 7tm_1 domain containing protein 0.0194 0.4705 0.4705
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Echinococcus multilocularis geminin 0.0175 0.4227 0.4227
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.045 0.1425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.4705 0.4705
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0194 0.4705 0.4705
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.3429 0.7273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.023 0.023
Brugia malayi nuclear hormone receptor 0.001 0.0068 0.0093
Echinococcus granulosus fmrfamide receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0651 0.1339
Echinococcus granulosus g protein coupled receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis Smad4 0.0008 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus granulosus Smad4 0.0008 0.0025 0.0025
Brugia malayi RE15519p 0.0194 0.4705 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0194 0.4705 0.4705
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0175 0.4227 0.4227
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0194 0.4705 0.4705
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0031 0.0611 0.5
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni neuropeptide receptor 0.0194 0.4705 0.4705
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.023 0.2591
Echinococcus granulosus neuropeptide s receptor 0.0194 0.4705 0.4705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.2885 0.2885
Brugia malayi Matrixin family protein 0.0026 0.047 0.095
Brugia malayi Cathepsin L-like precursor 0.0011 0.0095 0.015
Onchocerca volvulus 0.0194 0.4705 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0206 0.0206
Echinococcus granulosus neuropeptide Y receptor 0.0194 0.4705 0.4705
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0194 0.4705 0.4705
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) neuropeptide F receptor 0.0194 0.4705 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1374 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0194 0.4705 0.4705
Loa Loa (eye worm) hypothetical protein 0.0194 0.4705 1
Schistosoma mansoni thyroid hormone receptor 0.0132 0.3131 0.3131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.023 0.2322
Echinococcus granulosus neuropeptide Y receptor 0.0194 0.4705 0.4705

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 44 uM Cytotoxicity against human MT4 cells assessed as cell viability by MTT assay ChEMBL. 24618511
IC50 (binding) = 3.5 uM Inhibition of HIV-1 integrase ChEMBL. 25462257

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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