Detailed information for compound 1248738

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.273 | Formula: C18H19BrN4O2
  • H donors: 0 H acceptors: 2 LogP: 2.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cnn2c1ncc(c2)c1ccc(cc1)OCCN1CCOCC1
  • InChi: 1S/C18H19BrN4O2/c19-17-12-21-23-13-15(11-20-18(17)23)14-1-3-16(4-2-14)25-10-7-22-5-8-24-9-6-22/h1-4,11-13H,5-10H2
  • InChiKey: OQEOCGBTWFOYHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, AMP-activated, gamma 3 non-catalytic subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0239 0.1784 0.3129
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis proteasome subunit beta type 7 0.0064 0.0326 0.0316
Echinococcus granulosus death domain containing protein 0.0125 0.0838 0.0828
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0254 0.1914 0.3344
Echinococcus granulosus proteasome subunit alpha type 2 0.0064 0.0326 0.0316
Loa Loa (eye worm) TAR-binding protein 0.0254 0.1914 0.3344
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0096 0.0594 0.0584
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0064 0.0326 0.1154
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.1898 0.7575
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0026 0.0011 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0709 0.5702 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.0326 0.1265
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0625 0.2367
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0064 0.0326 0.1265
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0064 0.0326 0.0554
Brugia malayi Proteasome A-type and B-type family protein 0.0064 0.0326 0.0573
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0064 0.0326 0.1265
Echinococcus granulosus proteasome prosome macropain 0.0325 0.2502 0.2494
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1914 0.2234
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.0326 0.1265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0224 0.1663 0.1654
Echinococcus granulosus proteasome subunit alpha type 6 0.0064 0.0326 0.0316
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0064 0.0326 0.037
Toxoplasma gondii proteasome subunit beta type, putative 0.0325 0.2502 1
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0026 0.0011 0.002
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0064 0.0326 0.1154
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0064 0.0326 0.1265
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0064 0.0326 0.037
Echinococcus granulosus netrin receptor unc 5 0.0125 0.0838 0.0828
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0064 0.0326 0.1154
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0091 0.008
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1914 0.2234
Plasmodium vivax proteasome subunit beta type-3, putative 0.0064 0.0326 0.1154
Trypanosoma brucei proteasome beta 6 subunit 0.0252 0.1898 0.7544
Toxoplasma gondii peptidase, T1 family protein 0.0064 0.0326 0.1154
Loa Loa (eye worm) MBCTL1 0.0054 0.0243 0.0407
Toxoplasma gondii proteasome subunit alpha type, putative 0.0064 0.0326 0.1154
Brugia malayi Proteasome A-type and B-type family protein 0.0064 0.0326 0.0573
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0064 0.0326 0.1154
Brugia malayi Bromodomain containing protein 0.0074 0.0414 0.0725
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0224 0.1663 0.2917
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0594 0.2242
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0064 0.0326 0.1154
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0325 0.2502 1
Giardia lamblia Proteasome subunit beta type 2 0.0156 0.1098 0.4291
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0325 0.2502 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0709 0.5702 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0064 0.0326 0.0316
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0064 0.0326 0.1154
Loa Loa (eye worm) hypothetical protein 0.0484 0.3832 0.6715
Leishmania major DNA polymerase eta, putative 0.0055 0.025 0.0844
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0096 0.0594 0.1024
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0156 0.1098 0.1276
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0026 0.0011 0.002
Echinococcus granulosus Proteasome subunit alpha type 7 0.0064 0.0326 0.0316
Trypanosoma brucei proteasome beta 7 subunit 0.0064 0.0326 0.1154
Leishmania major proteasome beta 3 subunit, putative 0.0064 0.0326 0.1154
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0064 0.0326 0.0554
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0064 0.0326 0.1154
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0188 0.0311
Plasmodium vivax proteasome subunit beta type-7, putative 0.0064 0.0326 0.1154
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0064 0.0326 0.1154
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0026 0.0011 0.002
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis proteasome (prosome, macropain) 0.0325 0.2502 0.2494
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0064 0.0326 0.0316
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0064 0.0326 0.0554
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0064 0.0326 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0064 0.0326 0.0316
Mycobacterium ulcerans proteasome PrcB 0.0325 0.2502 1
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0064 0.0326 0.1154
Echinococcus granulosus geminin 0.1048 0.8529 0.8527
Echinococcus granulosus GPCR family 2 0.0224 0.1663 0.1654
Leishmania major DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0011 0.002
Schistosoma mansoni hypothetical protein 0.0484 0.3832 0.4487
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0064 0.0326 0.1154
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0325 0.2502 0.4378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0606 0.4843 0.5673
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0224 0.1663 0.1654
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0252 0.1898 0.7544
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0064 0.0326 0.1154
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0243 0.0232
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0064 0.0326 0.1154
Brugia malayi proteasome subunit beta type 2 0.0156 0.1098 0.1926
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.1382 0.1372
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0064 0.0326 0.037
Entamoeba histolytica hypothetical protein 0.0036 0.0092 0.0324
Echinococcus multilocularis geminin 0.1048 0.8529 0.8527
Schistosoma mansoni hypothetical protein 0.0224 0.1663 0.194
Schistosoma mansoni hypothetical protein 0.0224 0.1663 0.194
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0064 0.0326 0.1154
Echinococcus granulosus proteasome subunit beta type 7 0.0064 0.0326 0.0316
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0064 0.0326 0.1154
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0594 0.2242
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Brugia malayi proteasome subunit alpha type 1 0.0064 0.0326 0.0573
Echinococcus multilocularis Ankyrin 0.0126 0.0842 0.0832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0606 0.4843 0.8494
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0064 0.0326 0.0316
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0064 0.0326 0.1154
Schistosoma mansoni DNA polymerase eta 0.0121 0.0802 0.0928
Loa Loa (eye worm) hypothetical protein 0.0047 0.0188 0.0311
Loa Loa (eye worm) hypothetical protein 0.0126 0.0842 0.146
Trypanosoma cruzi 20S proteasome subunit 0.0156 0.1098 0.4291
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0064 0.0326 0.1265
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0096 0.0594 0.0584
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0156 0.1098 0.4291
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0176
Plasmodium vivax proteasome subunit beta type-1, putative 0.0252 0.1898 0.7544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0709 0.5702 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0064 0.0326 0.0316
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0011 0.002
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0064 0.0326 0.1154
Entamoeba histolytica hypothetical protein 0.0036 0.0092 0.0324
Toxoplasma gondii LsmAD domain-containing protein 0.01 0.0625 0.2367
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0064 0.0326 0.037
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0064 0.0326 0.0554
Leishmania major proteasome beta 2 subunit, putative 0.0064 0.0326 0.1154
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0625 0.2367
Echinococcus multilocularis proteasome subunit alpha type 2 0.0064 0.0326 0.0316
Echinococcus granulosus dna polymerase eta 0.0121 0.0802 0.0791
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0064 0.0326 0.1265
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0606 0.4843 0.4837
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0064 0.0326 0.037
Giardia lamblia 20S proteasome alpha subunit 2 0.0064 0.0326 0.1154
Trypanosoma cruzi DNA polymerase eta, putative 0.0055 0.025 0.0844
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0055
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0252 0.1898 0.7544
Brugia malayi polk-prov protein 0.003 0.0043 0.0075
Brugia malayi 20S proteasome alpha5 subunit 0.0064 0.0326 0.0573
Loa Loa (eye worm) hypothetical protein 0.015 0.1044 0.1815
Toxoplasma gondii proteasome subunit alpha1, putative 0.0064 0.0326 0.1154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0606 0.4843 0.5673
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0064 0.0326 0.0316
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0064 0.0326 0.1154
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0092 0.0081
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0064 0.0326 0.1154
Leishmania major proteasome beta 5 subunit, putative 0.0325 0.2502 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0064 0.0326 0.1154
Leishmania major proteasome beta-1 subunit, putative 0.0064 0.0326 0.1154
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0188 0.0177
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1784 0.3116
Loa Loa (eye worm) proteasome subunit beta type 2 0.0156 0.1098 0.191
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0188 0.1713
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0325 0.2502 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0606 0.4843 0.5673
Loa Loa (eye worm) hypothetical protein 0.0054 0.0243 0.0407
Brugia malayi Uncoordinated protein 44 0.0125 0.0838 0.147
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Echinococcus granulosus Proteasome subunit alpha beta 0.0064 0.0326 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0064 0.0326 0.1154
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0064 0.0326 0.1154
Trypanosoma brucei unspecified product 0.0066 0.0346 0.1233
Brugia malayi hypothetical protein 0.015 0.1044 0.1831
Brugia malayi proteasome subunit alpha type 2 0.0064 0.0326 0.0573
Trypanosoma brucei PAB1-binding protein , putative 0.01 0.0625 0.2367
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0188 0.0177
Echinococcus granulosus Ankyrin 0.0126 0.0842 0.0832
Brugia malayi Death domain containing protein 0.0125 0.0838 0.147
Plasmodium vivax proteasome subunit beta type-2, putative 0.0156 0.1098 0.4291
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0126 0.0842 0.0975
Giardia lamblia Proteasome subunit beta type 3 0.0064 0.0326 0.1154
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0092 0.0095
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0064 0.0326 0.1154
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0064 0.0326 0.037
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0156 0.1098 0.4291
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0064 0.0326 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0346 0.1233
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0064 0.0326 0.1154
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0055 0.025 0.0844
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0064 0.0326 0.0316
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0064 0.0326 0.1154
Brugia malayi latrophilin 2 splice variant baaae 0.0484 0.3832 0.6722
Echinococcus multilocularis netrin receptor unc 5 0.0125 0.0838 0.0828
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.0594 0.1042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0287 0.0276
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0243 0.0272
Giardia lamblia Proteasome subunit beta type 1 0.0252 0.1898 0.7544
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0325 0.2502 0.2925
Schistosoma mansoni ankyrin 23/unc44 0.0125 0.0838 0.0971
Schistosoma mansoni hypothetical protein 0.0125 0.0838 0.0971
Plasmodium vivax proteasome subunit beta type-6, putative 0.0064 0.0326 0.1154
Leishmania major proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Echinococcus granulosus proteasome subunit beta t family 0.0064 0.0326 0.0316
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0971 0.7885 0.7883
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0252 0.1898 0.7544
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0606 0.4843 0.8492
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.1382 0.1372
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0625 0.2367
Brugia malayi proteasome subunit alpha type 6 0.0064 0.0326 0.0573
Loa Loa (eye worm) latrophilin receptor protein 2 0.0224 0.1663 0.2904
Loa Loa (eye worm) hypothetical protein 0.0709 0.5702 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0064 0.0326 0.1265
Trypanosoma brucei unspecified product 0.0096 0.0594 0.2242
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0064 0.0326 0.037
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Leishmania major proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0252 0.1898 0.7544
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0064 0.0326 0.037
Entamoeba histolytica deoxycytidyl transferase, putative 0.0096 0.0594 0.234
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Loa Loa (eye worm) proteasome subunit beta type 1 0.0252 0.1898 0.3316
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0096 0.0594 0.2242
Giardia lamblia 20S proteasome alpha subunit 7 0.0064 0.0326 0.1154
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0064 0.0326 0.1154
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0325 0.2502 1
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0064 0.0326 0.1265
Giardia lamblia 20S proteasome alpha subunit 4 0.0064 0.0326 0.1154
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0064 0.0326 0.037
Giardia lamblia 20S proteasome alpha subunit 3 0.0064 0.0326 0.1154
Toxoplasma gondii proteasome beta subunit 0.0064 0.0326 0.1154
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0064 0.0326 0.1154
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0188 0.0208
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.0326 0.1265
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0064 0.0326 0.037
Brugia malayi proteasome subunit beta type 3 0.0064 0.0326 0.0573
Echinococcus multilocularis GPCR, family 2 0.0224 0.1663 0.1654
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0325 0.2502 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1784 0.3116
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1224 1 1
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0224 0.1663 0.1654
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0167 0.0156
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0091 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0594 0.2242
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0064 0.0326 0.5
Brugia malayi Proteasome A-type and B-type family protein 0.0325 0.2502 0.4389
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0064 0.0326 0.0554
Echinococcus multilocularis proteasome subunit alpha type 6 0.0064 0.0326 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1914 0.2234
Brugia malayi proteasome subunit alpha type 3 0.0064 0.0326 0.0573
Brugia malayi mbt repeat family protein 0.0047 0.0188 0.033
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0064 0.0326 0.1154
Echinococcus granulosus dna polymerase kappa 0.0096 0.0594 0.0584
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0156 0.1098 0.4291
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0064 0.0326 0.1265
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0224 0.1663 0.1654
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0026 0.0011 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0287 0.0276
Brugia malayi mbt repeat family protein 0.0047 0.0188 0.033
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0064 0.0326 0.1154
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0064 0.0326 0.1154
Schistosoma mansoni bromodomain containing protein 0.0063 0.0317 0.0359
Trypanosoma brucei unspecified product 0.0066 0.0346 0.1233
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0125 0.0838 0.0828
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0064 0.0326 0.1154
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0064 0.0326 0.1154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0606 0.4843 0.4837
Schistosoma mansoni netrin receptor unc5 0.0125 0.0838 0.0971
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0064 0.0326 0.1154
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0594 0.2242
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0064 0.0326 0.1154
Schistosoma mansoni terminal deoxycytidyl transferase 0.0096 0.0594 0.0684
Brugia malayi Immunoglobulin I-set domain containing protein 0.0125 0.0838 0.147
Brugia malayi ImpB/MucB/SamB family protein 0.0121 0.0802 0.1406
Giardia lamblia 20S proteasome alpha subunit 1 0.0064 0.0326 0.1154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.0326 0.1265
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0064 0.0326 0.0316
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0064 0.0326 0.1154
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0243 0.0232
Entamoeba histolytica hypothetical protein 0.0036 0.0092 0.0324
Echinococcus multilocularis dna polymerase kappa 0.0096 0.0594 0.0584
Plasmodium vivax proteasome subunit beta type-4, putative 0.0064 0.0326 0.1154
Brugia malayi hypothetical protein 0.0026 0.0011 0.002
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0156 0.1098 0.1088
Echinococcus granulosus tar DNA binding protein 0.0254 0.1914 0.1905
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0064 0.0326 0.1265
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0064 0.0326 0.1265
Plasmodium vivax proteasome subunit beta type-5, putative 0.0325 0.2502 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0064 0.0326 0.0316
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0064 0.0326 0.1154
Brugia malayi hypothetical protein 0.0064 0.033 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Plasmodium vivax ataxin-2 like protein, putative 0.01 0.0625 0.2367
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.0594 0.234
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0064 0.0326 0.037
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0064 0.0326 0.0316
Brugia malayi proteasome subunit beta type 1 0.0252 0.1898 0.3329
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0243 0.0232
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0325 0.2502 1
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1914 0.2234
Schistosoma mansoni DNA polymerase IV / kappa 0.003 0.0043 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.0121 0.0802 0.3086
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0064 0.0326 0.0554
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0188 0.0177
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0096 0.0594 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0064 0.0326 0.1154
Leishmania major proteasome beta 2 subunit, putative 0.0156 0.1098 0.4291
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0064 0.0326 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Brugia malayi Proteasome subunit alpha type 1 0.0064 0.0326 0.0573
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0092 0.0081
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0594 0.2242
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0252 0.1898 0.2216
Loa Loa (eye worm) PAS-3 protein 0.0064 0.0326 0.0554
Schistosoma mansoni hypothetical protein 0.1048 0.8529 1
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0064 0.0326 0.1154
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0064 0.0326 0.0316
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0064 0.0326 0.1154
Onchocerca volvulus 0.015 0.1044 1
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0064 0.0326 0.1154
Brugia malayi RNA binding protein 0.0254 0.1914 0.3357
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0096 0.0594 0.0684
Echinococcus granulosus proteasome subunit beta type 6 0.0064 0.0326 0.0316
Schistosoma mansoni hypothetical protein 0.1048 0.8529 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0064 0.0326 0.1154
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0064 0.0326 0.1154
Loa Loa (eye worm) hypothetical protein 0.0121 0.0802 0.1389
Onchocerca volvulus 0.0047 0.0188 0.1713
Loa Loa (eye worm) RNA binding protein 0.0254 0.1914 0.3344
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis tar DNA binding protein 0.0254 0.1914 0.1905
Leishmania major proteasome beta 7 subunit, putative 0.0064 0.0326 0.1154
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0064 0.0326 0.1154
Schistosoma mansoni hypothetical protein 0.0224 0.1663 0.194
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1914 0.2234
Brugia malayi Bromodomain containing protein 0.0038 0.0111 0.0194
Giardia lamblia 20S proteasome alpha subunit 5 0.0064 0.0326 0.1154
Giardia lamblia 20S proteasome alpha subunit 6 0.0064 0.0326 0.1154
Leishmania major proteasome alpha 1 subunit, putative 0.0064 0.0326 0.1154
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0064 0.0326 0.1265
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0325 0.2502 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0064 0.0326 0.1154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0606 0.4843 0.4837
Plasmodium falciparum proteasome subunit beta type-4 0.0064 0.0326 0.1154
Brugia malayi Latrophilin receptor protein 2 0.0224 0.1663 0.2917
Leishmania major proteasome alpha 3 subunit, putative 0.0064 0.0326 0.1154
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0064 0.0326 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0125 0.0838 0.1453
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0188 0.0208
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0156 0.1098 0.4291
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0156 0.1098 0.1276
Leishmania major hypothetical protein, conserved 0.01 0.0625 0.2367
Entamoeba histolytica hypothetical protein 0.0036 0.0092 0.0324
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0156 0.1098 0.4362
Leishmania major proteasome alpha 2 subunit, putative 0.0064 0.0326 0.1154
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0156 0.1098 0.4362
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0064 0.0326 0.0316
Trypanosoma brucei proteasome alpha 7 subunit 0.0064 0.0326 0.1154
Echinococcus multilocularis proteasome subunit beta type 6 0.0064 0.0326 0.0316
Brugia malayi G-protein alpha subunit 0.0026 0.0011 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0625 0.2367
Brugia malayi hypothetical protein 0.01 0.0625 0.1096
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0243 0.0426
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0026 0.0011 0.002
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0064 0.0326 0.1154
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0064 0.0326 0.1154
Brugia malayi hypothetical protein 0.0036 0.0092 0.0161
Loa Loa (eye worm) proteasome subunit beta type 3 0.0064 0.0326 0.0554
Brugia malayi RNA recognition motif domain containing protein 0.0254 0.1914 0.3357
Loa Loa (eye worm) hypothetical protein 0.01 0.0625 0.1078
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0156 0.1098 0.1088
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0064 0.0326 0.0554
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0064 0.0326 0.1265
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0011 0.002
Schistosoma mansoni hypothetical protein 0.0045 0.0167 0.0183
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0125 0.0838 0.0828
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Loa Loa (eye worm) hypothetical protein 0.0224 0.1663 0.2904
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0064 0.0326 0.1154
Plasmodium falciparum proteasome subunit beta type-5 0.0325 0.2502 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0064 0.0326 0.1154
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0252 0.1898 0.7544
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0064 0.0326 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0346 0.1233
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0064 0.0326 0.0554
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0064 0.0326 0.1154
Schistosoma mansoni hypothetical protein 0.0292 0.2224 0.2598
Schistosoma mansoni hypothetical protein 0.0224 0.1663 0.194
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.0594 0.234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0188 0.0177
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0064 0.0326 0.1154
Echinococcus multilocularis dna polymerase eta 0.0121 0.0802 0.0791
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0064 0.0326 0.037
Leishmania major proteasome alpha 1 subunit, putative 0.0064 0.0326 0.1154
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0064 0.0326 0.1265
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0064 0.0326 0.1154
Giardia lamblia DINP protein human, muc B family 0.0096 0.0594 0.2242
Loa Loa (eye worm) hypothetical protein 0.007 0.0378 0.0645
Mycobacterium ulcerans proteasome PrcA 0.0064 0.0326 0.1154
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0064 0.0326 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0346 0.1233
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0156 0.1098 0.4362
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0252 0.1898 0.1889
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0064 0.0326 0.1154
Onchocerca volvulus Netrin receptor homolog 0.0125 0.0838 0.8004
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0064 0.0326 0.0554
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0252 0.1898 0.7575
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0064 0.0326 0.1265
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0188 0.0208
Loa Loa (eye worm) hypothetical protein 0.004 0.0131 0.021
Echinococcus granulosus subfamily T1A non peptidase ue 0.0064 0.0326 0.0316
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0325 0.2502 1
Brugia malayi Proteasome A-type and B-type family protein 0.0064 0.0326 0.0573
Trypanosoma cruzi DNA polymerase eta, putative 0.0121 0.0802 0.3086
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0252 0.1898 0.1889
Brugia malayi Protein kinase domain containing protein 0.0125 0.0838 0.147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0606 0.4843 0.4837
Toxoplasma gondii heat shock protein hslv, putative 0.0064 0.0326 0.1154
Loa Loa (eye worm) hypothetical protein 0.0042 0.0146 0.0238
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0064 0.0326 0.1265
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0064 0.0326 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0594 0.2242
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0167 0.0156
Brugia malayi TAR-binding protein 0.0254 0.1914 0.3357
Mycobacterium tuberculosis Conserved hypothetical protein 0.0096 0.0594 0.123
Loa Loa (eye worm) hypothetical protein 0.0125 0.0838 0.1453
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0064 0.0326 0.1154
Leishmania major DNA polymerase eta, putative 0.0121 0.0802 0.3086
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0064 0.0326 0.037
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0243 0.0232
Brugia malayi Proteasome subunit alpha type 7-1 0.0064 0.0326 0.0573
Onchocerca volvulus Notchless protein homolog 0.0064 0.0326 0.3052
Schistosoma mansoni hypothetical protein 0.0036 0.0092 0.0095
Brugia malayi proteasome subunit alpha type 4 0.0064 0.0326 0.0573
Toxoplasma gondii proteasome subunit 0.0064 0.0326 0.1154

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.5 uM Inhibition of human AMPK alpha-2/beta-1/gamma-1 by Hot Spot filtration binding assay ChEMBL. 20932747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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