Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0608 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0608 | 0.5 | 0.5 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0608 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of glycoprotein 2b/3a activation in human platelets assessed as inhibition of thrombin-induced PAC-1 binding preincubated for 3 mins before thrombin challenge after 15 mins by flow cytometry | ChEMBL. | 20850977 | |
IC50 (functional) | > 20 uM | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay | ChEMBL. | 20850977 |
IC50 (functional) | > 20 uM | Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay | ChEMBL. | 20850977 |
Inhibition (functional) | = -2.1 % | Cytotoxicity against human HBL100 cells at 20 uM after 72 hrs by MTT assay | ChEMBL. | 20850977 |
Inhibition (functional) | = 2.5 % | Cytotoxicity against human MDA-MB-231 cells at 20 uM after 72 hrs by MTT assay | ChEMBL. | 20850977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.