Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0725 | 0.0954 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3859 | 0.869 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0725 | 0.0725 |
Trichomonas vaginalis | helicase, putative | 0.0015 | 0.042 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0531 | 0.0503 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.042 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1593 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1593 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0015 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.0771 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0725 | 0.0725 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1593 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0021 | 0.0839 | 0.1219 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0725 | 0.0954 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2409 | 0.4668 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3859 | 0.869 |
Loa Loa (eye worm) | histone methyltransferase | 0.0021 | 0.0839 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2409 | 0.2409 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2409 | 0.4668 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0016 | 0.0531 | 0.0503 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.042 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0531 | 0.0531 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0725 | 0.0725 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3859 | 0.869 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0021 | 0.0839 | 0.1219 |
Schistosoma mansoni | cpg binding protein | 0.007 | 0.4619 | 0.4619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.042 | 0.5 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0016 | 0.0531 | 0.0503 |
Echinococcus multilocularis | cpg binding protein | 0.007 | 0.4619 | 1 |
Schistosoma mansoni | cpg binding protein | 0.007 | 0.4619 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0531 | 0.0503 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0725 | 0.0954 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.042 | 0.5 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.002 | 0.0819 | 0.026 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1593 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1593 | 0.2406 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.1593 | 0.2406 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1593 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1593 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0725 | 0.0954 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0015 | 0.042 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0725 | 0.0954 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0126 | 0.8854 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0725 | 0.0725 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0015 | 0.042 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3859 | 0.869 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1593 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0725 | 0.0954 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.042 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0066 | 0.4331 | 1 |
Onchocerca volvulus | 0.0066 | 0.4331 | 0.5 | |
Schistosoma mansoni | cpg binding protein | 0.0066 | 0.4331 | 0.4331 |
Echinococcus granulosus | cpg binding protein | 0.007 | 0.4619 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0066 | 0.4331 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 67.539 uM | PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504766, AID504790] | ChEMBL. | No reference |
IC50 (functional) | > 67.539 uM | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): luminescence-based cell-based high throughput dose response assay to identify compounds that interfere with the UAS/Gal4 system and/or luciferase reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504766, AID504790] | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.