Detailed information for compound 1249684

Basic information

Technical information
  • TDR Targets ID: 1249684
  • Name: N-[5-dimethylamino-2-[morpholin-4-yl-[[3-(tri fluoromethyl)phenyl]amino]phosphoryl]phenyl]t hiophene-2-carboxamide
  • MW: 538.522 | Formula: C24H26F3N4O3PS
  • H donors: 2 H acceptors: 2 LogP: 5.08 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(c1ccc(c(c1)NC(=O)c1cccs1)P(=O)(N1CCOCC1)Nc1cccc(c1)C(F)(F)F)C
  • InChi: 1S/C24H26F3N4O3PS/c1-30(2)19-8-9-21(20(16-19)28-23(32)22-7-4-14-36-22)35(33,31-10-12-34-13-11-31)29-18-6-3-5-17(15-18)24(25,26)27/h3-9,14-16H,10-13H2,1-2H3,(H,28,32)(H,29,33)
  • InChiKey: WQUJYKZQNJONJV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[5-dimethylamino-2-[morpholino-[[3-(trifluoromethyl)phenyl]amino]phosphoryl]phenyl]thiophene-2-carboxamide
  • N-[5-dimethylamino-2-[morpholino-[[3-(trifluoromethyl)phenyl]amino]phosphoryl]phenyl]-2-thiophenecarboxamide
  • T0503-7624
  • MLS000391954
  • SMR000260987

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Starlite/ChEMBL No references
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei ABC transporter, putative ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 611 aa 557 aa 28.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2018 0.23
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2264 0.2255
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2018 0.2001
Plasmodium vivax vivapain-2 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Leishmania major cathepsin L-like protease 0.002 0.0463 0.126
Echinococcus multilocularis cysteine protease 0.002 0.0463 0.0443
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0094 0.5
Echinococcus multilocularis GPCR, family 2 0.0019 0.041 0.039
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0132 0.1032
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2967 0.2952
Onchocerca volvulus Cathepsin F homolog 0.002 0.0463 0.2135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0162 0.015
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0463 0.0443
Echinococcus granulosus geminin 0.0205 0.8772 0.8769
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Echinococcus granulosus cathepsin l1 0.0014 0.0162 0.0141
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0132 0.2505
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0132 0.2505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2018 0.2001
Echinococcus multilocularis cysteine protease 0.002 0.0463 0.0443
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0132 0.0111
Brugia malayi ABC transporter family protein 0.0013 0.0132 0.012
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0132 0.2505
Leishmania major cathepsin L-like protease 0.0077 0.3023 1
Schistosoma mansoni hypothetical protein 0.0019 0.041 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2967 0.3382
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.041 0.039
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0132 0.0111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.041 0.039
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0021 0.0024
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0132 0.0111
Onchocerca volvulus 0.002 0.0463 0.2135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0463 0.0451
Loa Loa (eye worm) cysteine protease 0.002 0.0463 0.0451
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.041 0.039
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0094 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2967 0.3382
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0094 0.0073
Echinococcus granulosus tar DNA binding protein 0.0076 0.2967 0.2952
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0132 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0463 0.0451
Onchocerca volvulus Cathepsin L homolog 0.002 0.0463 0.2135
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.228 0.7525
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2018 0.23
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Loa Loa (eye worm) hypothetical protein 0.006 0.2264 0.2255
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Giardia lamblia ABC transporter 0.0012 0.0081 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0132 0.0111
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0463 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0463 0.0451
Leishmania major cathepsin L-like protease 0.002 0.0463 0.126
Leishmania major cathepsin L-like protease 0.002 0.0463 0.126
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2018 0.2008
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0132 0.012
Schistosoma mansoni hypothetical protein 0.0205 0.8772 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0132 0.0111
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Brugia malayi Cathepsin L-like precursor 0.002 0.0463 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2967 0.2958
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0162 0.3182
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0094 0.0073
Brugia malayi multidrug resistance protein 3 0.0013 0.0132 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0132 0.012
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0162 0.0185
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0094 0.0073
Plasmodium vivax vivapain-2 0.002 0.0463 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0162 0.3182
Loa Loa (eye worm) hypothetical protein 0.0014 0.0162 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.1406 0.1395
Trypanosoma brucei ABC transporter, putative 0.0012 0.0094 0.0242
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis abcb9, putative 0.0013 0.0132 0.2505
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0021 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3023 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0132 0.0111
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0132 0.2505
Echinococcus granulosus cathepsin l1 0.002 0.0463 0.0443
Leishmania major cathepsin L-like protease 0.002 0.0463 0.126
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0162 0.015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0463 0.0443
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0132 0.2505
Leishmania major cathepsin L-like protease 0.0077 0.3023 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0132 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Schistosoma mansoni hypothetical protein 0.0019 0.041 0.0468
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0119 0.0098
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0132 0.2505
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0132 0.2505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0132 1
Trichomonas vaginalis taga, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0132 0.2505
Schistosoma mansoni hypothetical protein 0.0019 0.041 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0463 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 1 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0132 0.2505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0463 0.0528
Loa Loa (eye worm) hypothetical protein 0.0232 1 1
Onchocerca volvulus 0.002 0.0463 0.2135
Schistosoma mansoni multidrug resistance protein 0.0013 0.0132 0.015
Entamoeba histolytica cysteine protease, putative 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0463 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0132 0.012
Schistosoma mansoni hypothetical protein 0.0041 0.1406 0.1603
Leishmania major cysteine peptidase A (CPA) 0.002 0.0463 0.126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.3023 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3023 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0132 0.013
Onchocerca volvulus 0.002 0.0463 0.2135
Loa Loa (eye worm) ctsf protein 0.002 0.0463 0.0451
Loa Loa (eye worm) hypothetical protein 0.002 0.0463 0.0451
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0132 0.2505
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0463 0.0528
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0132 0.2505
Loa Loa (eye worm) hypothetical protein 0.0014 0.0162 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0463 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0463 0.0451
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2967 0.3382
Loa Loa (eye worm) fibroinase 0.002 0.0463 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.041 0.0398
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2018 0.2001
Onchocerca volvulus Cathepsin L homolog 0.002 0.0463 0.2135
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Leishmania major p-glycoprotein 0.0013 0.0132 0.013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0463 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Brugia malayi RNA binding protein 0.0076 0.2967 0.2958
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0162 0.3182
Leishmania major cathepsin L-like protease 0.0077 0.3023 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0132 0.2505
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0012 0.0094 0.0242
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2018 0.2008
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0132 0.0111
Onchocerca volvulus 0.002 0.0463 0.2135
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1683 0.1673
Trichomonas vaginalis abcb9, putative 0.0013 0.0132 0.2505
Brugia malayi TAR-binding protein 0.0076 0.2967 0.2958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Trypanosoma cruzi ABC transporter, putative 0.0012 0.0094 0.0242
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0094 0.5
Schistosoma mansoni hypothetical protein 0.0047 0.1683 0.1919
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0132 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0132 0.2505
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0463 0.0443
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0463 0.0443
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0132 0.2505
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2967 0.2958
Plasmodium falciparum ABC transporter G family member 2 0.0012 0.0094 0.1642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Schistosoma mansoni hypothetical protein 0.0205 0.8772 1
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0094 0.0073
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0094 0.0073
Brugia malayi Cathepsin L-like precursor 0.0014 0.0162 0.015
Echinococcus multilocularis geminin 0.0205 0.8772 0.8769
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0021 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.041 0.039
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0021 0.0009
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2722 0.8997
Brugia malayi Cathepsin L-like precursor 0.002 0.0463 0.0451
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0132 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2264 0.2255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.041 0.0398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2018 0.23
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0463 0.1472
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Onchocerca volvulus 0.002 0.0463 0.2135
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0094 0.0073
Schistosoma mansoni ABC transporter 0.001 0.0013 0.0014
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0132 0.2505
Loa Loa (eye worm) hypothetical protein 0.0013 0.0132 0.012
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0132 0.0111
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0463 0.0451
Schistosoma mansoni hypothetical protein 0.0019 0.041 0.0468
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1406 0.1395
Loa Loa (eye worm) RNA binding protein 0.0076 0.2967 0.2958
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Onchocerca volvulus 0.002 0.0463 0.2135
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0119 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3023 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0132 0.1032
Entamoeba histolytica ABC transporter, putative 0.0012 0.0094 0.1642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0463 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2967 0.2958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2018 0.2001
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0463 0.0443
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0132 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2264 0.2255
Onchocerca volvulus 0.0014 0.0162 0.0193
Toxoplasma gondii cathepsin CPL 0.002 0.0463 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0132 0.015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2967 0.3382
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0132 0.2505
Onchocerca volvulus 0.0047 0.1683 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0132 0.2505
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0132 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Leishmania major cathepsin L-like protease 0.002 0.0463 0.126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0119 0.0107
Trypanosoma brucei ATP-binding cassette protein, putative 0.0012 0.0094 0.0242
Brugia malayi Cathepsin L-like precursor 0.0014 0.0162 0.015
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0132 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0463 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0094 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.041 0.0398
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.041 0.0398
Schistosoma mansoni survival motor neuron protein 0.0047 0.1683 0.1919
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0021 0.0024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0132 0.2505
Brugia malayi Cathepsin L-like precursor 0.002 0.0463 0.0451
Echinococcus granulosus survival motor neuron protein 1 0.0232 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0132 0.0111
Onchocerca volvulus 0.002 0.0463 0.2135
Schistosoma mansoni smdr2 0.0013 0.0132 0.015
Plasmodium vivax ABC transporter G family member 2, putative 0.0012 0.0094 0.1642
Echinococcus granulosus GPCR family 2 0.0019 0.041 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3023 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2967 0.3382
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0132 0.2505
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0132 0.2505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0463 1
Brugia malayi cathepsin L-like precursor 0.0014 0.0162 0.015

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.2862 uM PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) = 1.21 uM PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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