Detailed information for compound 1249737

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.452 | Formula: C19H20N4O3S
  • H donors: 1 H acceptors: 4 LogP: 1.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc2c(c1)nc[nH]2
  • InChi: 1S/C19H20N4O3S/c1-14-2-5-16(6-3-14)27(25,26)23-10-8-22(9-11-23)19(24)15-4-7-17-18(12-15)21-13-20-17/h2-7,12-13H,8-11H2,1H3,(H,20,21)
  • InChiKey: VPJKAVZRVCVOIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) calpain family protein 1 0.0214 0.2298 0.3747
Giardia lamblia Hypothetical protein 0.002 0.0046 0.0154
Plasmodium vivax vivapain-1 0.0027 0.0129 0.1292
Toxoplasma gondii centrin 0.0019 0.0037 0.0107
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0889 0.0874
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0749 0.1204
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0251 0.1056
Trypanosoma brucei kinesin, putative 0.0056 0.0467 0.2288
Plasmodium falciparum serine repeat antigen 2 0.002 0.0046 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0048
Brugia malayi cathepsin L-like precursor 0.0031 0.0168 0.0275
Trichomonas vaginalis calcium binding protein, putative 0.0019 0.0037 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0715 0.1207
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0889 0.4586
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0168 0.0152
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0046 0.0075
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0046 0.0075
Giardia lamblia Cathepsin L precursor 0.002 0.0046 0.0154
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0168 0.1937
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0019 0.0037 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0129 0.144
Giardia lamblia Cathepsin B precursor 0.002 0.0046 0.0154
Onchocerca volvulus 0.0038 0.0251 0.1056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0176 0.0262
Trichomonas vaginalis calmodulin, putative 0.0037 0.0241 0.1182
Echinococcus multilocularis integrin beta 2 0.0235 0.2549 0.2537
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0048
Onchocerca volvulus Cathepsin L homolog 0.002 0.0046 0.0131
Leishmania major calpain family cysteine protease-like protein 0.0024 0.0093 0.0302
Brugia malayi beta-lactamase family protein 0.0078 0.0715 0.1172
Entamoeba histolytica cysteine protease, putative 0.002 0.0046 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0046 0.0154
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2585 0.2573
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0047 0.016
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0019 0.0037 0.0107
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0046 0.0374
Echinococcus granulosus EF hand domain containing family member A2 0.0019 0.0037 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.0249
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0127
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Plasmodium falciparum serine repeat antigen 6 0.002 0.0046 0.0374
Echinococcus granulosus GPCR family 2 0.0031 0.0176 0.016
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0715 0.3674
Trypanosoma cruzi centrin, putative 0.0037 0.0241 0.037
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0093 0.0406
Echinococcus granulosus cathepsin b 0.0541 0.6105 0.6099
Echinococcus multilocularis lamin 0.0027 0.0122 0.0106
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0046 0.0335
Brugia malayi fibroinase precursor 0.002 0.0046 0.0075
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.002 0.0046 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Brugia malayi EF hand family protein 0.0019 0.0037 0.006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0749 0.1204
Loa Loa (eye worm) hypothetical protein 0.0541 0.6105 1
Schistosoma mansoni ap endonuclease 0.002 0.0047 0.003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.1204
Entamoeba histolytica cysteine protease, putative 0.002 0.0046 0.0374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0715 0.1148
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0047 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0715 0.1172
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0103 0.0355
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0046 0.0335
Entamoeba histolytica cysteine protease, putative 0.002 0.0046 0.0374
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0129 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Trypanosoma cruzi calmodulin, putative 0.0019 0.0037 0.0033
Schistosoma mansoni hypothetical protein 0.0876 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0047 0.005
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0209 0.2244 1
Echinococcus granulosus calpain 7 C02 family 0.0081 0.0749 0.0734
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0037 0.0233
Echinococcus granulosus cathepsin L 0.0027 0.0129 0.0113
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Schistosoma mansoni neuronal calcium sensor 0.0019 0.0037 0.002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0127
Echinococcus granulosus centrin 2 0.0019 0.0037 0.002
Trypanosoma cruzi I/6 autoantigen, putative 0.0019 0.0037 0.0033
Onchocerca volvulus 0.0078 0.0715 0.3139
Trypanosoma cruzi kinesin, putative 0.0056 0.0467 0.0741
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0047 0.016
Schistosoma mansoni calpain-2 (C02 family) 0.0024 0.0093 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Giardia lamblia Cathepsin B precursor 0.0181 0.192 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0354 0.1685
Entamoeba histolytica hypothetical protein 0.002 0.0046 0.0374
Toxoplasma gondii EF hand domain-containing protein 0.0019 0.0037 0.0107
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0046 0.0029
Brugia malayi Probable myosin regulatory light chain 0.0018 0.0016 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0129 0.0211
Trypanosoma cruzi cruzipain precursor, putative 0.0038 0.0251 0.0386
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0127
Loa Loa (eye worm) calmodulin-like protein 0.0019 0.0037 0.0033
Trypanosoma cruzi kinesin, putative 0.0056 0.0467 0.0741
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Brugia malayi cathepsin L precursor 0.002 0.0046 0.0075
Toxoplasma gondii cathepsin CPC2 0.002 0.0046 0.0154
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0251 0.1056
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Schistosoma mansoni DNA polymerase eta 0.0077 0.0712 0.0697
Brugia malayi N-terminal motif family protein 0.0209 0.2244 0.3676
Giardia lamblia Cathepsin L precursor 0.002 0.0046 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0025 0.0106 0.0371
Schistosoma mansoni reticulocalbin 0.0019 0.0037 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0541 0.6105 0.6099
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0251 0.1236
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0251 0.0386
Schistosoma mansoni lamin 0.0027 0.0122 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Leishmania major kinesin, putative 0.0056 0.0467 0.2288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0715 0.1148
Schistosoma mansoni centrin-related 0.0019 0.0037 0.002
Schistosoma mansoni lamin 0.0027 0.0122 0.0106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Echinococcus multilocularis cysteine protease 0.0038 0.0251 0.0236
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0251 0.1056
Schistosoma mansoni hypothetical protein 0.0876 1 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0122 0.0106
Toxoplasma gondii centrin, putative 0.0019 0.0037 0.0107
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.1148
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0046 0.0335
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0354 0.1685
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0019 0.0037 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0715 0.8011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0541 0.6105 0.6099
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0019 0.0037 0.0107
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0129 0.144
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0122 0.02
Loa Loa (eye worm) hypothetical protein 0.0024 0.0093 0.0127
Loa Loa (eye worm) hypothetical protein 0.0209 0.2244 0.3659
Brugia malayi acetyltransferase, GNAT family protein 0.0315 0.3476 0.5693
Echinococcus granulosus calpain 5 0.0081 0.0749 0.0734
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0129 0.0185
Trypanosoma brucei hypothetical protein 0.0024 0.0093 0.0302
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.1148
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0715 0.1148
Brugia malayi hypothetical protein 0.0048 0.0373 0.0611
Leishmania major hypothetical protein, conserved 0.0078 0.0715 0.3605
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0046 0.0029
Schistosoma mansoni hypothetical protein 0.0049 0.0377 0.0362
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.0249
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Echinococcus multilocularis calpain family protein 1, d 0.0157 0.1642 0.1628
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0048
Brugia malayi calpain family protein 1 0.0214 0.2298 0.3764
Giardia lamblia Cathepsin B precursor 0.002 0.0046 0.0154
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0251 0.0386
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0103 0.0458
Trichomonas vaginalis calcineurin B subunit, putative 0.0019 0.0037 0.0107
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0046 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0251 0.0386
Leishmania major calpain protease-like protein 0.0024 0.0093 0.0302
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0251 0.0386
Onchocerca volvulus 0.0027 0.0122 0.0475
Loa Loa (eye worm) hypothetical protein 0.0068 0.0598 0.0955
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Trypanosoma cruzi calmodulin, putative 0.0019 0.0037 0.0033
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0354 0.1774
Trichomonas vaginalis hypothetical protein 0.0024 0.0093 0.0406
Echinococcus multilocularis centrin 2 0.0019 0.0037 0.002
Giardia lamblia Cathepsin L precursor 0.002 0.0046 0.0154
Trichomonas vaginalis calcium binding proteins, putative 0.0019 0.0037 0.0107
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0019 0.0037 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0046 0.0075
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0251 0.1236
Echinococcus multilocularis EF hand domain containing family member A2 0.0019 0.0037 0.002
Plasmodium falciparum serine repeat antigen 5 0.002 0.0046 0.0374
Trichomonas vaginalis calcium binding protein, putative 0.0019 0.0037 0.0107
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0046 0.0335
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0046 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0168 0.0797
Entamoeba histolytica calcium-binding protein, putative 0.0019 0.0037 0.026
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0093 0.0406
Schistosoma mansoni centrin 0.0019 0.0037 0.002
Plasmodium falciparum serine repeat antigen 8 0.002 0.0046 0.0374
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.3785
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0129 0.144
Plasmodium falciparum serine repeat antigen 9 0.002 0.0046 0.0374
Echinococcus granulosus neurocalcin 0.0019 0.0037 0.002
Trypanosoma brucei Calpain-like protein 1.1 0.0024 0.0093 0.0302
Echinococcus granulosus cathepsin L 0.002 0.0046 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0046 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Brugia malayi Cathepsin L-like precursor 0.0031 0.0168 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0129 0.0491
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0046 0.0075
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Echinococcus granulosus programmed cell death protein 0.0037 0.0241 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1425 0.1411
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0019 0.0037 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0354 0.0554
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0799 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Echinococcus multilocularis musashi 0.0027 0.0122 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0174
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.192 0.1907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0046 0.0154
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0037 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0093 0.0406
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0046 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0129 0.144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0712 0.1142
Trichomonas vaginalis esterase, putative 0.0078 0.0715 0.3674
Echinococcus granulosus calpain A 0.0233 0.2523 0.2511
Trichomonas vaginalis centrin, putative 0.0019 0.0037 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0046 0.0154
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0129 0.0113
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Giardia lamblia Cathepsin B precursor 0.002 0.0046 0.0154
Echinococcus multilocularis geminin 0.0876 1 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0046 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0154
Plasmodium vivax unspecified product 0.002 0.0046 0.0335
Onchocerca volvulus 0.0038 0.0251 0.1056
Echinococcus multilocularis calpain A 0.0233 0.2523 0.2511
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Brugia malayi calpain D 0.0024 0.0093 0.0153
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0093 0.0406
Schistosoma mansoni hypothetical protein 0.0031 0.0176 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0354 0.4593
Loa Loa (eye worm) hypothetical protein 0.0099 0.0962 0.1553
Echinococcus multilocularis calcium uptake protein 1 0.0019 0.0037 0.002
Loa Loa (eye worm) hypothetical protein 0.0133 0.136 0.2207
Schistosoma mansoni calpain (C02 family) 0.0081 0.0749 0.0734
Plasmodium falciparum serine repeat antigen 3 0.002 0.0046 0.0374
Trichomonas vaginalis calpain, putative 0.0024 0.0093 0.0406
Echinococcus multilocularis programmed cell death protein 0.0037 0.0241 0.0225
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0129 0.0113
Giardia lamblia Cathepsin L precursor 0.002 0.0046 0.0154
Echinococcus granulosus lamin dm0 0.0027 0.0122 0.0106
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0354 0.058
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.1148
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0129 0.0185
Brugia malayi Integrin beta pat-3 precursor 0.0318 0.3507 0.5744
Toxoplasma gondii calmodulin CAM1 0.0019 0.0037 0.0107
Echinococcus granulosus dna polymerase eta 0.0077 0.0712 0.0697
Trypanosoma brucei calpain, putative 0.0024 0.0093 0.0302
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0019 0.0037 0.0033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0315 0.3476 0.3465
Trichomonas vaginalis calcineurin B subunit, putative 0.0019 0.0037 0.0107
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0302
Brugia malayi Cathepsin L-like precursor 0.0038 0.0251 0.0412
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0046 0.0335
Brugia malayi Cathepsin L-like cysteine proteinase 0.0031 0.0168 0.0275
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.1148
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0046 0.0335
Plasmodium vivax vivapain-2 0.0038 0.0251 0.2694
Plasmodium falciparum serine repeat antigen 1 0.002 0.0046 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1425 0.2333
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0047 0.0388
Echinococcus multilocularis calumenin 0.0019 0.0037 0.002
Leishmania major hypothetical protein, unknown function 0.0024 0.0093 0.0302
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0046 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0354 0.0554
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0103 0.1114
Leishmania major DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Schistosoma mansoni calmodulin related calcium binding protein 0.0019 0.0037 0.002
Plasmodium falciparum calpain 0.0024 0.0093 0.0986
Loa Loa (eye worm) beta-lactamase 0.0078 0.0715 0.1148
Trypanosoma brucei Calpain-like protein 2 0.0024 0.0093 0.0302
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0233 0.2523 0.2511
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0233 0.2523 0.2511
Echinococcus granulosus calmodulin 0.0019 0.0037 0.002
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0046 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0181 0.192 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0715 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0046 0.0154
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0354 0.4311
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0799 0.4114
Brugia malayi hypothetical protein 0.0238 0.2585 0.4234
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0251 0.3003
Onchocerca volvulus 0.0038 0.0251 0.1056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0354 0.0338
Onchocerca volvulus 0.0031 0.0168 0.0681
Mycobacterium ulcerans lipase LipD 0.0078 0.0715 1
Giardia lamblia DINP protein human, muc B family 0.0047 0.0354 0.1774
Schistosoma mansoni ap endonuclease 0.002 0.0047 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0047 0.0053
Echinococcus granulosus calbindin 32 0.0019 0.0037 0.002
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0251 0.0236
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0749 0.1204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0033
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0251 0.0412
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0093 0.0127
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0496 0.5587 1
Loa Loa (eye worm) cathepsin B 0.0181 0.192 0.3126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0354 0.0554
Trypanosoma brucei unspecified product 0.0032 0.0186 0.0791
Echinococcus multilocularis calmodulin 0.0019 0.0037 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0715 0.3674
Giardia lamblia Cathepsin B precursor 0.0181 0.192 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.1204
Plasmodium vivax vivapain-3 0.0027 0.0129 0.1292
Schistosoma mansoni ef hand domain family member A2 0.0019 0.0037 0.002
Loa Loa (eye worm) calpain 5 0.0056 0.0467 0.0741
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0251 0.0236
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.3373 0.3362
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0251 0.0236
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0251 0.3003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1425 0.1411
Trypanosoma brucei caltractin, putative 0.0037 0.0241 0.1087
Loa Loa (eye worm) fibroinase 0.0038 0.0251 0.0386
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0019 0.0037 0.002
Brugia malayi Cathepsin L-like precursor 0.0038 0.0251 0.0412
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0127
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Schistosoma mansoni hypothetical protein 0.0031 0.0176 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0962 0.1576
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0251 0.3003
Toxoplasma gondii hypothetical protein 0.0024 0.0093 0.0406
Loa Loa (eye worm) integrin beta-2 0.0318 0.3507 0.5733
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0129 0.144
Trichomonas vaginalis centrin, putative 0.0019 0.0037 0.0107
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0093 0.0302
Trichomonas vaginalis calpain, putative 0.0024 0.0093 0.0406
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0031 0.0168 0.0249
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0715 0.07
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0354 0.0554
Schistosoma mansoni neuronal calcium sensor 0.0019 0.0037 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Entamoeba histolytica calpain large subunit domain III containing protein 0.0056 0.0467 0.5762
Giardia lamblia Cysteine protease 0.002 0.0046 0.0154
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0103 0.1114
Schistosoma mansoni calpain-7 (C02 family) 0.0084 0.0783 0.0768
Brugia malayi Cathepsin L-like precursor 0.0038 0.0251 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0046 0.0154
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0251 0.0236
Loa Loa (eye worm) hypothetical protein 0.0157 0.1642 0.267
Schistosoma mansoni Mername-AA248 (C02 family) 0.0081 0.0749 0.0734
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Loa Loa (eye worm) calpain D 0.0024 0.0093 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0107
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0046 0.0374
Giardia lamblia Hypothetical protein 0.0019 0.0037 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Brugia malayi calpain 7 0.0081 0.0749 0.1227
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0103 0.1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0176 0.016
Brugia malayi Myosin regulatory light chain 1 0.0018 0.0016 0.0027
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0889 0.4586
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Loa Loa (eye worm) ctsf protein 0.0038 0.0251 0.0386
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0046 0.0075
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0019 0.0037 0.002
Echinococcus granulosus dna polymerase kappa 0.0047 0.0354 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0129 0.0592
Leishmania major DNA polymerase eta, putative 0.0077 0.0712 0.3586
Leishmania major cysteine peptidase A (CPA) 0.0038 0.0251 0.1141
Onchocerca volvulus 0.0019 0.0037 0.0091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0962 0.1576
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0354 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Schistosoma mansoni calpain-7 (C02 family) 0.0084 0.0783 0.0768
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0176 0.0287
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0338 0.1689
Schistosoma mansoni reticulocalbin 0.0019 0.0037 0.002
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Echinococcus granulosus integrin beta 2 0.0235 0.2549 0.2537
Echinococcus multilocularis calbindin 32 0.0019 0.0037 0.002
Loa Loa (eye worm) calpain 0.0081 0.0749 0.1204
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0046 0.0154
Echinococcus multilocularis EF hand domain containing family member A2 0.0019 0.0037 0.002
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0749 0.3785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0046 0.0154
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0046 0.0048
Trypanosoma brucei cysteine peptidase C (CPC) 0.0181 0.192 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.3785
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0715 0.3674
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0176 0.016
Echinococcus multilocularis GPCR, family 2 0.0031 0.0176 0.016
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0129 0.0185
Brugia malayi Cathepsin L-like precursor 0.0038 0.0251 0.0412
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0046 0.0335
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.1204
Trypanosoma cruzi centrin-3 0.0037 0.0241 0.037
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0354 0.1685
Onchocerca volvulus 0.0019 0.0037 0.0091
Plasmodium vivax calpain, putative 0.0081 0.0749 0.8399
Loa Loa (eye worm) acetyltransferase 0.0315 0.3476 0.5682
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0093 0.0127
Giardia lamblia Cathepsin L precursor 0.002 0.0046 0.0154
Toxoplasma gondii cathepsin CPL 0.0038 0.0251 0.1236
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0047 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0354 0.0554
Plasmodium falciparum serine repeat antigen 7 0.002 0.0046 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0122 0.0174
Entamoeba histolytica cysteine protease, putative 0.002 0.0046 0.0374
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0176 0.016
Echinococcus multilocularis cathepsin L 0.002 0.0046 0.0029
Trypanosoma brucei calpain, putative 0.0024 0.0093 0.0302
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0233 0.2523 0.2511
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0129 0.0185
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.142 0.2306
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.3785
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Schistosoma mansoni survival motor neuron protein 0.0049 0.0377 0.0362
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0715 0.1207
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2585 0.2573
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0541 0.6105 0.6099
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Onchocerca volvulus 0.0038 0.0251 0.1056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0962 0.1553
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0046 0.0154
Entamoeba histolytica calpain family cysteine protease, putative 0.0024 0.0093 0.0986
Loa Loa (eye worm) calpain family protein 1 0.0157 0.1642 0.267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0168 0.0797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Echinococcus multilocularis hypothetical protein 0.0081 0.0749 0.0734
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0749 0.3785
Toxoplasma gondii cathepsin CPC1 0.002 0.0046 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0046 0.0154
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0799 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0081 0.0749 0.1204
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Schistosoma mansoni intermediate filament proteins 0.0027 0.0122 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Toxoplasma gondii cathepsin B 0.0181 0.192 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0889 0.4586
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.142 0.2306
Trypanosoma brucei unspecified product 0.0047 0.0354 0.1685
Onchocerca volvulus 0.0038 0.0251 0.1056
Schistosoma mansoni hypothetical protein 0.0031 0.0176 0.016
Echinococcus granulosus EF HAND 1 calcium binding site 0.0019 0.0037 0.002
Giardia lamblia Cathepsin B precursor 0.002 0.0046 0.0154
Trichomonas vaginalis calcium binding protein, putative 0.0019 0.0037 0.0107
Mycobacterium tuberculosis Conserved protein 0.0078 0.0715 0.1207
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0715 0.1207
Brugia malayi Neuronal calcium sensor family protein 1 0.0018 0.0016 0.0027
Trichomonas vaginalis myosin light chain 1, putative 0.0019 0.0037 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0046 0.0154
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0046 0.0029
Giardia lamblia Cathepsin B precursor 0.002 0.0046 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0046 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0176 0.016
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Echinococcus multilocularis calpain 0.0081 0.0749 0.0734
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0715 0.3674
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0214 0.2298 0.2285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1425 0.2313
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0129 0.0185
Trypanosoma brucei centrin-3 0.0037 0.0241 0.1087
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0046 0.0048
Loa Loa (eye worm) programmed cell death protein 6 0.0019 0.0037 0.0033
Entamoeba histolytica calcium binding family protein 0.0019 0.0037 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0046 0.0154
Trypanosoma brucei Calpain-like protein CALP1.3 0.0024 0.0093 0.0302
Entamoeba histolytica cysteine protease, putative 0.002 0.0046 0.0374
Giardia lamblia Encystation-specific protease 0.002 0.0046 0.0154
Schistosoma mansoni cathepsin C 0.002 0.0046 0.0029
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Entamoeba histolytica grainin, putative 0.0019 0.0037 0.026
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0047 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0598 0.0979
Echinococcus multilocularis cathepsin b 0.0541 0.6105 0.6099
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0233 0.2523 0.2511
Entamoeba histolytica calmodulin, putative 0.0019 0.0037 0.026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0715 0.07
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0715 0.3674
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1425 0.1411
Mycobacterium ulcerans hypothetical protein 0.0078 0.0715 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0024 0.0093 0.0127
Brugia malayi RasGEF domain containing protein 0.002 0.0045 0.0074
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.1148
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0715 0.1207
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0251 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0186 0.0791
Toxoplasma gondii troponin c, isotype gamma, putative 0.0019 0.0037 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0122 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0046 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0046 0.0154
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Plasmodium falciparum centrin-1 0.0019 0.0037 0.026
Brugia malayi Kelch motif family protein 0.0048 0.0373 0.0611
Trypanosoma brucei antigen, putative 0.0081 0.0749 0.3785
Loa Loa (eye worm) hypothetical protein 0.0189 0.2016 0.3284
Brugia malayi Cathepsin L-like precursor 0.0038 0.0251 0.0412
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Schistosoma mansoni mitochondrial solute carrier 0.0019 0.0037 0.002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Leishmania major hypothetical protein, conserved 0.0025 0.0103 0.0355
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0715 0.1207
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0047 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0181 0.192 1
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0046 0.0154
Mycobacterium tuberculosis Conserved protein 0.0078 0.0715 0.1207
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0019 0.0037 0.002
Loa Loa (eye worm) hypothetical protein 0.0078 0.0715 0.1148
Loa Loa (eye worm) EF hand family protein 0.0019 0.0037 0.0033
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0019 0.0037 0.0233
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0046 0.0335
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0354 0.0338
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0019 0.0037 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0186 0.0791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1425 0.1411
Mycobacterium tuberculosis Conserved protein 0.0078 0.0715 0.1207
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0129 0.144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1425 0.1411
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0354 0.0338
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0048 0.0373 0.0586
Schistosoma mansoni hypothetical protein 0.0031 0.0176 0.016
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0093 0.0406
Brugia malayi calpain 5 0.0024 0.0093 0.0153
Brugia malayi calpain 5 0.0056 0.0467 0.0766
Mycobacterium leprae Probable lipase LipE 0.0078 0.0715 0.5
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0024 0.0093 0.0406
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0354 0.1774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Giardia lamblia Cysteine protease 0.002 0.0046 0.0154
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.002
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0046 0.0154
Trypanosoma cruzi caltractin, putative 0.0019 0.0037 0.0033
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0093 0.0406
Loa Loa (eye worm) hypothetical protein 0.0238 0.2585 0.4219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0251 0.3003
Trypanosoma cruzi calmodulin, putative 0.0019 0.0037 0.0033
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0047 0.0348
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0046 0.0335
Trichomonas vaginalis calpain, putative 0.0024 0.0093 0.0406
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.0249
Trypanosoma cruzi I/6 autoantigen, putative 0.0019 0.0037 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0046 0.0154
Brugia malayi Calmodulin-like protein 0.0019 0.0037 0.006
Trypanosoma cruzi conserved protein 0.0024 0.0093 0.0127
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0251 0.3003
Brugia malayi hypothetical protein 0.0025 0.0103 0.017
Echinococcus multilocularis dna polymerase eta 0.0077 0.0712 0.0697
Leishmania major DNA polymerase eta, putative 0.0045 0.0338 0.1599
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0251 0.0386
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0241 0.1182
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0019 0.0037 0.0033
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0046 0.0029
Plasmodium vivax unspecified product 0.0027 0.0129 0.1292
Brugia malayi beta-lactamase 0.0078 0.0715 0.1172
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Onchocerca volvulus 0.002 0.0046 0.0131
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.192 0.3126
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0749 0.3785
Toxoplasma gondii exonuclease III APE 0.002 0.0047 0.016
Giardia lamblia Hypothetical protein 0.002 0.0046 0.0154
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0251 0.0236
Toxoplasma gondii ABC1 family protein 0.0078 0.0715 0.3674
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0103 0.0143
Loa Loa (eye worm) cysteine protease 0.0038 0.0251 0.0386
Echinococcus granulosus calcium uptake protein 1 0.0019 0.0037 0.002
Toxoplasma gondii calcium-dependent protein kinase 0.0019 0.0037 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0715 0.3605
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0046 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0338 0.0528
Echinococcus multilocularis neurocalcin 0.0019 0.0037 0.002
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0019 0.0037 0.0033
Trichomonas vaginalis calmodulin, putative 0.0019 0.0037 0.0107
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Trichomonas vaginalis calmodulin-2, putative 0.0019 0.0037 0.0107
Echinococcus multilocularis cysteine protease 0.0038 0.0251 0.0236
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0129 0.0113
Plasmodium falciparum serine repeat antigen 4 0.002 0.0046 0.0374
Brugia malayi calcium-binding protein 0.0019 0.0037 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0129 0.0211
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0046 0.0374
Schistosoma mansoni rab 0.0019 0.0037 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0093 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0046 0.0154
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Trypanosoma brucei Calpain-like protein 1.2 0.0024 0.0093 0.0302
Trypanosoma cruzi centrin, putative 0.0037 0.0241 0.037
Giardia lamblia Cathepsin B precursor 0.0181 0.192 1
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0354 0.4593
Schistosoma mansoni hypothetical protein 0.0024 0.0093 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Plasmodium vivax centrin-1, putative 0.0019 0.0037 0.0233
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0019 0.0037 0.026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0586
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0251 0.0236
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0354 0.1685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0354 0.0554
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0046 0.0154
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0048
Entamoeba histolytica grainin 2 0.0037 0.0241 0.2874
Echinococcus granulosus lamin 0.0027 0.0122 0.0106
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0046 0.0335
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0047 0.005
Onchocerca volvulus 0.0038 0.0251 0.1056
Brugia malayi MH2 domain containing protein 0.0138 0.142 0.2326
Onchocerca volvulus 0.0019 0.0037 0.0091
Onchocerca volvulus 0.0078 0.0715 0.3139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0046 0.0154
Echinococcus granulosus calpain A 0.0081 0.0749 0.0734
Brugia malayi cathepsin B-like cysteine proteinase 0.0541 0.6105 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Schistosoma mansoni hypothetical protein 0.0068 0.0598 0.0583
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0712 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0186 0.0791
Loa Loa (eye worm) hypothetical protein 0.0214 0.2298 0.3747
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0127
Onchocerca volvulus 0.0078 0.0715 0.3139
Mycobacterium ulcerans beta-lactamase 0.0078 0.0715 1
Echinococcus granulosus EF hand domain containing family member A2 0.0019 0.0037 0.002
Brugia malayi EF hand family protein 0.0019 0.0037 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0103 0.0143
Schistosoma mansoni calpain C (C02 family) 0.0081 0.0749 0.0734
Echinococcus multilocularis cathepsin L 0.0027 0.0129 0.0113
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0046 0.0029
Echinococcus granulosus calpain 0.0081 0.0749 0.0734
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0715 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0046 0.0029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0047 0.0388
Trypanosoma brucei cysteine peptidase, putative 0.0024 0.0093 0.0302
Entamoeba histolytica calmodulin, putative 0.0019 0.0037 0.026
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0047 0.5
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0093 0.0127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0143
Brugia malayi beta-lactamase family protein 0.0078 0.0715 0.1172
Giardia lamblia Cathepsin L-like protease 0.002 0.0046 0.0154
Echinococcus multilocularis calmodulin 0.0019 0.0037 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0046 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0129 0.0592
Echinococcus multilocularis cathepsin b 0.0541 0.6105 0.6099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0176 0.0287
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0046 0.0075
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0715 0.07
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0165
Schistosoma mansoni calmodulin 0.0019 0.0037 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0081 0.0749 0.3785
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0302
Leishmania major cathepsin L-like protease 0.0038 0.0251 0.1141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0715 0.1207
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0354 0.0554
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0541 0.6105 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0107
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0046 0.0075
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.1204
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0354 0.1685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Echinococcus multilocularis lamin dm0 0.0027 0.0122 0.0106
Schistosoma mansoni calmodulin 0.0019 0.0037 0.002
Entamoeba histolytica cysteine protease, putative 0.0038 0.0251 0.3003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0093 0.0127
Onchocerca volvulus 0.0027 0.0122 0.0475
Onchocerca volvulus 0.0133 0.136 0.6031
Echinococcus multilocularis neuronal calcium sensor 0.0019 0.0037 0.002
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0046 0.0335
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0129 0.144
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0889 0.4586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Echinococcus granulosus cathepsin l1 0.0031 0.0168 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0129 0.0491
Plasmodium vivax vivapain-2 0.0038 0.0251 0.2694
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0047 0.0053
Leishmania major hypothetical protein, conserved 0.0024 0.0093 0.0302
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0541 0.6105 0.6099
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0251 0.0236
Onchocerca volvulus 0.0038 0.0251 0.1056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1425 0.1411
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0749 0.1204
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0749 0.3785
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0251 0.0386
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0749 0.1204
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0889 1
Giardia lamblia Cathepsin L-like protease 0.002 0.0046 0.0154
Brugia malayi intermediate filament protein 0.0027 0.0122 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0251 0.1236
Echinococcus granulosus cathepsin b 0.0541 0.6105 0.6099
Echinococcus granulosus neuronal calcium sensor 0.0019 0.0037 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0176 0.0262
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0046 0.0029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0715 0.07
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0093 0.0127
Onchocerca volvulus 0.0049 0.0377 0.162
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0047 0.016
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0046 0.0048
Echinococcus granulosus cysteine protease 0.0027 0.0129 0.0113
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0712 0.3586
Echinococcus multilocularis calpain 5 0.0081 0.0749 0.0734
Giardia lamblia Cysteine protease 0.002 0.0046 0.0154
Schistosoma mansoni integrin beta subunit 0.0187 0.1988 0.1975
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0019 0.0037 0.026
Brugia malayi programmed cell death protein 6 0.0019 0.0037 0.006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0749 0.3785
Brugia malayi Cathepsin L-like precursor 0.0031 0.0168 0.0275
Entamoeba histolytica protein kinase, putative 0.0056 0.0467 0.5762
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0046 0.0048
Echinococcus granulosus cathepsin l1 0.0038 0.0251 0.0236
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0712 0.1142
Brugia malayi Cathepsin L-like precursor 0.0038 0.0251 0.0412
Giardia lamblia Cysteine protease 0.002 0.0046 0.0154
Entamoeba histolytica cysteine protease, putative 0.0027 0.0129 0.144
Echinococcus multilocularis programmed cell death protein 0.0037 0.0241 0.0225
Schistosoma mansoni neuronal calcium sensor 0.0019 0.0037 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0715 0.1207
Trypanosoma brucei unspecified product 0.0032 0.0186 0.0791
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0377 0.0618
Giardia lamblia Cathepsin L precursor 0.002 0.0046 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1425 0.1411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0251 0.1141
Echinococcus granulosus calumenin 0.0019 0.0037 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0251 0.1236
Brugia malayi calpain family protein 1 0.0214 0.2298 0.3764
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0715 1
Schistosoma mansoni neuronal calcium sensor 0.0019 0.0037 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0046 0.0029
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0315 0.3476 0.3465
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0046 0.0075
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0047 0.0076
Echinococcus multilocularis calpain 7 (C02 family) 0.0081 0.0749 0.0734
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0354 0.0338
Toxoplasma gondii EFHC1, putative 0.0019 0.0037 0.0107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0164 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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