TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 292.721 | Formula: C13H13ClN4O2
H donors: 2 H acceptors: 5 LogP: 1.37 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: ClCC(=O)Nc1ccc(nc1)c1nc(C)c(c(n1)O)C
InChi: 1S/C13H13ClN4O2/c1-7-8(2)16-12(18-13(7)20)10-4-3-9(6-15-10)17-11(19)5-14/h3-4,6H,5H2,1-2H3,(H,17,19)(H,16,18,20)
InChiKey: AGKSGGKPXNNQAV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase	0.0272	0.1173	0.1714
Toxoplasma gondii	PHD-finger domain-containing protein	0.0122	0.028	0.006
Echinococcus multilocularis	jumonji domain containing 1A	0.012	0.0271	0.0267
Echinococcus granulosus	beta LACTamase domain containing family member	0.0272	0.1173	0.117
Loa Loa (eye worm)	hypothetical protein	0.012	0.0271	0.0435
Schistosoma mansoni	zinc finger protein	0.0317	0.1445	0.1445
Schistosoma mansoni	hypothetical protein	0.1752	1	1
Echinococcus granulosus	muscleblind protein	0.0324	0.1484	0.148
Trichomonas vaginalis	glucosylceramidase, putative	0.0295	0.1311	0.1829
Brugia malayi	Bromodomain containing protein	0.0606	0.3171	0.4642
Schistosoma mansoni	hypothetical protein	0.0075	0.0004	0.0004
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Schistosoma mansoni	cpg binding protein	0.0123	0.0288	0.0288
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.1086	0.6029	0.9673
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0569	0.2947	0.2944
Schistosoma mansoni	methyl-cpg binding protein mbd	0.027	0.1165	0.1165
Echinococcus multilocularis	lysine specific demethylase 6a	0.012	0.0271	0.0267
Brugia malayi	CXXC zinc finger family protein	0.0123	0.0288	0.0416
Schistosoma mansoni	hypothetical protein	0.0122	0.028	0.028
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0388	0.1868	0.1865
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0276	0.1201	0.6189
Schistosoma mansoni	hypothetical protein	0.0326	0.15	0.15
Brugia malayi	Bromodomain containing protein	0.1195	0.6678	0.9783
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0952	0.5234	0.5232
Echinococcus granulosus	SAM and MBT domain containing protein	0.0098	0.0142	0.0138
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0272	0.1173	0.1714
Brugia malayi	PHD-finger family protein	0.0372	0.1774	0.2595
Brugia malayi	beta-lactamase family protein	0.0272	0.1173	0.1714
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1735	0.9898	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0272	0.1173	0.1628
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0129	0.0325	0.0357
Echinococcus multilocularis	muscleblind protein	0.0324	0.1484	0.148
Echinococcus multilocularis	zinc finger protein	0.0317	0.1445	0.1441
Onchocerca volvulus	Glucosylceramidase homolog	0.0193	0.0707	0.0834
Echinococcus granulosus	zinc finger protein	0.0317	0.1445	0.1441
Echinococcus multilocularis	jumonji domain containing protein	0.0518	0.2644	0.2641
Trichomonas vaginalis	conserved hypothetical protein	0.0244	0.1008	0.1387
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0099	0.0145	0.013
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0123	0.0288	0.0462
Brugia malayi	RNA, U transporter 1	0.0087	0.0073	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.0584	0.0769
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0262	0.1119	0.1441
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0108	0.0201	0.0201
Schistosoma mansoni	hypothetical protein	0.0327	0.1503	0.1503
Brugia malayi	jmjC domain containing protein	0.012	0.0271	0.0391
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.012	0.0271	0.0271
Entamoeba histolytica	hypothetical protein	0.0075	0.0004	0.5
Echinococcus multilocularis	chromobox protein 1	0.0435	0.2148	0.2145
Trichomonas vaginalis	set domain proteins, putative	0.1235	0.6921	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0122	0.028	0.006
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1173	0.1883
Brugia malayi	F/Y-rich N-terminus family protein	0.0195	0.0718	0.1047
Echinococcus multilocularis	phd:f box containing protein	0.012	0.0271	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0142	0.0227
Echinococcus granulosus	lysine specific demethylase 6a	0.012	0.0271	0.0267
Loa Loa (eye worm)	hypothetical protein	0.112	0.6232	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0769	0.4139	0.664
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0502	0.0806
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0122	0.028	0.01
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0372	0.1774	0.1774
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0272	0.1173	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0158	0.0497	0.0497
Mycobacterium ulcerans	hypothetical protein	0.0272	0.1173	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0244	0.1008	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1173	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1173	0.1883
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0267	0.1144	0.1144
Giardia lamblia	PHD finger protein 15	0.0372	0.1774	0.5
Schistosoma mansoni	hypothetical protein	0.0242	0.0999	0.0999
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0112	0.0223	0.0321
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0099	0.0145	0.013
Echinococcus multilocularis	geminin	0.0532	0.2726	0.2723
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0099	0.0145	0.013
Trichomonas vaginalis	glucosylceramidase, putative	0.0204	0.0769	0.1039
Mycobacterium ulcerans	beta-lactamase	0.0272	0.1173	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.0372	0.1774	1
Schistosoma mansoni	hypothetical protein	0.0532	0.2726	0.2726
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0428	0.2107	0.2104
Echinococcus granulosus	chromobox protein 1	0.0435	0.2148	0.2145
Brugia malayi	beta-lactamase family protein	0.0272	0.1173	0.1714
Plasmodium vivax	SET domain protein, putative	0.0158	0.0497	0.1501
Trypanosoma cruzi	ISWI complex protein	0.0242	0.0999	0.8068
Onchocerca volvulus		0.0272	0.1173	0.1522
Loa Loa (eye worm)	mbt repeat family protein	0.0098	0.0142	0.0227
Mycobacterium ulcerans	esterase/lipase LipP	0.0272	0.1173	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0295	0.1311	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0645	0.3401	0.5457
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0352	0.1654	0.1651
Onchocerca volvulus		0.0272	0.1173	0.1522
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0229	0.0921	0.0921
Brugia malayi	CHD4 protein	0.0108	0.0201	0.0289
Brugia malayi	Heterochromatin protein 1	0.0435	0.2148	0.3143
Echinococcus granulosus	cpg binding protein	0.016	0.051	0.0506
Echinococcus granulosus	phd:f box containing protein	0.012	0.0271	0.0267
Schistosoma mansoni	phosphatidylserine receptor	0.012	0.0271	0.0271
Echinococcus multilocularis	muscleblind protein 1	0.0324	0.1484	0.148
Loa Loa (eye worm)	beta-lactamase	0.0272	0.1173	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1173	0.1883
Mycobacterium leprae	Probable lipase LipE	0.0272	0.1173	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0326	0.15	0.2407
Echinococcus granulosus	jumonji domain containing 1A	0.012	0.0271	0.0267
Echinococcus granulosus	JmjC domain containing protein 4	0.012	0.0271	0.0267
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0098	0.0142	0.0138
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0099	0.0145	0.013
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.0004	0.0004
Leishmania major	hypothetical protein, conserved	0.0272	0.1173	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.015	0.0447	0.0443
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0569	0.2947	0.2944
Brugia malayi	Bromodomain containing protein	0.041	0.1998	0.2923
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2107	0.3381
Trichomonas vaginalis	chromobox protein, putative	0.0435	0.2148	0.3048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0352	0.1654	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1173	0.1883
Trichomonas vaginalis	esterase, putative	0.0272	0.1173	0.1628
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0295	0.1311	0.2104
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0428	0.2107	0.2107
Plasmodium vivax	hypothetical protein, conserved	0.0129	0.0325	0.0357
Trypanosoma cruzi	ISWI complex protein	0.0242	0.0999	0.8068
Loa Loa (eye worm)	PHD-finger family protein	0.0372	0.1774	0.2847
Loa Loa (eye worm)	jmjC domain-containing protein	0.0488	0.2464	0.3953
Echinococcus granulosus	methyl CpG binding domain protein 2	0.027	0.1165	0.1161
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0158	0.0497	0.1501
Brugia malayi	Pre-SET motif family protein	0.1086	0.6029	0.8831
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0272	0.1173	0.117
Schistosoma mansoni	hypothetical protein	0.0372	0.1774	0.1774
Schistosoma mansoni	methyl-cpg binding protein mbd	0.027	0.1165	0.1165
Echinococcus multilocularis	lysine specific demethylase 5A	0.0451	0.2242	0.2239
Trichomonas vaginalis	D-aminoacylase, putative	0.0272	0.1173	0.1628
Echinococcus granulosus	fetal alzheimer antigen falz	0.0364	0.1725	0.1722
Trichomonas vaginalis	conserved hypothetical protein	0.0244	0.1008	0.1387
Onchocerca volvulus		0.1235	0.6921	1
Brugia malayi	Pre-SET motif family protein	0.0158	0.0497	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0244	0.1008	0.1618
Loa Loa (eye worm)	jmjC domain-containing protein	0.012	0.0271	0.0435
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.0584	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0608	0.3178	0.5098
Trichomonas vaginalis	glucosylceramidase, putative	0.0295	0.1311	0.1829
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0112	0.0223	0.0223
Schistosoma mansoni	zinc finger protein	0.0242	0.0999	0.0999
Plasmodium falciparum	phd finger protein, putative	0.0372	0.1774	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0158	0.0496	0.0496
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0099	0.0145	0.013
Loa Loa (eye worm)	PHD-finger family protein	0.0327	0.1503	0.2411
Onchocerca volvulus		0.0272	0.1173	0.1522
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.027	0.1165	0.1161
Echinococcus multilocularis	chromobox protein 1	0.0435	0.2148	0.2145
Schistosoma mansoni	cpg binding protein	0.016	0.051	0.051
Onchocerca volvulus		0.0123	0.0288	0.0216
Loa Loa (eye worm)	bromodomain containing protein	0.028	0.1222	0.1961
Echinococcus granulosus	geminin	0.0532	0.2726	0.2723
Brugia malayi	jmjC domain containing protein	0.012	0.0271	0.0391
Brugia malayi	PHD-finger family protein	0.0401	0.1948	0.285
Schistosoma mansoni	phd/f-box containing protein	0.012	0.0271	0.0271
Trichomonas vaginalis	glucosylceramidase, putative	0.0204	0.0769	0.1039
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0157	0.0493	0.0489
Trypanosoma cruzi	hypothetical protein, conserved	0.0272	0.1173	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0122	0.028	0.01
Trichomonas vaginalis	penicillin-binding protein, putative	0.0272	0.1173	0.1628
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0108	0.0201	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0638	0.3361	0.5392
Loa Loa (eye worm)	heterochromatin protein 1	0.0435	0.2148	0.3447
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0158	0.0497	0.0493
Schistosoma mansoni	jumonji domain containing protein	0.012	0.0271	0.0271
Trypanosoma brucei	ISWI complex protein	0.0242	0.0999	0.8068
Echinococcus granulosus	snurportin 1	0.0326	0.15	0.1497
Loa Loa (eye worm)	hypothetical protein	0.012	0.0271	0.0435
Mycobacterium leprae	conserved hypothetical protein	0.0272	0.1173	0.5
Echinococcus multilocularis	peregrin	0.041	0.1998	0.1995
Brugia malayi	mbt repeat family protein	0.0098	0.0142	0.0202
Trichomonas vaginalis	D-aminoacylase, putative	0.0272	0.1173	0.1628
Echinococcus granulosus	histone acetyltransferase MYST2	0.0112	0.0223	0.0219
Entamoeba histolytica	hypothetical protein	0.0075	0.0004	0.5
Echinococcus multilocularis	dnaJ subfamily B	0.1752	1	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0694	0.1114
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0112	0.0223	0.0219
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0272	0.1173	0.1173
Onchocerca volvulus		0.0229	0.0921	0.115
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0352	0.1654	0.2655
Echinococcus granulosus	lysine specific demethylase 5A	0.0488	0.2464	0.2461
Loa Loa (eye worm)	hypothetical protein	0.0372	0.1774	0.2847
Schistosoma mansoni	bromodomain containing protein	0.1009	0.5572	0.5572
Echinococcus granulosus	histone lysine methyltransferase setb	0.0428	0.2107	0.2104
Mycobacterium ulcerans	lipase LipD	0.0272	0.1173	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.012	0.0271	0.0435
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0272	0.1173	0.1883
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0112	0.0223	0.0219
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0098	0.0142	0.0142
Loa Loa (eye worm)	MBCTL1	0.0112	0.0223	0.0357
Entamoeba histolytica	hypothetical protein	0.0075	0.0004	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0099	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0324	0.1484	0.2381
Echinococcus granulosus	PHD finger protein rhinoceros	0.0372	0.1774	0.1771
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0488	0.2464	0.2464
Plasmodium vivax	hypothetical protein, conserved	0.0372	0.1774	1
Schistosoma mansoni	chromobox protein	0.0435	0.2148	0.2148
Brugia malayi	SET domain containing protein	0.008	0.0029	0.0036
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0352	0.1654	0.1654
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0352	0.1654	0.1651
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0272	0.1173	0.1173
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0352	0.1654	0.2419
Onchocerca volvulus		0.0191	0.0694	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0682	0.3623	0.5813
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0157	0.0493	0.0489
Toxoplasma gondii	PHD-finger domain-containing protein	0.0372	0.1774	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0295	0.1311	0.1829
Schistosoma mansoni	protein phosphatase 2C	0.012	0.0271	0.0271
Echinococcus granulosus	jumonji domain containing protein	0.0518	0.2644	0.2641
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0112	0.0223	0.0219
Echinococcus multilocularis	snurportin 1	0.0326	0.15	0.1497
Brugia malayi	jmjC domain containing protein	0.1219	0.6826	1
Brugia malayi	jmjC domain containing protein	0.0488	0.2464	0.3606
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0952	0.5234	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0223	0.0357
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Echinococcus granulosus	peregrin	0.041	0.1998	0.1995
Entamoeba histolytica	hypothetical protein	0.0075	0.0004	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0099	0.0145	0.013
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0352	0.1654	0.1651
Trichomonas vaginalis	D-aminoacylase, putative	0.0272	0.1173	0.1628
Echinococcus granulosus	chromobox protein 1	0.0435	0.2148	0.2145
Brugia malayi	AF-10 protein	0.0122	0.028	0.0404
Schistosoma mansoni	chromobox protein	0.0435	0.2148	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0324	0.1484	0.2381
Trypanosoma brucei	hypothetical protein, conserved	0.0272	0.1173	1
Loa Loa (eye worm)	CHromoDomain protein family member	0.0108	0.0201	0.0322
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0099	0.0145	0.013
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0086	0.0068	0.0018
Brugia malayi	chromobox protein homolog 3	0.0244	0.1008	0.1472
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.1219	0.6826	0.6825
Brugia malayi	jmjC domain containing protein	0.012	0.0271	0.0391
Trypanosoma cruzi	hypothetical protein, conserved	0.0272	0.1173	1
Brugia malayi	mbt repeat family protein	0.0098	0.0142	0.0202
Schistosoma mansoni	sex comb on midleg homolog	0.0098	0.0142	0.0142
Schistosoma mansoni	jumonji domain containing protein	0.0969	0.5331	0.5331
Plasmodium vivax	hypothetical protein, conserved	0.0272	0.1173	0.6001
Schistosoma mansoni	sex comb on midleg homolog	0.0098	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1173	0.1883
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0428	0.2107	0.2107
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0068	0.0018
Echinococcus multilocularis	JmjC domain containing protein 4	0.012	0.0271	0.0267
Echinococcus multilocularis	cpg binding protein	0.016	0.051	0.0506
Echinococcus multilocularis	polycomb protein SCMH1	0.0098	0.0142	0.0138
Trichomonas vaginalis	glucosylceramidase, putative	0.0295	0.1311	0.1829
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0372	0.1774	0.1771
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Trichomonas vaginalis	glucosylceramidase, putative	0.0295	0.1311	0.1829
Toxoplasma gondii	ABC1 family protein	0.0272	0.1173	0.6001
Loa Loa (eye worm)	jmjC domain-containing protein	0.012	0.0271	0.0435
Schistosoma mansoni	hypothetical protein	0.0532	0.2726	0.2726
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0352	0.1654	0.1651
Onchocerca volvulus	Alhambra homolog	0.0372	0.1774	0.2409
Echinococcus granulosus	polycomb protein SCMH1	0.0098	0.0142	0.0138
Trichomonas vaginalis	chromobox protein, putative	0.0262	0.1119	0.1548
Brugia malayi	Muscleblind-like protein	0.0324	0.1484	0.2169
Trichomonas vaginalis	chromobox protein, putative	0.0435	0.2148	0.3048
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0108	0.0201	0.0197
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0295	0.1311	0.1916
Leishmania major	hypothetical protein, conserved	0.0242	0.0999	0.8068
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0388	0.1868	0.1865
Brugia malayi	jmjC domain containing protein	0.012	0.0271	0.0391
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0364	0.1725	0.1722
Schistosoma mansoni	cpg binding protein	0.016	0.051	0.051
Schistosoma mansoni	hypothetical protein	0.0599	0.3124	0.3124
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0364	0.1725	0.1725
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0707	0.0949
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0488	0.2464	0.2464
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0352	0.1654	0.1654
Trichomonas vaginalis	chromobox protein, putative	0.0262	0.1119	0.1548
Brugia malayi	PHD-finger family protein	0.0159	0.0502	0.073
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.1219	0.6826	0.6825

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 30 uM	Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay	ChEMBL.	20932758

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1269424

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1250178