TDR Targets

Basic information

Technical information

TDR Targets ID: 1250444
Name: 1-(2-thienylcarbonyl)benzo[cd]indol-2(1H)-one
MW: 279.313 | Formula: C16H9NO2S
H donors: 0 H acceptors: 2 LogP: 3.72 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C(n1c(=O)c2c3c1cccc3ccc2)c1cccs1
InChi: 1S/C16H9NO2S/c18-15-11-6-1-4-10-5-2-7-12(14(10)11)17(15)16(19)13-8-3-9-20-13/h1-9H
InChiKey: YEYXXMIZOTYIGN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000679744
ZINC02891134
SMR000296984

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-ets avian erythroblastosis virus E26 oncogene homolog	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	ets-related	Get druggable targets OG5_131947	All targets in OG5_131947
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	ko:K09435 transcriptional regulator ERG, putative	Get druggable targets OG5_131947	All targets in OG5_131947
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0122	0.0611	0.0806
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0044	0.0044
Loa Loa (eye worm)	MH2 domain-containing protein	0.0475	0.3287	0.3287
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0033	0.0044
Brugia malayi	hexokinase type II	0.0331	0.2196	0.2196
Echinococcus granulosus	chromobox protein 1	0.0084	0.0324	0.0427
Trypanosoma brucei	beta lactamase	0.0125	0.0637	0.0826
Brugia malayi	hypothetical protein	0.0072	0.0233	0.0233
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0155	0.0155
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0125	0.0637	0.0161
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Brugia malayi	RNA binding protein	0.0062	0.0155	0.0155
Mycobacterium tuberculosis	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	0.0334	0.2215	1
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0125	0.0637	1
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0963	0.6976	0.9045
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0033	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0711	0.507	0.507
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0324	0.0324
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.1004	0.7289	0.7289
Entamoeba histolytica	hypothetical protein	0.0072	0.0233	0.0308
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Schistosoma mansoni	ets-related	0.0265	0.1697	0.1697
Echinococcus multilocularis	hexokinase	0.1042	0.758	1
Loa Loa (eye worm)	glutaminase 2	0.1362	1	1
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.1004	0.7289	0.7289
Brugia malayi	hexokinase	0.1042	0.758	0.758
Loa Loa (eye worm)	hexokinase	0.0323	0.2129	0.2129
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0471	0.325	0.4214
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0471	0.325	0.4289
Schistosoma mansoni	kinase	0.0239	0.1498	0.1498
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.1004	0.7289	1
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0261	0.1666	0.1666
Loa Loa (eye worm)	transcription factor SMAD2	0.0475	0.3287	0.3287
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.1004	0.7289	0.5191
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0155	0.0155
Trypanosoma cruzi	hypothetical protein, conserved	0.106	0.7713	1
Loa Loa (eye worm)	fli-1 protein	0.0265	0.1697	0.1697
Trypanosoma brucei	hexokinase	0.1042	0.758	0.9827
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0155	0.0155
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0155	0.0155
Echinococcus granulosus	chromobox protein 1	0.0084	0.0324	0.0427
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0963	0.6976	0.9204
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0963	0.6976	0.9045
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0155	0.0155
Brugia malayi	Ets-domain containing protein	0.0087	0.0349	0.0349
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0963	0.6976	0.6976
Brugia malayi	chromobox protein homolog 3	0.0047	0.0044	0.0044
Leishmania major	hexokinase, putative	0.1042	0.758	0.9827
Schistosoma mansoni	hexokinase	0.1042	0.758	0.758
Onchocerca volvulus		0.0654	0.4638	0.6097
Echinococcus multilocularis	hexokinase type 2	0.1042	0.758	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0471	0.325	0.4255
Trypanosoma brucei	hypothetical protein, conserved	0.106	0.7713	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0471	0.325	0.4289
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.0349	0.046
Trypanosoma brucei	polo-like protein kinase	0.0471	0.325	0.4214
Treponema pallidum	hexokinase (hxk)	0.1042	0.758	1
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0122	0.0611	0.0792
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0233	0.0308
Brugia malayi	Hexokinase family protein	0.1042	0.758	0.758
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0071	0.0071
Brugia malayi	Hexokinase family protein	0.0654	0.4638	0.4638
Schistosoma mansoni	glutaminase	0.1362	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0155	0.0205
Brugia malayi	Hexokinase family protein	0.0323	0.2129	0.2129
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0963	0.6976	0.9204
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0044	0.0044
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0963	0.6976	0.9045
Trypanosoma cruzi	hypothetical protein, conserved	0.106	0.7713	1
Echinococcus granulosus	hexokinase	0.1042	0.758	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0033	0.0033
Echinococcus granulosus	hexokinase type 2	0.1042	0.758	1
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0319	0.2102	0.2726
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0471	0.325	0.4289
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0155	0.0155
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0963	0.6976	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0155	0.0155
Entamoeba histolytica	hexokinase 1	0.1042	0.758	1
Trichomonas vaginalis	CAMK family protein kinase	0.0233	0.1451	0.1451
Entamoeba histolytica	hypothetical protein	0.0072	0.0233	0.0308
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0122	0.0611	0.0611
Schistosoma mansoni	gabp alpha	0.0087	0.0349	0.0349
Echinococcus multilocularis	hexokinase	0.1042	0.758	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0075	0.0075
Onchocerca volvulus		0.1042	0.758	1
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0324	0.0427
Echinococcus granulosus	hexokinase	0.1042	0.758	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.0349	0.046
Brugia malayi	Heterochromatin protein 1	0.0084	0.0324	0.0324
Trichomonas vaginalis	glutaminase, putative	0.1362	1	1
Toxoplasma gondii	hexokinase	0.1042	0.758	1
Trypanosoma cruzi	hexokinase, putative	0.1042	0.758	0.9827
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0963	0.6976	0.6976
Mycobacterium ulcerans	hypothetical protein	0.0122	0.0611	0.0611
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0253	0.0253
Entamoeba histolytica	hypothetical protein	0.0072	0.0233	0.0308
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0122	0.0611	0.0792
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0122	0.0611	0.0611
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0033	0.0033
Echinococcus multilocularis	hexokinase	0.1042	0.758	1
Loa Loa (eye worm)	hypothetical protein	0.0331	0.2196	0.2196
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0471	0.325	0.325
Trichomonas vaginalis	CAMK family protein kinase	0.0233	0.1451	0.1451
Leishmania major	hexokinase, putative	0.1042	0.758	0.9827
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0233	0.0308
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0233	0.0233
Schistosoma mansoni	hypothetical protein	0.0072	0.0233	0.0233
Brugia malayi	MH2 domain containing protein	0.0475	0.3287	0.3287
Giardia lamblia	Kinase, PLK	0.0471	0.325	0.4459
Loa Loa (eye worm)	hexokinase	0.0654	0.4638	0.4638
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0122	0.0611	0.0611
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0155	0.0205
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0033	0.0033
Echinococcus granulosus	citrate lyase subunit beta protein	0.0122	0.0611	0.0806
Onchocerca volvulus	Hexokinase homolog	0.0654	0.4638	0.6097
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0324	0.0324
Trypanosoma cruzi	polo-like protein kinase, putative	0.0471	0.325	0.4214
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0629	0.4448	0.4448
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Onchocerca volvulus		0.1042	0.758	1
Schistosoma mansoni	chromobox protein	0.0084	0.0324	0.0324
Brugia malayi	Ets-domain containing protein	0.0087	0.0349	0.0349
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0155	0.0155
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0324	0.0427
Plasmodium falciparum	hexokinase	0.1042	0.758	1
Loa Loa (eye worm)	hexokinase type II	0.1042	0.758	0.758
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0324	0.0324
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.1004	0.7289	0.9073
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0071	0.0036
Plasmodium vivax	hexokinase, putative	0.1042	0.758	1
Trypanosoma cruzi	hexokinase, putative	0.1042	0.758	0.9827
Loa Loa (eye worm)	glutaminase	0.1362	1	1
Mycobacterium ulcerans	hypothetical protein	0.0122	0.0611	0.0611
Brugia malayi	serine/threonine-protein kinase plk-2	0.0471	0.325	0.325
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0963	0.6976	0.6976
Brugia malayi	Fli-1 protein	0.0265	0.1697	0.1697
Mycobacterium ulcerans	lipoprotein LpqF	0.0125	0.0637	0.0637
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0033	0.0033
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0071	0.0071
Trypanosoma cruzi	polo-like protein kinase, putative	0.0471	0.325	0.4214
Schistosoma mansoni	chromobox protein	0.0084	0.0324	0.0324
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0033	0.0044
Mycobacterium ulcerans	glutaminase	0.1362	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.1004	0.7289	0.7289
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0044	0.0044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0033	0.0033
Echinococcus granulosus	hexokinase	0.1042	0.758	1
Brugia malayi	TAR-binding protein	0.0062	0.0155	0.0155
Trypanosoma brucei	hexokinase, putative	0.1042	0.758	0.9827
Entamoeba histolytica	hypothetical protein	0.0072	0.0233	0.0308
Leishmania major	hypothetical protein, conserved	0.106	0.7713	1
Trichomonas vaginalis	CAMK family protein kinase	0.0471	0.325	0.325
Loa Loa (eye worm)	hypothetical protein	0.0331	0.2196	0.2196
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0963	0.6976	0.6976
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0963	0.6976	0.9204
Entamoeba histolytica	hexokinase 2	0.1042	0.758	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0075	0.0075
Loa Loa (eye worm)	hexokinase	0.1042	0.758	0.758
Schistosoma mansoni	serine/threonine protein kinase	0.0471	0.325	0.325
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0122	0.0611	0.0792
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0075	0.0075
Loa Loa (eye worm)	hexokinase	0.1042	0.758	0.758
Trypanosoma brucei	hexokinase	0.1042	0.758	0.9827
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0155	0.0155
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0075	0.0075
Onchocerca volvulus		0.1042	0.758	1
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0122	0.0611	0.0611
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.031	0.2032	0.2635
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0261	0.1666	0.6577
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0033	0.0044

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1122 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	2.0787 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	39.8107 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1332342

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1250444