Detailed information for compound 1250631

Basic information

Technical information
  • TDR Targets ID: 1250631
  • Name: N-cyclohexyl-2-[(5,7-dimethyl-[1,2,4]triazolo [1,5-a]pyrimidin-2-yl)sulfanyl]-N-methylaceta mide
  • MW: 333.452 | Formula: C16H23N5OS
  • H donors: 0 H acceptors: 4 LogP: 3.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C1CCCCC1)C)CSc1nn2c(n1)nc(cc2C)C
  • InChi: 1S/C16H23N5OS/c1-11-9-12(2)21-15(17-11)18-16(19-21)23-10-14(22)20(3)13-7-5-4-6-8-13/h9,13H,4-8,10H2,1-3H3
  • InChiKey: YPNLWBMYQOVDOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclohexyl-2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-methyl-acetamide
  • N-cyclohexyl-2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]-N-methylacetamide
  • N-cyclohexyl-2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]-N-methyl-acetamide
  • N-cyclohexyl-2-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-N-methyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0023 0.0382 0.0423
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0014 0.0138 0.0153
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0274 0.2271
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0274 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0065 0.0072
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.1047 0.1047
Schistosoma mansoni hypothetical protein 0.0049 0.1036 0.1145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0282 0.0282
Schistosoma mansoni ran 0.0022 0.0355 0.0393
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0382 0.043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1479 1
Brugia malayi hypothetical protein 0.0019 0.0282 0.0282
Echinococcus granulosus dna polymerase kappa 0.0023 0.0382 0.0423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.4578 0.5062
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.1207 1
Echinococcus granulosus ras GTP exchange factor 0.0014 0.0138 0.0153
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.1061 0.1193
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0365 0.0797
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0562 0.0631
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0365 0.0797
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0274 0.2271
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0065 0.0065
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0029 0.0526 0.1148
Schistosoma mansoni Smad4 0.0025 0.043 0.0476
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0269 0.6731 0.6731
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0057 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7846 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0414 0.0465
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0282 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.124 0.158
Echinococcus granulosus cpg binding protein 0.0037 0.0728 0.0805
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.4578 0.5062
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0414 0.0527
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0355 0.0399
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0355 0.0399
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.4094 0.4602
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0282 0.0312
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Schistosoma mansoni smad1 5 8 and 0.0025 0.043 0.0476
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Brugia malayi Importin beta-1 subunit 0.003 0.0562 0.0562
Brugia malayi MH2 domain containing protein 0.0369 0.9333 0.9333
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0436 0.0436
Onchocerca volvulus 0.0014 0.0138 0.0138
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0274 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.375 0.375
Schistosoma mansoni hypothetical protein 0.0049 0.1036 0.1145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0065 0.0065
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0274 0.0274
Schistosoma mansoni cpg binding protein 0.0035 0.0676 0.0748
Onchocerca volvulus 0.0035 0.0676 0.0676
Echinococcus granulosus geminin 0.0358 0.9043 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0274 0.0308
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2494 0.2494
Schistosoma mansoni smad 0.0011 0.007 0.0078
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0274 0.0303
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0009 0.001 0.0065
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0065 0.0072
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0282 0.0282
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0027 0.0482 0.1419
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0041 0.083 0.1812
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0282 0.0312
Giardia lamblia DINP protein human, muc B family 0.0023 0.0382 0.14
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.4578 0.5062
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.273 0.273
Brugia malayi RNA, U transporter 1 0.0086 0.2004 0.2004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Leishmania major DNA polymerase eta, putative 0.0023 0.0382 0.043
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0355 0.0355
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0382 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.4578 0.5062
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0065 0.0072
Leishmania major protein kinase, putative 0.0009 0.001 0.0011
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.007 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0065 0.0072
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.4094 0.4602
Loa Loa (eye worm) hypothetical protein 0.0014 0.0139 0.0139
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.1342 0.1508
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0274 0.2271
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.1036 0.1145
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.007 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0382 0.0834
Treponema pallidum NADH oxidase 0.0019 0.0274 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.043 0.0476
Loa Loa (eye worm) hypothetical protein 0.0046 0.096 0.096
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0065 0.0065
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0482 0.1053
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0138 0.0138
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0382 0.0423
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0274 0.0598
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0018 0.0244 0.0533
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Brugia malayi MH1 domain containing protein 0.0025 0.043 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.375 0.375
Brugia malayi glutathione reductase 0.0055 0.1207 0.1207
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0282 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0065 0.0065
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0064 0.0139
Echinococcus multilocularis GPCR, family 2 0.0049 0.1036 0.1145
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0103 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0352 0.8896 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0282 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0065 0.0065
Plasmodium falciparum thioredoxin reductase 0.0019 0.0274 0.2271
Loa Loa (eye worm) nuclear factor I 0.0014 0.0139 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7846 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0382 0.0942
Brugia malayi DIX domain containing protein 0.0019 0.0282 0.0282
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0355 0.0393
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0382 0.043
Brugia malayi CXXC zinc finger family protein 0.0035 0.0676 0.0676
Echinococcus granulosus smad 0.0025 0.043 0.0476
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0065 0.0065
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0382 0.043
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0274 0.0598
Mycobacterium ulcerans polyketide synthase 0.0029 0.0526 0.1148
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.001 0.0011
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0065 0.0065
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.3399 0.7418
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0282 0.0312
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0282 0.0282
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0482 0.1053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0065 0.0072
Schistosoma mansoni hypothetical protein 0.0049 0.1036 0.1145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0065 0.0072
Plasmodium falciparum thioredoxin reductase 0.0055 0.1207 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0065 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0195 0.0219
Loa Loa (eye worm) hypothetical protein 0.0023 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0349 0.8798 0.8798
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.1036 0.1145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0065 0.0072
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.043 0.0476
Echinococcus multilocularis snurportin 1 0.0323 0.8129 0.8989
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.007 0.0078
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0014 0.0138 0.0153
Brugia malayi N-terminal motif family protein 0.0014 0.0138 0.0138
Schistosoma mansoni Smad4 0.0011 0.007 0.0078
Echinococcus multilocularis Smad4 0.0025 0.043 0.0476
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0355 0.2942
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0274 0.0308
Plasmodium vivax glutathione reductase, putative 0.0055 0.1207 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.2494 0.2494
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0355 0.0399
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0065 0.0072
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0065 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0382 0.043
Schistosoma mansoni cpg binding protein 0.0037 0.0728 0.0805
Brugia malayi RasGEF domain containing protein 0.0014 0.0138 0.0138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0065 0.0072
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0382 0.0423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.7846 0.7846
Schistosoma mansoni smad1 5 8 and 0.0025 0.043 0.0476
Brugia malayi RasGEF domain containing protein 0.0014 0.0138 0.0138
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0274 0.1004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Entamoeba histolytica hypothetical protein 0.0025 0.0414 0.1063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.1036 0.1145
Trypanosoma brucei unspecified product 0.0023 0.0382 0.043
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0461 0.1006
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0482 0.0482
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0562 0.0631
Onchocerca volvulus 0.0011 0.0065 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0065 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.1036 0.1036
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0195 0.0219
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0482 0.1053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.3035 0.6625
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Toxoplasma gondii thioredoxin reductase 0.0055 0.1207 0.816
Brugia malayi photoreceptor-specific nuclear receptor 0.0269 0.6731 0.6731
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.1061 0.1193
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.5072 0.5072
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0282 0.0312
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0355 0.2942
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Schistosoma mansoni dishevelled 0.0019 0.0282 0.0312
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0345 0.0753
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.1112 0.1112
Echinococcus granulosus GPCR family 2 0.0049 0.1036 0.1145
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0282 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7846 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0274 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7846 1
Brugia malayi MH1 domain containing protein 0.0014 0.0139 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.4578 0.5062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0065 0.0072
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0355 0.2401
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0009 0.001 0.0011
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0009 0.0021 0.0046
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0014 0.0138 0.0155
Echinococcus granulosus cGMP dependent protein kinase 0.0009 0.001 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0369 0.9333 0.9333
Trypanosoma brucei unspecified product 0.0016 0.0195 0.0219
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0365 0.1075
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Onchocerca volvulus 0.0047 0.1003 0.1003
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.5357 0.6828
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0065 0.0065
Schistosoma mansoni kinase 0.0058 0.1279 0.1414
Brugia malayi hypothetical protein 0.0019 0.0282 0.0282
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0135 0.0911
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0065 0.0072
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0382 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0065 0.0065
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0482 0.1053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0041 0.083 0.1812
Mycobacterium ulcerans thioesterase 0.0023 0.0365 0.0797
Trypanosoma cruzi hypothetical protein 0.0014 0.0138 0.0155
Echinococcus multilocularis importin subunit beta 1 0.003 0.0562 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0065 0.0065
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0029 0.0526 0.1148
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0065 0.0065
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0065 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0179 0.0391
Mycobacterium leprae Polyketide synthase Pks13 0.0041 0.083 0.2442
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0482 0.1053
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.0526 0.3557
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0143 0.0143
Plasmodium falciparum cGMP-dependent protein kinase 0.0009 0.001 0.008
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0065 0.0065
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0053 0.0053
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.4094 0.4602
Brugia malayi steroid hormone receptor 0.0011 0.0065 0.0065
Echinococcus multilocularis son of sevenless 1 0.0014 0.0138 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0323 0.8129 0.8989
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0282 0.0312
Leishmania major DNA polymerase kappa, putative 0.0023 0.0382 0.043
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0138 0.0138
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0013 0.012 0.0133
Loa Loa (eye worm) hypothetical protein 0.0154 0.375 0.375
Echinococcus multilocularis geminin 0.0358 0.9043 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0029 0.0526 0.1548
Echinococcus granulosus cGMP dependent protein kinase 1 0.0009 0.001 0.0011
Loa Loa (eye worm) AGC/PKG protein kinase 0.0009 0.001 0.001
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0274 0.2271
Entamoeba histolytica Ran family GTPase 0.0022 0.0355 0.0837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.4578 0.5062
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0274 0.0308
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Echinococcus multilocularis cpg binding protein 0.0037 0.0728 0.0805
Trypanosoma brucei trypanothione reductase 0.0055 0.1207 0.1356
Schistosoma mansoni smad 0.0025 0.043 0.0476
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0065 0.0072
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0382 0.0423
Trypanosoma cruzi hypothetical protein 0.0014 0.0138 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.375 0.375
Echinococcus granulosus Smad4 0.0025 0.043 0.0476
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.273 0.3069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.3035 0.8931
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0274 0.1853
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0002
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.028 0.1892
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0065 0.0065
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0274 1
Plasmodium falciparum glutathione reductase 0.0055 0.1207 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0014 0.0138 0.0138
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0282 0.0282
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0274 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Brugia malayi nuclear hormone receptor 0.0011 0.0065 0.0065
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0274 0.0308
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0482 0.1053
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0274 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0065 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0382 0.043
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0382 0.043
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0009 0 0.0001
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0282 0.0312
Schistosoma mansoni dep domain containing protein 0.0019 0.0282 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0382 0.043
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0274 0.0303
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0274 0.0598
Schistosoma mansoni ras GTP exchange factor 0.0014 0.0138 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0382 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0138 0.0153
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0029 0.0526 0.1548
Echinococcus multilocularis muscleblind protein 0.0349 0.8798 0.9728
Brugia malayi ecdysteroid receptor 0.0011 0.0065 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.124 0.158
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0065 0.0072
Mycobacterium tuberculosis Probable reductase 0.0126 0.3035 0.6625
Echinococcus multilocularis dna polymerase eta 0.0023 0.0382 0.0423
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0562 0.3797
Echinococcus multilocularis smad 0.0025 0.043 0.0476
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0352 0.8896 1
Echinococcus multilocularis muscleblind protein 1 0.0349 0.8798 0.9728
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0065 0.0065
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0274 0.0303
Mycobacterium ulcerans polyketide synthase Pks13 0.0041 0.083 0.1812
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.007 0.007
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0065 0.0072
Brugia malayi MH2 domain containing protein 0.0025 0.043 0.043
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0284 0.0621
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.007 0.0078
Schistosoma mansoni smad1 5 8 and 0.0025 0.043 0.0476
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0355 0.0355
Mycobacterium ulcerans polyketide synthase Pks9 0.0018 0.0244 0.0533
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.3035 0.6625
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0014 0.0138 0.0153
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0014 0.0138 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0352 0.8896 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0065 0.0072
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0022 0.0345 0.1015
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.001 0.0011
Giardia lamblia Kinase, PLK 0.0114 0.273 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.1036 0.1036
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0009 0.001 0.0011
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0029 0.0526 0.1548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.4578 0.5062
Toxoplasma gondii hypothetical protein 0.0057 0.125 0.8451
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0414 0.0527
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.1061 0.1193
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0436 0.0436
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.1207 0.1334
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.273 0.3069
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0355 0.1301
Schistosoma mansoni coup transcription factor 0.0011 0.0065 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.3035 0.6625
Brugia malayi N-terminal motif family protein 0.0014 0.0138 0.0138
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.4581 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0235 0.1592
Brugia malayi Muscleblind-like protein 0.0349 0.8798 0.8798
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.273 0.3019
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0282 0.0312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0138 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.001 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0065 0.0072
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0018 0.0244 0.0719
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0065 0.0072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0065 0.0072
Loa Loa (eye worm) hypothetical protein 0.0395 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0065 0.0072
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.273 0.273
Brugia malayi MH1 domain containing protein 0.0025 0.043 0.043
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0002 0.0002
Loa Loa (eye worm) glutathione reductase 0.0055 0.1207 0.1207
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.8129 0.8129
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.043 0.043
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.3035 0.6625
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0282 0.0312
Trichomonas vaginalis ras GTP exchange factor, putative 0.0014 0.0138 0.0176
Echinococcus multilocularis expressed conserved protein 0.0009 0.001 0.0011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0143 0.0143
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0274 0.0308
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0014 0.0138 0.0176
Echinococcus granulosus cGMP dependent protein kinase 1 0.0009 0.001 0.0011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0382 0.0834
Echinococcus granulosus son of sevenless 1 0.0014 0.0138 0.0153
Loa Loa (eye worm) hypothetical protein 0.0019 0.0282 0.0282
Brugia malayi Thioredoxin reductase 0.0055 0.1207 0.1207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0057 0.0063
Schistosoma mansoni hypothetical protein 0.0049 0.1036 0.1145
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.3035 0.6625
Brugia malayi MH1 domain containing protein 0.0014 0.0139 0.0139
Trypanosoma brucei unspecified product 0.0016 0.0195 0.0219
Schistosoma mansoni DNA polymerase eta 0.0023 0.0382 0.0423
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0382 0.043
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.7846 0.7846
Echinococcus multilocularis Protein son of sevenless 0.0014 0.0138 0.0153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0382 0.0834
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0065 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0065 0.0065
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0473 0.0473
Leishmania major trypanothione reductase 0.0055 0.1207 0.1356
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0526 0.1148
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.5357 0.6828
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0065 0.0065
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0022 0.0345 0.0753
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0482 0.1053
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0274 0.0349
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0382 0.0423
Plasmodium falciparum glutathione reductase 0.0019 0.0274 0.2271
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.1036 0.1145
Echinococcus granulosus Protein son of sevenless 0.0014 0.0138 0.0153
Leishmania major importin beta-1 subunit, putative 0.0025 0.0414 0.0465
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0395 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.1207 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0282 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0274 0.0308
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0382 0.0423
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Brugia malayi MH2 domain containing protein 0.0011 0.007 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7846 1
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.1207 0.1356
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.1207 0.2634
Onchocerca volvulus 0.0019 0.0282 0.0282
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0382 0.0487
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0274 0.0308
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0096 0.2272 0.8235
Schistosoma mansoni Smad4 0.0011 0.007 0.0078
Plasmodium falciparum importin beta, putative 0.003 0.0562 0.4653
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0065 0.0065
Schistosoma mansoni importin beta-1 0.003 0.0562 0.0621
Echinococcus granulosus snurportin 1 0.0323 0.8129 0.8989
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0065 0.0072
Leishmania major mitochondrial DNA polymerase beta 0.0352 0.8896 1
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0065 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Loa Loa (eye worm) hypothetical protein 0.003 0.0562 0.0562
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0461 0.1006
Echinococcus granulosus muscleblind protein 0.0349 0.8798 0.9728
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.4578 0.4578
Loa Loa (eye worm) Smad1 0.0025 0.043 0.043
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.273 1
Schistosoma mansoni hypothetical protein 0.0358 0.9043 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0138 0.0138
Brugia malayi Egg laying defective protein 4 0.0009 0.001 0.001
Mycobacterium ulcerans polyketide synthase 0.0027 0.0482 0.1053
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0355 0.0393
Schistosoma mansoni hypothetical protein 0.0105 0.2494 0.2758
Brugia malayi RasGEF domain containing protein 0.0014 0.0138 0.0138
Loa Loa (eye worm) MH2 domain-containing protein 0.0369 0.9333 0.9333
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0526 0.1148
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0065 0.0072
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0282 0.0312
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0526 0.1148
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0065 0.0065
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0138 0.0153
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0436 0.0952
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.3399 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.273 0.3019
Leishmania major GTP-binding protein, putative 0.0022 0.0355 0.0399
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.1036 0.1036
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.1061 0.1193
Schistosoma mansoni dishevelled 0.0019 0.0282 0.0312
Toxoplasma gondii hypothetical protein 0.0019 0.0282 0.191
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0274 0.1853
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0014 0.0138 0.0176
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0382 0.0382
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.007 0.0078
Leishmania major protein kinase, putative 0.0009 0.001 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.3399 0.7418
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5072 0.6465
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Loa Loa (eye worm) hypothetical protein 0.0096 0.2272 0.2272
Trichomonas vaginalis ras GTP exchange factor, putative 0.0014 0.0138 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0065 0.0065
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.273 0.3069
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0282 0.0282
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0382 0.0487
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0414 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0382 0.043
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0096 0.2272 0.8235
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0282 0.0312
Brugia malayi nuclear receptor NHR-88 0.0011 0.0065 0.0065
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.273 0.3019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0676 0.0676
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.043 0.0476
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.273 0.273
Echinococcus multilocularis ras GTP exchange factor 0.0014 0.0138 0.0153
Schistosoma mansoni ran 0.0022 0.0355 0.0393
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0065 0.0065
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.3399 0.7418
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0274 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0195 0.0219
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0065 0.0072
Brugia malayi Latrophilin receptor protein 2 0.0049 0.1036 0.1036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0065 0.0072
Loa Loa (eye worm) hypothetical protein 0.0349 0.8798 0.8798
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1682 0.186
Brugia malayi Smad1 0.0025 0.043 0.043
Trichomonas vaginalis ran, putative 0.0022 0.0355 0.0452
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0065 0.0072
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0138 0.0153
Trypanosoma brucei polo-like protein kinase 0.0114 0.273 0.3069
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0382 0.043
Schistosoma mansoni hypothetical protein 0.0358 0.9043 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0065 0.0065
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.043 0.0476
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0354 0.0773
Plasmodium vivax importin-beta 2, putative 0.003 0.0562 0.4653
Schistosoma mansoni cpg binding protein 0.0037 0.0728 0.0805
Mycobacterium ulcerans hypothetical protein 0.0186 0.4581 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0282 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Echinococcus granulosus importin subunit beta 1 0.003 0.0562 0.0621
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.043 0.0476
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0014 0.0138 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.273 0.3479
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0002 0.0002
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0027 0.0482 0.1419
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0274 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7846 1
Onchocerca volvulus 0.0025 0.0436 0.0436
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0057 0.0057
Brugia malayi MH2 domain containing protein 0.0025 0.043 0.043
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.1207 0.1334
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.4578 0.4578
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0382 0.0382

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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