Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0057 | 0.07 | 0.07 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.6417 | 1 |
Onchocerca volvulus | 0.0057 | 0.07 | 1 | |
Schistosoma mansoni | gliotactin | 0.0057 | 0.07 | 0.07 |
Schistosoma mansoni | acetylcholinesterase | 0.0057 | 0.07 | 0.07 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | carboxylesterase | 0.0057 | 0.07 | 0.07 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0057 | 0.07 | 0.07 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0072 | 0.0072 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0057 | 0.07 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0057 | 0.07 | 0.07 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0057 | 0.07 | 1 |
Onchocerca volvulus | 0.0057 | 0.07 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | carboxylesterase | 0.0339 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0072 | 0.0072 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0339 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0339 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0057 | 0.07 | 0.07 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0057 | 0.07 | 0.1091 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Echinococcus granulosus | acetylcholinesterase | 0.0339 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0057 | 0.07 | 0.07 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0057 | 0.07 | 0.07 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0657 | 0.0657 |
Echinococcus granulosus | acetylcholinesterase | 0.0339 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0057 | 0.07 | 0.07 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0057 | 0.07 | 1 |
Onchocerca volvulus | 0.0057 | 0.07 | 1 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0657 | 0.0657 |
Onchocerca volvulus | 0.0057 | 0.07 | 1 | |
Onchocerca volvulus | 0.0057 | 0.07 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0057 | 0.07 | 0.07 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0057 | 0.07 | 0.1091 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0339 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0339 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0057 | 0.07 | 0.07 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0057 | 0.07 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0339 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0339 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0072 | 0.0072 |
Brugia malayi | Carboxylesterase family protein | 0.0057 | 0.07 | 0.07 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0057 | 0.07 | 0.1091 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Echinococcus multilocularis | acetylcholinesterase | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.07 | 0.07 |
Brugia malayi | Carboxylesterase family protein | 0.0057 | 0.07 | 0.07 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0057 | 0.07 | 0.07 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 16 ug ml-1 | Antimicrobial activity against Cryptococcus neoformans by broth microdilution method | ChEMBL. | 20933407 |
MIC90 (functional) | > 128 ug ml-1 | Antifungal activity against Candida albicans by broth microdilution method | ChEMBL. | 20933407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.