Detailed information for compound 1250781

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 252.311 | Formula: C16H16N2O
  • H donors: 1 H acceptors: 1 LogP: 4.8 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)Nc1nc2c(o1)ccc(c2)C
  • InChi: 1S/C16H16N2O/c1-3-12-5-7-13(8-6-12)17-16-18-14-10-11(2)4-9-15(14)19-16/h4-10H,3H2,1-2H3,(H,17,18)
  • InChiKey: NQAKLIGQCZLYKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0498 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0303 0.026
Echinococcus granulosus dnaJ subfamily B 0.0938 0.5899 0.5881
Schistosoma mansoni hypothetical protein 0.0039 0.0179 0.0179
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0498 0.0456
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0242 0.0631
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.016 0.0117
Schistosoma mansoni hypothetical protein 0.0018 0.0046 0.0046
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0213 0.0169
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0086 0.0476 0.0434
Brugia malayi Carboxylesterase family protein 0.0086 0.0476 0.1384
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.3153 1
Schistosoma mansoni hypothetical protein 0.0047 0.0231 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.016 0.016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.016 0.055
Echinococcus multilocularis protein patched 0.0049 0.0242 0.0199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0829 0.0829
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0127 0.1489
Loa Loa (eye worm) hypothetical protein 0.006 0.0312 0.0856
Brugia malayi CXXC zinc finger family protein 0.0066 0.0351 0.0981
Schistosoma mansoni cpg binding protein 0.007 0.0375 0.0375
Schistosoma mansoni survival motor neuron protein 0.0055 0.0281 0.0281
Onchocerca volvulus 0.0275 0.1681 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 1
Loa Loa (eye worm) carboxylesterase 0.0086 0.0476 0.1384
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 1
Onchocerca volvulus 0.0066 0.0351 0.1674
Brugia malayi Doublecortin family protein 0.0024 0.0083 0.012
Loa Loa (eye worm) carboxylesterase 0.0086 0.0476 0.1384
Schistosoma mansoni loxhd1 0.0024 0.0083 0.0083
Schistosoma mansoni acetylcholinesterase 0.0086 0.0476 0.0476
Mycobacterium ulcerans hypothetical protein 0.0027 0.0106 0.0238
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0051
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.0966 0.0926
Schistosoma mansoni hypothetical protein 0.0938 0.5899 0.5899
Loa Loa (eye worm) acetylcholinesterase 1 0.0506 0.3153 1
Echinococcus granulosus acetylcholinesterase 0.0506 0.3153 0.3123
Loa Loa (eye worm) hypothetical protein 0.0269 0.1644 0.5145
Schistosoma mansoni cpg binding protein 0.0066 0.0351 0.0351
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0796 0.2415
Loa Loa (eye worm) hypothetical protein 0.0049 0.0242 0.0631
Onchocerca volvulus 0.0027 0.0106 0.0142
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.1644 0.1608
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0106 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0242 0.1143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0268 0.0268
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0106 0.0238
Schistosoma mansoni hypothetical protein 0.0047 0.0231 0.0231
Brugia malayi Carboxylesterase family protein 0.0086 0.0476 0.1384
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0417 0.0375
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0086 0.0476 0.0476
Echinococcus multilocularis RUN 0.0024 0.0083 0.0039
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0655 0.0614
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0106 0.0238
Schistosoma mansoni lipoxygenase 0.01 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Echinococcus granulosus RUN 0.0024 0.0083 0.0039
Schistosoma mansoni hypothetical protein 0.0018 0.0046 0.0046
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0086 0.0476 0.0434
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0937 0.589 0.5872
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0193
Loa Loa (eye worm) hypothetical protein 0.0057 0.0293 0.0794
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0127 0.1489
Echinococcus multilocularis carboxylesterase 5A 0.0506 0.3153 0.3123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0268 0.0268
Trichomonas vaginalis set domain proteins, putative 0.0275 0.1681 0.8778
Brugia malayi Carboxylesterase family protein 0.0506 0.3153 1
Schistosoma mansoni gliotactin 0.0086 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0051
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0242 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0106 0.0193
Echinococcus granulosus neuroligin 0.0086 0.0476 0.0434
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0106 0.0238
Brugia malayi glutaminase DH11.1 0.0311 0.1912 0.6005
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0242 0.0199
Loa Loa (eye worm) glutaminase 2 0.0311 0.1912 0.6005
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0083 0.0039
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.0966 0.0926
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0046 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0506 0.3153 1
Schistosoma mansoni hypothetical protein 0.0018 0.0046 0.0046
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0417 0.5
Echinococcus multilocularis microtubule associated protein 2 0.1583 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0106 0.0238
Schistosoma mansoni cpg binding protein 0.007 0.0375 0.0375
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0417 0.1193
Schistosoma mansoni hypothetical protein 0.0018 0.0046 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0293 0.0794
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0417 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0303 0.5892
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0655 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0086 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0036 0.016 0.0368
Loa Loa (eye worm) histone methyltransferase 0.0022 0.007 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0046 0.0002
Brugia malayi hypothetical protein 0.0024 0.0083 0.012
Echinococcus multilocularis tumor protein p63 0.039 0.2414 0.2381
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0106 0.0193
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0242 0.0199
Brugia malayi hypothetical protein 0.0269 0.1644 0.5145
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0303 0.5024
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0838 0.0797
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.012
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0417 0.1193
Echinococcus multilocularis para nitrobenzyl esterase 0.0086 0.0476 0.0434
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 0.2358
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0086 0.0476 0.0476
Schistosoma mansoni rab6-interacting 0.0024 0.0083 0.0083
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0498 0.6118
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0303 0.5892
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0295 0.0295
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0303 0.026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0046 0.0002
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0213 0.0169
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0417 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0268 0.0225
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0106 0.1214
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0062 0.0169
Echinococcus multilocularis BC026374 protein (S09 family) 0.0086 0.0476 0.0434
Brugia malayi Pre-SET motif family protein 0.0242 0.147 0.4584
Plasmodium vivax SET domain protein, putative 0.0036 0.016 0.2254
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0417 0.566
Trichomonas vaginalis glutaminase, putative 0.0311 0.1912 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.016 0.0117
Brugia malayi Carboxylesterase family protein 0.0086 0.0476 0.1384
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.016 0.016
Echinococcus granulosus BC026374 protein S09 family 0.0086 0.0476 0.0434
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0083 0.0039
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0086 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Loa Loa (eye worm) carboxylesterase 0.0506 0.3153 1
Brugia malayi Pre-SET motif family protein 0.0036 0.016 0.0368
Loa Loa (eye worm) hypothetical protein 0.0089 0.0498 0.1455
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0083 0.0488
Schistosoma mansoni lipoxygenase 0.0142 0.0838 0.0838
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0498 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0268 0.0714
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0106 0.0238
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0506 0.3153 0.3153
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0293 0.0794
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0044 0.0044
Mycobacterium ulcerans carboxylesterase, LipT 0.0086 0.0476 0.2239
Mycobacterium ulcerans glutaminase 0.0311 0.1912 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Brugia malayi hypothetical protein 0.0024 0.0083 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0083 0.0039
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0417 0.5
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0666 0.0666
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0268 0.0225
Echinococcus multilocularis expressed conserved protein 0.0107 0.0611 0.057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.012
Schistosoma mansoni hypothetical protein 0.0024 0.0083 0.0083
Schistosoma mansoni glutaminase 0.0311 0.1912 0.1912
Loa Loa (eye worm) glutaminase 0.0311 0.1912 0.6005
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0068 0.007
Schistosoma mansoni hypothetical protein 0.0047 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Echinococcus multilocularis neuroligin 0.0086 0.0476 0.0434
Echinococcus multilocularis acetylcholinesterase 0.0506 0.3153 0.3123
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0083 0.0039
Schistosoma mansoni hypothetical protein 0.0047 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0802
Onchocerca volvulus 0.0036 0.016 0.0482
Onchocerca volvulus 0.0086 0.0476 0.2458
Echinococcus granulosus carboxylesterase 5A 0.0506 0.3153 0.3123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0143 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0106 0.0238
Echinococcus multilocularis protein dispatched 1 0.0056 0.0286 0.0243
Echinococcus multilocularis GPCR, family 2 0.0018 0.0046 0.0002
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0655 0.0614
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0498 0.0498
Schistosoma mansoni hypothetical protein 0.0055 0.0281 0.0281
Schistosoma mansoni patched 1 0.0049 0.0242 0.0242
Schistosoma mansoni neuroligin 3 (S09 family) 0.0086 0.0476 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0106 0.0238
Loa Loa (eye worm) hypothetical protein 0.0114 0.0655 0.1961
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0268 0.0714
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0193
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0083 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.1583 1 1
Echinococcus granulosus tumor protein p63 0.039 0.2414 0.2381
Echinococcus multilocularis acetylcholinesterase 0.0506 0.3153 0.3123
Brugia malayi Probable ClpP-like protease 0.0089 0.0498 0.1455
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0179 0.0427
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0193
Echinococcus granulosus expressed conserved protein 0.0107 0.0611 0.057
Trichomonas vaginalis spcc417.12 protein, putative 0.0086 0.0476 0.2384
Onchocerca volvulus 0.0086 0.0476 0.2458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0268 0.0268
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.147 0.4584
Schistosoma mansoni polycystin 1-related 0.0024 0.0083 0.0083
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0086 0.0476 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0293 0.0794
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0046 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0351 0.0981
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0838 0.0797
Loa Loa (eye worm) hypothetical protein 0.0086 0.0476 0.1384
Loa Loa (eye worm) hypothetical protein 0.0039 0.0179 0.0427
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0498 0.6118
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0417 0.0375
Brugia malayi CHE-14 protein 0.0049 0.0242 0.0631
Onchocerca volvulus 0.0086 0.0476 0.2458
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0086 0.0476 1
Schistosoma mansoni rab6-interacting 0.0024 0.0083 0.0083
Onchocerca volvulus 0.0055 0.0281 0.1238
Onchocerca volvulus 0.0057 0.0295 0.1326
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0083 0.012
Onchocerca volvulus 0.0086 0.0476 0.2458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.016 0.016
Echinococcus multilocularis cpg binding protein 0.007 0.0375 0.0332
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0281 0.0757
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0127 0.0534
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.016 0.0117
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0655 0.1961
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0106 0.1214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0268 0.0225
Echinococcus granulosus cpg binding protein 0.007 0.0375 0.0332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0268 0.0225
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.1644 0.1608
Mycobacterium tuberculosis Carboxylesterase LipT 0.0086 0.0476 1
Echinococcus granulosus acetylcholinesterase 0.0506 0.3153 0.3123
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0051
Onchocerca volvulus 0.0086 0.0476 0.2458
Brugia malayi Carboxylesterase family protein 0.0506 0.3153 1
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0083 0.0488
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0734 1
Echinococcus multilocularis dnaJ subfamily B 0.0938 0.5899 0.5881
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0796 0.2415
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.007 0.0026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0498 0.2358
Brugia malayi hypothetical protein 0.0086 0.0476 0.1384
Echinococcus granulosus GPCR family 2 0.0018 0.0046 0.0002
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0498 0.0456
Brugia malayi MH2 domain containing protein 0.0136 0.0796 0.2415
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0083 0.0039
Brugia malayi Carboxylesterase family protein 0.0086 0.0476 0.1384
Echinococcus granulosus para nitrobenzyl esterase 0.0086 0.0476 0.0434
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0086 0.0476 0.2384

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 19.21 ng/ml Antiasthamatic activity against ovalbumin-induced airway hyperresponsiveness mouse model assessed as reduction of plasma IgE level at 30 mg/kg, po measured 48 hrs after ovalbumin challenge (Rvb = 41.82 +/- 10.57 ng/ml) ChEMBL. 20870413
Activity (functional) = 64.3 ng/ml Antiasthamatic activity against ovalbumin-induced airway hyperresponsiveness mouse model assessed as reduction of bronchoalveolar lavage fluid IL-13 level at 30 mg/kg, po measured 48 hrs after ovalbumin challenge ChEMBL. 20870413
Activity (functional) = 116.92 ng/ml Antiasthamatic activity against ovalbumin-induced airway hyperresponsiveness mouse model assessed as reduction of bronchoalveolar lavage fluid IL-5 level at 30 mg/kg, po measured 48 hrs after ovalbumin challenge ChEMBL. 20870413
Activity (functional) = 198.34 ng/ml Antiasthamatic activity against ovalbumin-induced airway hyperresponsiveness mouse model assessed as reduction of bronchoalveolar lavage fluid IL-4 level at 30 mg/kg, po measured 48 hrs after ovalbumin challenge ChEMBL. 20870413
IC50 (binding) = 0.12 uM Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay ChEMBL. 20870413

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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