Detailed information for compound 1251274

Basic information

Technical information
  • TDR Targets ID: 1251274
  • Name: 2-(7-chloroquinolin-4-yl)sulfanylacetic acid
  • MW: 253.705 | Formula: C11H8ClNO2S
  • H donors: 1 H acceptors: 3 LogP: 2.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CSc1ccnc2c1ccc(c2)Cl
  • InChi: 1S/C11H8ClNO2S/c12-7-1-2-8-9(5-7)13-4-3-10(8)16-6-11(14)15/h1-5H,6H2,(H,14,15)
  • InChiKey: YFWVKWISZZSPFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(7-chloro-4-quinolyl)sulfanyl]acetic acid
  • 2-[(7-chloro-4-quinolyl)thio]acetic acid
  • 2-(7-chloroquinolin-4-yl)sulfanylethanoic acid
  • 5429-07-2
  • KM 10750
  • 2-[(7-chloro-4-quinolinyl)sulfanyl]acetic acid
  • MLS000850622
  • SMR000456640
  • Maybridge3_003910
  • NSC13352
  • IDI1_015297

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens prion protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) BRM protein 0.0012 0.0024 0.0032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0037 0.0037
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0038
Loa Loa (eye worm) beta-lactamase 0.011 0.1275 0.1681
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0022 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0132 0.1138
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0037 0.0043
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0072 0.0072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0132 0.0961
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0028
Echinococcus granulosus bromodomain containing protein 8 0.0012 0.0024 0.0028
Brugia malayi BRM protein 0.0012 0.0024 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0371 0.4602 0.607
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0022 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0793 0.25
Schistosoma mansoni hypothetical protein 0.0042 0.0413 0.0485
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0018 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1275 1
Mycobacterium ulcerans hypothetical protein 0.011 0.1275 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0113
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0036 0.0062
Brugia malayi MH1 domain containing protein 0.0014 0.0052 0.0088
Echinococcus multilocularis zinc finger protein 0.0049 0.0495 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus multilocularis bromodomain containing protein 8 0.0012 0.0024 0.0024
Brugia malayi MH1 domain containing protein 0.0025 0.0196 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0395 0.4915 0.6482
Trichomonas vaginalis bromodomain containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus CREB binding protein 0.0012 0.0024 0.0028
Loa Loa (eye worm) CBP-B 0.0012 0.0024 0.0032
Leishmania major trypanothione reductase 0.0037 0.0348 0.2675
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0068
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0861 0.101
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni zinc finger protein 0.0049 0.0495 0.0581
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0072 0.0489
Echinococcus multilocularis translational activator gcn1 0.0011 0.001 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0998 0.3154
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0411 0.1529
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0411 0.3168
Brugia malayi N-terminal motif family protein 0.0177 0.2137 0.3644
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0022 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0271 0.3329 0.3909
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1275 0.404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0271 0.3329 0.3329
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1275 0.1497
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0538 0.6204
Schistosoma mansoni bromodomain containing protein 0.0138 0.1637 0.1923
Schistosoma mansoni hypothetical protein 0.0031 0.0274 0.0321
Entamoeba histolytica Ran family GTPase 0.0042 0.0405 0.1507
Echinococcus multilocularis lamin dm0 0.0027 0.0212 0.0212
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0411 0.128
Brugia malayi CXXC zinc finger family protein 0.0029 0.0243 0.0414
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0271 0.3329 0.5677
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0405 0.3122
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1275 1
Toxoplasma gondii bromodomain-containing protein 0.0012 0.0024 0.0109
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1275 0.1407
Brugia malayi Probable ClpP-like protease 0.0077 0.0861 0.1467
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1078 0.1183
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0957 0.1045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi MH1 domain containing protein 0.0014 0.0052 0.0088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0072 0.0085
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0957 0.7002
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus smad 0.0025 0.0196 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1275 1
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0596 0.463
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0072 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0132 0.0862
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0271 0.3329 0.3909
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0012 0.0024 0.0028
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0026
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0022 0.0026
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0348 0.2675
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0348 0.2594
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0132 0.0464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0657 0.0772
Onchocerca volvulus 0.011 0.1275 0.2174
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0024 0.0044
Entamoeba histolytica acetyltransferase, GNAT family 0.0076 0.0847 0.3195
Loa Loa (eye worm) latrophilin receptor protein 2 0.0125 0.1469 0.1937
Trichomonas vaginalis esterase, putative 0.011 0.1275 0.404
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0432
Entamoeba histolytica bromodomain-containing protein 0.0012 0.0024 0.0053
Loa Loa (eye worm) nuclear factor I 0.0014 0.0052 0.0068
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0405 0.0534
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0203
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.1249 0.9793
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0459 0.3479
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0957 0.1045
Loa Loa (eye worm) hypothetical protein 0.011 0.1275 0.1681
Onchocerca volvulus 0.0012 0.0024 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trypanosoma brucei bromodomain factor 2 protein, putative 0.0012 0.0024 0.0109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0221
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1078 0.8141
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0022 0.0038
Plasmodium vivax SET domain containing protein 0.0012 0.0032 0.0173
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0196 0.023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0484 0.0568
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0013 0.0037 0.0085
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0055 0.0094
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0998 0.7807
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1275 0.404
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3141 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0521 0.0549
Schistosoma mansoni smad1 5 8 and 0.0025 0.0196 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0271 0.3329 0.3329
Brugia malayi isocitrate dehydrogenase 0.0016 0.0072 0.0123
Schistosoma mansoni cpg binding protein 0.0035 0.0314 0.0369
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1275 0.404
Plasmodium vivax bromodomain protein, putative 0.0012 0.0024 0.0109
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.0489
Echinococcus granulosus zinc finger protein 0.0049 0.0495 0.0581
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0038 0.0221
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0041
Schistosoma mansoni transcription initiation factor tfiid 0.0012 0.0024 0.0028
Echinococcus granulosus Bromodomain containing protein 0.0012 0.0024 0.0028
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0022 0.0038
Schistosoma mansoni hypothetical protein 0.0677 0.8517 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0196 0.023
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0012 0.0024 0.0044
Schistosoma mansoni ap endonuclease 0.002 0.0132 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0271 0.3329 0.439
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni alpha glucosidase 0.0042 0.0411 0.0482
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0038 0.0172
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Entamoeba histolytica hypothetical protein 0.0216 0.263 1
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0012 0.0024 0.0109
Plasmodium falciparum bromodomain protein 1 0.0012 0.0024 0.0162
Onchocerca volvulus 0.0012 0.0022 0.0038
Echinococcus multilocularis expressed protein 0.0012 0.0022 0.0022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1078 0.1183
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0411 0.3168
Echinococcus granulosus lamin dm0 0.0027 0.0212 0.0249
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0216 0.263 0.263
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni lamin 0.0027 0.0212 0.0249
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0022 0.0026
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0012 0.0024 0.0028
Schistosoma mansoni lamin 0.0027 0.0212 0.0249
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0024 0.0044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0521 0.2892
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0132 0.1309
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0038 0.0221
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.2295 0.3026
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0072 0.0489
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0024 0.0044
Echinococcus granulosus snurportin 1 0.0604 0.7582 0.8902
Onchocerca volvulus 0.0012 0.0022 0.0038
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0038 0.0089
Schistosoma mansoni hypothetical protein 0.0216 0.263 0.3088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0038 0.0221
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) transcription factor SMAD2 0.0371 0.4602 0.607
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0038 0.0221
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0171 0.0201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0029
Trypanosoma brucei ISWI complex protein 0.0031 0.0274 0.2083
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.1249 0.9795
Echinococcus multilocularis smad 0.0025 0.0196 0.0196
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0538 0.4171
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0079 0.0877 0.1156
Entamoeba histolytica bromodomain-containing protein 0.0012 0.0024 0.0053
Brugia malayi TAZ zinc finger family protein 0.0012 0.0024 0.0041
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0018 0.0021
Echinococcus granulosus global transcription activator snf2l2 0.0012 0.0024 0.0028
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.009 0.1027 0.1355
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0022 0.0022
Trichomonas vaginalis hypothetical protein 0.0012 0.0024 0.0044
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0348 0.0353
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.1249 0.9793
Entamoeba histolytica bromodomain-containing protein 0.0012 0.0024 0.0053
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0022 0.0026
Echinococcus granulosus bromodomain containing 2 0.0012 0.0024 0.0028
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0411 0.128
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0022 0.0029
Brugia malayi hypothetical protein 0.0216 0.263 0.4484
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0596 0.463
Echinococcus granulosus expressed protein 0.0012 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0125
Loa Loa (eye worm) hypothetical protein 0.011 0.1275 0.1681
Schistosoma mansoni importin-beta 2 0.0011 0.001 0.0012
Brugia malayi beta-lactamase family protein 0.011 0.1275 0.2174
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0596 0.0596
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0348 0.046
Mycobacterium leprae Probable lipase LipE 0.011 0.1275 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0596 0.0786
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0411 0.128
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Schistosoma mansoni zinc finger protein 0.0031 0.0274 0.0321
Brugia malayi Thioredoxin reductase 0.0037 0.0348 0.0594
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni bromodomain containing 0.0012 0.0024 0.0028
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0214 0.2134
Schistosoma mansoni smad 0.0025 0.0196 0.023
Schistosoma mansoni importin beta-1 0.0057 0.0596 0.0699
Brugia malayi polybromodomain protein 0.0012 0.0024 0.0041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1275 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.0384
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1275 0.404
Echinococcus granulosus CREB binding protein 0.0012 0.0024 0.0028
Echinococcus multilocularis geminin 0.0677 0.8517 0.8517
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.3141 0.5356
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0861 0.6724
Loa Loa (eye worm) hypothetical protein 0.0107 0.1242 0.1638
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0012 0.0024 0.0028
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0411 0.128
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0022 0.0022
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0196 0.023
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0793 0.25
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0405 0.3046
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.2295 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0221
Schistosoma mansoni phd finger protein 0.0012 0.0024 0.0028
Mycobacterium ulcerans beta-lactamase 0.011 0.1275 1
Brugia malayi kap beta 3 protein 0.0011 0.001 0.0017
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0022 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0411 0.3093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0405 0.0476
Schistosoma mansoni helicase 0.0012 0.0024 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0012 0.0024 0.0044
Echinococcus granulosus intermediate filament protein 0.0027 0.0212 0.0249
Entamoeba histolytica hypothetical protein 0.0216 0.263 1
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0413 0.0545
Plasmodium falciparum bromodomain protein, putative 0.0012 0.0024 0.0162
Trichomonas vaginalis bromodomain containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0077 0.0861 0.1135
Brugia malayi acetyltransferase, GNAT family protein 0.0288 0.3547 0.6048
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0203
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1275 0.1407
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0214 0.2393
Echinococcus multilocularis Bromodomain containing protein 0.0012 0.0024 0.0024
Entamoeba histolytica protein kinase, putative 0.0108 0.1249 0.4729
Trypanosoma brucei Bromodomain, putative 0.0012 0.0024 0.0109
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0212 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus multilocularis global transcription activator snf2l2 0.0012 0.0024 0.0024
Loa Loa (eye worm) inositol-1 0.0072 0.0793 0.1046
Entamoeba histolytica hypothetical protein 0.0216 0.263 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0243 0.0321
Plasmodium falciparum glutathione reductase 0.0013 0.0038 0.0329
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0998 0.7807
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0405 0.3046
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0861 0.101
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 0.665
Entamoeba histolytica bromodomain-containing protein 0.0012 0.0024 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0271 0.3329 0.3909
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Brugia malayi MH1 domain containing protein 0.0025 0.0196 0.0334
Brugia malayi polybromodomain protein 0.0012 0.0024 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1275 0.404
Echinococcus multilocularis transportin 1 0.0011 0.001 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0328 0.0328
Brugia malayi beta-lactamase 0.011 0.1275 0.2174
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0521 0.0521
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0074 0.0502
Onchocerca volvulus 0.0027 0.0212 0.0362
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0074 0.0203
Schistosoma mansoni CREB-binding protein 2 0.0012 0.0024 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0022 0.0029
Brugia malayi MH2 domain containing protein 0.0011 0.0018 0.003
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0012 0.0024 0.0041
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0038
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.2295 0.2295
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0074 0.0126
Mycobacterium tuberculosis Conserved protein 0.011 0.1275 0.1407
Schistosoma mansoni alpha-glucosidase 0.0163 0.1958 0.2298
Brugia malayi PHD-finger family protein 0.006 0.0634 0.1082
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3141 1
Toxoplasma gondii hypothetical protein 0.0027 0.0214 0.1609
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0538 0.4107
Echinococcus granulosus importin subunit beta 1 0.0057 0.0596 0.0699
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0411 0.0411
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0411 0.0701
Toxoplasma gondii bromodomain-containing protein 0.0012 0.0024 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3141 1
Echinococcus multilocularis GPCR, family 2 0.0125 0.1469 0.1469
Trypanosoma brucei Bromodomain, putative 0.0012 0.0024 0.0109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0212 0.028
Echinococcus multilocularis CREB binding protein 0.0012 0.0024 0.0024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0604 0.7582 1
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.1249 0.4729
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.1249 0.1647
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0319 0.0375
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Plasmodium vivax glutathione reductase, putative 0.0037 0.0348 0.2675
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0113
Toxoplasma gondii thioredoxin reductase 0.0037 0.0348 0.2675
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0861 0.0861
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0203
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0038
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0018 0.003
Onchocerca volvulus 0.011 0.1275 0.2174
Trypanosoma cruzi ISWI complex protein 0.0031 0.0274 0.1995
Schistosoma mansoni smad1 5 8 and 0.0025 0.0196 0.023
Plasmodium vivax importin-beta 2, putative 0.0057 0.0596 0.463
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0288 0.3547 0.4164
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Entamoeba histolytica protein kinase, putative 0.0108 0.1249 0.4729
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0484 0.0568
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0411 0.128
Schistosoma mansoni cpg binding protein 0.0035 0.0314 0.0369
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0793 0.25
Echinococcus granulosus importin 5 0.0011 0.001 0.0012
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0038 0.0089
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0074 0.0242
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0411 0.128
Entamoeba histolytica bromodomain-containing protein 0.0012 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1275 0.1497
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.5136 0.5136
Toxoplasma gondii ABC1 family protein 0.011 0.1275 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0203
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0024 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0113
Brugia malayi latrophilin 2 splice variant baaae 0.027 0.332 0.5661
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0024 0.0109
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0319 0.0375
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0012 0.0024 0.0028
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0405 0.3122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0196 0.0258
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.2295 0.3913
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0724 0.5644
Schistosoma mansoni bromodomain containing protein 0.0012 0.0024 0.0028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0132 0.0961
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0029
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0861 0.6724
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.011 0.1275 0.1681
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0793 0.6103
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0038 0.0221
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi hypothetical protein 0.0052 0.0538 0.0917
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0355 0.0417
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1275 0.1407
Mycobacterium tuberculosis Conserved protein 0.011 0.1275 0.1407
Brugia malayi ATPase, AAA family protein 0.0012 0.0024 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0271 0.3329 0.3909
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0038 0.0329
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0023
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0074 0.0398
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0405 0.4629
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Echinococcus granulosus transportin 1 0.0011 0.001 0.0012
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0022 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0538 0.6204
Schistosoma mansoni cpg binding protein 0.0029 0.0243 0.0285
Brugia malayi glutathione reductase 0.0037 0.0348 0.0594
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0861 0.6096
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0405 0.3122
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Plasmodium vivax hypothetical protein, conserved 0.011 0.1275 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0411 0.1529
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0521 0.0549
Echinococcus multilocularis cpg binding protein 0.0035 0.0314 0.0314
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0538 0.4171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0702 0.8826 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0813 0.0813
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1275 0.1407
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0132 0.143
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0022 0.0026
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0328 0.0385
Loa Loa (eye worm) hypothetical protein 0.0052 0.0538 0.0709
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0064 0.0697 0.455
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0411 0.3093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0957 0.1045
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0045
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0038 0.0221
Echinococcus granulosus histone acetyltransferase KAT2B 0.0275 0.3384 0.3973
Schistosoma mansoni Smad4 0.0025 0.0196 0.023
Leishmania major importin beta-1 subunit, putative 0.0046 0.0459 0.355
Toxoplasma gondii bromodomain-containing protein 0.0012 0.0024 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Mycobacterium tuberculosis Conserved protein 0.011 0.1275 0.1407
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0024 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0271 0.3329 0.3909
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0113
Brugia malayi Bromodomain containing protein 0.0085 0.0963 0.1643
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1275 0.1407
Schistosoma mansoni polybromo-1 0.0012 0.0024 0.0028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1275 1
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0012 0.0024 0.0109
Brugia malayi MH2 domain containing protein 0.0025 0.0196 0.0334
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0171 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0793 0.6147
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0074 0.0126
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0022 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1275 0.1497
Leishmania major GTP-binding protein, putative 0.0042 0.0405 0.3122
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.1544 0.1813
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2133 0.678
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.1544 0.1544
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0405 0.4643
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0957 0.1045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0132 0.0174
Entamoeba histolytica ankyrin repeat protein, putative 0.0012 0.0024 0.0053
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0132 0.0388
Schistosoma mansoni hypothetical protein 0.0125 0.1469 0.1724
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0038 0.0329
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0038 0.0065
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0998 0.3154
Echinococcus granulosus cpg binding protein 0.0035 0.0314 0.0369
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0038 0.0113
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0998 0.7807
Echinococcus granulosus geminin 0.0677 0.8517 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0038 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1249 0.1466
Loa Loa (eye worm) acetyltransferase 0.0288 0.3547 0.4678
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0038 0.0221
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0107 0.1242 0.1638
Schistosoma mansoni alpha-glucosidase 0.0163 0.1958 0.2298
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0072 0.0095
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.001 0.0013
Onchocerca volvulus 0.0469 0.5864 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0012 0.0024 0.0109
Echinococcus granulosus dnaJ subfamily B 0.0412 0.5136 0.603
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 1
Echinococcus multilocularis snurportin 1 0.0604 0.7582 0.7582
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.001 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0216 0.263 0.3088
Onchocerca volvulus 0.011 0.1275 0.2174
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Brugia malayi bromodomain containing protein 0.0012 0.0024 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0074 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0096 0.1098 0.1448
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0012 0.0024 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi MH2 domain containing protein 0.0025 0.0196 0.0334
Echinococcus multilocularis 0.0012 0.0024 0.0024
Toxoplasma gondii hypothetical protein 0.0012 0.0024 0.0109
Brugia malayi Bromodomain containing protein 0.0162 0.1944 0.3315
Schistosoma mansoni ran 0.0042 0.0405 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0328 0.0385
Loa Loa (eye worm) hypothetical protein 0.0177 0.2137 0.2818
Onchocerca volvulus 0.0012 0.0022 0.0038
Echinococcus granulosus Bromodomain containing protein 0.0012 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.0125 0.1469 0.1724
Trypanosoma brucei glucosidase, putative 0.0042 0.0411 0.3168
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0013 0.0037 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0064 0.0697 0.0749
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0132 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus dual specificity 0.0108 0.1249 0.1466
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0125 0.1469 0.1469
Giardia lamblia Histone acetyltransferase GCN5 0.0076 0.0847 1
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0459 0.1434
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0125 0.1469 0.1724
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0125 0.1469 0.1724
Loa Loa (eye worm) bromodomain containing protein 0.0043 0.0424 0.0559
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.3141 0.4142
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0196 0.0196
Echinococcus multilocularis importin 5 0.0011 0.001 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2133 0.678
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0097
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0203
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0793 0.6189
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus peregrin 0.0012 0.0024 0.0028
Plasmodium falciparum importin beta, putative 0.0057 0.0596 0.6885
Loa Loa (eye worm) glutathione reductase 0.0037 0.0348 0.046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0125 0.1469 0.1469
Echinococcus multilocularis lamin 0.0027 0.0212 0.0212
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0319 0.0375
Echinococcus granulosus PH interacting protein 0.0012 0.0024 0.0028
Mycobacterium ulcerans lipase LipD 0.011 0.1275 1
Entamoeba histolytica G protein alpha subunit, putative 0.0012 0.0022 0.0045
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0132 0.0757
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0328 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0074 0.0502
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0022 0.0026
Entamoeba histolytica hypothetical protein 0.0046 0.0459 0.1714
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0018 0.0023
Onchocerca volvulus 0.0029 0.0243 0.0414
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0288 0.3547 0.3547
Schistosoma mansoni Smad4 0.0011 0.0018 0.0021
Toxoplasma gondii bromodomain-containing protein 0.0012 0.0024 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0793 0.6147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0459 0.1434
Schistosoma mansoni Smad4 0.0011 0.0018 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1275 0.1681
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3141 1
Schistosoma mansoni inositol monophosphatase 0.0072 0.0793 0.0931
Plasmodium falciparum thioredoxin reductase 0.0013 0.0038 0.0329
Brugia malayi hypothetical protein 0.0012 0.0022 0.0038
Echinococcus granulosus GPCR family 2 0.0125 0.1469 0.1724
Trypanosoma cruzi ISWI complex protein 0.0031 0.0274 0.1995
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Entamoeba histolytica hypothetical protein 0.0108 0.1249 0.4729
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.0023 0.0171 0.0201
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0793 0.9177
Echinococcus multilocularis Bromodomain containing protein 0.0012 0.0024 0.0024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0861 0.6724
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis ran, putative 0.0042 0.0405 0.1261
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0022 0.0026
Entamoeba histolytica hypothetical protein 0.0012 0.0024 0.0053
Schistosoma mansoni hypothetical protein 0.0604 0.7582 0.8902
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0074 0.0203
Schistosoma mansoni inositol monophosphatase 0.0072 0.0793 0.0931
Trypanosoma brucei AAA ATPase, putative 0.0012 0.0024 0.0109
Entamoeba histolytica hypothetical protein 0.0216 0.263 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.1249 0.9795
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1078 0.1183
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0411 0.128
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0196 0.0196
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0221
Schistosoma mansoni hypothetical protein 0.0412 0.5136 0.603
Brugia malayi beta-lactamase family protein 0.011 0.1275 0.2174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0049
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0022 0.0026
Brugia malayi G-protein alpha subunit 0.0012 0.0022 0.0038
Onchocerca volvulus 0.011 0.1274 0.2172
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0793 0.0931
Schistosoma mansoni ap endonuclease 0.002 0.0132 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0125 0.1469 0.2504
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0405 0.0691
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0072 0.0489
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0596 0.463
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.027 0.332 0.4378
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0957 0.1045
Trichomonas vaginalis bromodomain containing protein, putative 0.0012 0.0024 0.0044
Trypanosoma brucei trypanothione reductase 0.0037 0.0348 0.2675
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0221
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0022 0.0029
Entamoeba histolytica bromodomain-containing protein 0.0012 0.0024 0.0053
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus multilocularis bromodomain containing 2 0.0012 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Mycobacterium leprae conserved hypothetical protein 0.011 0.1275 1
Brugia malayi hypothetical protein 0.0034 0.0302 0.0516
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi Smad1 0.0025 0.0196 0.0334
Plasmodium falciparum thioredoxin reductase 0.0037 0.0348 0.3978
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0212 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Schistosoma mansoni intermediate filament proteins 0.0027 0.0212 0.0249
Schistosoma mansoni hypothetical protein 0.027 0.332 0.3898
Leishmania major hypothetical protein, conserved 0.0031 0.0274 0.2083
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Echinococcus multilocularis PH interacting protein 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0125 0.1469 0.1937
Onchocerca volvulus 0.0012 0.0024 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0411 0.128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0214 0.1609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0038 0.0113
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1275 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus multilocularis dual specificity 0.0108 0.1249 0.1249
Echinococcus multilocularis Smad4 0.0025 0.0196 0.0196
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0538 0.4107
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0038 0.0113
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0793 0.6189
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0026
Plasmodium vivax bromodomain protein, putative 0.0012 0.0024 0.0109
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.2295 0.2694
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0029
Onchocerca volvulus 0.0012 0.0024 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0395 0.4915 0.8381
Brugia malayi hypothetical protein 0.0469 0.5864 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0793 0.2988
Onchocerca volvulus 0.0027 0.0212 0.0362
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0072 0.0384
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0038
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0085
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.011 0.1275 0.1681
Toxoplasma gondii exonuclease III APE 0.002 0.0132 0.0961
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0022 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3141 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0395 0.4915 0.6482
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0022 0.0038
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0998 0.1171
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Toxoplasma gondii bromodomain-containing protein 0.0012 0.0024 0.0109
Loa Loa (eye worm) hypothetical protein 0.011 0.1275 0.1681
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0022 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0072 0.0072
Brugia malayi Protein kinase domain containing protein 0.0108 0.1249 0.213
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0022 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0538 0.4171
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Leishmania major hypothetical protein, conserved 0.0052 0.0538 0.4171
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0319 0.0319
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0022 0.0038
Echinococcus multilocularis musashi 0.0027 0.0212 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0355 0.0355
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0038
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0521 0.0611
Schistosoma mansoni hypothetical protein 0.0125 0.1469 0.1724
Trypanosoma brucei Bromodomain factor 1 0.0012 0.0024 0.0109
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0132 0.0961
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0484 0.0484
Trichomonas vaginalis bromodomain containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0459 0.1434
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0041
Loa Loa (eye worm) bromodomain containing protein 0.0012 0.0024 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0212 0.028
Trichomonas vaginalis bromodomain containing protein, putative 0.0012 0.0024 0.0044
Leishmania major hypothetical protein, conserved 0.011 0.1275 1
Echinococcus granulosus protein kinase C binding protein 1 0.0012 0.0024 0.0028
Brugia malayi Inositol-1 0.0072 0.0793 0.1352
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1275 0.2174
Echinococcus multilocularis polybromo 1 0.0012 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0028
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0793 0.6189
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1275 0.1275
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0411 0.0482
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0072 0.0489
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0125 0.1469 0.2504
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.011 0.1275 0.1681
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0411 0.0542
Brugia malayi RNA, U transporter 1 0.0161 0.1927 0.3286
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0072 0.0727
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trypanosoma brucei Bromodomain, putative 0.0012 0.0024 0.0109
Schistosoma mansoni transcription factor LCR-F1 0.0216 0.263 0.3088
Mycobacterium tuberculosis Probable reductase 0.0085 0.0957 0.1045
Echinococcus multilocularis protein kinase C binding protein 1 0.0012 0.0024 0.0024
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.2017 0.344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.0272
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0012 0.0024 0.0044
Echinococcus granulosus Smad4 0.0025 0.0196 0.023
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0018 0.0018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0132 0.0155
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Onchocerca volvulus Brd8 homolog 0.0012 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0469 0.5864 0.7734
Plasmodium falciparum bromodomain protein 2, putative 0.0012 0.0024 0.0162
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0813 0.0955
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0055 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Plasmodium vivax bromodomain protein, putative 0.0012 0.0024 0.0109
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0074 0.0398
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0405 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0044
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0861 0.665
Schistosoma mansoni ran 0.0042 0.0405 0.0476
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0012 0.0024 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Brugia malayi intermediate filament protein 0.0027 0.0212 0.0362
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0132 0.0862
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Schistosoma mansoni smad 0.0011 0.0018 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0132 0.0107
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0018 0.003
Brugia malayi Importin beta-1 subunit 0.0057 0.0596 0.1016
Echinococcus multilocularis peregrin 0.0012 0.0024 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0132 0.0388
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0022 0.0038
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0022 0.0026
Plasmodium falciparum glutathione reductase 0.0037 0.0348 0.3978
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0018 0.0021
Brugia malayi Bromodomain containing protein 0.0012 0.0024 0.0041
Brugia malayi MH2 domain containing protein 0.0371 0.4602 0.7848
Trichomonas vaginalis bromodomain-containing protein, putative 0.0012 0.0024 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1275 0.1407
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0022 0.0029
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0017 0.0056
Plasmodium falciparum histone acetyltransferase GCN5 0.0076 0.0847 0.9842
Echinococcus granulosus translational activator gcn1 0.0011 0.001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2017 0.6411
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0411 0.128
Schistosoma mansoni bromodomain containing protein 0.0017 0.0095 0.0112
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0038 0.0113
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0196 0.0258
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Echinococcus granulosus polybromo 1 0.0012 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0029
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0132 0.1138
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0072 0.0039
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.0024 0.0044
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.0489
Schistosoma mansoni hypothetical protein 0.0677 0.8517 1
Schistosoma mansoni hypothetical protein 0.0125 0.1469 0.1724
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0793 0.0793
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0038 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3141 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0196 0.023
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.2137 0.3644
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0022 0.0026
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0395 0.4915 0.8381
Loa Loa (eye worm) Smad1 0.0025 0.0196 0.0258
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0109
Echinococcus granulosus lamin 0.0027 0.0212 0.0249
Loa Loa (eye worm) hypothetical protein 0.0145 0.1722 0.2272

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 7.924 uM PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] ChEMBL. No reference
IC50 (binding) = 2.97 Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate ChEMBL. 26976213
IC50 (functional) 4.04 uM PubChem BioAssay. TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 205 uM Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate preincubated for 5 mins followed by substrate addition measured every 17 secs for 20 mins by microplate reader analysis ChEMBL. 26477515
IC50 (binding) = 220 uM Inhibition of native signal containing Klebsiella pneumoniae OXA-48 using nitrocefin substrate pre-incubated for 5 mins before substrate addition LITERATURE. 27165692
IC50 (binding) = 1238 uM Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate ChEMBL. 26976213
Inhibition (binding) > 15 % Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate at 500 uM preincubated for 5 mins followed by substrate addition measured every 17 secs for 20 mins by microplate reader analysis relative to control ChEMBL. 26477515
Inhibition (binding) > 20 % Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells at 500 uM using imipinem as substrate ChEMBL. 26976213
Kd (binding) Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli assessed as dissociation constant by SPR assay LITERATURE. 27165692
Kd (binding) = 3.1 Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay ChEMBL. 26976213
Kd (binding) = 264 uM Binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis ChEMBL. 26477515
Kd (binding) = 804 uM Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay ChEMBL. 26976213
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 21.8103 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] ChEMBL. No reference
Potency (functional) 21.8103 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948] ChEMBL. No reference
Potency (functional) 21.8103 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] ChEMBL. No reference
Potency (functional) 21.8103 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.5625 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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