Detailed information for compound 1251384

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.386 | Formula: C20H17FN6O2
  • H donors: 2 H acceptors: 6 LogP: 3.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)c1nc(O)c2c(n1)n(nn2)Cc1cc(C)ccc1C
  • InChi: 1S/C20H17FN6O2/c1-11-3-4-12(2)13(9-11)10-27-18-16(25-26-27)19(28)24-17(23-18)20(29)22-15-7-5-14(21)6-8-15/h3-9H,10H2,1-2H3,(H,22,29)(H,23,24,28)
  • InChiKey: BLLWVWRTQUJQKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0076 0.1332 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0184 0.0552
Echinococcus multilocularis heat shock protein 90 0.0033 0.0428 0.1279
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0428 0.3147
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0137 0.0411
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0027 0.0111
Onchocerca volvulus 0.0022 0.0184 0.1305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1819 0.3094
Brugia malayi hypothetical protein 0.0152 0.2928 0.3344
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0184 0.0552
Brugia malayi hypothetical protein 0.0029 0.034 0.0376
Schistosoma mansoni hypothetical protein 0.0152 0.2928 0.4979
Schistosoma mansoni hypothetical protein 0.0292 0.588 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus sex peptide receptor 0.0022 0.0184 0.0552
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni opsin-like receptor 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0184 0.0552
Brugia malayi ORL1-like opioid receptor 0.0022 0.0184 0.0198
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.1332 0.1275
Brugia malayi CXXC zinc finger family protein 0.0063 0.1061 0.1203
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1332 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Onchocerca volvulus 0.0022 0.0184 0.1305
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0428 0.3147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1819 0.5443
Echinococcus granulosus somatostatin receptor 0.0022 0.0184 0.0552
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.034 0.2481
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Entamoeba histolytica hypothetical protein 0.0152 0.2928 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Onchocerca volvulus 0.0022 0.0184 0.1305
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.1332 0.1275
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Mycobacterium tuberculosis Conserved protein 0.0076 0.1332 0.1275
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0184 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0184 0.0552
Onchocerca volvulus 0.0022 0.0184 0.1305
Schistosoma mansoni hypothetical protein 0.0135 0.2573 0.4376
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni hypothetical protein 0.0022 0.0184 0.0314
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0184 0.0552
Onchocerca volvulus 0.0022 0.0184 0.1305
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Brugia malayi putative neuropeptide receptor 0.0022 0.0184 0.0198
Schistosoma mansoni hypothetical protein 0.0135 0.2573 0.4376
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0184 0.0314
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0184 0.0552
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0184 0.0552
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0184 0.0552
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.034 0.1459
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0197
Schistosoma mansoni amine GPCR 0.0022 0.0184 0.0314
Onchocerca volvulus 0.0022 0.0184 0.1305
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.2257 1
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0284 0.2061
Brugia malayi heat shock protein 90 0.0033 0.0428 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0184 0.0314
Loa Loa (eye worm) endoplasmin 0.0033 0.0428 0.0476
Echinococcus multilocularis GPCR, family 2 0.0135 0.2573 0.7699
Brugia malayi RE15519p 0.0022 0.0184 0.0198
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0184 0.0198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0184 0.0552
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0184 0.0552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1819 0.3094
Brugia malayi G protein-coupled receptor 0.0022 0.0184 0.0198
Echinococcus multilocularis heat shock protein 0.0033 0.0428 0.1279
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0184 0.0552
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0184 0.0314
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0056 0.0095
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0184 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.1332 0.1514
Schistosoma mansoni biogenic amine receptor 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0076 0.1332 0.1514
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0184 0.0314
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0184 0.0552
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0184 0.0552
Echinococcus granulosus cpg binding protein 0.0067 0.1137 0.3402
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0197
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0184 0.0552
Brugia malayi AKH receptor 0.0022 0.0184 0.0198
Brugia malayi Endoplasmin precursor 0.0033 0.0428 0.0476
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.1332 0.1514
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0184 0.1305
Echinococcus multilocularis serotonin receptor 0.0022 0.0184 0.0552
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Brugia malayi neuropeptide F receptor 0.0022 0.0184 0.0198
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0184 0.0314
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Schistosoma mansoni endoplasmin 0.0033 0.0428 0.0727
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0184 0.0198
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0184 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Schistosoma mansoni opsin-like receptor 0.0022 0.0184 0.0314
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0184 0.0552
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0184 0.1305
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0184 0.0552
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0428 0.3147
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Brugia malayi Dopamine receptor 0.0022 0.0184 0.0198
Schistosoma mansoni neuropeptide receptor 0.0022 0.0184 0.0314
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0184 0.0552
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0135 0.2573 0.2938
Echinococcus multilocularis serotonin receptor 0.0022 0.0184 0.0552
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0184 0.0198
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0184 0.0314
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1332 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0056 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.256 0.4354
Onchocerca volvulus 0.0022 0.0184 0.1305
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Echinococcus granulosus heat shock protein 0.0033 0.0428 0.1279
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0184 0.0198
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2768 0.3161
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0132 0.0138
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0428 0.185
Schistosoma mansoni amine GPCR 0.0022 0.0184 0.0314
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.2928 0.4979
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Mycobacterium ulcerans beta-lactamase 0.0076 0.1332 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0427 0.873 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0111
Brugia malayi beta-lactamase family protein 0.0076 0.1332 0.1514
Onchocerca volvulus 0.0022 0.0184 0.1305
Brugia malayi neuropeptide F receptor 0.0022 0.0184 0.0198
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0184 0.0552
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0056 0.0167
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Brugia malayi isocitrate dehydrogenase 0.0016 0.0066 0.0062
Echinococcus granulosus neuropeptide receptor 0.0022 0.0184 0.0552
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0184 0.0552
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.2928 0.8759
Brugia malayi larval opioid receptor 0.0022 0.0184 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.1332 1
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.1332 0.3986
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.1819 0.2073
Echinococcus granulosus hypothetical protein 0.0022 0.0184 0.0552
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0184 0.0314
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0184 0.0552
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0428 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0184 0.0198
Trichomonas vaginalis esterase, putative 0.0076 0.1332 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.1061 0.1203
Brugia malayi Dopamine receptor protein 2 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0428 0.1425
Onchocerca volvulus 0.0063 0.1061 0.7945
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0184 0.0314
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0111
Schistosoma mansoni hypothetical protein 0.0022 0.0184 0.0314
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0284 0.022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.1332 1
Toxoplasma gondii ABC1 family protein 0.0076 0.1332 0.588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1332 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0184 0.0198
Schistosoma mansoni histamine h1 receptor 0.0022 0.0184 0.0314
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0184 0.0552
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1819 0.5443
Echinococcus granulosus geminin 0.0171 0.3343 1
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.1332 0.1275
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1819 0.5443
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.1332 0.1514
Schistosoma mansoni cpg binding protein 0.0067 0.1137 0.1934
Brugia malayi Dopamine receptor protein 1 0.0022 0.0184 0.0198
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0184 0.0552
Echinococcus multilocularis sex peptide receptor 0.0022 0.0184 0.0552
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0184 0.0552
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0184 0.0314
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0184 0.0552
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0184 0.0314
Echinococcus multilocularis heat shock protein 90 0.0027 0.0284 0.085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0184 0.0198
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Schistosoma mansoni hypothetical protein 0.0022 0.0184 0.0314
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0428 0.3147
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0184 0.0314
Schistosoma mansoni hypothetical protein 0.0171 0.3343 0.5684
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.1332 0.1275
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0066 0.0407
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0056 0.0167
Schistosoma mansoni biogenic amine receptor 0.0022 0.0184 0.0314
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0184 0.0198
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.1332 0.1275
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1332 1
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0184 0.0198
Brugia malayi beta-lactamase family protein 0.0076 0.1332 0.1514
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Onchocerca volvulus 0.0022 0.0184 0.1305
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0428 0.1425
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Echinococcus granulosus GPCR family 2 0.0135 0.2573 0.7699
Onchocerca volvulus 0.0022 0.0184 0.1305
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0184 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0184 0.0552
Echinococcus granulosus heat shock protein 90 0.0033 0.0428 0.1279
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Brugia malayi Latrophilin receptor protein 2 0.0135 0.2573 0.2938
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0135 0.2573 0.7699
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0184 0.0314
Onchocerca volvulus 0.0022 0.0184 0.1305
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0184 0.0314
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1332 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0137 0.0411
Onchocerca volvulus 0.0076 0.1332 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0056 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0427 0.873 1
Plasmodium vivax endoplasmin, putative 0.0033 0.0428 0.3147
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0284 0.2061
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0111
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0284 0.2061
Trichomonas vaginalis helicase, putative 0.0014 0.0027 0.0111
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0284 0.2061
Onchocerca volvulus 0.0076 0.1332 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0184 0.0552
Treponema pallidum heat shock protein 90 0.0027 0.0284 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.034 0.7885
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0184 0.0552
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0284 0.2061
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0184 0.0314
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Entamoeba histolytica hypothetical protein 0.0152 0.2928 1
Schistosoma mansoni hypothetical protein 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1332 0.2266
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.1332 0.1514
Brugia malayi latrophilin 2 splice variant baaae 0.0292 0.588 0.6731
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0184 0.0552
Schistosoma mansoni heat shock protein 0.0014 0.0012 0.0021
Echinococcus granulosus g protein coupled receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2768 0.3161
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Brugia malayi hypothetical protein 0.0019 0.0121 0.0125
Echinococcus multilocularis geminin 0.0171 0.3343 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0135 0.2573 0.2938
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.1332 0.1514
Leishmania major hypothetical protein, conserved 0.0029 0.034 0.2481
Echinococcus multilocularis somatostatin receptor 0.0022 0.0184 0.0552
Trichomonas vaginalis endoplasmin, putative 0.002 0.0155 0.1086
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.034 0.2481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.1332 0.3986
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0428 0.185
Schistosoma mansoni cpg binding protein 0.0067 0.1137 0.1934
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni adenoreceptor 0.0022 0.0184 0.0314
Schistosoma mansoni opsin-like receptor 0.0022 0.0184 0.0314
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0066 0.0407
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0184 0.0552
Schistosoma mansoni neuropeptide receptor 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0066 0.0239
Echinococcus granulosus g protein coupled receptor 0.0022 0.0184 0.0552
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0135 0.2573 0.7699
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0428 0.3147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0111
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0428 0.0476
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.2928 0.8759
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Onchocerca volvulus 0.0022 0.0184 0.1305
Echinococcus granulosus orexin receptor type 2 0.0022 0.0184 0.0552
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0139 0.0962
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0066 0.0239
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0184 0.0552
Brugia malayi Serotonin receptor 0.0022 0.0184 0.0198
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0184 0.0552
Schistosoma mansoni heat shock protein 0.0033 0.0428 0.0727
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0427 0.873 1
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0184 0.0552
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0184 0.0314
Entamoeba histolytica hypothetical protein 0.0152 0.2928 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0428 0.3147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0066 0.1293
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0184 0.0198
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0184 0.0314
Schistosoma mansoni endoplasmin 0.0033 0.0428 0.0727
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0066 0.0407
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0184 0.0552
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0184 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0428 0.3147
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0284 0.085
Schistosoma mansoni hypothetical protein 0.0135 0.2573 0.4376
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0066 0.0407
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0184 0.0552
Brugia malayi hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0135 0.2573 0.7699
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0012 0.0036
Echinococcus granulosus endoplasmin 0.0027 0.0284 0.085
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0066 0.0407
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Leishmania major hypothetical protein, conserved 0.0076 0.1332 1
Echinococcus granulosus allatostatin A receptor 0.0022 0.0184 0.0552
Mycobacterium leprae conserved hypothetical protein 0.0076 0.1332 1
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0184 0.0198
Onchocerca volvulus 0.0022 0.0184 0.1305
Plasmodium falciparum endoplasmin, putative 0.002 0.0155 0.345
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0184 0.0552
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0428 0.3147
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus heat shock protein 90 0.0027 0.0284 0.085
Trichomonas vaginalis heat shock protein, putative 0.002 0.0155 0.1086
Loa Loa (eye worm) histone methyltransferase 0.002 0.0137 0.0144
Brugia malayi G-protein coupled receptor 0.0022 0.0184 0.0198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.1332 0.1514
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0066 0.0062
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0184 0.0198
Trypanosoma brucei heat shock protein, putative 0.0033 0.0428 0.3147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1819 0.5443
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0184 0.0198
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0376
Schistosoma mansoni biogenic amine receptor 0.0022 0.0184 0.0314
Brugia malayi sulfakinin receptor protein 0.0022 0.0184 0.0198
Onchocerca volvulus 0.0022 0.0184 0.1305
Loa Loa (eye worm) hypothetical protein 0.0135 0.2573 0.2938
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0184 0.0198
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0184 0.0552
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Mycobacterium ulcerans lipase LipD 0.0076 0.1332 1
Schistosoma mansoni hypothetical protein 0.0171 0.3343 0.5684
Onchocerca volvulus 0.0076 0.1332 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0184 0.0552
Schistosoma mansoni amine GPCR 0.0022 0.0184 0.0314
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.1332 0.1275
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Plasmodium falciparum heat shock protein 90 0.0033 0.0428 1
Echinococcus granulosus serotonin receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Schistosoma mansoni amine GPCR 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.034 0.2481
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0428 0.3147
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1332 0.2266
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0066 0.0062
Mycobacterium tuberculosis Conserved protein 0.0076 0.1332 0.1275
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.0111
Onchocerca volvulus 0.0022 0.0184 0.1305
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0292 0.588 0.6731
Echinococcus granulosus fmrfamide receptor 0.0022 0.0184 0.0552
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0012 0.0036
Brugia malayi MH2 domain containing protein 0.0144 0.2768 0.3161
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.034 0.2481
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0184 0.0552
Onchocerca volvulus 0.0022 0.0184 0.1305
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0184 0.0552
Brugia malayi beta-lactamase 0.0076 0.1332 0.1514
Echinococcus granulosus g protein coupled receptor 0.0022 0.0184 0.0552
Schistosoma mansoni amine GPCR 0.0022 0.0184 0.0314
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0184 0.0552
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0027 0.0111
Brugia malayi G-protein coupled receptor 0.0022 0.0184 0.0198
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0428 0.3147
Echinococcus multilocularis cpg binding protein 0.0067 0.1137 0.3402
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0284 0.5
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0066 0.0197
Entamoeba histolytica hypothetical protein 0.0152 0.2928 1
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0184 0.0552
Brugia malayi GnHR receptor homolog 0.0022 0.0184 0.0198
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.034 0.7885
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0066 0.0197
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0284 0.2061
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0066 0.0407
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0066 0.0112
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.1332 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0184 0.0314
Echinococcus multilocularis endoplasmin 0.0027 0.0284 0.085
Loa Loa (eye worm) beta-lactamase 0.0076 0.1332 0.1514
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0184 0.0198
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Schistosoma mansoni cpg binding protein 0.0063 0.1061 0.1804
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.1332 0.1275
Schistosoma mansoni neuropeptide receptor 0.0022 0.0184 0.0314
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0184 0.0552
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Brugia malayi Serotonin receptor 0.0022 0.0184 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1819 0.3094
Leishmania major heat shock protein 83-1 0.0033 0.0428 0.3147
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0184 0.0552
Schistosoma mansoni hypothetical protein 0.0135 0.2573 0.4376
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1332 1
Onchocerca volvulus 0.0022 0.0184 0.1305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0027 0.0111
Echinococcus granulosus neuropeptide receptor 0.0022 0.0184 0.0552
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0184 0.0552
Brugia malayi Melatonin receptor type 1A 0.0022 0.0184 0.0198
Schistosoma mansoni myosin xvIII 0.0022 0.0184 0.0314
Loa Loa (eye worm) hypothetical protein 0.0076 0.1332 0.1514
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0184 0.0552
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0427 0.873 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198
Mycobacterium tuberculosis Conserved protein 0.0076 0.1332 0.1275
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0184 0.0552
Mycobacterium leprae Probable lipase LipE 0.0076 0.1332 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0184 0.0314
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.1819 0.2073
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0184 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1332 1
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0184 0.0552
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0184 0.0552
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0135 0.2573 0.7699
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0184 0.0552
Schistosoma mansoni heat shock protein 0.0033 0.0428 0.0727
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0184 0.0314
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0184 0.0198
Plasmodium vivax hypothetical protein, conserved 0.0076 0.1332 1
Schistosoma mansoni neuropeptide receptor 0.0022 0.0184 0.0314
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0066 0.0197
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0184 0.0552
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0198

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 58.4789 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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