Detailed information for compound 1251442

Basic information

Technical information
  • TDR Targets ID: 1251442
  • Name: 3-(4-chlorophenyl)-6-[3-chloro-5-(trifluorome thyl)pyridin-2-yl]pyrazolo[1,5-a]pyrimidine
  • MW: 409.192 | Formula: C18H9Cl2F3N4
  • H donors: 0 H acceptors: 3 LogP: 4.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1cnn2c1ncc(c2)c1ncc(cc1Cl)C(F)(F)F
  • InChi: 1S/C18H9Cl2F3N4/c19-13-3-1-10(2-4-13)14-8-26-27-9-11(6-25-17(14)27)16-15(20)5-12(7-24-16)18(21,22)23/h1-9H
  • InChiKey: RRHNECFQPDUOPU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(4-chlorophenyl)-6-[3-chloro-5-(trifluoromethyl)-2-pyridyl]pyrazolo[1,5-a]pyrimidine
  • 3-(4-chlorophenyl)-6-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]pyrazolo[1,5-a]pyrimidine
  • MLS000325622
  • SMR000169920
  • 5H-034

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Schistosoma mansoni protein-tyrosine phosphatase n9 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1185 0.9943 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.003 0.0084 0.0084
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.003 0.0084 0.0084
Onchocerca volvulus 4.1 G protein, putative homolog 0.003 0.0084 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.003 0.0084 1
Schistosoma mansoni protein tyrosine phosphatase 0.003 0.0084 0.0084
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0485 0.1723
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 1
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0508 0.0511
Echinococcus multilocularis protein tyrosine phosphatase n9 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Echinococcus granulosus geminin 0.0173 0.1302 0.131
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 0.9998
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Toxoplasma gondii hypothetical protein 0.0027 0.0062 0.1217
Schistosoma mansoni rgs-gaip interacting protein gipc 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Leishmania major cathepsin L-like protease 0.0077 0.0485 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0273 0.5
Onchocerca volvulus 0.003 0.0084 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.003 0.0084 0.0084
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0173 0.1302 0.131
Leishmania major cathepsin L-like protease 0.0077 0.0485 1
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) protein tyrosine phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.008 0.0508 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.003 0.0084 0.0298
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0062 0.1217
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0428 0.1521
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.003 0.0084 0.0298
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase 0.003 0.0084 0.0084
Entamoeba histolytica protein tyrosine phosphatase, putative 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Trichomonas vaginalis pten, drome, putative 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 1
Leishmania major protein-tyrosine phosphatase 1-like protein 0.003 0.0084 0.1727
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.003 0.0084 0.0298
Echinococcus multilocularis 0.003 0.0084 0.0084
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 1
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 0.9998
Trypanosoma brucei trans-sialidase, putative 0.035 0.2815 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1185 0.9943 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.003 0.0084 0.0084
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 0.9998
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Schistosoma mansoni pcd6 interacting protein-related 0.003 0.0084 0.0084
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.003 0.0084 0.0084
Trichomonas vaginalis Sialidase-1 precursor, putative 0.1191 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Onchocerca volvulus 0.003 0.0084 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1185 0.9943 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 0.9998
Brugia malayi Probable ClpP-like protease 0.008 0.0508 0.0511
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Leishmania major cathepsin L-like protease 0.0077 0.0485 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.003 0.0084 0.0084
Echinococcus granulosus protein tyrosine phosphatase n9 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Giardia lamblia Protein tyrosine phosphatase 0.003 0.0084 0.5
Onchocerca volvulus 0.003 0.0084 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.003 0.0084 0.0084
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0508 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Trypanosoma brucei trans-sialidase, putative 0.035 0.2815 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Schistosoma mansoni protein tyrosine phosphatase 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 0.5
Onchocerca volvulus 0.003 0.0084 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, putative 0.035 0.2815 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1185 0.9943 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.003 0.0084 0.0084
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0273 0.4744
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0273 0.5
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Brugia malayi Dual specificity protein phosphatase CDC14B 0.003 0.0084 0.0084
Leishmania major tyrosine specific protein phosphatase, putative 0.003 0.0084 0.1727
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.003 0.0084 0.0084
Schistosoma mansoni receptor protein tyrosine phosphatase 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.003 0.0084 0.0084
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0273 0.0275
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.003 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0173 0.1302 0.131
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0273 0.0275
Onchocerca volvulus 0.003 0.0084 1
Trypanosoma brucei trans-sialidase, putative 0.035 0.2815 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0508 0.0511
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.003 0.0084 0.0084
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0485 0.1723
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0508 0.0511
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0485 0.1723
Brugia malayi Protein-tyrosine phosphatase 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.003 0.0084 0.0084
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.003 0.0084 0.0084
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0062 0.1217
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.003 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0485 0.1469
Brugia malayi Protein-tyrosine phosphatase 1 0.003 0.0084 0.0084
Trypanosoma cruzi trans-sialidase, Group I, putative 0.035 0.2815 1
Onchocerca volvulus 0.003 0.0084 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Echinococcus multilocularis geminin 0.0173 0.1302 0.131
Trypanosoma brucei trans-sialidase, putative 0.035 0.2815 1
Trypanosoma brucei trans-sialidase 0.035 0.2815 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0344 0.1223
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.003 0.0084 0.0084
Onchocerca volvulus 0.003 0.0084 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0741 0.6154 0.6154
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0508 1
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 1
Schistosoma mansoni protein tyrosine phosphatase 0.003 0.0084 0.0084
Trypanosoma brucei trans-sialidase, putative 0.035 0.2815 1
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.003 0.0084 0.0084
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0485 0.1723
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1185 0.9943 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.003 0.0084 0.0084
Echinococcus multilocularis hypothetical protein 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0508 1
Onchocerca volvulus 0.003 0.0084 1
Onchocerca volvulus 0.003 0.0084 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0508 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0508 1
Onchocerca volvulus 0.003 0.0084 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.003 0.0084 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.003 0.0084 0.0084
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.003 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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