Detailed information for compound 1251620

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.481 | Formula: C22H27N5O3
  • H donors: 2 H acceptors: 4 LogP: 2.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccnc1N[C@H]1CCN(C1)C(=O)O[C@@H]1C2CC3CC1C[C@](C2)(C3)C(=O)N
  • InChi: 1S/C22H27N5O3/c23-11-14-2-1-4-25-19(14)26-17-3-5-27(12-17)21(29)30-18-15-6-13-7-16(18)10-22(8-13,9-15)20(24)28/h1-2,4,13,15-18H,3,5-10,12H2,(H2,24,28)(H,25,26)/t13?,15?,16?,17-,18-,22-/m0/s1
  • InChiKey: BNIGHFUMARRMFX-VFNAPQHXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0045 0.0096 0.0107
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.039 0.26
Echinococcus multilocularis GPCR, family 2 0.0135 0.0371 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0021
Mycobacterium ulcerans acetyl-CoA synthetase 0.0074 0.0184 0.1787
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0037 0.0041
Leishmania major DNA polymerase eta, putative 0.0065 0.0155 0.0175
Echinococcus granulosus dna polymerase kappa 0.004 0.0078 0.008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.0346 0.23
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0074 0.0083
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0006
Echinococcus granulosus serine protein kinase ATM 0.0053 0.0119 0.0127
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.002 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.0561 0.063
Onchocerca volvulus 0.0077 0.0192 0.1168
Leishmania major hypothetical protein, conserved 0.0077 0.0192 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0013 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0204
Onchocerca volvulus 0.0074 0.0184 0.1117
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0013
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0038 0.0072 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0015 0.0052
Loa Loa (eye worm) beta-lactamase 0.0077 0.0192 0.0217
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.002 0.0021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.4107
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.004 0.0044
Mycobacterium ulcerans 6-phosphofructokinase 0.0231 0.0666 0.6496
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0387 0.0439
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0011
Schistosoma mansoni 6-phosphofructokinase 0.0231 0.0666 0.0756
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0119 0.0133
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.0561 0.0636
Leishmania major hypothetical protein, conserved 0.0027 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.007 0.0172 0.0194
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0015 0.0126
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0038 0.0072 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Trichomonas vaginalis antibiotic synthetase, putative 0.0074 0.0184 0.1238
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.002 0.0015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0084 0.0094
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0038 0.0072 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0192 0.1237
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0135 0.0371 0.0414
Brugia malayi CXXC zinc finger family protein 0.0028 0.0043 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0253 0.0734 1
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0038 0.0072 0.1132
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0038 0.0072 0.1132
Brugia malayi oxidoreductase 0.0027 0.004 0.0043
Schistosoma mansoni cpg binding protein 0.0028 0.0043 0.0046
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0074 0.0071
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0148 0.2578
Giardia lamblia DINP protein human, muc B family 0.004 0.0078 0.4848
Mycobacterium ulcerans hypothetical protein 0.0077 0.0192 0.186
Brugia malayi AMP-binding enzyme family protein 0.0253 0.0734 0.0834
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0084 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0013
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0038 0.0074 0.0076
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0253 0.0734 0.4858
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.2039 0.2033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0084 0.0094
Brugia malayi Ets-domain containing protein 0.0079 0.0198 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Brugia malayi nuclear hormone receptor 0.0021 0.002 0.0021
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0008 0.0001
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.002 0.0021
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0074 0.0184 0.1185
Schistosoma mansoni acetyl-CoA synthetase 0.0074 0.0184 0.0207
Trypanosoma brucei ISWI complex protein 0.0015 0.0003 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.0561 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0021
Echinococcus granulosus FTZ F1 alpha 0.0021 0.002 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0074 0.0184 0.3276
Brugia malayi latrophilin 2 splice variant baaae 0.0291 0.0852 0.0969
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.0277 0.0314
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.0239 0.0271
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0053 0.0119 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0192 0.186
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0074 0.0184 0.1185
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1067 0.3239 0.3686
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0203 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0013 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0387 0.0439
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.0277 0.504
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.039 0.26
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0277 0.504
Brugia malayi Thioredoxin reductase 0.0056 0.0127 0.0143
Brugia malayi phosphofructokinase 0.0231 0.0666 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0078 0.0087
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.002 0.002
Leishmania major trypanothione reductase 0.0056 0.0127 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0074 0.0184 0.0177
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0078 0.0909
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0074 0.0184 0.1787
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.0347 0.1025 0.6974
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0015
Schistosoma mansoni ets-related 0.0239 0.0691 0.0784
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0013 0.0012
Leishmania major acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0231 0.0666 0.0757
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.0561 0.0636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0021
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0039 0.0075 0.0083
Mycobacterium tuberculosis Conserved protein 0.0077 0.0192 0.1237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.0346 0.23
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0253 0.0734 1
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0192 0.0217
Echinococcus multilocularis dna polymerase eta 0.0092 0.0239 0.0232
Leishmania major 0.2869 0.8784 1
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2869 0.8784 1
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0015 0.0103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0135 0.0139
Schistosoma mansoni coup transcription factor 0.0021 0.002 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0253 0.0734 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.004 0.0044
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Echinococcus granulosus GPCR family 2 0.0135 0.0371 0.0414
Echinococcus multilocularis musashi 0.0026 0.0037 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Brugia malayi Fli-1 protein 0.0239 0.0691 0.0785
Plasmodium vivax glutathione reductase, putative 0.0056 0.0127 0.2182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.005 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.004 0.0044
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0135 0.0847
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0147 0.0164
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0112 0.0126
Mycobacterium tuberculosis Probable reductase 0.0127 0.0346 0.23
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.223
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0353 0.04
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0074 0.0184 0.1787
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0013 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0192 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0011
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0015 0.0052
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.005 0.072
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0078 0.0747
Leishmania major DNA polymerase eta, putative 0.0092 0.0239 0.0271
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0074 0.0858
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.0561 0.0635
Leishmania major 4-coumarate:coa ligase-like protein 0.0253 0.0734 0.0834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0008
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0043
Brugia malayi beta-lactamase 0.0077 0.0192 0.0217
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0013 0.0012
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.3323
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0127 0.2182
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0192 0.186
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.023 0.0222
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0229
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0022 0.0023 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0119 0.0797
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0024 0.003 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0038 0.0072 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0436 0.292
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0078 0.008
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.0346 0.23
Schistosoma mansoni hypothetical protein 0.0047 0.01 0.0111
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0189 0.0538 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.002 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0074 0.0184 0.0208
Plasmodium vivax acyl-CoA synthetase, putative 0.0189 0.0538 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0114 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.0561 0.0553
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0053 0.0119 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0043 0.0047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0135 0.0371 0.0414
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Echinococcus multilocularis geminin 0.0518 0.1549 0.1543
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Schistosoma mansoni fkbp-rapamycin associated protein 0.0022 0.0023 0.0023
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0074 0.0083
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0078 0.0086
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0078 0.0086
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0143 0.0155
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0155 0.0175
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0022 0.0023 0.0015
Plasmodium falciparum thioredoxin reductase 0.0056 0.0127 0.2182
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.01 0.0105
Mycobacterium tuberculosis Conserved protein 0.0077 0.0192 0.1237
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0015 0.0103
Trichomonas vaginalis set domain proteins, putative 0.0499 0.149 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0015
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0062 0.0148 0.1875
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Schistosoma mansoni DNA polymerase eta 0.0092 0.0239 0.027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.002 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.023 0.0253
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0148 0.2539
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0192 0.1237
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0062 0.0148 0.207
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0192 0.1289
Brugia malayi AMP-binding enzyme family protein 0.0253 0.0734 0.0834
Onchocerca volvulus 0.0026 0.0037 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0868 0.0986
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0198 0.0217
Echinococcus multilocularis lamin dm0 0.0026 0.0037 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0277 0.0314
Giardia lamblia GTOR 0.0038 0.0074 0.4574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.1067 0.3239 0.3686
Toxoplasma gondii propionate-CoA ligase 0.0074 0.0184 0.0196
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0135 0.0128
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2869 0.8784 0.8783
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0192 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Schistosoma mansoni 6-phosphofructokinase 0.0231 0.0666 0.0756
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0135 0.0371 0.0363
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0184 0.1787
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0021
Echinococcus multilocularis serine protein kinase ATM 0.0053 0.0119 0.0111
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0387 0.0439
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0064 0.0153 0.0966
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0013 0.0006
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.039 0.5042
Schistosoma mansoni nuclear hormone receptor 0.0021 0.002 0.002
Echinococcus multilocularis dna polymerase kappa 0.004 0.0078 0.0071
Loa Loa (eye worm) hypothetical protein 0.0426 0.1267 0.1441
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0192 0.1237
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Trypanosoma brucei unspecified product 0.004 0.0078 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0192 0.0216
Schistosoma mansoni hypothetical protein 0.002 0.0019 0.0019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0013 0.0012
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0053 0.0119 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0078
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0027 0.004 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.0561 0.063
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Onchocerca volvulus 0.0077 0.0192 0.1168
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.223
Brugia malayi ecdysteroid receptor 0.0021 0.002 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0184 0.2086
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0074 0.0083
Schistosoma mansoni gabp alpha 0.0079 0.0198 0.0223
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.1304 0.1483
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0078 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0184 0.0208
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0074 0.0184 0.1185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.002 0.002
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0155 0.0175
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0155 0.0174
Mycobacterium ulcerans hypothetical protein 0.0253 0.0734 0.7161
Mycobacterium ulcerans acyl-CoA synthetase 0.0253 0.0734 0.7161
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0062 0.0148 0.0154
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.0834
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0135 0.0371 0.0363
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0038 0.0072 0.1132
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0006
Leishmania major acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.0015
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.005 0.0154
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.018 0.0172
Plasmodium falciparum acyl-CoA synthetase 0.0189 0.0538 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0231 0.0666 0.0757
Trichomonas vaginalis dullard protein, putative 0.0038 0.0072 0.0483
Echinococcus granulosus zinc finger protein 0.0021 0.0021 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0078 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0253 0.0734 0.4973
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Echinococcus granulosus 6 phosphofructokinase 0.0231 0.0666 0.075
Onchocerca volvulus 0.0026 0.0037 0.0116
Echinococcus multilocularis 6 phosphofructokinase 0.0231 0.0666 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2869 0.8784 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.0346 0.4415
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0074 0.0184 0.1185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0142 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0192 0.1289
Leishmania major hypothetical protein, conserved 0.0038 0.0072 0.008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0143 0.0136
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0192 0.1237
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0192 0.1237
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0253 0.0734 0.4973
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0426 0.1267 0.1441
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0666 0.9057
Trypanosoma cruzi DNA polymerase eta, putative 0.0092 0.0239 0.0271
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0078 0.0452
Mycobacterium ulcerans beta-lactamase 0.0077 0.0192 0.186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) hypothetical protein 0.0045 0.0096 0.0107
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0074 0.0184 0.2086
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0078 0.0524
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0074 0.0184 0.0208
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0155 0.0175
Trypanosoma brucei unspecified product 0.0027 0.004 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0253 0.0734 0.0834
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0037 0.0071 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.0561 0.0553
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0203 0.0228
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0015 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Toxoplasma gondii ABC1 family protein 0.0077 0.0192 0.0205
Brugia malayi AMP-binding enzyme family protein 0.0253 0.0734 0.0834
Mycobacterium tuberculosis Conserved protein 0.0077 0.0192 0.1237
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0231 0.0666 0.0757
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0277 0.0314
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0074 0.0082
Echinococcus multilocularis tumor protein p63 0.035 0.1034 0.1028
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.003 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0074 0.0184 0.1787
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0066 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.003 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0078 0.0087
Brugia malayi hypothetical protein 0.0067 0.0163 0.0184
Brugia malayi nuclear receptor NHR-88 0.0021 0.002 0.0021
Brugia malayi MH2 domain containing protein 0.0129 0.0353 0.04
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0253 0.0734 1
Entamoeba histolytica hypothetical protein 0.0053 0.0119 0.1471
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0253 0.0734 0.7161
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0074 0.0184 0.1787
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0012
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0074 0.0083
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0015 0.0133
Brugia malayi Latrophilin receptor protein 2 0.0135 0.0371 0.042
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0006
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0155 0.1978
Mycobacterium ulcerans short chain dehydrogenase 0.0347 0.1025 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.2039 0.2319
Brugia malayi hypothetical protein 0.0073 0.018 0.0202
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Loa Loa (eye worm) hypothetical protein 0.0291 0.0852 0.0969
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0192 0.0217
Echinococcus granulosus CTD small phosphatase protein like 0.0038 0.0072 0.0073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0151 0.0143
Plasmodium falciparum glutathione reductase 0.0056 0.0127 0.2182
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.4107
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0104 0.0277 0.0314
Brugia malayi PHD-finger family protein 0.0026 0.0037 0.004
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0074 0.0184 0.1787
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0021
Toxoplasma gondii hypothetical protein 0.0031 0.005 0.0043
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0148 0.2578
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Toxoplasma gondii FATC domain-containing protein 0.0053 0.0119 0.0121
Plasmodium vivax acetyl-CoA synthetase, putative 0.0074 0.0184 0.3276
Loa Loa (eye worm) hypothetical protein 0.0104 0.0277 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0135 0.0847
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0135 0.138
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.0834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.039 0.26
Loa Loa (eye worm) latrophilin receptor protein 2 0.0135 0.0371 0.042
Toxoplasma gondii 6-phosphofructokinase 0.0062 0.0148 0.0154
Schistosoma mansoni lamin 0.0026 0.0037 0.0039
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0062 0.0148 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0012
Brugia malayi Pre-SET motif family protein 0.0438 0.1304 0.1483
Trypanosoma brucei NAD(P)-dependent steroid dehydrogenase protein, putative 0.0027 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.0074 0.0184 0.0208
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.0346 0.23
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0127 0.0789
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.018 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0015
Onchocerca volvulus 0.0088 0.0228 0.141
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0074 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0037 0.0041
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.4138
Onchocerca volvulus 0.0077 0.0192 0.1168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0039
Toxoplasma gondii thioredoxin reductase 0.0056 0.0127 0.0131
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0666 0.9057
Trypanosoma brucei unspecified product 0.0027 0.004 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0203 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0192 0.1289
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.002 0.0021
Brugia malayi Probable ClpP-like protease 0.0089 0.023 0.026
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0114 0.0127
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0074 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi Bromodomain containing protein 0.0076 0.019 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0192 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Echinococcus granulosus lamin 0.0026 0.0037 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0027 0.004 0.0266
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0189 0.0538 0.5238
Brugia malayi hypothetical protein 0.0027 0.004 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0074 0.0184 0.1117
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0071 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0135 0.0371 0.042
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.002 0.0013
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.0023 0.0024
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0038 0.0072 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0151 0.0169
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0074 0.0184 0.0196
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0078 0.0747
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.01 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Schistosoma mansoni cpg binding protein 0.0032 0.0053 0.0058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.0015
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0074 0.0184 0.0196
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0078 0.0524
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Brugia malayi fructose-1,6-bisphosphatase 0.2869 0.8784 1
Onchocerca volvulus 0.0027 0.004 0.0131
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0084 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0155 0.0175
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.0277 0.0302
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0037 0.0041
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0192 0.1237
Schistosoma mansoni cpg binding protein 0.0032 0.0053 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0192 0.1289
Entamoeba histolytica acyl-coA synthetase, putative 0.0253 0.0734 1
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Onchocerca volvulus 0.0051 0.0114 0.0636
Leishmania major NAD(p)-dependent steroid dehydrogenase-like protein 0.0027 0.004 0.0043
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.003 0.0033
Leishmania major phosphatidylinositol kinase related protein, putative 0.0039 0.0075 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Loa Loa (eye worm) fli-1 protein 0.0239 0.0691 0.0785
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0024
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0135 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0074 0.0184 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Plasmodium vivax SET domain protein, putative 0.0063 0.0151 0.2637
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0868 0.0986
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0051
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.023 0.2738
Plasmodium falciparum glutathione reductase 0.0019 0.0015 0.0052
Brugia malayi beta-lactamase family protein 0.0077 0.0192 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.0561 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0021
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.023 0.4138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0021
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0198 0.0191
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0074 0.0184 0.1787
Trypanosoma brucei DNA polymerase eta, putative 0.0092 0.0239 0.0271
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.001 0.0009
Echinococcus granulosus cpg binding protein 0.0032 0.0053 0.0052
Leishmania major DNA polymerase kappa, putative 0.004 0.0078 0.0087
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.2086
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0015 0.0052
Trichomonas vaginalis dullard protein, putative 0.0038 0.0072 0.0483
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.023 0.0259
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.002 0.0015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0151 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0133
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.0868 0.0986
Brugia malayi Bromodomain containing protein 0.0038 0.0073 0.0081
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0074 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Brugia malayi 6-phosphofructokinase 0.0231 0.0666 0.0757
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0038 0.0072 0.0824
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Schistosoma mansoni intermediate filament proteins 0.0026 0.0037 0.0039
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0062 0.0148 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0065 0.0155 0.0163
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Toxoplasma gondii phosphofructokinase PFKII 0.0062 0.0148 0.0154
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0127 0.012
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.1067 0.3239 0.3678
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Brugia malayi beta-lactamase family protein 0.0077 0.0192 0.0217
Schistosoma mansoni lamin 0.0026 0.0037 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Leishmania major ATP-dependent phosphofructokinase 0.0231 0.0666 0.0757
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0078 0.0071
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0677 0.2039 0.2315
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.002 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0192 0.2194
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0192 0.0217
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0038 0.0074 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0015 0.0015
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0074 0.0858
Loa Loa (eye worm) phosphofructokinase 0.0231 0.0666 0.0757
Brugia malayi steroid hormone receptor 0.0021 0.002 0.0021
Brugia malayi FAT domain containing protein 0.0017 0.0008 0.0007
Onchocerca volvulus 0.0499 0.149 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0074 0.0184 0.1185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0426 0.1267 0.1441
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0155 0.0175
Trichomonas vaginalis antibiotic synthetase, putative 0.0074 0.0184 0.1238
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0021
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0155 0.0175
Loa Loa (eye worm) hypothetical protein 0.0135 0.0371 0.042
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0192 0.0185
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0253 0.0734 0.7161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0013
Mycobacterium leprae Probable lipase LipE 0.0077 0.0192 0.2194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0001
Mycobacterium ulcerans lipase LipD 0.0077 0.0192 0.186
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0127 0.0143
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0072 0.008
Trichomonas vaginalis esterase, putative 0.0077 0.0192 0.1289
Echinococcus multilocularis zinc finger protein 0.0021 0.0021 0.0013
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0074 0.0184 0.1787
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0015 0.0126
Loa Loa (eye worm) 6-phosphofructokinase 0.0231 0.0666 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0192 0.021
Echinococcus multilocularis 0.0038 0.0072 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0074 0.0083
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0192 0.0217
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0155 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0253 0.0734 0.7161
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.023 0.0248
Plasmodium falciparum thioredoxin reductase 0.0019 0.0015 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0253 0.0734 0.7161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.002 0.0015
Echinococcus granulosus intermediate filament protein 0.0026 0.0037 0.0034
Brugia malayi 6-phosphofructokinase 0.0231 0.0666 0.0757
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Toxoplasma gondii fructose-bisphospatase II 0.2869 0.8784 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0023 0.0024
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0127 0.0143
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.0834
Schistosoma mansoni hypothetical protein 0.0291 0.0852 0.0967
Echinococcus multilocularis lamin 0.0026 0.0037 0.003
Schistosoma mansoni hypothetical protein 0.0518 0.1549 0.1761
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0074 0.0184 0.1185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0013
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0022 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.005 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0015 0.0015
Mycobacterium ulcerans hypothetical protein 0.0156 0.0436 0.4248
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0001
Trichomonas vaginalis hydroxysteroid dehydrogenase, putative 0.0027 0.004 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0015 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2869 0.8784 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0015 0.0003
Schistosoma mansoni zinc finger protein 0.0021 0.0021 0.0021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.023 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi intermediate filament protein 0.0026 0.0037 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0043
Echinococcus granulosus geminin 0.0518 0.1549 0.1756
Loa Loa (eye worm) glutathione reductase 0.0056 0.0127 0.0143
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0148 0.2578
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0021
Brugia malayi Pre-SET motif family protein 0.0063 0.0151 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0253 0.0734 0.7161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0155 0.0148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0253 0.0734 0.7161
Onchocerca volvulus 0.0074 0.0184 0.1117
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0015 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.1464 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0231 0.0666 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0277 0.504
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0127 0.0136
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0231 0.0666 0.4504
Brugia malayi glutathione reductase 0.0056 0.0127 0.0143
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0038 0.0072 0.4393
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0253 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0426 0.1267 0.1441
Schistosoma mansoni bromodomain containing protein 0.0064 0.0154 0.0173
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0019 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0074 0.0083
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0015 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0021
Brugia malayi hypothetical protein 0.0104 0.0277 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0192 0.0216
Brugia malayi Ets-domain containing protein 0.0079 0.0198 0.0224
Treponema pallidum NADH oxidase 0.0019 0.0015 0.0042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0074 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0198 0.0224
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0192 0.3418
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0078 0.0452
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0015 0.0003
Mycobacterium ulcerans cholesterol dehydrogenase 0.0027 0.004 0.0371
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2869 0.8784 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.002 0.0013
Echinococcus granulosus lamin dm0 0.0026 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0092 0.0239 0.0271
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0189 0.0538 0.3617
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1067 0.3239 0.3686
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0203 0.0196
Mycobacterium tuberculosis 3-beta-hydroxysteroid dehydrogenase 0.0027 0.004 0.0187
Toxoplasma gondii hypothetical protein 0.0048 0.0103 0.0103
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0013 0.0012
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0038 0.0072 0.0064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.018 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0353 0.04
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0078 0.0087
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0074 0.0083
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0148 0.2578
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0015 0.0019
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0074 0.0067
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0074 0.0184 0.2383
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2869 0.8784 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0078 0.0087
Entamoeba histolytica protein kinase rad3, putative 0.0022 0.0023 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma brucei NAD(p)-dependent steroid dehydrogenase-like protein 0.0027 0.004 0.0043
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0666 0.9057
Trypanosoma brucei nadh-ubiquinone oxidoreductase 39 kda subunit 0.0027 0.004 0.0043
Onchocerca volvulus 0.0063 0.0151 0.0889
Trypanosoma brucei trypanothione reductase 0.0056 0.0127 0.0143
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0148 0.2539
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.002
Echinococcus granulosus dna polymerase eta 0.0092 0.0239 0.0264
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.003 0.0022
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0071 0.0073
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0074 0.0184 0.0202
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0027 0.004 0.0266
Schistosoma mansoni hypothetical protein 0.0073 0.018 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.002 0.0021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0038 0.0074 0.0082
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.0346 0.23
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0151 0.0169
Echinococcus granulosus tumor protein p63 0.035 0.1034 0.117
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2869 0.8784 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) oxidoreductase 0.0074 0.0184 0.0208
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.003 0.0031
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.002 0.0021
Echinococcus multilocularis cpg binding protein 0.0032 0.0053 0.0046
Schistosoma mansoni hypothetical protein 0.0518 0.1549 0.1761
Onchocerca volvulus 0.0028 0.0043 0.0152
Toxoplasma gondii fructose-bisphospatase I 0.1067 0.3239 0.3678
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0231 0.0666 0.9021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) hypothetical protein 0.0067 0.0163 0.0184
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Trichomonas vaginalis dullard protein, putative 0.0038 0.0072 0.0483
Leishmania major phosphatidylinositol 3-kinase, putative 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0013 0.0106
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.0868 0.0986
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0155 0.0168
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0038 0.0072 0.0079
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.6 nM Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader ChEMBL. 20864344
IC50 (binding) = 7.6 nM Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader ChEMBL. 20864344
IC50 (ADMET) = 18600 nM Inhibition of CYP3A4 ChEMBL. 20864344
IC50 (ADMET) > 30000 nM Inhibition of CYP2C9 ChEMBL. 20864344
IC50 (ADMET) = 30000 nM Inhibition of CYP2D6 ChEMBL. 20864344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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