Detailed information for compound 1252355

Basic information

Technical information
  • TDR Targets ID: 1252355
  • Name: [1-[(3-chlorophenyl)amino]-1-oxopropan-2-yl] 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)ac etate
  • MW: 393.822 | Formula: C18H20ClN3O5
  • H donors: 2 H acceptors: 4 LogP: 2.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)NC2(C1=O)CCCC2)OC(C(=O)Nc1cccc(c1)Cl)C
  • InChi: 1S/C18H20ClN3O5/c1-11(15(24)20-13-6-4-5-12(19)9-13)27-14(23)10-22-16(25)18(21-17(22)26)7-2-3-8-18/h4-6,9,11H,2-3,7-8,10H2,1H3,(H,20,24)(H,21,26)
  • InChiKey: JKAKWXOLQVVIAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(3-chlorophenyl)amino]-1-methyl-2-oxo-ethyl] 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetate
  • 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetic acid [2-[(3-chlorophenyl)amino]-1-methyl-2-oxoethyl] ester
  • 2-(2,4-diketo-1,3-diazaspiro[4.4]nonan-3-yl)acetic acid [2-[(3-chlorophenyl)amino]-2-keto-1-methyl-ethyl] ester
  • [1-[(3-chlorophenyl)amino]-1-oxo-propan-2-yl] 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)ethanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0065 0.0218 0.0564
Schistosoma mansoni importin beta-1 0.0029 0.0045 0.0044
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0452 0.2061 0.5421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Echinococcus multilocularis GPCR, family 2 0.0035 0.0072 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0218 0.0537
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0182 0.0776 0.2073
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0243
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0099 0.0098
Echinococcus multilocularis tensin 0.0023 0.0014 0.0013
Echinococcus granulosus phd:f box containing protein 0.0065 0.0218 0.0217
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0107 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Giardia lamblia Fructose-bisphosphate aldolase 0.0925 0.4318 1
Brugia malayi AIDA-1b 0.0023 0.0014 0.0035
Brugia malayi chromobox protein homolog 3 0.008 0.029 0.0717
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0107 0.0106
Mycobacterium ulcerans hypothetical protein 0.0052 0.0153 0.019
Plasmodium vivax heat shock protein 90, putative 0.0067 0.0224 0.0579
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0107 0.0106
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0099 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0107 0.0265
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0084 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0449 0.2049 0.5486
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0178 0.0368
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0099 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0107 0.0265
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0802 0.3732 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0178 0.0754 0.0753
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0416
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0176
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0099 0.0098
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0099 0.0098
Plasmodium vivax JmjC domain containing protein 0.0065 0.0218 0.0564
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.0319 0.0689
Loa Loa (eye worm) hypothetical protein 0.0206 0.0888 0.2191
Echinococcus multilocularis lamin 0.0028 0.0042 0.0041
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0018 0.0045
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0018 0.0017
Schistosoma mansoni chromobox protein 0.0143 0.0591 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Onchocerca volvulus 0.0028 0.0042 0.0088
Echinococcus granulosus endoplasmin 0.008 0.0287 0.0286
Echinococcus granulosus hypothetical protein 0.0023 0.0014 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0107 0.0106
Plasmodium falciparum endoplasmin, putative 0.0062 0.0201 0.0518
Schistosoma mansoni tensin-related 0.0023 0.0014 0.0013
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0191 0.082 0.2026
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0178 0.0754 0.1618
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0107 0.023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0107 0.0106
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0018 0.0022
Onchocerca volvulus 0.0152 0.0632 0.1366
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0198
Brugia malayi protein M110.5 0.0023 0.0014 0.0035
Schistosoma mansoni amyloid beta A4 protein related 0.0214 0.0928 0.0927
Echinococcus multilocularis chromobox protein 2 0.0023 0.0018 0.0017
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0099 0.0198
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.03 0.1335 0.1334
Toxoplasma gondii heat shock protein 75, putative 0.0067 0.0224 0.0579
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0105 0.0104
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0107 0.0106
Trichomonas vaginalis heat shock protein, putative 0.008 0.0287 0.0604
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0107 0.0265
Brugia malayi jmjC domain containing protein 0.0065 0.0218 0.0539
Brugia malayi acetyltransferase, GNAT family protein 0.0604 0.279 0.6894
Echinococcus granulosus amyloid beta A4 protein 0.0214 0.0928 0.0927
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.008 0.0287 0.1111
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0802 0.3732 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0018 0.0042
Echinococcus multilocularis musashi 0.0028 0.0042 0.0041
Loa Loa (eye worm) voltage-dependent calcium channel 0.0063 0.0205 0.0505
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0099 0.0098
Trichomonas vaginalis set domain proteins, putative 0.0988 0.4619 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0045 0.0098
Brugia malayi PXA domain containing protein 0.004 0.0099 0.0245
Echinococcus multilocularis Smad4 0.0025 0.0025 0.0024
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0018 0.0017
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0099 0.0098
Trypanosoma cruzi phosphomannose isomerase, putative 0.0802 0.3732 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0024
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0168 0.0347
Brugia malayi hypothetical protein 0.0466 0.2132 0.5267
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0018 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0107 0.0106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0022
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0264 0.0702
Schistosoma mansoni aldehyde dehydrogenase 0.0253 0.1114 0.1113
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0072 0.0071
Echinococcus granulosus chromobox protein 2 0.0023 0.0018 0.0017
Brugia malayi hypothetical protein 0.0249 0.1094 0.2704
Entamoeba histolytica phosphomannose isomerase, putative 0.0802 0.3732 0.8641
Plasmodium vivax endoplasmin, putative 0.0075 0.0264 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0218 0.0537
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0356 0.0355
Echinococcus multilocularis X box binding protein 1 0.029 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.0252 0.111 0.2741
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0802 0.3732 0.9222
Toxoplasma gondii phosphomannose isomerase type I protein 0.0802 0.3732 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0065 0.0218 0.0217
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.1652 0.4081
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0067 0.0224 0.0223
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0107 0.0265
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0105 0.0104
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.1094 0.1093
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0065 0.0218 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0152 0.0632 0.1559
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0394 0.1786 0.1785
Trichomonas vaginalis chromobox protein, putative 0.0143 0.0591 0.1264
Brugia malayi hypothetical protein 0.0152 0.0632 0.1561
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0182 0.0776 0.2061
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0052 0.0153 0.0403
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0051 0.0116
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Loa Loa (eye worm) hypothetical protein 0.0124 0.05 0.1234
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0245 0.1076 0.1075
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0098 0.0372 0.0976
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0052 0.0153 0.019
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0018 0.0022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0012 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0107 0.0265
Entamoeba histolytica hypothetical protein 0.0098 0.0372 0.0843
Brugia malayi Importin beta-1 subunit 0.0029 0.0045 0.011
Onchocerca volvulus 0.0028 0.0042 0.0088
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0802 0.3732 0.8077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.05 0.0499
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0018 0.0017
Schistosoma mansoni heat shock protein 0.0075 0.0264 0.0263
Brugia malayi RNA recognition motif domain containing protein 0.02 0.0862 0.2131
Brugia malayi nuclear receptor NHR-67 0.002 0.0001 0.0003
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0068 0.0231 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0031
Schistosoma mansoni hypothetical protein 0.029 0.1289 0.1289
Schistosoma mansoni hypothetical protein 0.031 0.1384 0.1383
Loa Loa (eye worm) hypothetical protein 0.0075 0.0265 0.0653
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0107 0.0265
Brugia malayi SET domain containing protein 0.0028 0.004 0.0099
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0398 0.0397
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Brugia malayi hypothetical protein 0.002 0.0001 0.0003
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Brugia malayi jmjC domain containing protein 0.0245 0.1076 0.266
Schistosoma mansoni inositol monophosphatase 0.0037 0.0084 0.0082
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0099 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.05 0.1321
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0802 0.3732 0.9222
Brugia malayi MH2 domain containing protein 0.0025 0.0025 0.0062
Onchocerca volvulus 0.0023 0.0014 0.0028
Toxoplasma gondii hypothetical protein 0.0055 0.0169 0.0433
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0107 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0107 0.0263
Schistosoma mansoni survival motor neuron protein 0.0051 0.0149 0.0148
Plasmodium falciparum importin beta, putative 0.0029 0.0045 0.0098
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0065 0.0218 0.0564
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0011
Trichomonas vaginalis heat shock protein, putative 0.008 0.0287 0.0604
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0084 0.0082
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0008 0.0007
Echinococcus granulosus Smad4 0.0025 0.0025 0.0024
Brugia malayi Pre-SET motif family protein 0.0868 0.4047 1
Brugia malayi TBC domain containing protein 0.0023 0.0014 0.0035
Brugia malayi jmjC domain containing protein 0.0245 0.1076 0.266
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0105 0.0104
Schistosoma mansoni voltage-gated cation channel 0.03 0.1335 0.1334
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0011
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0099 0.0098
Toxoplasma gondii heat shock protein 90, putative 0.0075 0.0264 0.0688
Echinococcus granulosus chromobox protein 1 0.0143 0.0591 0.059
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0042 0.0105 0.026
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0099 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0099 0.0098
Echinococcus multilocularis carboxyl terminal PDZ ligand of neuronal nitric 0.0023 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0023 0.0018 0.0024
Brugia malayi serine/threonine-protein kinase plk-2 0.0394 0.1786 0.4412
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Mycobacterium ulcerans heat shock protein 90 0.008 0.0287 0.0557
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Brugia malayi PXA domain containing protein 0.004 0.0099 0.0245
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0178 0.0754 0.2003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0001 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0107 0.0106
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0067 0.0224 0.0223
Schistosoma mansoni endoplasmin 0.0075 0.0264 0.0263
Echinococcus multilocularis endoplasmin 0.008 0.0287 0.0286
Echinococcus granulosus tar DNA binding protein 0.02 0.0862 0.0861
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0001 0.0003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0398 0.0397
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0201 0.0419
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0067 0.0224 0.05
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0099 0.0098
Schistosoma mansoni mannose-6-phosphate isomerase 0.0802 0.3732 0.3732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0356 0.0355
Echinococcus multilocularis heat shock protein 90 0.0068 0.0231 0.023
Echinococcus granulosus Chromobox protein 3 0.0023 0.0018 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0107 0.0106
Echinococcus multilocularis expressed protein 0.0788 0.3665 0.3665
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0018 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0075 0.0264 0.0556
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0051 0.0116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.03 0.1335 0.1334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0072 0.0071
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Schistosoma mansoni intermediate filament proteins 0.0028 0.0042 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0107 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0107 0.0265
Schistosoma mansoni shc transforming protein 0.0023 0.0014 0.0013
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0105 0.0258
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0245 0.1076 0.1075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0435 0.1981 0.9595
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0098 0.0372 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0072 0.0179
Brugia malayi jmjC domain containing protein 0.0065 0.0218 0.0539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0107 0.0106
Entamoeba histolytica hypothetical protein 0.0023 0.0018 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0356 0.0876
Brugia malayi CED-6 protein 0.0023 0.0014 0.0035
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0432 0.1067
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0107 0.023
Echinococcus multilocularis amyloid beta A4 protein 0.0214 0.0928 0.0927
Echinococcus multilocularis chromobox protein 1 0.0143 0.0591 0.059
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0018 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0084 0.0217
Onchocerca volvulus 0.0051 0.0149 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0107 0.0265
Onchocerca volvulus Heterochromatin protein 1 homolog 0.008 0.029 0.0626
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0218 0.0217
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0045 0.0098
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0008 0.0015
Toxoplasma gondii transporter, cation channel family protein 0.0063 0.0205 0.053
Schistosoma mansoni hypothetical protein 0.0035 0.0072 0.0071
Loa Loa (eye worm) calcium channel 0.03 0.1335 0.3298
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0231 0.0613
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0025 0.0024
Echinococcus granulosus lysine specific demethylase 5A 0.0245 0.1076 0.1075
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0099 0.0245
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0107 0.0106
Echinococcus granulosus axis inhibition protein axin 0.004 0.0099 0.0098
Onchocerca volvulus 0.0042 0.0107 0.023
Leishmania major hypothetical protein, conserved 0.0449 0.2049 0.5479
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Onchocerca volvulus 0.0023 0.0018 0.0037
Entamoeba histolytica heat shock protein 90, putative 0.0075 0.0264 0.0594
Echinococcus granulosus heat shock protein 0.0075 0.0264 0.0263
Plasmodium falciparum heat shock protein 90, putative 0.0506 0.2318 0.6203
Echinococcus multilocularis protein numb 0.0023 0.0014 0.0013
Schistosoma mansoni phd/f-box containing protein 0.0065 0.0218 0.0217
Trypanosoma brucei hypothetical protein, conserved 0.0098 0.0372 0.0976
Plasmodium vivax heat shock protein, putative 0.0506 0.2318 0.6203
Schistosoma mansoni serine/threonine protein kinase 0.0394 0.1786 0.1785
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.03 0.1335 0.33
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0098 0.0372 0.0976
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.008 0.0287 0.7056
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0105 0.0104
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Echinococcus granulosus chromobox protein 1 0.0143 0.0591 0.059
Loa Loa (eye worm) X11 protein 0.0214 0.0928 0.229
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0001 0.0003
Leishmania major heat shock protein, putative 0.0067 0.0224 0.0579
Brugia malayi TAR-binding protein 0.02 0.0862 0.2131
Schistosoma mansoni tar DNA-binding protein 0.02 0.0862 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0198
Loa Loa (eye worm) hypothetical protein 0.0065 0.0218 0.0537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.03 0.1335 0.1334
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0019 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0105 0.0104
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0008 0.0015
Loa Loa (eye worm) heat shock protein 90 0.0075 0.0264 0.0651
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0099 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0435 0.1981 0.9595
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Loa Loa (eye worm) hypothetical protein 0.0249 0.1094 0.2702
Brugia malayi Nuclear hormone receptor E75 0.002 0.0001 0.0003
Brugia malayi hypothetical protein 0.003 0.0051 0.0127
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0107 0.0106
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0099 0.0243
Echinococcus multilocularis smad 0.0025 0.0025 0.0024
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0604 0.279 0.2789
Schistosoma mansoni kinase 0.02 0.0861 0.086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.05 0.0499
Onchocerca volvulus 0.0988 0.4619 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0098 0.0372 0.0976
Schistosoma mansoni lozenge 0.0059 0.0185 0.0184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0084 0.0164
Plasmodium vivax heat shock protein 86, putative 0.0075 0.0264 0.0688
Trypanosoma brucei hypothetical protein, conserved 0.0449 0.2049 0.5479
Leishmania major hypothetical protein, conserved 0.0065 0.0218 0.0564
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Schistosoma mansoni Smad4 0.0025 0.0025 0.0024
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Echinococcus multilocularis Chromo domain 0.0023 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0035 0.0072 0.0071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0042 0.01
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0264 0.0702
Brugia malayi Inositol-1 0.0037 0.0084 0.0207
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0099 0.0098
Echinococcus multilocularis heat shock protein 0.0075 0.0264 0.0263
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0072 0.0176
Echinococcus granulosus protein numb 0.0023 0.0014 0.0013
Brugia malayi RNA binding protein 0.02 0.0862 0.2131
Echinococcus granulosus SHC transforming protein 3 0.0023 0.0014 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0449 0.2049 0.5486
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0098 0.0372 0.0789
Schistosoma mansoni inositol monophosphatase 0.0037 0.0084 0.0082
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0099 0.0098
Echinococcus multilocularis JmjC domain containing protein 4 0.0065 0.0218 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0107 0.0106
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.05 0.0499
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0802 0.3732 0.9222
Entamoeba histolytica hypothetical protein 0.004 0.0099 0.0211
Plasmodium falciparum JmjC domain-containing protein, putative 0.0065 0.0218 0.0564
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.03 0.1335 0.1334
Echinococcus multilocularis sodium channel protein 0.0127 0.0513 0.0511
Brugia malayi ecdysone receptor 0.002 0.0001 0.0003
Schistosoma mansoni smad1 5 8 and 0.0025 0.0025 0.0024
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0127 0.0513 0.0511
Trypanosoma brucei phosphomannose isomerase 0.0802 0.3732 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0042 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0218 0.0537
Entamoeba histolytica heat shock protein 90, putative 0.0075 0.0264 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0107 0.0265
Trichomonas vaginalis bromodomain-containing protein, putative 0.0178 0.0754 0.1618
Echinococcus granulosus heat shock protein 90 0.0075 0.0264 0.0263
Schistosoma mansoni regulator of G protein signaling 0.004 0.0099 0.0098
Brugia malayi hypothetical protein 0.0023 0.0014 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Loa Loa (eye worm) TAR-binding protein 0.02 0.0862 0.2129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0094
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0234 0.049
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0051 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0124
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0018 0.0027
Brugia malayi hypothetical protein 0.0252 0.111 0.2743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0356 0.0355
Schistosoma mansoni lamin 0.0028 0.0042 0.0041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0356 0.0879
Onchocerca volvulus 0.0466 0.2132 0.4614
Mycobacterium ulcerans aldehyde dehydrogenase 0.0253 0.1114 0.2825
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0107 0.0106
Trypanosoma cruzi heat shock protein, putative 0.0067 0.0224 0.0592
Toxoplasma gondii heat shock protein HSP90 0.0075 0.0264 0.0688
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0025 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Trypanosoma cruzi Heat shock protein 83, putative 0.0075 0.0264 0.0702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0356 0.0355
Echinococcus multilocularis voltage dependent calcium channel 0.03 0.1335 0.1334
Echinococcus granulosus intermediate filament protein 0.0028 0.0042 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0245 0.1076 0.1075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0107 0.0263
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.1076 0.2658
Onchocerca volvulus 0.0063 0.0207 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0356 0.0355
Echinococcus multilocularis lysine specific demethylase 6a 0.0065 0.0218 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0051 0.0131
Schistosoma mansoni ran 0.0021 0.0008 0.0007
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0234 0.0233
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0018 0.0017
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0098 0.0372 0.0789
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0072 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0107 0.0106
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0398 0.1047
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0253 0.1114 0.1113
Toxoplasma gondii Hsp90 domain-containing protein 0.0506 0.2318 0.6203
Brugia malayi nuclear receptor RXR 0.002 0.0001 0.0003
Schistosoma mansoni heat shock protein 0.0075 0.0264 0.0263
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0218 0.0537
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Trypanosoma cruzi phosphomannose isomerase, putative 0.0802 0.3732 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0398 0.0397
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0416
Trypanosoma brucei polo-like protein kinase 0.0394 0.1786 0.4773
Entamoeba histolytica hypothetical protein 0.004 0.0099 0.0211
Schistosoma mansoni regulator of G protein signaling 0.004 0.0099 0.0098
Loa Loa (eye worm) heterochromatin protein 1 0.0143 0.0591 0.1458
Schistosoma mansoni heat shock protein 0.0067 0.0224 0.0223
Echinococcus granulosus L aminoadipate semialdehyde 0.0347 0.156 0.156
Brugia malayi Smad1 0.0025 0.0025 0.0062
Schistosoma mansoni tar DNA-binding protein 0.02 0.0862 0.0861
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0084 0.0203
Entamoeba histolytica hypothetical protein 0.0024 0.0019 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0432 0.1067
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0837 0.1797
Schistosoma mansoni tar DNA-binding protein 0.02 0.0862 0.0861
Loa Loa (eye worm) hypothetical protein 0.0466 0.2132 0.5266
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0025 0.0024
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0001 0.0003
Brugia malayi MH1 domain containing protein 0.0025 0.0025 0.0062
Trypanosoma brucei heat shock protein 90, putative 0.0075 0.0264 0.0688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0107 0.0263
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0398 0.0397
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0107 0.0265
Schistosoma mansoni hypothetical protein 0.0051 0.0149 0.0148
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1384 0.3418
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0107 0.0106
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0218 0.0578
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0245 0.1076 0.1075
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0025 0.0024
Echinococcus granulosus smad 0.0025 0.0025 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.03 0.1335 0.1334
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0107 0.0265
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Brugia malayi hypothetical protein 0.004 0.0099 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Giardia lamblia Heat shock protein HSP 90-alpha 0.0068 0.0231 0.0517
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Onchocerca volvulus 0.0023 0.0014 0.0028
Schistosoma mansoni axis inhibition protein axin 0.004 0.0099 0.0098
Trichomonas vaginalis endoplasmin, putative 0.0062 0.0201 0.0419
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0347 0.156 0.156
Loa Loa (eye worm) RNA binding protein 0.02 0.0862 0.2129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.05 0.0499
Echinococcus granulosus lamin 0.0028 0.0042 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0098 0.0372 0.1535
Schistosoma mansoni regulator of G protein signaling 0.0049 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Brugia malayi hypothetical protein 0.004 0.0099 0.0245
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0243
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.03 0.1335 0.1334
Plasmodium falciparum heat shock protein 90 0.0075 0.0264 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0107 0.0265
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0107 0.0106
Echinococcus multilocularis snurportin 1 0.031 0.1384 0.1383
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0356 0.0355
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0042 0.0103
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0398 0.0397
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0028
Brugia malayi Mammalian fe65 homolog protein 1 0.0023 0.0014 0.0035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0347 0.156 0.3854
Schistosoma mansoni hypothetical protein 0.0075 0.0265 0.0264
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0394 0.1786 0.1785
Brugia malayi hypothetical protein 0.002 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0063 0.0205 0.0505
Echinococcus granulosus histone acetyltransferase KAT2B 0.0587 0.2709 0.2708
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Echinococcus multilocularis voltage dependent calcium channel 0.03 0.1335 0.1334
Schistosoma mansoni endoplasmin 0.0075 0.0264 0.0263
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0051 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0243
Echinococcus multilocularis lamin dm0 0.0028 0.0042 0.0041
Onchocerca volvulus Huntingtin homolog 0.0252 0.111 0.2401
Schistosoma mansoni smad1 5 8 and 0.0025 0.0025 0.0024
Brugia malayi jmjC domain containing protein 0.0065 0.0218 0.0539
Echinococcus granulosus heat shock protein 90 0.0068 0.0231 0.023
Brugia malayi Melibiase family protein 0.0069 0.0234 0.0579
Mycobacterium tuberculosis Conserved protein 0.0052 0.0153 0.0441
Brugia malayi MH2 domain containing protein 0.0366 0.1652 0.4083
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.1652 0.4081
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.1094 0.1093
Brugia malayi CHD4 protein 0.0023 0.0018 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0107 0.0263
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0098 0.0372 0.021
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0099 0.0098
Plasmodium vivax importin-beta 2, putative 0.0029 0.0045 0.0098
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.03 0.1335 0.1334
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0052 0.0153 0.019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.01
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.175 0.8254 0.8254
Giardia lamblia Histone acetyltransferase GCN5 0.0163 0.0684 0.1567
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0107 0.0106
Brugia malayi Hsp90 protein 0.0067 0.0224 0.0553
Brugia malayi nuclear hormone receptor 0.0042 0.0107 0.0265
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0178 0.0754 0.2003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0107 0.0106
Schistosoma mansoni ran 0.0021 0.0008 0.0007
Mycobacterium ulcerans hypothetical protein 0.0052 0.0153 0.019
Entamoeba histolytica hypothetical protein 0.004 0.0099 0.0211
Onchocerca volvulus 0.0148 0.0612 0.1323
Brugia malayi heat shock protein 90 0.0075 0.0264 0.0653
Echinococcus multilocularis chromobox protein 1 0.0143 0.0591 0.059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0452 0.2061 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0028
Plasmodium vivax SET domain protein, putative 0.0124 0.05 0.1321
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0008 0.0007
Treponema pallidum fructose-bisphosphate aldolase 0.0925 0.4318 1
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Brugia malayi tailless protein 0.002 0.0001 0.0003
Brugia malayi nuclear receptor NHR-88 0.0042 0.0107 0.0265
Leishmania major phosphomannose isomerase 0.0802 0.3732 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.0862 0.2129
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0243
Echinococcus granulosus Chromo domain 0.0023 0.0018 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0107 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Entamoeba histolytica serine/threonine protein kinase, putative 0.0394 0.1786 0.4124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Schistosoma mansoni tar DNA-binding protein 0.02 0.0862 0.0861
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0025 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0107 0.0263
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0837 0.1797
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0018 0.0027
Schistosoma mansoni smad 0.0025 0.0025 0.0024
Brugia malayi hypothetical protein 0.0022 0.0012 0.0031
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.03 0.1335 0.1334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0028
Loa Loa (eye worm) helicase 0.0023 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0319 0.0674
Brugia malayi MH1 domain containing protein 0.0025 0.0025 0.0062
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0067 0.0224 0.0482
Brugia malayi ecdysteroid receptor 0.0042 0.0107 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0107 0.0265
Echinococcus granulosus mannose 6 phosphate isomerase 0.0802 0.3732 0.3732
Echinococcus granulosus voltage dependent calcium channel 0.03 0.1335 0.1334
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0025 0.006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0012 0.0011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0253 0.1114 0.297
Loa Loa (eye worm) Smad1 0.0025 0.0025 0.006
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Echinococcus granulosus citrate lyase subunit beta protein 0.0052 0.0153 0.0152
Echinococcus multilocularis microtubule associated protein 2 0.2116 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0253 0.1114 0.2825
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.05 0.0499
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0084 0.0217
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0319 0.0674
Trypanosoma cruzi heat shock protein 90, putative 0.0068 0.0231 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0069 0.0234 0.0576
Giardia lamblia Grp94/Hsp90 0.008 0.0287 0.0646
Schistosoma mansoni hypothetical protein 0.0035 0.0072 0.0071
Trichomonas vaginalis hypothetical protein 0.0023 0.0018 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0264 0.0702
Schistosoma mansoni chromobox protein 0.0143 0.0591 0.059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Loa Loa (eye worm) endoplasmin 0.0075 0.0264 0.0651
Schistosoma mansoni numb 0.0023 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.008 0.029 0.0611
Brugia malayi Endoplasmin precursor 0.0075 0.0264 0.0653
Echinococcus multilocularis lysine specific demethylase 5A 0.0245 0.1076 0.1075
Loa Loa (eye worm) AIDA-1b 0.0023 0.0014 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0253 0.1114 0.2825
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0198
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0018 0.0017
Entamoeba histolytica acetyltransferase, GNAT family 0.0163 0.0684 0.1567
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0107 0.0106
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0802 0.3732 0.9222
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0098 0.0372 0.1535
Loa Loa (eye worm) hypothetical protein 0.008 0.029 0.0714
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0802 0.3732 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0178 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0107 0.0263
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0107 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0148 0.0612 0.0611
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0018 0.0027
Schistosoma mansoni jumonji domain containing protein 0.0245 0.1076 0.1075
Giardia lamblia Kinase, PLK 0.0394 0.1786 0.4124
Plasmodium falciparum heat shock protein 90, putative 0.0055 0.0168 0.0429
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0065 0.0218 0.0564
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0051 0.0116
Echinococcus granulosus X box binding protein 1 0.029 0.1289 0.1289
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0107 0.0106
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0052 0.0153 0.0389
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0018 0.0027
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0099 0.0098
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0018 0.0022
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0098 0.0372 0.5
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0052 0.0153 0.0314
Brugia malayi nuclear hormone receptor 0.002 0.0001 0.0003
Trypanosoma brucei Heat shock protein 83, putative 0.0075 0.0264 0.0688
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0108
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0018 0.0022
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0084 0.0164
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0099 0.0245
Echinococcus multilocularis citrate lyase subunit beta protein 0.0052 0.0153 0.0152
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0018 0.0017
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0084 0.0175
Echinococcus granulosus jumonji domain containing 1A 0.0065 0.0218 0.0217
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0022
Onchocerca volvulus Serine\/threonine kinase homolog 0.0394 0.1786 0.3864
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0107 0.0263
Echinococcus granulosus axis inhibition protein axin 0.004 0.0099 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0018 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0253 0.1114 0.1113
Echinococcus multilocularis SHC transforming protein 3 0.0023 0.0014 0.0013
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0802 0.3732 0.3732
Brugia malayi Pre-SET motif family protein 0.0124 0.05 0.1236
Brugia malayi conserved hypotetical protein 0.002 0.0001 0.0003
Schistosoma mansoni microtubule-associated protein tau 0.2116 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0107 0.0106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0432 0.1064
Echinococcus granulosus snurportin 1 0.031 0.1384 0.1383
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0045 0.0098
Schistosoma mansoni regulator of G protein signaling 0.004 0.0099 0.0098
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0052 0.0153 0.019
Schistosoma mansoni axis inhibition protein axin 0.004 0.0099 0.0098
Schistosoma mansoni phosphatidylserine receptor 0.0065 0.0218 0.0217
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0042 0.0105 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0107 0.0263
Schistosoma mansoni protein phosphatase 2C 0.0065 0.0218 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0367 0.1658 0.3828
Schistosoma mansoni hypothetical protein 0.0023 0.0014 0.0013
Echinococcus granulosus JmjC domain containing protein 4 0.0065 0.0218 0.0217
Loa Loa (eye worm) hypothetical protein 0.0063 0.0207 0.0509
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Loa Loa (eye worm) hypothetical protein 0.0466 0.2132 0.5266
Onchocerca volvulus 0.0023 0.0018 0.0037
Echinococcus granulosus GPCR family 2 0.0035 0.0072 0.0071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0253 0.1114 0.5256
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0042
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0024
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0347 0.156 0.3856
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0265 0.0656
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Schistosoma mansoni tensin-related 0.0023 0.0014 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.03 0.1335 0.3298
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0398 0.0397
Schistosoma mansoni lamin 0.0028 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0252 0.111 0.2741
Leishmania major phosphopantetheinyl transferase-like protein 0.0098 0.0372 0.0976
Leishmania major hypothetical protein, conserved 0.003 0.0051 0.0116
Plasmodium falciparum histone acetyltransferase GCN5 0.0163 0.0684 0.1814
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0452 0.2061 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0019 0.0028
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0107 0.0106
Loa Loa (eye worm) RGS-3 protein 0.004 0.0099 0.0243
Trypanosoma cruzi polo-like protein kinase, putative 0.0394 0.1786 0.478
Echinococcus multilocularis heat shock protein 90 0.0075 0.0264 0.0263
Onchocerca volvulus Huntingtin homolog 0.0252 0.111 0.2401
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0099 0.0098
Brugia malayi nuclear receptor NHR-88 0.002 0.0001 0.0003
Brugia malayi hypothetical protein 0.0022 0.0012 0.0031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0149 0.0367
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0099 0.0098
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0925 0.4318 1
Brugia malayi jmjC domain containing protein 0.0065 0.0218 0.0539
Trypanosoma cruzi polo-like protein kinase, putative 0.0394 0.1786 0.478
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0084 0.0082
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0031
Echinococcus multilocularis Protein lozenge 0.0059 0.0185 0.0184
Brugia malayi Nuclear hormone receptor E75 0.002 0.0001 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.0075 0.0264 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0107 0.0265
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0018 0.0017
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0018 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0143 0.0591 0.1264
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0018 0.0045
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0478 0.0477
Brugia malayi hypothetical protein 0.0023 0.0018 0.0045
Brugia malayi hypothetical protein 0.0206 0.0888 0.2194
Brugia malayi MH2 domain containing protein 0.0025 0.0025 0.0062
Brugia malayi steroid hormone receptor 0.0042 0.0107 0.0265
Loa Loa (eye worm) hypothetical protein 0.011 0.0432 0.1064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0925 0.4318 0.9347
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0868 0.4047 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0263
Echinococcus multilocularis jumonji domain containing 1A 0.0065 0.0218 0.0217
Echinococcus granulosus importin subunit beta 1 0.0029 0.0045 0.0044
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0107 0.0106
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.03 0.1335 0.1334
Echinococcus granulosus carboxyl terminal PDZ ligand of neuronal nitric 0.0023 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.1786 0.3855
Echinococcus granulosus lamin dm0 0.0028 0.0042 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.008 0.029 0.0611
Schistosoma mansoni tar DNA-binding protein 0.02 0.0862 0.0861
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0604 0.279 0.2789
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0072 0.0179
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0052 0.0153 0.0403
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0178 0.0754 0.2003
Entamoeba histolytica hypothetical protein 0.0023 0.0018 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0925 0.4318 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0025 0.006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0018 0.0022
Giardia lamblia Heat shock protein HSP 90-alpha 0.0075 0.0264 0.0594
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0018 0.0027
Echinococcus granulosus lysine specific demethylase 6a 0.0065 0.0218 0.0217
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0018 0.0045
Schistosoma mansoni smad1 5 8 and 0.0025 0.0025 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.0022
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0052 0.0153 0.0441
Echinococcus multilocularis L aminoadipate semialdehyde 0.0347 0.156 0.156
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.008 0.0287 0.1111
Schistosoma mansoni chromobox protein 0.0023 0.0018 0.0017
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0231 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0356 0.0355
Schistosoma mansoni regulator of G protein signaling 0.004 0.0099 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0218 0.0537
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0084 0.0203
Brugia malayi Protein cec-1. 0.0023 0.0018 0.0045
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.008 0.0287 0.0748
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0084 0.0203
Trypanosoma brucei heat shock protein, putative 0.0075 0.0264 0.0688
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0234 0.0233
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0243
Schistosoma mansoni coup transcription factor 0.0042 0.0107 0.0106
Brugia malayi intermediate filament protein 0.0028 0.0042 0.0103
Brugia malayi Heterochromatin protein 1 0.0143 0.0591 0.146
Loa Loa (eye worm) acetyltransferase 0.0604 0.279 0.6893
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0051 0.0116
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0098 0.0372 0.0976
Trypanosoma brucei heat shock protein 90, putative 0.0075 0.0264 0.0688
Echinococcus granulosus expressed protein 0.0788 0.3665 0.3665
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0218 0.0578
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0065 0.0218 0.0217
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0099 0.0245
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0253 0.1114 0.1113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0032
Loa Loa (eye worm) inositol-1 0.0037 0.0084 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0028
Loa Loa (eye worm) runx1 0.0059 0.0185 0.0456
Loa Loa (eye worm) heat shock protein 75 0.0067 0.0224 0.055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0107 0.0265
Echinococcus multilocularis phd:f box containing protein 0.0065 0.0218 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0018 0.0022
Leishmania major heat shock protein 83-1 0.0075 0.0264 0.0688
Onchocerca volvulus 0.0347 0.156 0.3377
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0099 0.0245
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0394 0.1786 0.4773
Trypanosoma brucei heat shock protein 84, putative 0.0067 0.0224 0.0579
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0243
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0107 0.0106
Brugia malayi nuclear receptor RXR 0.0022 0.0012 0.0031
Echinococcus granulosus voltage dependent calcium channel 0.0063 0.0205 0.0204
Brugia malayi RNA, U transporter 1 0.0083 0.03 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0198
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0394 0.1786 0.4411
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0035 0.0072 0.0071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0398 0.0397
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0099 0.0245
Echinococcus multilocularis tar DNA binding protein 0.02 0.0862 0.0861
Schistosoma mansoni chromobox protein 0.0023 0.0018 0.0017
Toxoplasma gondii aldehyde dehydrogenase 0.0253 0.1114 0.297
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.05 0.0499

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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