Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2909 | 0.6198 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0.0167 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0635 | 0.1353 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0025 | 0.0167 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0.0167 | 0.0575 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0025 | 0.0167 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0635 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2909 | 0.6198 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0167 | 0.0356 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0.0167 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0635 | 0.2182 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1182 | 0.2518 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1182 | 0.2518 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0025 | 0.0167 | 0.0356 |
Leishmania major | oxidoreductase-like protein | 0.0025 | 0.0167 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0025 | 0.0167 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0025 | 0.0167 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1182 | 0.2518 |
Trypanosoma brucei | pteridine reductase 1 | 0.0025 | 0.0167 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0.0167 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0367 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.012 | 0.2909 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.012 | 0.2909 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0025 | 0.0167 | 0.0356 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.012 | 0.2909 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.012 | 0.2909 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0025 | 0.0167 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0.0167 | 0.0575 |
Leishmania major | pteridine reductase 1 | 0.0025 | 0.0167 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0025 | 0.0167 | 0.0575 |
Brugia malayi | hypothetical protein | 0.0182 | 0.4693 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0025 | 0.0167 | 0.0356 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0367 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4693 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0.0167 | 0.0356 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1182 | 0.2518 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0025 | 0.0167 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0367 | 1 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0.0167 | 0.0356 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0367 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 0.4693 | 1 | |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0367 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0367 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0367 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0.0167 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0367 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.