Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | 0.0074 | 0.5964 | 0.5392 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6301 | 0.5897 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6301 | 0.6301 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6301 | 0.5897 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0043 | 0.2371 | 0.3107 |
Loa Loa (eye worm) | glutamate receptor | 0.0035 | 0.1406 | 0.1406 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6301 | 0.5897 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6301 | 0.8259 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6301 | 0.8259 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6301 | 0.8259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6301 | 0.5897 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.01 | 0.9035 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6301 | 0.6301 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6301 | 0.0835 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6301 | 0.6301 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0108 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6301 | 0.0835 |
Loa Loa (eye worm) | glutamate receptor | 0.0088 | 0.7629 | 0.7629 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6301 | 0.5897 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0088 | 0.7629 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.008 | 0.6665 | 0.8736 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.