Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0032 | 0.3234 | 0.2749 |
Echinococcus multilocularis | hypothetical protein | 0.0019 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5683 | 0.6066 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0044 | 0.5683 | 0.5683 |
Loa Loa (eye worm) | calpain | 0.0019 | 0.0669 | 0.0714 |
Echinococcus granulosus | calpain | 0.0019 | 0.0669 | 0.0669 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma cruzi | kinesin, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0066 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0063 | 0.9367 | 1 |
Echinococcus multilocularis | calpain | 0.0019 | 0.0669 | 0.0669 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0066 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.3234 | 0.3234 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0669 | 0.5 |
Onchocerca volvulus | 0.0044 | 0.5683 | 1 | |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus multilocularis | musashi | 0.0032 | 0.3234 | 0.3234 |
Schistosoma mansoni | lamin | 0.0032 | 0.3234 | 0.2749 |
Leishmania major | kinesin, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus granulosus | calpain 7 C02 family | 0.0019 | 0.0669 | 0.0669 |
Plasmodium vivax | calpain, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.3234 | 0.3452 |
Trypanosoma cruzi | kinesin, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5683 | 0.6066 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.3234 | 0.3212 |
Echinococcus multilocularis | calpain 5 | 0.0019 | 0.0669 | 0.0669 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.3234 | 0.3234 |
Trypanosoma brucei | kinesin, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.3234 | 0.3234 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.3234 | 0.2749 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.9367 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3234 | 0.3452 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0063 | 0.9367 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0044 | 0.5683 | 0.6066 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus multilocularis | calpain A | 0.0066 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Brugia malayi | calpain family protein 1 | 0.0063 | 0.9367 | 1 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Loa Loa (eye worm) | calpain 5 | 0.0019 | 0.0669 | 0.0714 |
Echinococcus multilocularis | calpain 7 (C02 family) | 0.0019 | 0.0669 | 0.0669 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0066 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus granulosus | lamin | 0.0032 | 0.3234 | 0.3234 |
Trypanosoma brucei | antigen, putative | 0.0019 | 0.0669 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3119 | 0.333 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.3234 | 0.3212 |
Brugia malayi | calpain 7 | 0.0019 | 0.0669 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.9367 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.3234 | 0.3452 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Brugia malayi | calpain 5 | 0.0019 | 0.0669 | 0.0373 |
Echinococcus granulosus | calpain A | 0.0019 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0332 | 0.0354 |
Echinococcus granulosus | calpain 5 | 0.0019 | 0.0669 | 0.0669 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0669 | 0.5 |
Echinococcus multilocularis | lamin | 0.0032 | 0.3234 | 0.3234 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0019 | 0.0669 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0063 | 0.9367 | 0.9322 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0669 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0066 | 1 | 1 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.0019 | 0.0669 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 96.2 um | PUBCHEM_BIOASSAY: In Vitro HePTP Dose Response Colorimetric Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 521 ] | ChEMBL. | No reference |
IC50 (binding) | > 100 um | PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1054, AID1055, AID425, AID553, AID566] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: In Vitro MKP-3 Dose Response Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1052, AID1661, AID2085, AID2679, AID425, AID553, AID566] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.