Detailed information for compound 1253113

Basic information

Technical information
  • TDR Targets ID: 1253113
  • Name: 2-methyl-8-(1-phenyltetrazol-5-yl)oxyquinolin e
  • MW: 303.318 | Formula: C17H13N5O
  • H donors: 0 H acceptors: 4 LogP: 3.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)c(ccc2)Oc1nnnn1c1ccccc1
  • InChi: 1S/C17H13N5O/c1-12-10-11-13-6-5-9-15(16(13)18-12)23-17-19-20-21-22(17)14-7-3-2-4-8-14/h2-11H,1H3
  • InChiKey: NHEVVTFETNWIMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methyl-8-(1-phenyltetrazol-5-yl)oxy-quinoline
  • 2-methyl-8-[(1-phenyl-5-tetrazolyl)oxy]quinoline
  • 2-methyl-8-[(1-phenyl-1,2,3,4-tetrazol-5-yl)oxy]quinoline
  • ZINC03449735
  • MLS000098645
  • SMR000068678
  • T5346474

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0071 0.0071
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1078 0.1078
Brugia malayi nuclear hormone receptor 0.0012 0.0071 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1078 0.1078
Brugia malayi beta-lactamase 0.0043 0.0561 0.0561
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0071 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5409 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0071 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0071 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0561 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0071 0.0071
Leishmania major 0.0646 1 1
Schistosoma mansoni coup transcription factor 0.0012 0.0071 0.0071
Loa Loa (eye worm) beta-lactamase 0.0043 0.0561 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0071 0.0071
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.024 0.3644 0.3644
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1078 0.1078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0561 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0071 0.0071
Brugia malayi beta-lactamase family protein 0.0043 0.0561 0.0561
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0561 0.0561
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0071 0.0071
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0048 0.0048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0561 0.0561
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.024 0.3644 0.3644
Echinococcus granulosus tar DNA binding protein 0.0076 0.1078 0.1078
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0071 0.0071
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1078 0.1078
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0071 0.0071
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1078 0.1078
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.5409 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0561 0.0561
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0071 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0561 0.1038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Brugia malayi N-terminal motif family protein 0.0218 0.3295 0.3295
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0071 0.0071
Brugia malayi nuclear receptor NHR-88 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.024 0.3644 0.3613
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0561 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0071 0.0071
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0071 0.0071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0071 0.0217
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0048 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0071 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0071 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0071 0.0071
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.5409 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0071 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0071 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0071 0.0071
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0048 0.0048
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2581 1
Brugia malayi hypothetical protein 0.0011 0.0048 0.0048
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0071 0.0217
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0071 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0071 0.0071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0071 0.0071
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0561 0.1038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0071 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0071 0.0071
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1078 0.1078
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0071 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1078 0.1078
Loa Loa (eye worm) RNA binding protein 0.0076 0.1078 0.1078
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0048 0.0048
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0048 0.0048
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0071 0.0217
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0048 0.0048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4231 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0071 0.0071
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2581 1
Trichomonas vaginalis esterase, putative 0.0043 0.0561 0.1038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0048 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0071 0.0071
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0646 1 1
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0048 0.0048
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2581 0.5503
Brugia malayi hypothetical protein 0.0011 0.0048 0.0048
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0071 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0071 0.0071
Brugia malayi DIX domain containing protein 0.0011 0.0048 0.0048
Schistosoma mansoni dep domain containing protein 0.0011 0.0048 0.0048
Toxoplasma gondii ABC1 family protein 0.0043 0.0561 0.0515
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0646 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0071 0.0071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0071 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0561 0.0561
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1078 0.1078
Brugia malayi TAR-binding protein 0.0076 0.1078 0.1078
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0646 1 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0646 1 1
Brugia malayi beta-lactamase family protein 0.0043 0.0561 0.0561
Schistosoma mansoni dishevelled 0.0011 0.0048 0.0048
Toxoplasma gondii fructose-bisphospatase II 0.0646 1 1
Brugia malayi ecdysteroid receptor 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0071 0.0071
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0048 0.0048
Onchocerca volvulus 0.0043 0.0561 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0071 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Brugia malayi steroid hormone receptor 0.0012 0.0071 0.0071
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0646 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0561 0.1038
Onchocerca volvulus 0.0011 0.0048 0.0146
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Onchocerca volvulus 0.0012 0.0071 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0561 0.1038
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0071 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.0561
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0646 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1078 0.1078
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0561 0.1038
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0048 0.0048
Onchocerca volvulus 0.0043 0.0561 0.1703
Toxoplasma gondii fructose-bisphospatase I 0.024 0.3644 0.3613
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0071 0.0071
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.3295 1
Brugia malayi RNA binding protein 0.0076 0.1078 0.1078
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0071 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0071 0.0071
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0048 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0071 0.0071
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0071 0.0071
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0048 0.0048
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.024 0.3644 0.3266
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0048 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0071 0.0071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0071 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0561 0.0561
Onchocerca volvulus 0.0043 0.0561 0.1703
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5409 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0071 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5409 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0048 0.0048
Schistosoma mansoni dishevelled 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0218 0.3295 0.3295
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0646 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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