Detailed information for compound 1254109

Basic information

Technical information
  • TDR Targets ID: 1254109
  • Name: N-[4-methyl-5-(4-methylphenoxy)-6-oxo-3H-pyri midin-2-yl]acetamide
  • MW: 273.287 | Formula: C14H15N3O3
  • H donors: 2 H acceptors: 4 LogP: 1.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1nc(C)c(c(n1)O)Oc1ccc(cc1)C
  • InChi: 1S/C14H15N3O3/c1-8-4-6-11(7-5-8)20-12-9(2)15-14(16-10(3)18)17-13(12)19/h4-7H,1-3H3,(H2,15,16,17,18,19)
  • InChiKey: IUPWLIOJYRLKRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-keto-6-methyl-5-(4-methylphenoxy)-1H-pyrimidin-2-yl]acetamide
  • N-[4-methyl-5-(4-methylphenoxy)-6-oxo-3H-pyrimidin-2-yl]ethanamide
  • ZINC00123645
  • Maybridge1_008641
  • MLS001111108
  • N1-[4-hydroxy-6-methyl-5-(4-methylphenoxy)pyrimidin-2-yl]acetamide
  • SMR000457042
  • Oprea1_460893

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 1 0.0073 0.0678 0.0678
Trichomonas vaginalis adenosine deaminase, putative 0.0344 1 0.5
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0678 0.0678
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0678 0.0678
Brugia malayi Melatonin receptor type 1A 0.0073 0.0678 0.0678
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0678 0.0678
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0678 0.0678
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0678 0.0678
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.0678 0.0678
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Entamoeba histolytica adenosine deaminase, putative 0.0344 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0678 0.0678
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.0678 0.0678
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.0678 0.0678
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.0678 0.0678
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.0678 0.0678
Schistosoma mansoni amine GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0678 0.0678
Brugia malayi GnHR receptor homolog 0.0073 0.0678 0.0678
Brugia malayi RE15519p 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 0.0678 0.0678
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.0678 0.0678
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0344 1 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0678 0.0678
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0678 0.0678
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0344 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.0678 0.0678
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0232 0.614 0.614
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0678 0.0678
Trypanosoma brucei AMP deaminase, putative 0.0112 0.201 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.0678 0.0678
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis AMP deaminase 2 0.0112 0.201 0.201
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0678 0.0678
Schistosoma mansoni neuropeptide receptor 0.0073 0.0678 0.0678
Brugia malayi ORL1-like opioid receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.0678 0.0678
Brugia malayi neuropeptide F receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus somatostatin receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0678 0.0678
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.0678 0.0678
Echinococcus granulosus orexin receptor type 2 0.0073 0.0678 0.0678
Brugia malayi adenosine monophosphate deaminase 0.0112 0.201 0.201
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus g protein coupled receptor 0.0073 0.0678 0.0678
Schistosoma mansoni amine GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus AMP deaminase 2 0.0112 0.201 0.201
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0678 0.0678
Echinococcus granulosus sex peptide receptor 0.0073 0.0678 0.0678
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.0678 0.0678
Echinococcus granulosus g protein coupled receptor 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine receptor 0.0073 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0073 0.0678 0.0678
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0112 0.201 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0678 0.0678
Echinococcus granulosus g protein coupled receptor 0.0073 0.0678 0.0678
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.0678 0.0678
Loa Loa (eye worm) AMP deaminase 0.0112 0.201 0.201
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide s receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni neuropeptide receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni neuropeptide receptor 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Mycobacterium ulcerans adenosine deaminase 0.0344 1 0.5
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0112 0.201 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.0678 0.0678
Trypanosoma cruzi AMP deaminase, putative 0.0112 0.201 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Brugia malayi G-protein coupled receptor 0.0073 0.0678 0.0678
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0344 1 1
Schistosoma mansoni adenosine deaminase 0.0344 1 1
Echinococcus multilocularis adenosine deaminase 0.0344 1 1
Brugia malayi Dopamine receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0678 0.0678
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Trypanosoma cruzi AMP deaminase, putative 0.0112 0.201 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Trypanosoma brucei AMP deaminase, putative 0.0112 0.201 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.0678 0.0678
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0344 1 0.5
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.0678 0.0678
Echinococcus granulosus serotonin receptor 0.0073 0.0678 0.0678
Trypanosoma cruzi AMP deaminase, putative 0.0112 0.201 0.5
Trypanosoma cruzi AMP deaminase, putative 0.0112 0.201 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.0678 0.0678
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.0678 0.0678
Schistosoma mansoni opsin-like receptor 0.0073 0.0678 0.0678
Brugia malayi follicle stimulating hormone receptor 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide receptor A26 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine receptor 0.0073 0.0678 0.0678
Brugia malayi Serotonin receptor 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Echinococcus multilocularis G protein coupled receptor 139 0.0073 0.0678 0.0678
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.0678 0.0678
Leishmania major adenine aminohydrolase 0.0344 1 1
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis serotonin receptor 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide receptor 0.0073 0.0678 0.0678
Schistosoma mansoni histamine h1 receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis serotonin receptor 0.0073 0.0678 0.0678
Brugia malayi larval opioid receptor 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus adenosine deaminase 0.0344 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.614 0.614
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis allatostatin A receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Brugia malayi Serotonin receptor 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide receptor 0.0073 0.0678 0.0678
Brugia malayi AKH receptor 0.0073 0.0678 0.0678
Treponema pallidum adenosine deaminase 0.0344 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0678 0.0678
Trypanosoma cruzi AMP deaminase, putative 0.0112 0.201 0.5
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.0678 0.0678
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0678 0.0678
Brugia malayi Dopamine receptor protein 2 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0678 0.0678
Schistosoma mansoni neuropeptide receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni amine GPCR 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0112 0.201 0.201
Schistosoma mansoni adenoreceptor 0.0073 0.0678 0.0678
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0678 0.0678
Schistosoma mansoni biogenic amine receptor 0.0073 0.0678 0.0678
Trypanosoma cruzi AMP deaminase 2, putative 0.0112 0.201 0.5
Echinococcus multilocularis sex peptide receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis neuropeptide receptor A26 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni adenosine deaminase-related 0.0344 1 1
Echinococcus granulosus allatostatin A receptor 0.0073 0.0678 0.0678
Plasmodium falciparum adenosine deaminase 0.0344 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Brugia malayi G protein-coupled receptor 0.0073 0.0678 0.0678
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0232 0.614 0.614
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.0678 0.0678
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 0.0678 0.0678
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0112 0.201 0.5
Brugia malayi sulfakinin receptor protein 0.0073 0.0678 0.0678
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis orexin receptor type 2 0.0073 0.0678 0.0678
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0678 0.0678
Echinococcus multilocularis neuropeptide s receptor 0.0073 0.0678 0.0678
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0678 0.0678
Schistosoma mansoni amine GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.0678 0.0678
Brugia malayi G-protein coupled receptor 0.0073 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0678 0.0678
Entamoeba histolytica adenosine deaminase, putative 0.0344 1 1
Schistosoma mansoni AMP deaminase 0.0112 0.201 0.201
Schistosoma mansoni opsin-like receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0232 0.614 0.614
Echinococcus granulosus fmrfamide receptor 0.0073 0.0678 0.0678
Brugia malayi hypothetical protein 0.0073 0.0678 0.0678
Echinococcus multilocularis somatostatin receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.0678 0.0678
Plasmodium vivax adenosine deaminase, putative 0.0344 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.0678 0.0678
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Trichomonas vaginalis adenosine deaminase, putative 0.0344 1 0.5
Brugia malayi neuropeptide F receptor 0.0073 0.0678 0.0678
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.0678 0.0678
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.0678 0.0678
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.0678 0.0678
Brugia malayi putative neuropeptide receptor 0.0073 0.0678 0.0678
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.0678 0.0678
Schistosoma mansoni myosin xvIII 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Onchocerca volvulus Adenosine deaminase homolog 0.0344 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0678 0.0678
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni amine GPCR 0.0073 0.0678 0.0678
Trypanosoma brucei AMP deaminase, putative 0.0112 0.201 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Onchocerca volvulus AMP deaminase 2 homolog 0.0112 0.201 0.1429
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.0678 0.0678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0678 0.0678
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0678 0.0678
Onchocerca volvulus 0.0112 0.201 0.1429
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Schistosoma mansoni opsin-like receptor 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0073 0.0678 0.0678
Echinococcus granulosus g-protein coupled receptor 0.0073 0.0678 0.0678

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0465 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.