Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0059 | 0.7667 | 0.6841 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0059 | 0.7667 | 0.6841 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0059 | 0.7667 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0059 | 0.7667 | 0.6841 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0036 | 0.2855 | 0.0327 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0059 | 0.7667 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0059 | 0.7667 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0069 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.7667 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0059 | 0.7667 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 1 | 1 |
Onchocerca volvulus | 0.0059 | 0.7667 | 0.6841 | |
Onchocerca volvulus | 0.0069 | 1 | 1 | |
Brugia malayi | intracellular kinase | 0.0059 | 0.7667 | 0.6841 |
Echinococcus multilocularis | protein kinase shaggy | 0.0059 | 0.7667 | 0.6841 |
Echinococcus granulosus | protein kinase shaggy | 0.0059 | 0.7667 | 0.6841 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0069 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0.7667 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0059 | 0.7667 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0.7667 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0059 | 0.7667 | 0.6841 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 1 | 1 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0035 | 0.2614 | 0.3409 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0059 | 0.7667 | 0.6841 |
Giardia lamblia | Kinase, CDC7 | 0.0069 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0059 | 0.7667 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 100 nM | Inhibition of GSK3-beta | ChEMBL. | 20873740 |
IC50 (binding) | = 0.008 uM | Inhibition of Cdc7 | ChEMBL. | 20873740 |
IC50 (functional) | = 0.5 uM | Antiproliferative activity against human A2780 cells expressing p53 after 72 hrs by celltiter-glo assay | ChEMBL. | 20873740 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20873740 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.