Detailed information for compound 1254283

Basic information

Technical information
  • TDR Targets ID: 1254283
  • Name: 3-(3-methoxyphenyl)-1-[[2-(5-methyl-3-nitropy razol-1-yl)acetyl]amino]thiourea
  • MW: 364.38 | Formula: C14H16N6O4S
  • H donors: 2 H acceptors: 4 LogP: 2.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=NNC(=O)Cn1nc(cc1C)[N+](=O)[O-])S
  • InChi: 1S/C14H16N6O4S/c1-9-6-12(20(22)23)18-19(9)8-13(21)16-17-14(25)15-10-4-3-5-11(7-10)24-2/h3-7H,8H2,1-2H3,(H,16,21)(H2,15,17,25)
  • InChiKey: JGIICNDIDPGOKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-methoxyphenyl)-1-[[2-(5-methyl-3-nitro-pyrazol-1-yl)acetyl]amino]thiourea
  • 3-(3-methoxyphenyl)-1-[[2-(5-methyl-3-nitro-1-pyrazolyl)-1-oxoethyl]amino]thiourea
  • 3-(3-methoxyphenyl)-1-[2-(5-methyl-3-nitro-pyrazol-1-yl)ethanoylamino]thiourea
  • SMR000228109
  • AK-968/41923189
  • ZINC02739333
  • 2-({3-nitro-5-methyl-1H-pyrazol-1-yl}acetyl)-N-(3-methoxyphenyl)hydrazinecarbothioamide
  • MLS000698584

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0304 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.2108 0.2578
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.1061 0.1039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0304 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0304 0.0401
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0304 0.0329
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0575 0.0624
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.004 0.0053
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0304 0.0401
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.9003 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0614 0.0751
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.3127 0.4131
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.2772 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0614 0.0751
Schistosoma mansoni lamin 0.0026 0.0486 0.0486
Echinococcus granulosus lamin dm0 0.0026 0.0486 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.1703 0.2083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0304 0.0401
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0304 0.0304
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0617 0.0617
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0615 0.0667
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0139 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.211 0.2223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0277
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Echinococcus multilocularis GPCR, family 2 0.0031 0.0665 0.0665
Echinococcus granulosus GPCR family 2 0.0031 0.0665 0.0721
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0617 0.0539
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0139 0.0151
Echinococcus multilocularis lamin 0.0026 0.0486 0.0486
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.1465 0.1792
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0665 0.0721
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0617 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0615 0.2644
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0665 0.0878
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0304 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0304 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1276 0.156
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.7568 0.9229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1276 0.156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0304 0.0401
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0209 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.2108 0.2578
Onchocerca volvulus 0.0026 0.0486 0.0232
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.2772 0.3006
Brugia malayi nuclear receptor NHR-88 0.0021 0.0304 0.0401
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0304 0.0329
Plasmodium vivax SET domain protein, putative 0.003 0.0615 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.2772 0.297
Brugia malayi steroid hormone receptor 0.0021 0.0304 0.0401
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0486 0.0643
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.2297 0.281
Schistosoma mansoni hypothetical protein 0.0031 0.0665 0.0665
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.2772 0.2572
Loa Loa (eye worm) hypothetical protein 0.0218 0.7568 1
Schistosoma mansoni thyroid hormone receptor 0.0284 1 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0617 0.5
Brugia malayi Pre-SET motif family protein 0.003 0.0615 0.0813
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0665 0.0665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0615 0.0615
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0304 0.0304
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0615 0.0615
Onchocerca volvulus 0.0026 0.0486 0.0232
Giardia lamblia GTOR 0.0088 0.2772 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0139 0.0184
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0665 0.0878
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1987 0.2626
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.004 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0304 0.0304
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0617 0.0669
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0617 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0304 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0304 0.0401
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0304 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0139 0.017
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0304 0.0401
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0304 0.0304
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0304 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0304 0.0401
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0031 0.0665 0.0665
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.2772 0.2572
Echinococcus granulosus intermediate filament protein 0.0026 0.0486 0.0528
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0617 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0665 0.0878
Brugia malayi intermediate filament protein 0.0026 0.0486 0.0643
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0615 0.0615
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.9003 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.2772 0.297
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0139 0.0139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0665 0.0721
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0304 0.0329
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0304 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0304 0.0401
Schistosoma mansoni hypothetical protein 0.0067 0.1987 0.1987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.1465 0.1792
Mycobacterium ulcerans hypothetical protein 0.003 0.0617 0.5
Mycobacterium ulcerans hypothetical protein 0.003 0.0617 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.2772 0.339
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0304 0.0304
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0263 0.9222 0.9222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.2772 0.339
Brugia malayi ecdysteroid receptor 0.0021 0.0304 0.0401
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.3127 0.4131
Trichomonas vaginalis set domain proteins, putative 0.0234 0.8176 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0615 0.0615
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0614 0.0536
Loa Loa (eye worm) hypothetical protein 0.003 0.0615 0.0813
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0617 0.5
Brugia malayi nuclear hormone receptor 0.0021 0.0304 0.0401
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.211 0.2223
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.7126 0.9415
Loa Loa (eye worm) hypothetical protein 0.0067 0.1987 0.2626
Onchocerca volvulus 0.003 0.0615 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.2108 0.2578
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0304 0.0329
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0874 0.0829
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0614 0.0751
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0665 0.0665
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.2772 0.2772
Echinococcus granulosus lamin 0.0026 0.0486 0.0528
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0617 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0469 0.062
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0665 0.0878
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.3127 0.4131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0139 0.0151
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0304 0.0304
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Brugia malayi Pre-SET motif family protein 0.0206 0.7126 0.9415
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0304 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.9003 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1276 0.156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.1278 0.1564
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.2772 0.2772
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.2772 0.3662
Schistosoma mansoni lamin 0.0026 0.0486 0.0486
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0486 0.0643
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Schistosoma mansoni thyroid hormone receptor 0.0284 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0139 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0304 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0617 0.0754
Leishmania major hypothetical protein, conserved 0.0257 0.9003 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.1278 0.1564
Schistosoma mansoni hypothetical protein 0.0031 0.0665 0.0665
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0304 0.0401
Echinococcus multilocularis musashi 0.0026 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0304 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0396 0.0485
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0304 0.0329
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0304 0.0329
Brugia malayi N-terminal motif family protein 0.0218 0.7568 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0304 0.0401
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0614 0.0666
Loa Loa (eye worm) hypothetical protein 0.0018 0.0187 0.0247
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.2772 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0026 0.0486 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1446 0.1769
Mycobacterium tuberculosis Conserved protein 0.003 0.0617 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.194 1
Schistosoma mansoni hypothetical protein 0.0263 0.9222 0.9222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.1633 0.1997
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.2772 0.339
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0304 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0139 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0304 0.0401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0304 0.0304
Echinococcus multilocularis lamin dm0 0.0026 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.2108 0.2578
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0304 0.0401
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0614 0.0536
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0614 0.0811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0304 0.0304
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0614 0.0536
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0304 0.0304
Schistosoma mansoni amine GPCR 0.0163 0.5539 0.5539
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.2108 0.2578
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.2772 0.297
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0263 0.9222 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.1278 0.1564
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.2772 0.297
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0304 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0139 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.2772 0.3662
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0304 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0614 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0304 0.0401
Schistosoma mansoni hypothetical protein 0.0031 0.0665 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0209 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0614 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.194 0.2373
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0614 0.0536
Onchocerca volvulus 0.0234 0.8176 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0304 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0304 0.0401
Loa Loa (eye worm) hypothetical protein 0.0098 0.3127 0.4131
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0304 0.0304
Schistosoma mansoni coup transcription factor 0.0021 0.0304 0.0304
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0304 0.0401
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.211 0.1783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.1465 0.1792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.1278 0.1564
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0304 0.0401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0614 0.0811
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0304 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1446 0.1769
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0401
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0486 0.0643
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0304 0.0304

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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