TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.387 | Formula: C18H16F6N2O3S
H donors: 2 H acceptors: 4 LogP: 4.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1ccccc1C1CCN(CC1)c1ncc(s1)C(C(F)(F)F)(C(F)(F)F)O
InChi: 1S/C18H16F6N2O3S/c19-17(20,21)16(29,18(22,23)24)13-9-25-15(30-13)26-7-5-10(6-8-26)11-3-1-2-4-12(11)14(27)28/h1-4,9-10,29H,5-8H2,(H,27,28)
InChiKey: IWYOXAHNVDYMAB-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	malonyl-CoA decarboxylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma brucei gambiense	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Brugia malayi	putative malonyl-CoA decarboxylase	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania mexicana	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania braziliensis	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania donovani	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania infantum	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma congolense	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	geminin	0.0186	0.3626	0.3889
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0138	0.0132
Brugia malayi	nuclear hormone receptor family member odr-7	0.0005	0.0015	0.0011
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0138	0.0133
Onchocerca volvulus		0.0012	0.0138	0.2229
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0015	0.0011
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3872	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0069	0.0059
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0138	0.0132
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.2527	0.2524
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0084	0.009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0055	0.5
Brugia malayi	MH2 domain containing protein	0.0009	0.0084	0.008
Brugia malayi	tailless protein	0.0005	0.0015	0.0011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0138	0.0133
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0005	0.0015	0.0011
Echinococcus multilocularis	smad	0.0009	0.0084	0.0074
Schistosoma mansoni	nuclear receptor	0.0005	0.0015	0.0016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.091	0.0964
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0138	0.0148
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0138	0.0133
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0138	0.0133
Loa Loa (eye worm)	DR-78	0.0005	0.0015	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0138	0.0133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.091	0.0964
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0138	0.0148
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0028	0.0014
Brugia malayi	MH1 domain containing protein	0.0009	0.0084	0.008
Brugia malayi	orphan nuclear receptor NR2E1	0.0005	0.0015	0.0011
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0084	0.0074
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.091	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0028	0.0024
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0015	0.0011
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0138	0.0132
Loa Loa (eye worm)	nuclear hormone receptor	0.0005	0.0015	0.0011
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0138	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0138	0.0148
Brugia malayi	MH2 domain containing protein	0.0009	0.0084	0.008
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0084	0.009
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.1155	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Brugia malayi	hypothetical protein	0.0005	0.0015	0.0011
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0138	0.0132
Loa Loa (eye worm)	Smad1	0.0009	0.0084	0.008
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0055	0.5
Schistosoma mansoni	coup transcription factor	0.0012	0.0138	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0028	0.0024
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0138	0.0148
Echinococcus multilocularis	cpg binding protein	0.0035	0.0603	0.0633
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0055	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0084	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0138	0.0133
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.091	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0138	0.0133
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0138	0.2229
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0138	0.0148
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0109	0.0105
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0138	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0015	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0005	0.0015	0.0011
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1305	0.1403
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0138	0.0133
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0138	0.0133
Schistosoma mansoni	zinc finger protein	0.0005	0.0015	0.0016
Onchocerca volvulus		0.0033	0.0565	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.2527	0.2524
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0138	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0084	0.0074
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.091	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0138	0.0132
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0069	0.0074
Schistosoma mansoni	cpg binding protein	0.0033	0.0565	0.0608
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0138	0.0132
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0055	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0138	0.0132
Brugia malayi	nuclear receptor NHR-88	0.0005	0.0015	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0138	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0138	0.0133
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0005	0.0015	0.0011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0138	0.0133
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0084	0.0074
Brugia malayi	Smad1	0.0009	0.0084	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0109	0.0102
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0109	0.0102
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0138	0.0148
Schistosoma mansoni	Smad4	0.0009	0.0084	0.009
Brugia malayi	ecdysone receptor	0.0005	0.0015	0.0011
Echinococcus granulosus	geminin	0.0186	0.3626	0.3889
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0138	0.0133
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0084	0.008
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0015	0.0016
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0069	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0028	0.0024
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0055	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0028	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0138	0.0133
Brugia malayi	hypothetical protein	0.0005	0.0015	0.0011
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.091	0.0978
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0138	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0138	0.0133
Schistosoma mansoni	cpg binding protein	0.0035	0.0603	0.0648
Schistosoma mansoni	hypothetical protein	0.0186	0.3626	0.3899
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0028	0.0024
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0055	0.5
Echinococcus granulosus	dnaJ subfamily B	0.0469	0.9301	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0015	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0565	0.0561
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0138	0.0132
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0138	0.0132
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0138	0.0148
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0138	0.0133
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0028	0.003
Leishmania major	malonyl-coa decarboxylase-like protein	0.0198	0.3872	0.5
Schistosoma mansoni	hypothetical protein	0.0469	0.9301	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Brugia malayi	hypothetical protein	0.0006	0.0028	0.0024
Echinococcus multilocularis	dnaJ subfamily B	0.0469	0.9301	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0138	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0138	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Brugia malayi	MH2 domain containing protein	0.0131	0.2527	0.2524
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Echinococcus granulosus	smad	0.0009	0.0084	0.0074
Brugia malayi	MH1 domain containing protein	0.0009	0.0084	0.008
Brugia malayi	hypothetical protein	0.0006	0.0028	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0138	0.0133
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0055	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0028	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0005	0.0015	0.0011
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0107	0.0103
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0138	0.2229
Trichomonas vaginalis	helicase, putative	0.0007	0.0055	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0028	0.0024
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0138	0.0133
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0504	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0138	0.0133
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0138	0.0133
Brugia malayi	nuclear hormone receptor	0.0012	0.0138	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0138	0.0133
Brugia malayi	steroid hormone receptor	0.0012	0.0138	0.0133
Brugia malayi	nuclear receptor RXR	0.0005	0.0015	0.0011
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0069	0.0059
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.091	0.0978
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0084	0.009
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Schistosoma mansoni	cpg binding protein	0.0035	0.0603	0.0648
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0138	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0138	0.0133
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0138	0.0148
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3872	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0055	0.5
Brugia malayi	ecdysteroid receptor	0.0012	0.0138	0.0133
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0069	0.0059
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0015	0.0016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0138	0.0133
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0084	0.009
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0138	0.0133
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0138	0.2229
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0138	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0504	1	1
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0565	0.0561
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0138	0.0148
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0015	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0028	0.0024
Brugia malayi	conserved hypotetical protein	0.0005	0.0015	0.0011
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0138	0.0148
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.091	0.0964
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0138	0.0132
Schistosoma mansoni	nuclear receptor	0.0005	0.0015	0.0016
Brugia malayi	nuclear hormone receptor	0.0005	0.0015	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0028	0.0024
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3872	0.5
Echinococcus granulosus	cpg binding protein	0.0035	0.0603	0.0633
Brugia malayi	nuclear receptor RXR	0.0006	0.0028	0.0024
Schistosoma mansoni	smad	0.0009	0.0084	0.009
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0138	0.0132
Brugia malayi	nuclear receptor NHR-67	0.0005	0.0015	0.0011
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0028	0.003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.091	0.0978
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0138	0.0148
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0055	0.5
Echinococcus multilocularis	Smad4	0.0009	0.0084	0.0074
Echinococcus granulosus	Smad4	0.0009	0.0084	0.0074
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0138	0.0132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0138	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0011
Schistosoma mansoni	hypothetical protein	0.0186	0.3626	0.3899
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0084	0.008

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.7 nM	Inhibition of human MCD	ChEMBL.	20832306

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1257548

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1254327