Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0352 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0352 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.309 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0352 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.309 | 1 | 1 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0352 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.309 | 1 | 1 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0352 | 0 | 0.5 |
Giardia lamblia | Ribokinase | 0.0352 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0352 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0352 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.1442 | 0.3981 | 0.3981 |
Schistosoma mansoni | adenosine kinase | 0.309 | 1 | 1 |
Entamoeba histolytica | kinase, PfkB family | 0.0352 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.309 | 1 | 1 |
Onchocerca volvulus | 0.2737 | 0.8714 | 1 | |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0352 | 0 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.0352 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.309 | 1 | 1 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0352 | 0 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.309 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.309 | 1 | 1 |
Leishmania major | adenosine kinase, putative | 0.309 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1442 | 0.3981 | 0.3981 |
Entamoeba histolytica | ribokinase, putative | 0.0352 | 0 | 0.5 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0352 | 0 | 0.5 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0352 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.309 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.309 | 1 | 1 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0352 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 13 nM | Inverse agonist activity at human recombinant histamine H3 receptor assessed as effect on [35S]GTPgammaS binding | ChEMBL. | 20801030 |
Inhibition (binding) | = 3 % | Displacement of [3H]-mepyramine from human histamine H1 receptor | ChEMBL. | 20801030 |
Inhibition (binding) | = 3 % | Displacement of [3H]-tiotidine from human histamine H2 receptor | ChEMBL. | 20801030 |
Inhibition (binding) | = 3 % | Displacement of [3H]-histamine from human histamine H4 receptor | ChEMBL. | 20801030 |
Ki (binding) | = 5 nM | Displacement of [3H]-RAMH from human histamine H3 receptor | ChEMBL. | 20801030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.