Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.0186 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0186 | 0.0131 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0186 | 0.0131 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.1273 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0034 | 0.0186 | 0.0131 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0285 | 0.0231 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0186 | 1 |
Echinococcus multilocularis | expressed protein | 0.0034 | 0.0186 | 0.0131 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0186 | 0.0082 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0186 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0285 | 0.0231 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0033 | 0.018 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.1273 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.0186 | 0.9457 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0186 | 0.0131 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0033 | 0.018 | 0.018 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.018 | 0.018 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0186 | 0.0186 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.0186 | 0.0186 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.013 | 0.0074 |
Trichomonas vaginalis | rotamase, putative | 0.0034 | 0.0186 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.1273 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.0186 | 1 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0473 | 0.3668 | 0.3668 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.0186 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0285 | 0.0101 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.0186 | 0.0082 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0473 | 0.3668 | 0.3668 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0285 | 0.0231 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.018 | 0.018 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0186 | 0.0082 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0186 | 0.0186 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1273 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.1273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0186 | 0.0082 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.0186 | 0.9457 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0473 | 0.3668 | 0.3668 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1273 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0285 | 0.0231 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0186 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0034 | 0.0186 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0034 | 0.0186 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.0186 | 0.0186 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0033 | 0.018 | 0.018 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0033 | 0.018 | 0.018 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0186 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.0186 | 0.0186 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0017 | 0.0056 | 0.0056 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0285 | 0.0182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0285 | 0.0231 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0186 | 0.0082 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0285 | 0.0231 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0186 | 0.0131 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.0186 | 0.5 |
Leishmania major | 0.1273 | 1 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0285 | 0.0231 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0473 | 0.3668 | 0.3668 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0186 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.1273 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0186 | 0.0186 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0473 | 0.3668 | 0.3668 |
Toxoplasma gondii | fructose-bisphospatase II | 0.1273 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0186 | 0.0131 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0186 | 0.0131 |
Schistosoma mansoni | rotamase | 0.0034 | 0.0186 | 0.0131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.