Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.1907 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.297 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.297 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.1907 | 0.6421 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.297 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.1907 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.1907 | 0.6421 |
Onchocerca volvulus | 0.0023 | 0.297 | 1 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.297 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.297 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.297 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.297 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.297 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.1907 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30 % | Inhibition of Wnt2 signaling pathway in human A549 cells assessed as inhibition of beta-casein-mediated Tcf/Lef transcriptional activity after 24 hrs by dual luciferase reporter gene assay relative to control | ChEMBL. | 20729080 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.