Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, gamma | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0306 | 0.6255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7221 | 0.711 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.1298 | 0.2075 |
Echinococcus granulosus | protein kinase C gamma type | 0.0228 | 0.3435 | 0.5492 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.9186 | 0.9153 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0228 | 0.3435 | 0.5492 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0283 | 0.54 | 0.8634 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0244 | 0.4017 | 0.6423 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0143 | 0.0384 | 0.0613 |
Brugia malayi | protein kinase C II. | 0.0306 | 0.6255 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0306 | 0.6255 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0306 | 0.6255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7221 | 0.711 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0283 | 0.54 | 0.8634 |
Onchocerca volvulus | 0.0333 | 0.7221 | 0.5 | |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0143 | 0.0384 | 0.0613 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0283 | 0.54 | 0.8634 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.1298 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0152 | 0.0716 | 0.0345 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0306 | 0.6255 | 0.6105 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0143 | 0.0384 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7221 | 0.711 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2349 | 0.2043 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0283 | 0.54 | 0.8634 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 170 nM | Inhibition of [3H]PDBu binding to PKCtheta C1B peptide | ChEMBL. | 20817520 |
Ki (binding) | = 170 nM | Inhibition of [3H]PDBu binding to PKC delta C1B peptide | ChEMBL. | 20817520 |
Ki (binding) | = 180 nM | Inhibition of [3H]PDBu binding to PKCeta C1B peptide | ChEMBL. | 20817520 |
Ki (binding) | = 820 nM | Inhibition of [3H]PDBu binding to PKCepsilon C1B peptide | ChEMBL. | 20817520 |
Ki (binding) | = 1600 nM | Inhibition of [3H]PDBu binding to PKC gamma C1A peptide | ChEMBL. | 20817520 |
Ki (binding) | = 2400 nM | Inhibition of [3H]PDBu binding to PKC alpha C1A peptide | ChEMBL. | 20817520 |
Ki (binding) | = 3500 nM | Inhibition of [3H]PDBu binding to PKC beta C1A peptide | ChEMBL. | 20817520 |
Ki (binding) | = 6800 nM | Inhibition of [3H]PDBu binding to PKC delta C1A peptide | ChEMBL. | 20817520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.