Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.22047 | 1 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.195046 | 0.881654 | 0.881654 |
Trypanosoma brucei | phosphomannose isomerase | 0.22047 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0703276 | 0.301087 | 0.259719 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.22047 | 1 | 1 |
Echinococcus granulosus | caspase | 0.0253597 | 0.0917603 | 0.0917603 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.22047 | 1 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0194643 | 0.0643172 | 0.00893535 |
Echinococcus multilocularis | caspase 3 | 0.0199223 | 0.0664493 | 0.0111937 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0703276 | 0.301087 | 0.259719 |
Plasmodium vivax | phosphomannomutase, putative | 0.017652 | 0.0558811 | 0.0558811 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.22047 | 1 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.195046 | 0.881654 | 0.881654 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.22047 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.195046 | 0.881654 | 0.881654 |
Trichomonas vaginalis | phosphomannomutase, putative | 0.017652 | 0.0558811 | 0.0558811 |
Leishmania major | hypothetical protein, conserved | 0.0678509 | 0.289557 | 0.247507 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0253597 | 0.0917603 | 0.0380028 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.22047 | 1 | 1 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.22047 | 1 | 1 |
Echinococcus granulosus | phosphomannomutase | 0.017652 | 0.0558811 | 0.0558811 |
Echinococcus granulosus | caspase 3 | 0.0199223 | 0.0664493 | 0.0664493 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.22047 | 1 | 1 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.22047 | 1 | 1 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.22047 | 1 | 1 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0253597 | 0.0917603 | 0.0917603 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.22047 | 1 | 1 |
Onchocerca volvulus | Putative phosphomannomutase | 0.017652 | 0.0558811 | 0.5 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.22047 | 1 | 1 |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.118952 | 0.527433 | 0.5 |
Entamoeba histolytica | mannose-6-phosphate isomerase, putative | 0.101518 | 0.446278 | 0.413504 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.22047 | 1 | 1 |
Trypanosoma brucei | Putative Phosphatase/Protein of unknown function DUF89, putative | 0.0678509 | 0.289557 | 0.247507 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.195046 | 0.881654 | 0.874649 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0190612 | 0.0624406 | 0.0624406 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0253597 | 0.0917603 | 0.0380028 |
Loa Loa (eye worm) | acetyltransferase | 0.0194643 | 0.0643172 | 0.00893535 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.195046 | 0.881654 | 0.874649 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0194643 | 0.0643172 | 0.00893535 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.22047 | 1 | 1 |
Brugia malayi | Bm-MIF-1, identical | 0.195046 | 0.881654 | 0.874649 |
Mycobacterium leprae | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO | 0.118952 | 0.527433 | 0.5 |
Toxoplasma gondii | phosphomannomutase | 0.017652 | 0.0558811 | 0.0558811 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.195046 | 0.881654 | 0.881654 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.195046 | 0.881654 | 0.874649 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.195046 | 0.881654 | 0.5 |
Trypanosoma cruzi | Putative Phosphatase/Protein of unknown function DUF89, putative | 0.0678509 | 0.289557 | 0.247507 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.195046 | 0.881654 | 0.874649 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0194643 | 0.0643172 | 0.00893535 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0253597 | 0.0917603 | 0.0380028 |
Echinococcus multilocularis | caspase | 0.0253597 | 0.0917603 | 0.0380028 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.195046 | 0.881654 | 0.874649 |
Trypanosoma cruzi | Putative Phosphatase/Protein of unknown function DUF89, putative | 0.0678509 | 0.289557 | 0.247507 |
Leishmania major | phosphomannose isomerase | 0.22047 | 1 | 1 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.22047 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 267 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 20801652 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20801652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.