TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 635.918 | Formula: C43H57NO3
H donors: 1 H acceptors: 2 LogP: 9.68 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: O=C1C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@]2([C@]2([C@H]1[C@@]1(C)CC[C@@H](C([C@@H]1CC2)(C)C)N)C)C)C(=O)OC(c1ccccc1)c1ccccc1
InChi: 1S/C43H57NO3/c1-38(2)33-18-21-43(7)36(41(33,5)20-19-34(38)44)32(45)26-30-31-27-40(4,23-22-39(31,3)24-25-42(30,43)6)37(46)47-35(28-14-10-8-11-15-28)29-16-12-9-13-17-29/h8-17,26,31,33-36H,18-25,27,44H2,1-7H3/t31-,33-,34-,36+,39+,40-,41-,42+,43+/m0/s1
InChiKey: CZQYFCGOKWXLID-URSBUWNLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein kinase domain containing protein	0.0255	0.6054	0.5961
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.003	0.023	0.023
Trichomonas vaginalis	CMGC family protein kinase	0.0407	1	1
Trichomonas vaginalis	cyclins, putative	0.0031	0.0253	0.0253
Schistosoma mansoni	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0248	0.589	0.5793
Trypanosoma cruzi	cdc2-related kinase 3	0.0255	0.6054	0.5961
Echinococcus multilocularis	neuropeptide receptor A26	0.0057	0.0928	0.0924
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0045	0.0616	0.0396
Echinococcus multilocularis	serotonin receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trypanosoma brucei	protein kinase, putative	0.0407	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0057	0.0928	0.0715
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0394	0.0168
Echinococcus multilocularis	expressed conserved protein	0.0036	0.0394	0.039
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0928	0.0715
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.003	0.023	0.0225
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0057	0.0928	0.0715
Giardia lamblia	G2/mitotic-specific cyclin B	0.0031	0.0253	0.0024
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0928	0.0924
Echinococcus granulosus	cyclin dependent kinase	0.0255	0.6054	0.6052
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0057	0.0928	0.0715
Trypanosoma cruzi	membrane transporter protein, putative	0.0039	0.0461	0.0237
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0045	0.0616	0.0612
Onchocerca volvulus		0.0057	0.0928	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0045	0.0616	0.0616
Brugia malayi	Serotonin receptor	0.0057	0.0928	0.0715
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0255	0.6054	0.5961
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0928	0.0924
Echinococcus granulosus	cyclin dependent kinase 5	0.0255	0.6054	0.6052
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0057	0.0928	0.0715
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0461	0.0237
Trypanosoma cruzi	cyclin, putative	0.0031	0.0253	0.0024
Onchocerca volvulus		0.0057	0.0928	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0045	0.0616	0.0612
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0928	0.0715
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0407	1	1
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0253	0.0253
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0227	0.533	0.5328
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0928	0.0924
Mycobacterium ulcerans	hypothetical protein	0.003	0.023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0394	0.0168
Echinococcus multilocularis	cyclin dependent kinase 1	0.0255	0.6054	0.6052
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0066	0.1156	0.0948
Brugia malayi	Serotonin receptor	0.0057	0.0928	0.0715
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Echinococcus granulosus	mitogen activated protein kinase	0.0407	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0057	0.0928	0.0924
Brugia malayi	Egg laying defective protein 4	0.0036	0.0394	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trypanosoma brucei	cAMP response protein 1, putative	0.003	0.023	0.0073
Mycobacterium leprae	Conserved hypothetical protein	0.003	0.023	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0253	0.0024
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0057	0.0928	0.0715
Plasmodium falciparum	protein kinase 5	0.0255	0.6054	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0461	0.0237
Schistosoma mansoni	hypothetical protein	0.0057	0.0928	0.0715
Trichomonas vaginalis	cyclins, putative	0.0031	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Plasmodium vivax	protein kinase Crk2	0.0255	0.6054	1
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.003	0.023	0.0225
Brugia malayi	G protein-coupled receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0036	0.0394	0.039
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0928	0.0924
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0197	0.4554	0.4426
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.003	0.023	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Onchocerca volvulus		0.0057	0.0928	1
Leishmania major	protein kinase, putative	0.0036	0.0394	0.0168
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0928	0.0715
Brugia malayi	Dopamine receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	cyclin dependent kinase 5	0.0255	0.6054	0.6052
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0928	0.0715
Mycobacterium ulcerans	regulatory protein	0.003	0.023	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0057	0.0928	0.0924
Schistosoma mansoni	myosin xvIII	0.0057	0.0928	0.0715
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0255	0.6054	0.5961
Schistosoma mansoni	60S ribosomal protein L21	0.0036	0.038	0.0154
Mycobacterium ulcerans	transcriptional regulatory protein	0.003	0.023	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Brugia malayi	Dopamine receptor protein 2	0.0057	0.0928	0.0715
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.003	0.023	0.0225
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0045	0.0616	0.0612
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trypanosoma cruzi	cdc2-related kinase 3	0.0255	0.6054	0.5961
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.003	0.023	0.0225
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0407	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0057	0.0928	1
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0928	0.0715
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0255	0.6054	0.5961
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.003	0.023	0.5
Trypanosoma brucei	mitotic cyclin 6	0.0031	0.0253	0.0097
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0057	0.0928	0.0715
Trichomonas vaginalis	CMGC family protein kinase	0.0407	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	dro:myosuppressin receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0057	0.0928	0.0924
Entamoeba histolytica	cell division protein kinase 2, putative	0.0255	0.6054	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0928	0.0924
Trichomonas vaginalis	CMGC family protein kinase	0.0407	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	RE15519p	0.0057	0.0928	0.0715
Trypanosoma cruzi	cyclin 6, putative	0.0031	0.0253	0.0024
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.003	0.023	0.0073
Mycobacterium tuberculosis	Conserved hypothetical protein	0.003	0.023	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	follicle stimulating hormone receptor	0.0057	0.0928	0.0715
Mycobacterium ulcerans	hypothetical protein	0.003	0.023	0.5
Onchocerca volvulus		0.0057	0.0928	1
Onchocerca volvulus		0.0057	0.0928	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0057	0.0928	0.0715
Echinococcus granulosus	allatostatin A receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0045	0.0616	0.0612
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Echinococcus granulosus	hyperpolarization activated cyclic	0.0045	0.0616	0.0612
Trichomonas vaginalis	CMGC family protein kinase	0.0255	0.6054	0.6054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Trypanosoma cruzi	cdc2-related kinase 1	0.0255	0.6054	0.5961
Echinococcus granulosus	G protein coupled receptor 139	0.0057	0.0928	0.0924
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0928	0.0715
Trypanosoma brucei	Flagellar Member 6	0.003	0.023	0.0073
Brugia malayi	G protein-coupled receptor F59B2.13	0.0057	0.0928	0.0715
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0045	0.0616	0.0612
Giardia lamblia	Kinase, CMGC CDK	0.0255	0.6054	0.5961
Echinococcus granulosus	orexin receptor type 2	0.0057	0.0928	0.0924
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0928	0.0715
Echinococcus multilocularis	g-protein coupled receptor	0.0057	0.0928	0.0924
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0928	0.0924
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0212	0.4943	0.4943
Schistosoma mansoni	amine GPCR	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0031	0.0253	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1156	0.0948
Leishmania major	protein kinase, putative	0.0036	0.0394	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0045	0.0616	0.0396
Echinococcus multilocularis	sex peptide receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0057	0.0928	0.0715
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0407	1	1
Trypanosoma cruzi	cyclin, putative	0.0031	0.0253	0.0024
Treponema pallidum	catabolite gene activator	0.003	0.023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Giardia lamblia	Kinase, CMGC CDK	0.0255	0.6054	0.5961
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	Dopamine receptor protein 1	0.0057	0.0928	0.0715
Trichomonas vaginalis	cyclin A, putative	0.0031	0.0253	0.0253
Echinococcus granulosus	g-protein coupled receptor	0.0057	0.0928	0.0924
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0057	0.0928	0.0715
Schistosoma mansoni	opsin-like receptor	0.0057	0.0928	0.0715
Trichomonas vaginalis	CMGC family protein kinase	0.0255	0.6054	0.6054
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.003	0.023	0.0225
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.003	0.023	0.023
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.003	0.023	0.0225
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	G-protein coupled receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	voltage-gated potassium channel	0.0036	0.038	0.0154
Schistosoma mansoni	voltage-gated potassium channel	0.0066	0.1156	0.0948
Onchocerca volvulus		0.0031	0.0253	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0928	0.0924
Schistosoma mansoni	cyclin B	0.0031	0.0253	0.0024
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0253	0.0024
Echinococcus granulosus	patatin phospholipase domain containing protein	0.003	0.023	0.0225
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0057	0.0928	0.0715
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0407	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0057	0.0928	0.0715
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0057	0.0928	0.0924
Trichomonas vaginalis	CMGC family protein kinase	0.0255	0.6054	0.6054
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0057	0.0928	0.0924
Treponema pallidum	cyclic nucleotide binding protein	0.003	0.023	0.5
Schistosoma mansoni	amine GPCR	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0616	0.0396
Schistosoma mansoni	opsin-like receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	amine GPCR	0.0057	0.0928	0.0715
Echinococcus multilocularis	neuropeptide s receptor	0.0057	0.0928	0.0924
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0928	0.0924
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.003	0.023	0.0225
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0928	0.0924
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0928	0.0924
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	mitogen activated protein kinase 3	0.0407	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	histamine h1 receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	hypothetical protein	0.0057	0.0928	0.0715
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0407	1	1
Echinococcus multilocularis	somatostatin receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	neuropeptide F receptor	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0253	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0394	0.0168
Mycobacterium tuberculosis	Conserved protein	0.003	0.023	0.5
Mycobacterium ulcerans	hypothetical protein	0.003	0.023	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0461	0.0237
Leishmania major	cyclin	0.0031	0.0253	0.0024
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0036	0.0394	0.039
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trichomonas vaginalis	CMGC family protein kinase	0.0407	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0227	0.533	0.522
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0255	0.6054	0.5961
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0253	0.0253
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0036	0.0394	0.039
Echinococcus multilocularis	voltage gated potassium channel	0.0066	0.1156	0.1152
Loa Loa (eye worm)	TYRA-2 protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0928	0.0924
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0616	0.0396
Echinococcus granulosus	neuropeptide FF receptor 2	0.0057	0.0928	0.0924
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	serine/threonine protein kinase	0.0407	1	1
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.0039	0.0461	0.0457
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0045	0.0616	0.0396
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0057	0.0928	0.0715
Echinococcus multilocularis	cyclin B	0.0031	0.0253	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0255	0.6054	0.5961
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0045	0.0616	0.0396
Plasmodium falciparum	cGMP-dependent protein kinase	0.0036	0.0394	0.0282
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0928	0.0924
Brugia malayi	larval opioid receptor	0.0057	0.0928	0.0715
Brugia malayi	GnHR receptor homolog	0.0057	0.0928	0.0715
Onchocerca volvulus		0.0057	0.0928	1
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0253	0.0253
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0928	0.0715
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0045	0.0616	0.0612
Trichomonas vaginalis	cyclins, putative	0.0031	0.0253	0.0253
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0928	0.0924
Giardia lamblia	Kinase, CMGC MAPK	0.0407	1	1
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.003	0.023	0.0225
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0057	0.0928	0.0924
Treponema pallidum	cyclic nucleotide binding protein	0.003	0.023	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0255	0.6054	0.5961
Echinococcus granulosus	sex peptide receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	neuropeptide receptor A26	0.0057	0.0928	0.0924
Echinococcus granulosus	fmrfamide receptor	0.0057	0.0928	0.0924
Trypanosoma brucei	protein kinase A regulatory subunit	0.003	0.023	0.0073
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0928	0.0924
Brugia malayi	cell division control protein 2 homolog	0.0255	0.6054	0.5961
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0066	0.1156	0.1152
Brugia malayi	G-protein coupled receptor	0.0057	0.0928	0.0715
Brugia malayi	sulfakinin receptor protein	0.0057	0.0928	0.0715
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0057	0.0928	0.0715
Echinococcus granulosus	cGMP dependent protein kinase	0.0036	0.0394	0.039
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0928	0.0924
Echinococcus granulosus	voltage gated potassium channel	0.0066	0.1156	0.1152
Trypanosoma brucei	cdc2-related kinase 3	0.0255	0.6054	0.5991
Schistosoma mansoni	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.0039	0.0461	0.0457
Schistosoma mansoni	multidrug resistance protein	0.0039	0.0461	0.0237
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0407	1	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0255	0.6054	0.6052
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0253	0.0024
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0057	0.0928	0.0715
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0057	0.0928	0.0924
Brugia malayi	putative neuropeptide receptor	0.0057	0.0928	0.0715
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.003	0.023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0045	0.0616	0.0616
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0407	1	1
Onchocerca volvulus		0.0057	0.0928	1
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0045	0.0616	0.0612
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0928	0.0715
Brugia malayi	AKH receptor	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	neuropeptide s receptor	0.0057	0.0928	0.0924
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.003	0.023	0.0073
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.003	0.023	0.023
Echinococcus granulosus	7tm_1 domain containing protein	0.0057	0.0928	0.0924
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0928	0.0924
Schistosoma mansoni	opsin-like receptor	0.0057	0.0928	0.0715
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0036	0.0394	0.0168
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Mycobacterium ulcerans	hypothetical protein	0.003	0.023	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Trypanosoma brucei	membrane transporter protein, putative	0.0039	0.0461	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	amine GPCR	0.0057	0.0928	0.0715
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.003	0.023	0.0225
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.003	0.023	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0057	0.0928	0.0924
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0928	0.0924
Echinococcus granulosus	somatostatin receptor	0.0057	0.0928	0.0924
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.003	0.023	0.023
Trypanosoma brucei	cdc2-related kinase 1	0.0255	0.6054	0.5991
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0227	0.533	0.5328
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.003	0.023	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0057	0.0928	0.0924
Schistosoma mansoni	amine GPCR	0.0057	0.0928	0.0715
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0928	0.0924
Trypanosoma brucei	membrane transporter protein, putative	0.0039	0.0461	0.0309
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	cyclin dependent kinase 1	0.0255	0.6054	0.6052
Mycobacterium tuberculosis	Conserved hypothetical protein	0.003	0.023	0.5
Leishmania major	hypothetical protein, conserved	0.0039	0.0461	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0057	0.0928	0.0715
Trichomonas vaginalis	cyclins, putative	0.0031	0.0253	0.0253
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0057	0.0928	0.0715
Schistosoma mansoni	voltage-gated potassium channel	0.0248	0.587	0.5773
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0045	0.0616	0.0396
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus granulosus	serotonin receptor	0.0057	0.0928	0.0924
Onchocerca volvulus		0.0057	0.0928	1
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	neuropeptide f receptor 76f	0.0057	0.0928	0.0715
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0045	0.0616	0.0396
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0057	0.0928	0.0715
Schistosoma mansoni	serine/threonine protein kinase	0.0255	0.6054	0.5961
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0461	0.0237
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0928	0.0924
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0928	0.0924
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0045	0.0616	0.0396
Echinococcus granulosus	cyclin B	0.0031	0.0253	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.023	0.023
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0928	0.0715
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0407	1	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0407	1	1
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0057	0.0928	0.0924
Echinococcus granulosus	cyclin dependent kinase 1	0.0255	0.6054	0.6052
Echinococcus multilocularis	mitogen activated protein kinase	0.0407	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0057	0.0928	0.0924
Mycobacterium ulcerans	transmembrane transport protein	0.003	0.023	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Echinococcus multilocularis	serotonin receptor	0.0057	0.0928	0.0924
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0227	0.533	0.522
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Schistosoma mansoni	growth hormone secretagogue receptor	0.0057	0.0928	0.0715
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0407	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0057	0.0928	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0928	0.0715
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0031	0.0253	0.0024
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0255	0.6054	0.5961
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0928	0.0924
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0057	0.0928	0.0715
Schistosoma mansoni	voltage-gated potassium channel	0.0066	0.1156	0.0948
Echinococcus granulosus	hypothetical protein	0.0057	0.0928	0.0924
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.003	0.023	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0248	0.587	0.5773
Trypanosoma brucei	MATE efflux family protein, putative	0.0039	0.0461	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0928	0.0924
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0045	0.0616	0.0612
Brugia malayi	ORL1-like opioid receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0066	0.1156	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus granulosus	dro:myosuppressin receptor	0.0057	0.0928	0.0924
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0045	0.0616	0.0396
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0461	0.0237
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0928	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0057	0.0928	0.0924
Brugia malayi	neuropeptide F receptor	0.0057	0.0928	0.0715
Trypanosoma brucei	membrane transporter protein, putative	0.0039	0.0461	0.0309
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0036	0.0394	0.0168
Schistosoma mansoni	adenoreceptor	0.0057	0.0928	0.0715
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0928	0.0924
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0212	0.4943	0.4943
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0928	0.0924
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0036	0.0394	0.039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Echinococcus multilocularis	orexin receptor type 2	0.0057	0.0928	0.0924
Treponema pallidum	catabolite gene activator (Crp)	0.003	0.023	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0928	0.0715
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0057	0.0928	0.0715
Onchocerca volvulus		0.0057	0.0928	1
Echinococcus multilocularis	cyclin dependent kinase	0.0255	0.6054	0.6052
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Brugia malayi	hypothetical protein	0.0057	0.0928	0.0715
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0928	0.0715
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0045	0.0616	0.0612
Trypanosoma brucei	cAMP binding protein, putative	0.003	0.023	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0928	0.0715
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.0035	0.0373	0.0369
Trypanosoma cruzi	cdc2-related kinase 1	0.0255	0.6054	0.5961
Brugia malayi	Melatonin receptor type 1A	0.0057	0.0928	0.0715
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0928	0.0924
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0928	0.0715
Echinococcus granulosus	hyperpolarization activated cyclic	0.0045	0.0616	0.0612
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0461	0.0237
Entamoeba histolytica	cell division protein kinase 2, putative	0.0255	0.6054	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0057	0.0928	0.0924
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0057	0.0928	0.0924

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 15 %	Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as residual conversion of [1,2-3H]-cortisone to cortisol at 1 uM by scintillation counting	ChEMBL.	20851614
Activity (binding)	= 42 %	Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as residual conversion of [1,2,6,7-3H]-cortisol to cortisone at 1 uM by scintillation counting	ChEMBL.	20851614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1269267

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1255765