Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0205 | 0.5494 | 0.5494 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.1202 | 0.1202 |
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.8769 | 0.8769 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0129 | 0.3247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0779 | 0.1225 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0628 | 0.0989 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0027 | 0.0027 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.1202 | 0.1202 |
Loa Loa (eye worm) | TAR-binding protein | 0.0138 | 0.3526 | 0.555 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.099 | 0.1558 |
Leishmania major | DNA polymerase eta, putative | 0.0032 | 0.0386 | 0.3877 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0953 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0865 | 0.0865 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.099 | 0.099 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0953 | 0.2873 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.1202 | 0.1202 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 0.0779 | 0.8119 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.099 | 0.099 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.099 | 0.099 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0953 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.1202 | 0.1202 |
Echinococcus granulosus | dna polymerase eta | 0.0045 | 0.0779 | 0.0779 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0027 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.6354 | 0.6354 |
Echinococcus granulosus | tar DNA binding protein | 0.0138 | 0.3526 | 0.3526 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.099 | 0.1558 |
Echinococcus multilocularis | dna polymerase eta | 0.0045 | 0.0779 | 0.0779 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0953 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0027 | 0.0027 |
Echinococcus multilocularis | tar DNA binding protein | 0.0138 | 0.3526 | 0.3526 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0027 | 0.0027 |
Brugia malayi | RNA binding protein | 0.0138 | 0.3526 | 0.555 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0027 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0116 | 0.2867 | 0.8819 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.117 | 0.1841 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.02 | 0.5344 | 0.5344 |
Onchocerca volvulus | 0.0052 | 0.099 | 1 | |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0116 | 0.2867 | 0.8819 |
Echinococcus multilocularis | geminin | 0.0358 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0865 | 0.1361 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0027 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0628 | 0.0628 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0027 | 0.0027 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0129 | 0.3247 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0027 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.1202 | 0.1892 |
Mycobacterium tuberculosis | Probable reductase | 0.0116 | 0.2867 | 0.8819 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0953 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0953 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0045 | 0.0779 | 0.8119 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.6354 | 0.6354 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1202 | 0.1892 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0045 | 0.0779 | 0.1225 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.117 | 0.1841 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.117 | 0.1841 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.02 | 0.5344 | 0.5344 |
Schistosoma mansoni | hypothetical protein | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.099 | 0.1558 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3526 | 0.3526 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0027 | 0.0043 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0953 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6354 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0138 | 0.3526 | 0.555 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.02 | 0.5344 | 0.5344 |
Loa Loa (eye worm) | RNA binding protein | 0.0138 | 0.3526 | 0.555 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3526 | 0.3526 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.099 | 0.099 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 0.0779 | 0.8119 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3526 | 0.3526 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0953 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.02 | 0.5344 | 0.5344 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.02 | 0.5344 | 0.841 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0032 | 0.0386 | 0.3877 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.1202 | 0.1202 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0027 | 0.5 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.099 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0045 | 0.0779 | 0.0779 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0138 | 0.3526 | 0.555 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.1202 | 0.1892 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.117 | 0.1841 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.099 | 0.099 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0953 | 0.0953 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.099 | 0.099 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0953 | 0.0953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3526 | 0.3526 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0953 | 0.1499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3526 | 0.3526 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.02 | 0.5344 | 0.5344 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0129 | 0.3247 | 1 |
Brugia malayi | hypothetical protein | 0.0234 | 0.6354 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0129 | 0.3247 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.02 | 0.5344 | 0.5344 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0116 | 0.2867 | 0.8819 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0027 | 0.0027 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0953 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0953 | 0.1499 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0953 | 0.1499 |
Schistosoma mansoni | hypothetical protein | 0.0358 | 1 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0205 | 0.5494 | 0.5494 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0116 | 0.2867 | 0.8819 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.099 | 0.099 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0628 | 0.0989 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0953 | 0.5 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.099 | 0.1558 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.02 | 0.5344 | 0.5344 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.02 | 0.5344 | 0.841 |
Brugia malayi | TAR-binding protein | 0.0138 | 0.3526 | 0.555 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0865 | 0.0865 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0116 | 0.2867 | 0.8819 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0027 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 20 mm | Antimicrobial activity against Escherichia coli ATCC 2522 after 24 hrs by disk diffusion method | ChEMBL. | 20800487 |
IZ (functional) | = 24 mm | Antimicrobial activity against Candida albicans after 48 hrs by agar dilution method | ChEMBL. | 20800487 |
MIC (functional) | = 3.125 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 2522 after 24 hrs by broth dilution method | ChEMBL. | 20800487 |
MIC (functional) | = 12.5 ug ml-1 | Antimicrobial activity against Candida albicans after 48 hrs by broth dilution method | ChEMBL. | 20800487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.