Detailed information for compound 1256067

Basic information

Technical information
  • TDR Targets ID: 1256067
  • Name: 4-nitro-N-[3-(phenylamino)quinoxalin-2-yl]ben zenesulfonamide
  • MW: 421.429 | Formula: C20H15N5O4S
  • H donors: 2 H acceptors: 6 LogP: 3.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1nc2ccccc2nc1Nc1ccccc1
  • InChi: 1S/C20H15N5O4S/c26-25(27)15-10-12-16(13-11-15)30(28,29)24-20-19(21-14-6-2-1-3-7-14)22-17-8-4-5-9-18(17)23-20/h1-13H,(H,21,22)(H,23,24)
  • InChiKey: BBMVOYPOJCJDBG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-nitro-N-[3-(phenylamino)-2-quinoxalinyl]benzenesulfonamide
  • MLS000716971
  • SMR000278488
  • ZINC00874640
  • 4-Nitro-N-(3-phenylamino-quinoxalin-2-yl)-benzenesulfonamide
  • BAS 00634895

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0817 0.0817
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Echinococcus multilocularis endoplasmin 0.0031 0.0563 0.0563
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1687 0.6863
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0167 0.0167
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.0082 0.2457 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1687 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.3871 0.3871
Plasmodium vivax heat shock protein 86, putative 0.0039 0.086 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1687 0.1687
Brugia malayi MAP kinase sur-1 0.0062 0.1687 0.1687
Schistosoma mansoni endoplasmin 0.0039 0.086 0.3498
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0195 0.0195
Brugia malayi Bromodomain containing protein 0.0046 0.1119 0.1119
Schistosoma mansoni hypothetical protein 0.0038 0.0817 0.3324
Schistosoma mansoni zinc finger protein 0.0024 0.028 0.1141
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.086 1
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0263 0.1559
Loa Loa (eye worm) hypothetical protein 0.0046 0.1123 0.1123
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0413 0.1682
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.086 0.5097
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.2457 0.2457
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.2079 0.2079
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Schistosoma mansoni endoplasmin 0.0039 0.086 0.3498
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.3871 0.3871
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1687 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Trypanosoma cruzi ISWI complex protein 0.0018 0.0089 0.0526
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0167 0.0681
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.086 0.5097
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1013 0.1013
Brugia malayi heat shock protein 90 0.0039 0.086 0.086
Plasmodium falciparum endoplasmin, putative 0.0024 0.0297 0.345
Echinococcus granulosus heat shock protein 90 0.0031 0.0563 0.0563
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1565 0.1565
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1687 1
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.086 0.5097
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0167 0.0167
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Plasmodium vivax endoplasmin, putative 0.0039 0.086 1
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0563 0.5
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Schistosoma mansoni hypothetical protein 0.0025 0.0328 0.1334
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0297 0.1759
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0817 0.0817
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.086 0.5097
Loa Loa (eye worm) heat shock protein 90 0.0039 0.086 0.086
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1687 0.1687
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0563 0.3339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0167 0.0681
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.012 0.3871 0.3871
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.086 0.5097
Schistosoma mansoni heat shock protein 0.0039 0.086 0.3498
Echinococcus granulosus zinc finger protein 0.0024 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0052 0.1314 0.1314
Echinococcus multilocularis heat shock protein 90 0.0039 0.086 0.086
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Plasmodium falciparum heat shock protein 90 0.0039 0.086 1
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.086 1
Schistosoma mansoni hypothetical protein 0.0058 0.1565 0.6367
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.086 0.5097
Toxoplasma gondii heat shock protein HSP90 0.0039 0.086 0.5097
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4753 0.4753
Loa Loa (eye worm) hypothetical protein 0.0049 0.1229 0.1229
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.3871 0.3871
Onchocerca volvulus 0.0058 0.1565 1
Schistosoma mansoni bromodomain containing protein 0.0076 0.2239 0.9111
Schistosoma mansoni heat shock protein 0.0039 0.086 0.3498
Echinococcus granulosus GPCR family 2 0.0038 0.0817 0.0817
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.086 0.5097
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0563 0.5
Echinococcus granulosus heat shock protein 0.0039 0.086 0.086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0167 0.0167
Echinococcus granulosus heat shock protein 90 0.0039 0.086 0.086
Schistosoma mansoni hypothetical protein 0.0038 0.0817 0.3324
Loa Loa (eye worm) hypothetical protein 0.0085 0.2572 0.2572
Schistosoma mansoni survival motor neuron protein 0.0058 0.1565 0.6367
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1687 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0089 0.0526
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0563 0.3339
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1687 0.1687
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.2079 0.2079
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4753 0.4753
Brugia malayi Endoplasmin precursor 0.0039 0.086 0.086
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Loa Loa (eye worm) endoplasmin 0.0039 0.086 0.086
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Echinococcus granulosus endoplasmin 0.0031 0.0563 0.0563
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0297 0.1759
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0563 0.3339
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0563 0.5
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0563 0.3339
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1687 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0817 0.0817
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Leishmania major hypothetical protein, conserved 0.0018 0.0089 0.0526
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0167 0.0681
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1687 0.1687
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1687 1
Trypanosoma brucei ISWI complex protein 0.0018 0.0089 0.0526
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1687 1
Brugia malayi Bromodomain containing protein 0.0091 0.2764 0.2764
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1687 1
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Schistosoma mansoni hypothetical protein 0.0018 0.0089 0.0361
Echinococcus multilocularis GPCR, family 2 0.0038 0.0817 0.0817
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0082 0.2457 0.2457
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.086 0.5097
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Echinococcus multilocularis zinc finger protein 0.0024 0.028 0.028
Trichomonas vaginalis heat shock protein, putative 0.0039 0.086 0.5097
Brugia malayi MH2 domain containing protein 0.0144 0.4753 0.4753
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0563 0.3339
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0563 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1013 0.1013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0817 0.0817
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0817 0.0817
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0328 0.0328
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0563 0.3339
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0817 0.0817
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1687 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1687 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1687 1
Schistosoma mansoni zinc finger protein 0.0018 0.0089 0.0361
Treponema pallidum heat shock protein 90 0.0031 0.0563 0.5
Trypanosoma brucei protein kinase, putative 0.0062 0.1687 1
Schistosoma mansoni hypothetical protein 0.0038 0.0817 0.3324
Echinococcus multilocularis heat shock protein 90 0.0031 0.0563 0.0563
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1687 1
Schistosoma mansoni hypothetical protein 0.0038 0.0817 0.3324
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0167 0.0681
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0817 0.0817
Brugia malayi PHD-finger family protein 0.003 0.0519 0.0519
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0563 0.0563
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0413 0.0413
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Echinococcus multilocularis heat shock protein 0.0039 0.086 0.086
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.086 0.264
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.086 0.5097
Trypanosoma brucei heat shock protein, putative 0.0039 0.086 0.5097
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1687 1
Leishmania major heat shock protein 83-1 0.0039 0.086 0.5097
Loa Loa (eye worm) hypothetical protein 0.0038 0.0817 0.0817
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1687 0.1687

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.441 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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