Detailed information for compound 1256122

Basic information

Technical information
  • TDR Targets ID: 1256122
  • Name: 4-(2,5-dimethylphenyl)-5-pyridin-4-yl-2H-1,2, 4-triazole-3-thione
  • MW: 282.363 | Formula: C15H14N4S
  • H donors: 0 H acceptors: 3 LogP: 2.89 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)n1c(S)nnc1c1ccncc1)C
  • InChi: 1S/C15H14N4S/c1-10-3-4-11(2)13(9-10)19-14(17-18-15(19)20)12-5-7-16-8-6-12/h3-9H,1-2H3,(H,18,20)
  • InChiKey: IQVBUVZXVALZRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,5-dimethylphenyl)-5-(4-pyridyl)-2H-1,2,4-triazole-3-thione
  • ZINC00193823
  • STK150126
  • EU-0049078
  • 4-(2,5-Dimethyl-phenyl)-5-pyridin-4-yl-4H-[1,2,4]triazole-3-thiol
  • MLS000762643
  • SMR000438162

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0466 0.7184
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0403 0.0403
Plasmodium falciparum pyruvate kinase 0.004 0.0083 0.5383
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1414 1
Leishmania major pyruvate kinase 0.004 0.0083 0.0075
Giardia lamblia Pyruvate kinase 0.004 0.0083 0.059
Schistosoma mansoni chromobox protein 0.0084 0.027 0.027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0982 0.0974
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1414 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0251 0.0251
Onchocerca volvulus Huntingtin homolog 0.0148 0.0542 0.4494
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0009 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Echinococcus granulosus peregrin 0.0035 0.0062 0.0062
Trypanosoma brucei trypanothione reductase 0.0057 0.0155 0.0147
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0108 0.0108
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0251 0.0251
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0155 0.0155
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0128 0.0849
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0083 0.0083
Brugia malayi glutathione reductase 0.0057 0.0155 0.0147
Onchocerca volvulus 0.005 0.0124 0.0583
Leishmania major hypothetical protein, conserved 0.0257 0.1006 0.0998
Schistosoma mansoni pyruvate kinase 0.004 0.0083 0.0083
Schistosoma mansoni pyruvate kinase 0.004 0.0083 0.0083
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0062 0.0062
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0038 0.0029
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0083 0.0202
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0881 0.3663 0.3663
Brugia malayi jmjC domain containing protein 0.0043 0.0093 0.0085
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0128 0.0619
Echinococcus multilocularis pyruvate kinase 0.004 0.0083 0.0083
Toxoplasma gondii thioredoxin reductase 0.0057 0.0155 0.0155
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0061
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0093 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0093 0.0085
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0083 0.0075
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0466 0.7184
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0083 0.1174
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0023
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0121 0.0121
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0009 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0155 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0038 0.0459
Echinococcus granulosus chromobox protein 1 0.0084 0.027 0.027
Leishmania major trypanothione reductase 0.0057 0.0155 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0065 0.0065
Brugia malayi Pre-SET motif family protein 0.0251 0.0982 0.0974
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0251 0.0243
Brugia malayi hypothetical protein 0.0148 0.0542 0.0534
Echinococcus multilocularis chromobox protein 1 0.0084 0.027 0.027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0038 0.0038
Onchocerca volvulus Huntingtin homolog 0.0148 0.0542 0.4494
Chlamydia trachomatis pyruvate kinase 0.004 0.0083 0.5
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0038 0.0029
Echinococcus multilocularis pyruvate kinase 0.0032 0.0047 0.0047
Loa Loa (eye worm) pyruvate kinase 0.004 0.0083 0.0075
Plasmodium vivax SET domain protein, putative 0.0036 0.0065 0.422
Loa Loa (eye worm) pyruvate kinase 0.004 0.0083 0.0075
Onchocerca volvulus 0.0037 0.0069 0.007
Brugia malayi jmjC domain containing protein 0.0115 0.0403 0.0395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Trypanosoma brucei pyruvate kinase 1 0.004 0.0083 0.0075
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.237 1 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0038 0.0459
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0113 0.0477
Plasmodium vivax glutathione reductase, putative 0.0057 0.0155 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0083 0.0202
Mycobacterium ulcerans hypothetical protein 0.003 0.0038 0.0459
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0251 0.1726
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0881 0.3663 0.3658
Trichomonas vaginalis chromobox protein, putative 0.0084 0.027 0.186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.006 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0065 0.0065
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0038 0.0038
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0302 0.0302
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0083 0.0075
Echinococcus multilocularis chromobox protein 1 0.0084 0.027 0.027
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0083 0.0532
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0083 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.027 0.0262
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0646 1
Toxoplasma gondii exonuclease III APE 0.0023 0.0009 0.0009
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0038 0.0029
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0032 0.0023
Trichomonas vaginalis chromobox protein, putative 0.0084 0.027 0.186
Brugia malayi Bromodomain containing protein 0.0035 0.0062 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0083 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0054 0.0323
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0062 0.0062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0528 0.7909
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0075
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0155 0.0155
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1414 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0466 0.6809
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0065 0.0065
Echinococcus granulosus chromobox protein 1 0.0084 0.027 0.027
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0038 0.0459
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0646 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0251 0.0243
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0251 0.0251
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.237 1 1
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0009
Plasmodium falciparum thioredoxin reductase 0.0057 0.0155 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0083 0.0075
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0466 0.7184
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0009 0.0009
Echinococcus granulosus pyruvate kinase 0.004 0.0083 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0124 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0065 0.0065
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0009
Mycobacterium tuberculosis Probable reductase 0.013 0.0466 0.7184
Toxoplasma gondii fructose-bisphospatase II 0.237 1 1
Plasmodium falciparum glutathione reductase 0.0057 0.0155 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.006 0.0169 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.1006 0.0998
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0528 0.8155
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0083 0.0532
Trichomonas vaginalis set domain proteins, putative 0.0286 0.113 0.7974
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0093 0.0093
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0881 0.3663 0.3658
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0466 0.7184
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0038 0.0459
Schistosoma mansoni chromobox protein 0.0084 0.027 0.027
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0065 0.0065
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0083 0.0075
Mycobacterium ulcerans pyruvate kinase 0.004 0.0083 0.1174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0128 0.0849
Plasmodium vivax pyruvate kinase, putative 0.004 0.0083 0.5383
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0155 0.2297
Echinococcus multilocularis peregrin 0.0035 0.0062 0.0062
Mycobacterium ulcerans hypothetical protein 0.003 0.0038 0.0459
Plasmodium falciparum phd finger protein, putative 0.0035 0.0062 0.3989
Onchocerca volvulus 0.0286 0.113 1
Echinococcus granulosus fructose 16 bisphosphatase 1 0.237 1 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0062 0.3989
Brugia malayi PHD-finger family protein 0.0035 0.0062 0.0053
Brugia malayi chromobox protein homolog 3 0.0047 0.0113 0.0104
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1414 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0062 0.0062
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0542 0.0534
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0121 0.0121
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0528 0.8155
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0065 0.0065
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.1006 0.0998
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0062
Leishmania major pyruvate kinase 0.004 0.0083 0.0075
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.237 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1414 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0221 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.1006 0.0998
Toxoplasma gondii fructose-bisphospatase I 0.0881 0.3663 0.3663
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0403 0.0403
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0559
Loa Loa (eye worm) glutathione reductase 0.0057 0.0155 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0054 0.0323
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0062 0.0053
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0528 0.8155
Loa Loa (eye worm) hypothetical protein 0.0148 0.0542 0.0534
Echinococcus granulosus pyruvate kinase 0.004 0.0083 0.0083
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0251 0.0243
Mycobacterium tuberculosis Conserved protein 0.003 0.0038 0.0459
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0251 0.0243
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0155 0.0147
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0155 0.0147
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0251 0.0243
Leishmania major 0.237 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0113 0.0104
Brugia malayi Pre-SET motif family protein 0.0036 0.0065 0.0057
Giardia lamblia PHD finger protein 15 0.0035 0.0062 0.0437
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0093 0.0093
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0038 0.0208
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0559
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.0057
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0113 0.074
Loa Loa (eye worm) pyruvate kinase 0.004 0.0083 0.0075
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0881 0.3663 0.3658
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0032 0.0163
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0093 0.0093
Brugia malayi Thioredoxin reductase 0.0057 0.0155 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0065 0.0065
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0251 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0113 0.074
Echinococcus multilocularis pyruvate kinase 0.004 0.0083 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0466 0.7184
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0053
Trypanosoma brucei fructose-1,6-bisphosphatase 0.237 1 1
Schistosoma mansoni fructose-16-bisphosphatase-related 0.237 1 1
Brugia malayi Heterochromatin protein 1 0.0084 0.027 0.0262
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.237 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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