Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.205 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.205 | 1 | 1 |
Leishmania major | 0.205 | 1 | 1 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.205 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.205 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.205 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.205 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0324 | 0.1484 | 0.1484 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0066 | 0.0066 |
Toxoplasma gondii | fructose-bisphospatase II | 0.205 | 1 | 1 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.1005 | 0.4846 | 0.4846 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0066 | 0.0066 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.1005 | 0.4846 | 0.4846 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0066 | 0.0066 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0762 | 0.3648 | 0.3648 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0762 | 0.3648 | 0.3648 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0066 | 0.0066 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0762 | 0.3648 | 0.3648 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.205 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0762 | 0.3648 | 0.3648 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0066 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0066 | 0.0066 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0323 | 0.148 | 0.9976 | |
Onchocerca volvulus | 0.0324 | 0.1484 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0324 | 0.1484 | 0.1484 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0066 | 0.0066 |
Onchocerca volvulus | 0.0286 | 0.1299 | 0.8696 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0066 | 0.0066 |
Echinococcus multilocularis | rho associated protein kinase | 0.0324 | 0.1484 | 0.1484 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.1128 | 0.1128 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.1299 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0762 | 0.3648 | 0.3648 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.1128 | 0.1128 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0066 | 0.0066 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0066 | 0.0066 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0066 | 0.0066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0398 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.4654 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.