Detailed information for compound 1256183

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.481 | Formula: C22H27N5O3
  • H donors: 2 H acceptors: 4 LogP: 2.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccnc1N[C@@H]1CCN(C1)C(=O)O[C@@H]1C2CC3CC1C[C@](C2)(C3)C(=O)N
  • InChi: 1S/C22H27N5O3/c23-11-14-2-1-4-25-19(14)26-17-3-5-27(12-17)21(29)30-18-15-6-13-7-16(18)10-22(8-13,9-15)20(24)28/h1-2,4,13,15-18H,3,5-10,12H2,(H2,24,28)(H,25,26)/t13?,15?,16?,17-,18-,22-/m1/s1
  • InChiKey: BNIGHFUMARRMFX-GPJGMNBASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 2 Starlite/ChEMBL References
Homo sapiens hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Dehydrogenase:reductase SDR family hydroxysteroid (17-beta) dehydrogenase 2 387 aa 359 aa 24.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Trypanosoma brucei NAD(P)-dependent steroid dehydrogenase protein, putative hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 372 aa 365 aa 23.8 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0038 0.0072 0.0824
Brugia malayi 6-phosphofructokinase 0.0231 0.0666 0.0757
Schistosoma mansoni intermediate filament proteins 0.0026 0.0037 0.0039
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0065 0.0155 0.0163
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0062 0.0148 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0074 0.0083
Schistosoma mansoni lamin 0.0026 0.0037 0.0039
Leishmania major ATP-dependent phosphofructokinase 0.0231 0.0666 0.0757
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0078 0.0071
Toxoplasma gondii phosphofructokinase PFKII 0.0062 0.0148 0.0154
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0127 0.012
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.1067 0.3239 0.3678
Brugia malayi beta-lactamase family protein 0.0077 0.0192 0.0217
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Brugia malayi FAT domain containing protein 0.0017 0.0008 0.0007
Brugia malayi steroid hormone receptor 0.0021 0.002 0.0021
Loa Loa (eye worm) phosphofructokinase 0.0231 0.0666 0.0757
Onchocerca volvulus 0.0499 0.149 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0074 0.0184 0.1185
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0155 0.0175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0426 0.1267 0.1441
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0192 0.2194
Echinococcus granulosus microtubule associated protein 2 0.0677 0.2039 0.2315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0192 0.0217
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0038 0.0074 0.0067
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0074 0.0858
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0253 0.0734 0.7161
Mycobacterium leprae Probable lipase LipE 0.0077 0.0192 0.2194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trichomonas vaginalis antibiotic synthetase, putative 0.0074 0.0184 0.1238
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0155 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0021
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0192 0.0185
Loa Loa (eye worm) hypothetical protein 0.0135 0.0371 0.042
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0074 0.0184 0.1787
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.002 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0021
Loa Loa (eye worm) 6-phosphofructokinase 0.0231 0.0666 0.0757
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0015 0.0126
Echinococcus multilocularis 0.0038 0.0072 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0192 0.021
Mycobacterium ulcerans lipase LipD 0.0077 0.0192 0.186
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0127 0.0143
Trypanosoma cruzi ISWI complex protein 0.0015 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0072 0.008
Trichomonas vaginalis esterase, putative 0.0077 0.0192 0.1289
Echinococcus multilocularis zinc finger protein 0.0021 0.0021 0.0013
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0155 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0192 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0253 0.0734 0.7161
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.023 0.0248
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0074 0.0083
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Brugia malayi 6-phosphofructokinase 0.0231 0.0666 0.0757
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Toxoplasma gondii fructose-bisphospatase II 0.2869 0.8784 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.0015 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0253 0.0734 0.7161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.002 0.0015
Echinococcus granulosus intermediate filament protein 0.0026 0.0037 0.0034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.005 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Mycobacterium ulcerans hypothetical protein 0.0156 0.0436 0.4248
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Trichomonas vaginalis hydroxysteroid dehydrogenase, putative 0.0027 0.004 0.0266
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0127 0.0143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0023 0.0024
Echinococcus multilocularis lamin 0.0026 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.0834
Schistosoma mansoni hypothetical protein 0.0291 0.0852 0.0967
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0518 0.1549 0.1761
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0074 0.0184 0.1185
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.026
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0022 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.023 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Loa Loa (eye worm) glutathione reductase 0.0056 0.0127 0.0143
Echinococcus granulosus geminin 0.0518 0.1549 0.1756
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0043
Brugia malayi intermediate filament protein 0.0026 0.0037 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0015 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2869 0.8784 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0015 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Schistosoma mansoni zinc finger protein 0.0021 0.0021 0.0021
Onchocerca volvulus 0.0074 0.0184 0.1117
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.1464 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0231 0.0666 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0277 0.504
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0148 0.2578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0021
Brugia malayi Pre-SET motif family protein 0.0063 0.0151 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium ulcerans acyl-CoA synthetase 0.0253 0.0734 0.7161
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0155 0.0148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0253 0.0734 0.7161
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0019 0.002
Schistosoma mansoni bromodomain containing protein 0.0064 0.0154 0.0173
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0015 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0074 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.002 0.0021
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0231 0.0666 0.4504
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0038 0.0072 0.4393
Brugia malayi glutathione reductase 0.0056 0.0127 0.0143
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0127 0.0136
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0253 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0426 0.1267 0.1441
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0198 0.0224
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0192 0.3418
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.002 0.0013
Mycobacterium ulcerans cholesterol dehydrogenase 0.0027 0.004 0.0371
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2869 0.8784 1
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0015 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0078 0.0452
Echinococcus granulosus lamin dm0 0.0026 0.0037 0.0034
Brugia malayi hypothetical protein 0.0104 0.0277 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0192 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0074 0.0083
Treponema pallidum NADH oxidase 0.0019 0.0015 0.0042
Brugia malayi Ets-domain containing protein 0.0079 0.0198 0.0224
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0078 0.0087
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0353 0.04
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.018 0.0196
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0074 0.0083
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0015 0.0019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0148 0.2578
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Entamoeba histolytica protein kinase rad3, putative 0.0022 0.0023 0.0142
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0074 0.0184 0.2383
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0074 0.0067
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2869 0.8784 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0078 0.0087
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0189 0.0538 0.3617
Loa Loa (eye worm) hypothetical protein 0.0092 0.0239 0.0271
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0013 0.0012
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1067 0.3239 0.3686
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0203 0.0196
Mycobacterium tuberculosis 3-beta-hydroxysteroid dehydrogenase 0.0027 0.004 0.0187
Toxoplasma gondii hypothetical protein 0.0048 0.0103 0.0103
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0038 0.0072 0.0064
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0074 0.0184 0.0202
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0071 0.0073
Echinococcus granulosus dna polymerase eta 0.0092 0.0239 0.0264
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.003 0.0022
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0027 0.004 0.0266
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.002 0.0021
Schistosoma mansoni hypothetical protein 0.0073 0.018 0.0201
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0038 0.0074 0.0082
Trypanosoma brucei NAD(p)-dependent steroid dehydrogenase-like protein 0.0027 0.004 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma brucei nadh-ubiquinone oxidoreductase 39 kda subunit 0.0027 0.004 0.0043
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0666 0.9057
Trypanosoma brucei trypanothione reductase 0.0056 0.0127 0.0143
Onchocerca volvulus 0.0063 0.0151 0.0889
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0148 0.2539
Toxoplasma gondii fructose-bisphospatase I 0.1067 0.3239 0.3678
Onchocerca volvulus 0.0028 0.0043 0.0152
Schistosoma mansoni hypothetical protein 0.0518 0.1549 0.1761
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0231 0.0666 0.9021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0151 0.0169
Echinococcus granulosus tumor protein p63 0.035 0.1034 0.117
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.0346 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2869 0.8784 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0053 0.0046
Loa Loa (eye worm) oxidoreductase 0.0074 0.0184 0.0208
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.002 0.0021
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.003 0.0031
Leishmania major phosphatidylinositol 3-kinase, putative 0.0038 0.0074 0.0083
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.0868 0.0986
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0013 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.008
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0155 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0074 0.0083
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0038 0.0072 0.0079
Loa Loa (eye worm) hypothetical protein 0.0067 0.0163 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Schistosoma mansoni thyroid hormone receptor 0.0021 0.002 0.002
Trichomonas vaginalis dullard protein, putative 0.0038 0.0072 0.0483
Mycobacterium tuberculosis Conserved protein 0.0077 0.0192 0.1237
Brugia malayi AMP-binding enzyme family protein 0.0253 0.0734 0.0834
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0074 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0277 0.0314
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0231 0.0666 0.0757
Echinococcus multilocularis tumor protein p63 0.035 0.1034 0.1028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0037 0.0071 0.0077
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0253 0.0734 0.0834
Toxoplasma gondii ABC1 family protein 0.0077 0.0192 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0015 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.0561 0.0553
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0203 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0074 0.0184 0.1787
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0066 0.0058
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.003 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0078 0.0087
Brugia malayi hypothetical protein 0.0067 0.0163 0.0184
Brugia malayi nuclear receptor NHR-88 0.0021 0.002 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Brugia malayi MH2 domain containing protein 0.0129 0.0353 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.003 0.0204
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0155 0.1978
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0006
Brugia malayi hypothetical protein 0.0073 0.018 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.2039 0.2319
Mycobacterium ulcerans short chain dehydrogenase 0.0347 0.1025 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0291 0.0852 0.0969
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0192 0.0217
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0253 0.0734 0.7161
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0074 0.0184 0.1787
Entamoeba histolytica hypothetical protein 0.0053 0.0119 0.1471
Entamoeba histolytica acyl-CoA synthetase, putative 0.0253 0.0734 1
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0015 0.0133
Brugia malayi Latrophilin receptor protein 2 0.0135 0.0371 0.042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0074 0.0083
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0148 0.2578
Toxoplasma gondii hypothetical protein 0.0031 0.005 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Echinococcus granulosus CTD small phosphatase protein like 0.0038 0.0072 0.0073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0151 0.0143
Plasmodium falciparum glutathione reductase 0.0056 0.0127 0.2182
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.002 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.4107
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0074 0.0184 0.1787
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Leishmania major hypothetical protein, conserved 0.0104 0.0277 0.0314
Brugia malayi PHD-finger family protein 0.0026 0.0037 0.004
Toxoplasma gondii 6-phosphofructokinase 0.0062 0.0148 0.0154
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.039 0.26
Loa Loa (eye worm) latrophilin receptor protein 2 0.0135 0.0371 0.042
Schistosoma mansoni lamin 0.0026 0.0037 0.0039
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0062 0.0148 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0074 0.0184 0.0208
Trypanosoma brucei NAD(P)-dependent steroid dehydrogenase protein, putative 0.0027 0.004 0.0043
Brugia malayi Pre-SET motif family protein 0.0438 0.1304 0.1483
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.002 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0135 0.0847
Plasmodium vivax acetyl-CoA synthetase, putative 0.0074 0.0184 0.3276
Toxoplasma gondii FATC domain-containing protein 0.0053 0.0119 0.0121
Loa Loa (eye worm) hypothetical protein 0.0104 0.0277 0.0314
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.0834
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0135 0.138
Onchocerca volvulus 0.0088 0.0228 0.141
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0037 0.0041
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0074 0.0083
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.4138
Onchocerca volvulus 0.0077 0.0192 0.1168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0039
Toxoplasma gondii thioredoxin reductase 0.0056 0.0127 0.0131
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.0346 0.23
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0127 0.0789
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.018 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0015
Brugia malayi Probable ClpP-like protease 0.0089 0.023 0.026
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0114 0.0127
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0666 0.9057
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0192 0.1289
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0014
Trypanosoma brucei unspecified product 0.0027 0.004 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0203 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.002 0.0021
Echinococcus granulosus lamin 0.0026 0.0037 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0027 0.004 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0074 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Brugia malayi Bromodomain containing protein 0.0076 0.019 0.0214
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0192 0.1237
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0135 0.0371 0.042
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.0023 0.0024
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0038 0.0072 0.0079
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.002 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0151 0.0169
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0074 0.0184 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Brugia malayi hypothetical protein 0.0027 0.004 0.0043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0189 0.0538 0.5238
Onchocerca volvulus 0.0074 0.0184 0.1117
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0071 0.0064
Schistosoma mansoni cpg binding protein 0.0032 0.0053 0.0058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.0015
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0074 0.0184 0.0196
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0078 0.0747
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.01 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.0277 0.0302
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0155 0.0175
Schistosoma mansoni cpg binding protein 0.0032 0.0053 0.0058
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0192 0.1237
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0037 0.0041
Entamoeba histolytica acyl-coA synthetase, putative 0.0253 0.0734 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0192 0.1289
Onchocerca volvulus 0.0051 0.0114 0.0636
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0078 0.0524
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 1
Onchocerca volvulus 0.0027 0.004 0.0131
Brugia malayi fructose-1,6-bisphosphatase 0.2869 0.8784 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0084 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0024
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0135 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Plasmodium vivax SET domain protein, putative 0.0063 0.0151 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0074 0.0184 0.1185
Leishmania major NAD(p)-dependent steroid dehydrogenase-like protein 0.0027 0.004 0.0043
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.003 0.0033
Loa Loa (eye worm) fli-1 protein 0.0239 0.0691 0.0785
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0066 0.0066
Leishmania major phosphatidylinositol kinase related protein, putative 0.0039 0.0075 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.0561 0.0635
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.002 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.002 0.0021
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.023 0.4138
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0198 0.0191
Trypanosoma brucei DNA polymerase eta, putative 0.0092 0.0239 0.0271
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0074 0.0184 0.1787
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.023 0.2738
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0868 0.0986
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0008 0.0051
Plasmodium falciparum glutathione reductase 0.0019 0.0015 0.0052
Brugia malayi beta-lactamase family protein 0.0077 0.0192 0.0217
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0015 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Trichomonas vaginalis dullard protein, putative 0.0038 0.0072 0.0483
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.023 0.0259
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.002 0.0015
Echinococcus granulosus cpg binding protein 0.0032 0.0053 0.0052
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.001 0.0009
Leishmania major DNA polymerase kappa, putative 0.004 0.0078 0.0087
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.2086
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.0868 0.0986
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0133
Brugia malayi Bromodomain containing protein 0.0038 0.0073 0.0081
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0074 0.0083
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0151 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.002 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0013 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0192 0.186
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0127 0.2182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.3323
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0043
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0015 0.0015
Brugia malayi beta-lactamase 0.0077 0.0192 0.0217
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.002 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0436 0.292
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0078 0.008
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0189 0.0538 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.0346 0.23
Schistosoma mansoni hypothetical protein 0.0047 0.01 0.0111
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.023 0.0222
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0022 0.0023 0.0142
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0229
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0024 0.003 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0119 0.0797
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0038 0.0072 0.0073
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0053 0.0119 0.0133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.0561 0.0553
Loa Loa (eye worm) hypothetical protein 0.0051 0.0114 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0074 0.0184 0.0208
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.002 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0189 0.0538 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0078 0.0086
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0143 0.0155
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0078 0.0086
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0022 0.0023 0.0015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0155 0.0175
Plasmodium falciparum thioredoxin reductase 0.0056 0.0127 0.2182
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0135 0.0371 0.0414
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0043 0.0047
Echinococcus multilocularis geminin 0.0518 0.1549 0.1543
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Schistosoma mansoni fkbp-rapamycin associated protein 0.0022 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0074 0.0083
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0015 0.0103
Trichomonas vaginalis set domain proteins, putative 0.0499 0.149 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0062 0.0148 0.1875
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.01 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Mycobacterium tuberculosis Conserved protein 0.0077 0.0192 0.1237
Onchocerca volvulus 0.0026 0.0037 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0868 0.0986
Echinococcus multilocularis lamin dm0 0.0026 0.0037 0.003
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0198 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0277 0.0314
Schistosoma mansoni DNA polymerase eta 0.0092 0.0239 0.027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.002 0.0021
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0192 0.1237
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.023 0.0253
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0148 0.2539
Brugia malayi AMP-binding enzyme family protein 0.0253 0.0734 0.0834
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0192 0.1289
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0062 0.0148 0.207
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0192 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.004 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0135 0.0371 0.0363
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0184 0.1787
Schistosoma mansoni 6-phosphofructokinase 0.0231 0.0666 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0021
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Giardia lamblia GTOR 0.0038 0.0074 0.4574
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.1067 0.3239 0.3686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0135 0.0128
Toxoplasma gondii propionate-CoA ligase 0.0074 0.0184 0.0196
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2869 0.8784 0.8783
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0064 0.0153 0.0966
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0013 0.0006
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.039 0.5042
Echinococcus multilocularis serine protein kinase ATM 0.0053 0.0119 0.0111
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0387 0.0439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0192 0.0216
Trypanosoma brucei unspecified product 0.004 0.0078 0.0087
Schistosoma mansoni hypothetical protein 0.002 0.0019 0.0019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0013 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0426 0.1267 0.1441
Echinococcus multilocularis dna polymerase kappa 0.004 0.0078 0.0071
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0192 0.1237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.0561 0.063
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.002 0.0013
Onchocerca volvulus 0.0077 0.0192 0.1168
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.223
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0053 0.0119 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0078
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.0027 0.004 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0506 0.3399
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0081
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0078 0.0087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.1304 0.1483
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.002 0.002
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0155 0.0175
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0074 0.0184 0.1185
Loa Loa (eye worm) hypothetical protein 0.0074 0.0184 0.0208
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi ecdysteroid receptor 0.0021 0.002 0.0021
Schistosoma mansoni gabp alpha 0.0079 0.0198 0.0223
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0074 0.0083
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0184 0.2086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0135 0.0371 0.0363
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.0217
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0038 0.0072 0.1132
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0253 0.0734 0.7161
Mycobacterium ulcerans hypothetical protein 0.0253 0.0734 0.7161
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0155 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0062 0.0148 0.0154
Loa Loa (eye worm) hypothetical protein 0.0253 0.0734 0.0834
Trichomonas vaginalis dullard protein, putative 0.0038 0.0072 0.0483
Echinococcus granulosus zinc finger protein 0.0021 0.0021 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0253 0.0734 0.4973
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0078 0.0087
Leishmania major acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.005 0.0154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.0015
Plasmodium falciparum acyl-CoA synthetase 0.0189 0.0538 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.018 0.0172
Loa Loa (eye worm) 6-phosphofructokinase 0.0231 0.0666 0.0757
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.0346 0.4415
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0074 0.0184 0.1185
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0015 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0142 0.0153
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Echinococcus multilocularis 6 phosphofructokinase 0.0231 0.0666 0.0659
Onchocerca volvulus 0.0026 0.0037 0.0116
Echinococcus granulosus 6 phosphofructokinase 0.0231 0.0666 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2869 0.8784 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0253 0.0734 0.4973
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0426 0.1267 0.1441
Entamoeba histolytica hypothetical protein 0.0073 0.018 0.2313
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0666 0.9057
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0192 0.1237
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0078 0.0452
Trypanosoma cruzi DNA polymerase eta, putative 0.0092 0.0239 0.0271
Leishmania major hypothetical protein, conserved 0.0038 0.0072 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0192 0.1289
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0192 0.1237
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0143 0.0136
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0078 0.0524
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0074 0.0184 0.0208
Trypanosoma brucei unspecified product 0.0027 0.004 0.0044
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0155 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium ulcerans beta-lactamase 0.0077 0.0192 0.186
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0096 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0148 0.0992
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0074 0.0184 0.2086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.002 0.0021
Mycobacterium ulcerans acetyl-CoA synthetase 0.0074 0.0184 0.1787
Leishmania major DNA polymerase eta, putative 0.0065 0.0155 0.0175
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0037 0.0041
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.039 0.26
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0045 0.0096 0.0107
Echinococcus multilocularis GPCR, family 2 0.0135 0.0371 0.0363
Onchocerca volvulus 0.0074 0.0184 0.1117
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0013 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0204
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0038 0.0072 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0015 0.0052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.002 0.0013
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.0346 0.23
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0074 0.0083
Echinococcus granulosus dna polymerase kappa 0.004 0.0078 0.008
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Echinococcus granulosus serine protein kinase ATM 0.0053 0.0119 0.0127
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.0561 0.063
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.002 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Leishmania major hypothetical protein, conserved 0.0077 0.0192 0.0217
Onchocerca volvulus 0.0077 0.0192 0.1168
Mycobacterium ulcerans 6-phosphofructokinase 0.0231 0.0666 0.6496
Schistosoma mansoni 6-phosphofructokinase 0.0231 0.0666 0.0756
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0119 0.0133
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0387 0.0439
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.0561 0.0636
Loa Loa (eye worm) beta-lactamase 0.0077 0.0192 0.0217
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.002 0.0021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.4107
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0666 0.4471
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.004 0.0044
Trichomonas vaginalis antibiotic synthetase, putative 0.0074 0.0184 0.1238
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0084 0.0094
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.002 0.0015
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0192 0.1237
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0038 0.0072 0.008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0015 0.0126
Loa Loa (eye worm) hypothetical protein 0.007 0.0172 0.0194
Leishmania major hypothetical protein, conserved 0.0027 0.004 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0184 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0038 0.0072 0.008
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0038 0.0072 0.1132
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0038 0.0072 0.1132
Schistosoma mansoni cpg binding protein 0.0028 0.0043 0.0046
Brugia malayi oxidoreductase 0.0027 0.004 0.0043
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0074 0.0071
Giardia lamblia DINP protein human, muc B family 0.004 0.0078 0.4848
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0148 0.2578
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0135 0.0371 0.0414
Brugia malayi CXXC zinc finger family protein 0.0028 0.0043 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0253 0.0734 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0253 0.0734 0.4858
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.2039 0.2033
Brugia malayi Ets-domain containing protein 0.0079 0.0198 0.0224
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0084 0.0094
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0015
Brugia malayi nuclear hormone receptor 0.0021 0.002 0.0021
Mycobacterium ulcerans hypothetical protein 0.0077 0.0192 0.186
Brugia malayi AMP-binding enzyme family protein 0.0253 0.0734 0.0834
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0084 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0013
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0038 0.0074 0.0076
Echinococcus granulosus FTZ F1 alpha 0.0021 0.002 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.002 0.0021
Trypanosoma brucei ISWI complex protein 0.0015 0.0003 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.0561 0.0635
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0008 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.002 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Schistosoma mansoni hypothetical protein 0.0135 0.0371 0.0419
Schistosoma mansoni acetyl-CoA synthetase 0.0074 0.0184 0.0207
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0074 0.0184 0.1185
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0038 0.0072 0.0483
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.0277 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0074 0.0184 0.3276
Brugia malayi latrophilin 2 splice variant baaae 0.0291 0.0852 0.0969
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0078 0.0087
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0053 0.0119 0.0133
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0192 0.186
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.0239 0.0271
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0387 0.0439
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.0277 0.504
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0277 0.504
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.039 0.26
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1067 0.3239 0.3686
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0074 0.0184 0.1185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0203 0.0223
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0013 0.0084
Leishmania major trypanothione reductase 0.0056 0.0127 0.0143
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.002 0.002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0074 0.0184 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0078 0.0909
Brugia malayi Thioredoxin reductase 0.0056 0.0127 0.0143
Brugia malayi phosphofructokinase 0.0231 0.0666 0.0757
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0078 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.0561 0.0636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.002 0.0021
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0074 0.0184 0.1787
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0078 0.0087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.002 0.0015
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0074 0.0184 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.002 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.0347 0.1025 0.6974
Leishmania major acetyl-CoA synthetase, putative 0.0074 0.0184 0.0208
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0013 0.0012
Schistosoma mansoni ets-related 0.0239 0.0691 0.0784
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0231 0.0666 0.0757
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0192 0.0217
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0253 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.0538 0.061
Leishmania major 0.2869 0.8784 1
Echinococcus multilocularis dna polymerase eta 0.0092 0.0239 0.0232
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2869 0.8784 1
Schistosoma mansoni coup transcription factor 0.0021 0.002 0.002
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0015 0.0103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0135 0.0139
Mycobacterium tuberculosis Conserved protein 0.0077 0.0192 0.1237
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0039 0.0075 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.002 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.0346 0.23
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0147 0.0164
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0135 0.0847
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.004 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0112 0.0126
Mycobacterium tuberculosis Probable reductase 0.0127 0.0346 0.23
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0038 0.0074 0.0083
Echinococcus granulosus GPCR family 2 0.0135 0.0371 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.004 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0253 0.0734 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Echinococcus multilocularis musashi 0.0026 0.0037 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.002 0.0013
Plasmodium vivax glutathione reductase, putative 0.0056 0.0127 0.2182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.005 0.0578
Brugia malayi Fli-1 protein 0.0239 0.0691 0.0785
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0192 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0023 0.0153
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0353 0.04
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.023 0.223
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0074 0.0184 0.1787
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0013 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.05
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.0561 0.0635
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0184 0.1185
Leishmania major 4-coumarate:coa ligase-like protein 0.0253 0.0734 0.0834
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.005 0.072
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0015 0.0052
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0078 0.0747
Leishmania major DNA polymerase eta, putative 0.0092 0.0239 0.0271
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0074 0.0858
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.4 nM Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader ChEMBL. 20864344
IC50 (binding) = 0.87 nM Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader ChEMBL. 20864344
IC50 (binding) = 2.4 nM Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader in presence of plasma ChEMBL. 20864344
IC50 (binding) = 7350 nM Inhibition of 11betaHSD2 ChEMBL. 20864344
IC50 (binding) > 10000 nM Inhibition of 3betaHSD2 ChEMBL. 20864344
IC50 (binding) > 10000 nM Inhibition of 17betaHSD2 ChEMBL. 20864344
IC50 (ADMET) = 17100 nM Inhibition of CYP3A4 ChEMBL. 20864344
IC50 (ADMET) > 30000 nM Inhibition of CYP2C9 ChEMBL. 20864344
IC50 (ADMET) = 30000 nM Inhibition of CYP2D6 ChEMBL. 20864344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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