Detailed information for compound 1256185

Basic information

Technical information
  • TDR Targets ID: 1256185
  • Name: 2-[4-[di(phenyl)methyl]piperazin-1-yl]-N-meth yl-N-(phenylmethyl)acetamide
  • MW: 413.555 | Formula: C27H31N3O
  • H donors: 0 H acceptors: 1 LogP: 4.29 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)CN1CCN(CC1)C(c1ccccc1)c1ccccc1)Cc1ccccc1
  • InChi: 1S/C27H31N3O/c1-28(21-23-11-5-2-6-12-23)26(31)22-29-17-19-30(20-18-29)27(24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-16,27H,17-22H2,1H3
  • InChiKey: RMPUCWLQCSXYGC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-[di(phenyl)methyl]-1-piperazinyl]-N-methyl-N-(phenylmethyl)acetamide
  • N-(benzyl)-2-[4-[di(phenyl)methyl]piperazin-1-yl]-N-methyl-acetamide
  • 2-[4-[di(phenyl)methyl]piperazin-1-yl]-N-methyl-N-(phenylmethyl)ethanamide
  • MLS001005825
  • SMR000349034
  • T0513-4196

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens solute carrier family 5 (sodium/choline cotransporter), member 7 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni high-affinity choline transporter Get druggable targets OG5_131601 All targets in OG5_131601
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GH02984p Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum High affinity choline transporter 1, putative Get druggable targets OG5_131601 All targets in OG5_131601
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR001734,Na+/solute symporter,domain-containing Get druggable targets OG5_131601 All targets in OG5_131601
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0076 0.025 0.025
Brugia malayi hypothetical protein 0.0054 0.0158 0.0154
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0271 0.0267
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.5
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0124 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Toxoplasma gondii fructose-bisphospatase I 0.0877 0.3672 0.367
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.02 0.0195
Brugia malayi Guanylyl cyclase protein 23 0.002 0.001 0.0006
Leishmania major 0.2359 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0065 0.0061
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0097 0.034 0.0336
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.0286 1
Toxoplasma gondii LsmAD domain-containing protein 0.0084 0.0286 0.0282
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2359 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0271 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.025 1
Echinococcus multilocularis glutamate receptor 2 0.002 0.001 0.0006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0184 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0149 0.07
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0029 0.0024
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2359 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0005 0.0005
Echinococcus granulosus high affinity choline transporter 1 0.042 0.1719 0.1715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0173 0.0816
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0086
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0097 0.034 0.0336
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0877 0.3672 0.367
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.001 0.001
Schistosoma mansoni high-affinity choline transporter 0.042 0.1719 0.1715
Trypanosoma brucei PAB1-binding protein , putative 0.0084 0.0286 0.0282
Onchocerca volvulus 0.0503 0.2074 1
Echinococcus granulosus GPCR family 2 0.0035 0.0075 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0162 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0271 0.0267
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus multilocularis GPCR, family 3, C terminal 0.0034 0.0071 0.0067
Echinococcus granulosus tyrosine kinase 0.002 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0265 0.1056 0.1056
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.001 0.0006
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0008 0.0003
Brugia malayi hypothetical protein 0.002 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.1814 0.1814
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2359 1 1
Echinococcus granulosus cpg binding protein 0.0039 0.0091 0.0086
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.2311 0.2308
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0008 0.0003
Giardia lamblia GTOR 0.0097 0.034 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.0396 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Schistosoma mansoni hypothetical protein 0.0494 0.2036 0.2032
Schistosoma mansoni zinc finger protein 0.0021 0.0016 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0162 0.0162
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0124 0.012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0075 0.007
Brugia malayi hypothetical protein 0.0084 0.0286 0.0282
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.001 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0271 0.0267
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.042 0.1719 0.1719
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0189 0.0735 0.073
Echinococcus granulosus solute carrier family 5 0.0046 0.0124 0.012
Schistosoma mansoni tyrosine kinase 0.002 0.001 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0247 0.0247
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0029 0.0024
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0061
Brugia malayi Pre-SET motif family protein 0.0442 0.1814 0.181
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.034 0.034
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0038 0.0088 0.0083
Echinococcus granulosus metabotropic glutamate receptor 2 0.0175 0.0674 0.067
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0008 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0396 0.0392
Schistosoma mansoni hypothetical protein 0.0075 0.0247 0.0243
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0124 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.034 0.1621
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Brugia malayi PHD-finger family protein 0.0026 0.0039 0.0034
Schistosoma mansoni cpg binding protein 0.0039 0.0091 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0204 0.0963
Onchocerca volvulus 0.0046 0.0124 0.0551
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2359 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0075 0.0075
Schistosoma mansoni cpg binding protein 0.0035 0.0074 0.007
Brugia malayi CXXC zinc finger family protein 0.0035 0.0074 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2036 0.2032
Leishmania major hypothetical protein, conserved 0.0084 0.0286 0.0279
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.001 0.0006
Echinococcus multilocularis cpg binding protein 0.0039 0.0091 0.0086
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0054 0.0155 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0075 0.007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0097 0.034 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Echinococcus multilocularis GPCR, family 2 0.0035 0.0075 0.007
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0139 0.0134
Onchocerca volvulus 0.0265 0.1056 0.5067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0076 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.034 0.1621
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0124 0.012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0139 0.4744
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0877 0.3672 0.367
Brugia malayi metabotropic glutamate receptor type 2 0.0102 0.0361 0.0357
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2359 1 1
Brugia malayi hypothetical protein 0.0037 0.0082 0.0078
Echinococcus multilocularis glutamate receptor 2 0.002 0.001 0.0006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0076 0.0072
Echinococcus granulosus tumor protein p63 0.1808 0.7646 0.7645
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.0286 0.0282
Schistosoma mansoni bromodomain containing protein 0.0064 0.0199 0.0195
Leishmania major extracellular receptor, putative 0.002 0.001 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0271 0.0267
Echinococcus granulosus metabotropic glutamate receptor 5 0.0257 0.1025 0.1021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.034 0.1621
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0239 0.0235
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0139 0.0134
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.002 0.001 0.0006
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.2311 0.2308
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0239 0.0235
Brugia malayi Bromodomain containing protein 0.0075 0.0248 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0075 0.0075
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 1
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0124 0.012
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.001 0.001
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.001 0.0006
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0077 0.0256 0.0248
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Schistosoma mansoni sodium/solute symporter 0.0046 0.0124 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0082 0.0078
Schistosoma mansoni cpg binding protein 0.0039 0.0091 0.0086
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4108 0.4106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0239 0.0235
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.025 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0195 0.092
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.5
Schistosoma mansoni tyrosine kinase 0.002 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0038 0.0088 0.0083
Echinococcus granulosus glutamate receptor 2 0.002 0.001 0.0006
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0877 0.3672 0.367
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0038 0.0088 0.0083
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.025 0.0246
Trichomonas vaginalis set domain proteins, putative 0.0503 0.2074 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.034 0.0336
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0008 0.0008
Echinococcus granulosus nmda type glutamate receptor 0.002 0.001 0.0006
Brugia malayi GH02984p 0.042 0.1719 0.1715
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0029 0.0024
Echinococcus granulosus neuropeptide s receptor 0.0558 0.2311 0.2308
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0065 0.0061
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0227 0.0222
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0034 0.0071 0.0295
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.02 0.0195
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0008 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0082 0.0078
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0097 0.034 0.0336
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0008 0.0003
Onchocerca volvulus 0.0035 0.0074 0.0311
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0097 0.034 0.0336
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0184 0.018
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2359 1 1
Brugia malayi Receptor family ligand binding region containing protein 0.0054 0.0155 0.0151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0075 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0396 0.0396
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.025 0.8719
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0065 0.0061
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2359 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0222 0.0222
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0124 0.012
Schistosoma mansoni cellular tumor antigen P53 0.0265 0.1056 0.1052
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0238 0.0941 0.0937
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0097 0.034 0.0336
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0075 0.007
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0139 0.5654
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.025 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0173 0.0816
Loa Loa (eye worm) hypothetical protein 0.0054 0.0155 0.0155
Echinococcus granulosus glutamate receptor 2 0.002 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.0124
Onchocerca volvulus 0.0064 0.02 0.0919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0043
Entamoeba histolytica hypothetical protein 0.002 0.001 0.0168
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0096
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0082 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0149 0.07
Loa Loa (eye worm) Smad1 0.0018 0.0005 0.0005
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0054 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.027 0.1078 0.1078
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0065 0.0061
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0057
Brugia malayi Metabotropic glutamate receptor precursor. 0.0209 0.0819 0.0814
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 0.8719
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0065 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0158
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0013 0.0009
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0034 0.0071 0.0067
Echinococcus multilocularis tumor protein p63 0.1808 0.7646 0.7645
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.001 0.0006
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.001 0.0006
Brugia malayi Probable ClpP-like protease 0.0076 0.025 0.0246
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0046 0.0122 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0239 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0173 0.0816
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0012 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0158
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0239 0.0235
Loa Loa (eye worm) hypothetical protein 0.0084 0.0286 0.0286
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0038 0.1085
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Brugia malayi MH2 domain containing protein 0.027 0.1078 0.1074
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.001 0.001
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0124 0.012
Echinococcus granulosus zinc finger protein 0.0021 0.0016 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.0286 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Toxoplasma gondii fructose-bisphospatase II 0.2359 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0097 0.034 0.0333
Onchocerca volvulus Poor gastrulation protein homolog 0.0034 0.0071 0.0295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0158
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.025 0.0246
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0008 0.0003
Echinococcus multilocularis tyrosine kinase 0.002 0.001 0.0006
Schistosoma mansoni metabotropic glutamate receptor 0.0175 0.0674 0.067
Brugia malayi Bromodomain containing protein 0.0037 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0004 0.000000011328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0158
Loa Loa (eye worm) glutamate receptor 0.0209 0.0819 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0149 0.07
Schistosoma mansoni hypothetical protein 0.0037 0.0082 0.0078
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0065 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0171 0.0805
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0097 0.034 0.0333
Schistosoma mansoni hypothetical protein 0.0035 0.0075 0.007
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0247 0.0243
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0097 0.034 1
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0124 0.012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0097 0.034 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0239 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.2311 0.2308
Schistosoma mansoni glutamate receptor NMDA 0.002 0.001 0.0006
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2036 0.2032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0187 0.0182
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.001 0.0006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0065 0.0061
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.025 0.0246
Echinococcus multilocularis solute carrier family 5 0.0046 0.0124 0.012
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2324
Schistosoma mansoni inositol transporter 0.0046 0.0124 0.012
Plasmodium vivax ataxin-2 like protein, putative 0.0084 0.0286 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0257 0.1025 0.1021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0071 0.0071
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0038 0.1085
Schistosoma mansoni inositol transporter 0.0046 0.0124 0.012
Trypanosoma cruzi extracellular receptor, putative 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0171 0.0805
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0139 0.5654
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0239 0.0235
Loa Loa (eye worm) hypothetical protein 0.0044 0.0113 0.0113
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0124 0.012
Brugia malayi Pre-SET motif family protein 0.0064 0.02 0.0195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.025 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0396 0.0392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0075 0.007
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0097 0.034 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.001
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.1719 0.1715
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0008 0.0003
Loa Loa (eye worm) glutamate receptor 0.0082 0.0277 0.0277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.02 0.0195
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.02 0.0195
Schistosoma mansoni hypothetical protein 0.0034 0.0071 0.0067
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.001 0.0006
Echinococcus granulosus GPCR family 3 C terminal 0.0034 0.0071 0.0067
Trypanosoma cruzi target of rapamycin kinase 3 0.0077 0.0256 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Echinococcus multilocularis zinc finger protein 0.0021 0.0016 0.0012
Schistosoma mansoni protein kinase 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.015 0.0701
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0098 0.0094
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.028 0.1329
Brugia malayi isocitrate dehydrogenase 0.0019 0.0008 0.0003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0077 0.0256 0.0251
Plasmodium vivax SET domain protein, putative 0.0064 0.02 0.6902
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.025 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0255 0.1212
Toxoplasma gondii target of rapamycin (TOR), putative 0.0072 0.0234 0.023
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0008 0.0003
Schistosoma mansoni metabotropic glutamate receptor 0.0102 0.0361 0.0357
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.001 0.0006
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0175 0.0674 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0234 0.1109
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0037 0.0158
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0877 0.3672 0.367
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0026 0.0038 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0065 0.0292
Loa Loa (eye worm) transcription factor SMAD2 0.027 0.1078 0.1078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0008 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0075 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0257 0.1025 0.1025
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.0286 0.0282

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 11.46197552 uM PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488975, AID488997, AID493221, AID493222] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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