Detailed information for compound 1256611

Basic information

Technical information
  • TDR Targets ID: 1256611
  • Name: (5Z)-1-(furan-2-ylmethyl)-5-[[1-[2-(4-methylp henoxy)ethyl]pyrrol-2-yl]methylidene]-1,3-dia zinane-2,4,6-trione
  • MW: 419.43 | Formula: C23H21N3O5
  • H donors: 1 H acceptors: 3 LogP: 2.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)OCCn1cccc1/C=C\1/C(=O)NC(=O)N(C1=O)Cc1ccco1
  • InChi: 1S/C23H21N3O5/c1-16-6-8-18(9-7-16)31-13-11-25-10-2-4-17(25)14-20-21(27)24-23(29)26(22(20)28)15-19-5-3-12-30-19/h2-10,12,14H,11,13,15H2,1H3,(H,24,27,29)/b20-14-
  • InChiKey: MBFWLLMQLRTWSM-ZHZULCJRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(furan-2-ylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]pyrrol-2-yl]methylidene]-1,3-diazinane-2,4,6-trione
  • 1-(2-furylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]pyrrol-2-yl]methylene]hexahydropyrimidine-2,4,6-trione
  • (5Z)-1-(2-furylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]pyrrol-2-yl]methylene]hexahydropyrimidine-2,4,6-trione
  • 1-(2-furylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]-2-pyrrolyl]methylene]hexahydropyrimidine-2,4,6-trione
  • (5Z)-1-(2-furylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]-2-pyrrolyl]methylene]hexahydropyrimidine-2,4,6-trione
  • 1-(2-furylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]pyrrol-2-yl]methylene]barbituric acid
  • (5Z)-1-(2-furylmethyl)-5-[[1-[2-(4-methylphenoxy)ethyl]pyrrol-2-yl]methylene]barbituric acid
  • STOCK3S-61023
  • ZINC02219860
  • 1-Furan-2-ylmethyl-5-[1-[1-(2-p-tolyloxy-ethyl)-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-pyrimidine-2,4,6-trione
  • MLS000769050
  • SMR000433820

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi polk-prov protein 0.0014 0.041 0.041
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1925 0.3227
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0033 0.0064
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0234 0.0234
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.5186 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.1925 0.3078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0304 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0135 0.0264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0304 0.0595
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0234 0.0459
Treponema pallidum NADH oxidase 0.0016 0.0475 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2389 0.4587
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0304 0.0459
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.1925 0.2907
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0304 0.0595
Leishmania major DNA polymerase eta, putative 0.0045 0.186 0.3088
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0304 0.0304
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0769
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0475 0.0137
Schistosoma mansoni dishevelled 0.0011 0.0234 0.0354
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.191 0.3742
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0135 0.0264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0304 0.0595
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.5186 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0234 0.0459
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.1925 0.2907
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.1925 0.3661
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0475 0.0137
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.041 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Brugia malayi nuclear receptor RXR 0.0006 0.0033 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0304 0.0459
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0099 0.002
Trypanosoma brucei trypanothione reductase 0.0046 0.1881 0.3134
Leishmania major DNA polymerase eta, putative 0.0077 0.3374 0.6316
Brugia malayi nuclear receptor NHR-88 0.0012 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0077 0.3374 0.3374
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0475 0.0424
Brugia malayi DIX domain containing protein 0.0011 0.0234 0.0234
Brugia malayi steroid hormone receptor 0.0012 0.0304 0.0304
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0228 0.0228
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0475 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0033 0.0049
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1881 0.1881
Schistosoma mansoni cpg binding protein 0.0037 0.1456 0.2199
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0475 0.0437
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0033
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.1925 0.3661
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Echinococcus multilocularis Protein son of sevenless 0.0008 0.0089 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0011 0.0234 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0008 0.0089 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0769
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.4638 0.8837
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0234 0.0354
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1881 0.2985
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0234 0.0459
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3195 0.4825
Giardia lamblia DINP protein human, muc B family 0.0047 0.1925 0.3227
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0234 0.0459
Toxoplasma gondii thioredoxin reductase 0.0046 0.1881 0.6358
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0304 0.0459
Onchocerca volvulus 0.0182 0.8326 0.8326
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0304 0.0304
Brugia malayi RasGEF domain containing protein 0.0008 0.0089 0.0089
Loa Loa (eye worm) glutathione reductase 0.0046 0.1881 0.1881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0304 0.0304
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0304 0.0595
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0008 0.0089 0.0175
Onchocerca volvulus 0.0012 0.0304 0.0304
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0304 0.0595
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0033 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0475 0.0437
Brugia malayi hypothetical protein 0.0182 0.8326 0.8326
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.191 0.3742
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0033 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1925 0.3661
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.3374 0.6316
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0475 0.093
Mycobacterium tuberculosis Probable reductase 0.0104 0.4638 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0304 0.0304
Onchocerca volvulus 0.0035 0.1363 0.1363
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0234 0.0234
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0089 0.0089
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.4638 0.8837
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0475 0.0475
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0475 0.0769
Onchocerca volvulus 0.0008 0.0089 0.0089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0475 0.093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1925 0.3661
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0135 0.0264
Echinococcus granulosus dna polymerase kappa 0.0047 0.1925 0.3772
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1925 0.3227
Echinococcus multilocularis son of sevenless 1 0.0008 0.0089 0.0175
Plasmodium falciparum thioredoxin reductase 0.0046 0.1881 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.1243 0.1775
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1881 0.3574
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0072 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.041 0.0641
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0475 0.0437
Schistosoma mansoni dishevelled 0.0011 0.0234 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.041 0.0641
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1925 0.3661
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0304 0.0459
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.5103 0.5103
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.5103 0.7707
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.5103 0.5103
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0277 0.0277
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.041 0.068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.5186 1
Brugia malayi nuclear hormone receptor 0.0012 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0304 0.0459
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0475 0.0424
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.1925 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0277 0.0277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0099 0.002
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.5103 0.5103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0304 0.0595
Echinococcus multilocularis ras GTP exchange factor 0.0008 0.0089 0.0175
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0475 0.5
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0008 0.0089 0.0175
Brugia malayi hypothetical protein 0.0011 0.0234 0.0234
Schistosoma mansoni cpg binding protein 0.0035 0.1363 0.2058
Echinococcus granulosus ras GTP exchange factor 0.0008 0.0089 0.0175
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0304 0.0595
Trichomonas vaginalis helicase, putative 0.0008 0.0099 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0475 0.0769
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.5103 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0234 0.0234
Brugia malayi RasGEF domain containing protein 0.0008 0.0089 0.0089
Brugia malayi hypothetical protein 0.0006 0.0033 0.0033
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0218 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0304 0.0304
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0234 0.0459
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0475 0.5
Echinococcus granulosus son of sevenless 1 0.0008 0.0089 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0304 0.0459
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0475 0.0137
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1363 0.1363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.4638 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0769
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0099 0.002
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0234 0.0459
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0304 0.0459
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0008 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.1243 0.1775
Brugia malayi hypothetical protein 0.0011 0.0234 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Leishmania major DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0475 0.0769
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0304 0.0595
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0304 0.0595
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.5103 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0234 0.0459
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0089 0.0135
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0304 0.0595
Schistosoma mansoni dep domain containing protein 0.0011 0.0234 0.0354
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.4638 0.8837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.1243 0.1775
Trypanosoma brucei polo-like protein kinase 0.0114 0.5103 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0304 0.0304
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0475 0.0769
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0475 0.0437
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0099 0.002
Brugia malayi CXXC zinc finger family protein 0.0035 0.1363 0.1363
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0089 0.0089
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.3374 0.6552
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.1925 0.3227
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0033 0.0049
Brugia malayi ecdysteroid receptor 0.0012 0.0304 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0304 0.0459
Schistosoma mansoni ras GTP exchange factor 0.0008 0.0089 0.0135
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0475 0.0137
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0135 0.0264
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0234 0.0459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0304 0.0304
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0033 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2389 0.4587
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0304 0.0595
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0304 0.0304
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0089 0.0135
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.1925 0.3661
Onchocerca volvulus 0.0011 0.0234 0.0234
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.5103 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0304 0.0304
Plasmodium vivax glutathione reductase, putative 0.0046 0.1881 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0304 0.0304
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.1925 0.3772
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0137
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.1925 0.1925
Echinococcus granulosus Protein son of sevenless 0.0008 0.0089 0.0175
Trypanosoma brucei unspecified product 0.0047 0.1925 0.3227
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.1925 0.3772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0304 0.0304
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0475 0.5
Brugia malayi hypothetical protein 0.0006 0.0033 0.0033
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.186 0.6275
Schistosoma mansoni coup transcription factor 0.0012 0.0304 0.0459
Plasmodium falciparum glutathione reductase 0.0016 0.0475 0.0437
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0304 0.0459
Echinococcus multilocularis cpg binding protein 0.0037 0.1456 0.2853
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Brugia malayi glutathione reductase 0.0046 0.1881 0.1881
Trypanosoma brucei unspecified product 0.0032 0.1243 0.1775
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0234 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0304 0.0304
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0008 0.0089 0.0175
Leishmania major trypanothione reductase 0.0046 0.1881 0.3134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.5186 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0475 0.0137
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.041 0.0641
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0033
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0475 0.0928
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0304 0.0595
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0008 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0234 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0304 0.0304
Plasmodium falciparum glutathione reductase 0.0046 0.1881 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1925 0.3661
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.2824 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Giardia lamblia Kinase, PLK 0.0114 0.5103 1
Schistosoma mansoni kinase 0.0058 0.246 0.3716
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0234 0.0234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0135 0.0203
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0099 0.002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.5103 1
Brugia malayi RasGEF domain containing protein 0.0008 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Echinococcus multilocularis dna polymerase eta 0.0077 0.3374 0.6612
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.041 0.068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0234 0.0234
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0008 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Schistosoma mansoni cpg binding protein 0.0037 0.1456 0.2199
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.1925 0.1925
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0089 0.0135
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0304 0.0595
Loa Loa (eye worm) hypothetical protein 0.0182 0.8326 0.8326
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5103 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.5103 1
Echinococcus granulosus dna polymerase eta 0.0077 0.3374 0.6612
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.041 0.0641
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0304 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0304 0.0304
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0475 0.0928
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0769
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0234 0.0354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.1925 0.3078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0304 0.0595
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0234 0.0459
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0234 0.0459
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0234 0.0354
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.4638 0.8837
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0304 0.0304
Echinococcus granulosus cpg binding protein 0.0037 0.1456 0.2853
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0304 0.0595
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0033
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.5103 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0304 0.0304
Brugia malayi Thioredoxin reductase 0.0046 0.1881 0.1881
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0234 0.0234
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0304 0.0459
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1925 0.3227
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0475 0.0424
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0008 0.0089 0.0135
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0033
Trypanosoma brucei unspecified product 0.0032 0.1243 0.1775
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.1925 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0304 0.0595
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0475 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0304 0.0304
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.3374 0.3374
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0475 0.0437
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0304 0.0304
Brugia malayi N-terminal motif family protein 0.0008 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0014 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0304 0.0304
Schistosoma mansoni DNA polymerase eta 0.0077 0.3374 0.5096
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0234 0.0459
Brugia malayi N-terminal motif family protein 0.0008 0.0089 0.0089
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0304 0.0459
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0475 0.0717
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0475 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0099 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0304 0.0304
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0304 0.0459
Echinococcus multilocularis dna polymerase kappa 0.0047 0.1925 0.3772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0769
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0475 0.0769
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0234 0.0459
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.186 0.3531
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0304 0.0595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0099 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1925 0.3227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0099 0.002
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1881 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0099 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0033 0.0033

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 55.688 um PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). (Class of assay: confirmatory) [Related pubchem assays: 1963 (Summary AID.), 1962 (Primary screen (TPT1 inhibitors).), 2153 (Counterscreen (RNase inhibitors).), 2149 (Confirmation screen (TPT1 inhibitors).)] ChEMBL. No reference
IC50 (binding) > 55.688 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of tRNA 2'-phosphotransferase (TPT1): fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of RNAse T1. (Class of assay: confirmatory) [Related pubchem assays: 1963 (Summary AID.), 1962 (Primary screen (TPT1 inhibitors).), 2153 (Counterscreen (RNase inhibitors).), 2149 (Confirmation screen (TPT1 inhibitors).)] ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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