Detailed information for compound 1256916

Basic information

Technical information
  • TDR Targets ID: 1256916
  • Name: [5-acetamido-3-acetyloxy-2-(acetyloxymethyl)- 6-(phenylmethoxy)oxan-4-yl] acetate
  • MW: 437.44 | Formula: C21H27NO9
  • H donors: 1 H acceptors: 4 LogP: 0.61 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCC1OC(OCc2ccccc2)C(C(C1OC(=O)C)OC(=O)C)NC(=O)C
  • InChi: 1S/C21H27NO9/c1-12(23)22-18-20(30-15(4)26)19(29-14(3)25)17(11-27-13(2)24)31-21(18)28-10-16-8-6-5-7-9-16/h5-9,17-21H,10-11H2,1-4H3,(H,22,23)
  • InChiKey: IDEBBPWXWFHKBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [5-acetamido-3-acetoxy-2-(acetoxymethyl)-6-(phenylmethoxy)tetrahydropyran-4-yl] acetate
  • acetic acid [5-acetamido-3-acetoxy-2-(acetoxymethyl)-6-(phenylmethoxy)-4-tetrahydropyranyl] ester
  • acetic acid [5-acetamido-3-acetoxy-2-(acetoxymethyl)-6-(benzyloxy)tetrahydropyran-4-yl] ester
  • [5-acetamido-3-acetyloxy-2-(acetyloxymethyl)-6-(phenylmethoxy)oxan-4-yl] ethanoate
  • BAS 00673621
  • Benzyl N,3,4,6-tetra-O-acetyl-.alpha.-d-mannosaminide
  • Acetic acid 3-acetoxy-2-acetoxymethyl-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester
  • MLS000563989
  • SMR000175806
  • T5484691
  • ChemDiv1_019595
  • Oprea1_562262

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phd:f box containing protein 0.0106 0.0452 0.0862
Toxoplasma gondii NAD(P) transhydrogenase subunit beta, putative 0.0057 0.017 0.065
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0028 0.0097
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0088 0.0233
Brugia malayi TAR-binding protein 0.0189 0.0938 0.2023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.012 0.0531 0.1146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0138 0.0297
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0481 0.1864
Toxoplasma gondii exonuclease III APE 0.0038 0.0056 0.0205
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0106 0.0452 0.0862
Loa Loa (eye worm) hypothetical protein 0.0088 0.0348 0.075
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Echinococcus granulosus PHD finger protein rhinoceros 0.0088 0.0348 0.0661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Mycobacterium ulcerans NAD(P) transhydrogenase PntA 0.0057 0.017 0.0241
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.009 0.0062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0481 0.1785
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0342 0.0396
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0071 0.0078
Schistosoma mansoni glutamate synthase 0.0043 0.0088 0.0098
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0854 0.4801 0.7067
Echinococcus multilocularis tar DNA binding protein 0.0189 0.0938 0.1806
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0938 0.1092
Schistosoma mansoni aldehyde dehydrogenase 0.0363 0.1948 0.2273
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0088 0.0155
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0043 0.0088 0.0059
Echinococcus multilocularis muscleblind protein 0.018 0.0885 0.1703
Treponema pallidum oxidoreductase 0.0043 0.0088 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0028 0.004
Loa Loa (eye worm) TAR-binding protein 0.0189 0.0938 0.2023
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0163 0.0782 1
Echinococcus granulosus microtubule associated protein 2 0.0669 0.3724 0.7215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0071 0.0152
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0056 0.0205
Echinococcus granulosus tar DNA binding protein 0.0189 0.0938 0.1806
Echinococcus multilocularis JmjC domain containing protein 4 0.0106 0.0452 0.0862
Echinococcus multilocularis neuropeptide receptor A26 0.0916 0.5159 1
Trypanosoma brucei NADH dehydrogenase 0.0043 0.0088 0.0328
Schistosoma mansoni coup transcription factor 0.004 0.0071 0.0078
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0071 0.0122
Echinococcus multilocularis transcription factor Dp 1 0.0151 0.0714 0.1371
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0106 0.0452 0.1748
Onchocerca volvulus 0.0114 0.0498 0.0891
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Treponema pallidum fructose-bisphosphate aldolase 0.1749 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0052 0.0138 0.0297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0071 0.0122
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0071 0.008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0261 0.1352 0.5264
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0043 0.0088 0.0066
Schistosoma mansoni importin beta-1 0.0029 0.0007 0.0005
Echinococcus multilocularis glutamate synthase 0.0043 0.0088 0.0155
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0071 0.0152
Loa Loa (eye worm) PHD-finger family protein 0.0088 0.0348 0.075
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0163 0.0782 0.3039
Echinococcus granulosus snurportin 1 0.0314 0.1662 0.3212
Plasmodium falciparum JmjC domain-containing protein, putative 0.0106 0.0452 0.1748
Mycobacterium ulcerans aldehyde dehydrogenase 0.0363 0.1948 0.3987
Brugia malayi glutathione reductase 0.047 0.2566 0.5535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.018 0.0884 0.1701
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0028 0.0029
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0043 0.0088 0.0066
Schistosoma mansoni lipoxygenase 0.0116 0.0512 0.0595
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0056 0.0121
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0163 0.0782 0.3039
Schistosoma mansoni glutamate synthase 0.0043 0.0088 0.0098
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0043 0.0088 0.0155
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0261 0.1352 0.1577
Echinococcus multilocularis thioredoxin glutathione reductase 0.0472 0.2581 0.4995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Giardia lamblia Fructose-bisphosphate aldolase 0.1749 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0363 0.1948 0.3767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1191 0.6758 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0088 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0363 0.1948 0.3767
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0163 0.0782 0.3039
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0071 0.0122
Trichomonas vaginalis set domain proteins, putative 0.094 0.5299 0.5286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0071 0.0152
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0163 0.0782 0.3039
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.0567 0.2124
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.1662 0.3585
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0163 0.0782 0.2971
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0043 0.0088 0.0066
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0115 0.0504 0.1874
Onchocerca volvulus 0.004 0.0071 0.008
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0261 0.1352 0.2611
Onchocerca volvulus 0.0087 0.0342 0.0595
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0071 0.0122
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0071 0.0078
Plasmodium vivax glutathione reductase, putative 0.047 0.2566 1
Echinococcus multilocularis nadp transhydrogenase 0.0057 0.017 0.0316
Echinococcus multilocularis peregrin 0.0088 0.0348 0.0661
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0363 0.1948 0.2823
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0056 0.0205
Mycobacterium ulcerans ferredoxin reductase 0.0043 0.0088 0.0066
Echinococcus multilocularis phd:f box containing protein 0.0106 0.0452 0.0862
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0028 0.004
Schistosoma mansoni glutamate synthase 0.0043 0.0088 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0071 0.0152
Toxoplasma gondii alanine dehydrogenase/pyridine nucleotide transhydrogenase domain-containing protein 0.0057 0.017 0.065
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0088 0.0233
Brugia malayi Importin beta-1 subunit 0.0029 0.0007 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.018 0.0884 0.1701
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0088 0.0328
Schistosoma mansoni NADP transhydrogenase 0.0057 0.017 0.0195
Brugia malayi glutaminase DH11.1 0.0269 0.1403 0.3025
Plasmodium vivax pyridine nucleotide transhydrogenase, putative 0.0057 0.017 0.065
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.0481 0.0454
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0118 0.0525 0.1004
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0088 0.0233
Echinococcus granulosus glutamate synthase 0.0043 0.0088 0.0155
Trypanosoma brucei trypanothione reductase 0.047 0.2566 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0088 0.0328
Echinococcus granulosus geminin 0.0521 0.2862 0.554
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0106 0.0452 0.1748
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0261 0.1352 0.1328
Echinococcus multilocularis snurportin 1 0.0314 0.1662 0.3212
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.0452 0.0974
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0071 0.0152
Mycobacterium ulcerans aldehyde dehydrogenase 0.0363 0.1948 0.3987
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0056 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.052 0.1123
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0028 0.0029
Leishmania major NADH dehydrogenase, putative 0.0043 0.0088 0.0233
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0163 0.0782 0.0911
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0039 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.009 0.0062
Schistosoma mansoni hypothetical protein 0.0314 0.1662 0.1939
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0088 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0118 0.0525 0.061
Trichomonas vaginalis alcohol dehydrogenase, putative 0.051 0.28 0.278
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.0938 0.2023
Schistosoma mansoni protein phosphatase 2C 0.0106 0.0452 0.0524
Loa Loa (eye worm) hypothetical protein 0.0118 0.0525 0.1132
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0028 0.0097
Echinococcus granulosus neuropeptide s receptor 0.0916 0.5159 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.009 0.0062
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0099 0.0414 0.0534
Treponema pallidum thioredoxin reductase (trxB) 0.0043 0.0088 0.0032
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0043 0.0088 0.0066
Mycobacterium ulcerans glutaminase 0.0269 0.1403 0.2838
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0525 0.061
Schistosoma mansoni alpha-glucosidase 0.0169 0.0821 0.0955
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0088 0.0059
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0261 0.1352 0.5218
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1191 0.6758 1
Schistosoma mansoni thyroid hormone receptor 0.004 0.0071 0.0078
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0088 0.0233
Giardia lamblia PHD finger protein 15 0.0088 0.0348 0.0293
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0163 0.0782 0.3039
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0163 0.0782 0.1531
Mycobacterium tuberculosis Possible dehydrogenase 0.051 0.28 0.4095
Plasmodium vivax SET domain protein, putative 0.0118 0.0525 0.2034
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0043 0.0088 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0106 0.0452 0.1668
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0579 0.3199 0.6195
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.009 0.0338
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0071 0.0152
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0088 0.0059
Brugia malayi RNA, U transporter 1 0.0084 0.0323 0.0696
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0043 0.0088 0.0155
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.009 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0938 0.1092
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0071 0.0122
Plasmodium falciparum importin beta, putative 0.0029 0.0007 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0071 0.0152
Mycobacterium leprae SECRETED L-ALANINE DEHYDROGENASE ALD (40 KDA ANTIGEN) (TB43) 0.0057 0.017 0.0124
Echinococcus granulosus transcription factor Dp 1 0.0151 0.0714 0.1371
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0579 0.3199 0.6195
Echinococcus granulosus cathepsin l1 0.0033 0.0028 0.004
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0111 0.0481 0.5854
Trypanosoma cruzi trypanothione reductase, putative 0.047 0.2566 1
Schistosoma mansoni ap endonuclease 0.0038 0.0056 0.0061
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0028 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0525 0.061
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0088 0.0059
Echinococcus granulosus jumonji domain containing 1A 0.0106 0.0452 0.0862
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0043 0.0088 0.0155
Plasmodium falciparum glutathione reductase 0.0163 0.0782 0.3039
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0938 0.1092
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.0567 0.2124
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0071 0.0152
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0088 0.0059
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0342 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0071 0.0152
Schistosoma mansoni glutaminase 0.0269 0.1403 0.1636
Schistosoma mansoni jumonji/arid domain-containing protein 0.0397 0.2143 0.2501
Brugia malayi steroid hormone receptor 0.004 0.0071 0.0152
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.009 0.0194
Schistosoma mansoni jumonji/arid domain-containing protein 0.0397 0.2143 0.2501
Echinococcus multilocularis jumonji domain containing 1A 0.0106 0.0452 0.0862
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0163 0.0782 0.3039
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0088 0.0328
Brugia malayi PHD-finger family protein 0.0029 0.0004 0.0008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.098 0.2114
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Trichomonas vaginalis mercuric reductase, putative 0.0163 0.0782 0.0756
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1071 0.6063 0.8958
Echinococcus multilocularis geminin 0.0521 0.2862 0.554
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0088 0.0233
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0029 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Entamoeba histolytica thioredoxin reductase, putative 0.0043 0.0088 0.0059
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0043 0.0088 0.0059
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.009 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0118 0.0525 0.1004
Mycobacterium tuberculosis Probable oxidoreductase 0.1191 0.6758 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0056 0.0094
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1071 0.6063 0.8963
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0071 0.0122
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0088 0.0433
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0042 0.0091
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0042
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0106 0.0452 0.0524
Plasmodium vivax JmjC domain containing protein 0.0106 0.0452 0.1748
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0088 0.0233
Loa Loa (eye worm) glutaminase 0.0269 0.1403 0.3025
Echinococcus granulosus lysine specific demethylase 6a 0.0106 0.0452 0.0862
Echinococcus multilocularis CREB binding protein 0.0086 0.0338 0.0642
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.009 0.0161
Trichomonas vaginalis nADP transhydrogenase, putative 0.0057 0.017 0.0142
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0481 0.1785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Plasmodium falciparum thioredoxin reductase 0.047 0.2566 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0088 0.0059
Schistosoma mansoni hypothetical protein 0.0088 0.0348 0.0402
Brugia malayi nuclear receptor NHR-88 0.004 0.0071 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0363 0.1948 0.2273
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Echinococcus granulosus muscleblind protein 0.018 0.0885 0.1703
Trichomonas vaginalis glutaminase, putative 0.0269 0.1403 0.1378
Echinococcus multilocularis PHD finger protein rhinoceros 0.0088 0.0348 0.0661
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0088 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0938 0.1092
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.0512 0.098
Brugia malayi Cathepsin L-like precursor 0.0033 0.0028 0.0061
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.098 0.1888
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0061
Onchocerca volvulus 0.0118 0.0525 0.0942
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.018 0.0884 0.1906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0348 0.1343
Brugia malayi PHD-finger family protein 0.0088 0.0348 0.075
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0088 0.0098
Schistosoma mansoni disulfide oxidoreductase 0.0043 0.0088 0.0098
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.012 0.0531 0.1146
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0056 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0043 0.0088 0.0047
Leishmania major hypothetical protein, conserved 0.0043 0.0088 0.0233
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0088 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0397 0.2143 0.4622
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0011
Loa Loa (eye worm) hypothetical protein 0.0087 0.0342 0.0737
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0043 0.0088 0.0047
Echinococcus granulosus lysine specific demethylase 5A 0.0397 0.2143 0.4145
Echinococcus granulosus jumonji domain containing protein 0.0122 0.0548 0.1049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0071 0.0078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.0938 0.2023
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1071 0.6063 0.8963
Schistosoma mansoni CREB-binding protein 2 0.0086 0.0338 0.0391
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0028 0.004
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0088 0.0233
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Loa Loa (eye worm) inositol-1 0.0111 0.0481 0.1038
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0043 0.0088 0.0328
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0071 0.0122
Brugia malayi hypothetical protein 0.0035 0.0039 0.0084
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0043 0.0088 0.0328
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.009 0.0062
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0056 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.0363 0.1948 0.7587
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.009 0.0062
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0043 0.0088 0.0032
Mycobacterium tuberculosis Probable reductase 0.1071 0.6063 0.8963
Loa Loa (eye worm) cysteine protease 0.0033 0.0028 0.0061
Brugia malayi jmjC domain containing protein 0.0397 0.2143 0.4622
Mycobacterium ulcerans NADH dehydrogenase 0.0043 0.0088 0.0066
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.051 0.28 0.278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0071 0.0078
Brugia malayi Pre-SET motif family protein 0.0118 0.0525 0.1132
Loa Loa (eye worm) glutaminase 2 0.0269 0.1403 0.3025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Toxoplasma gondii selenide, water dikinase 0.0043 0.0088 0.0328
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0043 0.0088 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0071 0.0152
Mycobacterium ulcerans glutamate synthase subunit beta 0.0043 0.0088 0.0066
Loa Loa (eye worm) fibroinase 0.0033 0.0028 0.0061
Schistosoma mansoni nuclear hormone receptor 0.004 0.0071 0.0078
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0043 0.0088 0.0189
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0088 0.0328
Mycobacterium tuberculosis Probable dehydrogenase 0.1071 0.6063 0.8963
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0088 0.0155
Loa Loa (eye worm) hypothetical protein 0.0106 0.0452 0.0974
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0088 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0071 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.018 0.0884 0.1701
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0088 0.0059
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.098 0.1888
Toxoplasma gondii PHD-finger domain-containing protein 0.0088 0.0348 0.1343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0525 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1071 0.6063 0.8963
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0043 0.0088 0.0328
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0029 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0071 0.0122
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0088 0.0233
Mycobacterium ulcerans monoxygenase 0.0043 0.0088 0.0066
Schistosoma mansoni hypothetical protein 0.0035 0.0042 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.018 0.0884 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0071 0.0152
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0056 0.0205
Plasmodium vivax thioredoxin reductase, putative 0.047 0.2566 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0342 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0071 0.0152
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0071 0.008
Loa Loa (eye worm) CBP-B 0.0086 0.0338 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0071 0.0152
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0163 0.0782 0.2971
Schistosoma mansoni hypothetical protein 0.0043 0.0088 0.0098
Schistosoma mansoni phd/f-box containing protein 0.0106 0.0452 0.0524
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0043 0.0088 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0043 0.0088 0.0155
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Mycobacterium ulcerans secreted L-alanine dehydrogenase Ald (40 kDa antigen) 0.0057 0.017 0.0241
Loa Loa (eye worm) hypothetical protein 0.018 0.0885 0.1909
Onchocerca volvulus 0.0043 0.0088 0.0112
Echinococcus multilocularis lysine specific demethylase 5A 0.0397 0.2143 0.4145
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0163 0.0782 0.1688
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0088 0.0059
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0088 0.0098
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0163 0.0782 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0163 0.0782 0.1504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Loa Loa (eye worm) jmjC domain-containing protein 0.0182 0.0892 0.1924
Plasmodium vivax vivapain-2 0.0033 0.0028 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.018 0.0884 0.1906
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0854 0.4801 0.708
Echinococcus granulosus CREB binding protein 0.0086 0.0338 0.0642
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.009 0.0062
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.0411 0.1508
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.009 0.0062
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0099 0.0414 0.0489
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0363 0.1948 0.7564
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.009 0.0194
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.0481 0.1785
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0938 0.1092
Brugia malayi Muscleblind-like protein 0.018 0.0885 0.1909
Brugia malayi Pre-SET motif family protein 0.0826 0.4636 1
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.3724 0.435
Schistosoma mansoni phosphatidylserine receptor 0.0106 0.0452 0.0524
Plasmodium falciparum thioredoxin reductase 0.0163 0.0782 0.3039
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0043 0.0088 0.0155
Plasmodium falciparum phd finger protein, putative 0.0088 0.0348 0.1343
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0007 0.0015
Trichomonas vaginalis apoptosis inducing factor, putative 0.0043 0.0088 0.0059
Entamoeba histolytica NAD(P)( ) transhydrogenase (AB-specific), alpha subunit, putative 0.0057 0.017 0.0142
Loa Loa (eye worm) RNA binding protein 0.0189 0.0938 0.2023
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0261 0.1352 0.2917
Echinococcus multilocularis jumonji domain containing protein 0.0122 0.0548 0.1049
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0163 0.0782 0.1504
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.05 0.0955
Echinococcus granulosus nadp transhydrogenase 0.0057 0.017 0.0316
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0088 0.0328
Mycobacterium tuberculosis Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part; catalytic part] (pyridine nucleotide transhydrogenase subuni 0.0057 0.017 0.017
Plasmodium vivax vivapain-2 0.0033 0.0028 0.0097
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0028 0.0061
Echinococcus multilocularis neuropeptide s receptor 0.0916 0.5159 1
Leishmania major cathepsin L-like protease 0.0126 0.0567 0.2124
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0043 0.0088 0.0047
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0088 0.0328
Trichomonas vaginalis inositol monophosphatase, putative 0.0111 0.0481 0.0454
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0106 0.0452 0.0974
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0043 0.0088 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0071 0.0152
Loa Loa (eye worm) hypothetical protein 0.0228 0.1163 0.2509
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0138 0.0297
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0088 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.3724 0.7215
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0043 0.0088 0.0189
Treponema pallidum NADH oxidase 0.0163 0.0782 0.073
Echinococcus multilocularis lysine specific demethylase 6a 0.0106 0.0452 0.0862
Schistosoma mansoni hypothetical protein 0.0521 0.2862 0.3342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0043 0.0088 0.0328
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0071 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.0452 0.0974
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0163 0.0782 0.2971
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0071 0.0078
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0043 0.0088 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0071 0.0152
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0163 0.0782 0.1531
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0163 0.0782 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0071 0.0122
Trichomonas vaginalis alcohol dehydrogenase, putative 0.051 0.28 0.278
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0088 0.0328
Echinococcus granulosus peregrin 0.0088 0.0348 0.0661
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0854 0.4801 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0043 0.0088 0.0233
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0043 0.0088 0.0047
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1749 1 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0028 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0071 0.0152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0043 0.0088 0.0155
Brugia malayi Thioredoxin reductase 0.047 0.2566 0.5535
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0071 0.0152
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0043 0.0088 0.0233
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.0452 0.0974
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0028 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.009 0.0062
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0043 0.0088 0.0047
Loa Loa (eye worm) ctsf protein 0.0033 0.0028 0.0061
Echinococcus granulosus thioredoxin glutathione reductase 0.0472 0.2581 0.4995
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.009 0.0062
Brugia malayi jmjC domain containing protein 0.0106 0.0452 0.0974
Trichomonas vaginalis glutathione reductase, putative 0.0163 0.0782 0.0756
Schistosoma mansoni thyroid hormone receptor 0.004 0.0071 0.0078
Brugia malayi ecdysteroid receptor 0.004 0.0071 0.0152
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0071 0.008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0071 0.0122
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0163 0.0782 0.2971
Leishmania major hypothetical protein, conserved 0.0043 0.0088 0.0233
Brugia malayi Cathepsin L-like precursor 0.0033 0.0028 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0007 0.0015
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0088 0.0328
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0111 0.0481 0.0454
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.009 0.0244
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0043 0.0088 0.0155
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0071 0.0152
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0071 0.0078
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1071 0.6063 0.8963
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0071 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0071 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0071 0.0152
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0091
Leishmania major trypanothione reductase 0.047 0.2566 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0111 0.0481 0.0896
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.018 0.0884 0.1029
Brugia malayi RNA binding protein 0.0189 0.0938 0.2023
Mycobacterium ulcerans hypothetical protein 0.0043 0.0088 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0016
Schistosoma mansoni inositol monophosphatase 0.0111 0.0481 0.0558
Trichomonas vaginalis alcohol dehydrogenase, putative 0.051 0.28 0.278
Brugia malayi jmjC domain containing protein 0.0106 0.0452 0.0974
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0056 0.0121
Toxoplasma gondii cathepsin CPL 0.0033 0.0028 0.0097
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0028 0.004
Brugia malayi AF-10 protein 0.0029 0.0004 0.0008
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0163 0.0782 0.1084
Toxoplasma gondii alanine dehydrogenase 0.0057 0.017 0.065
Entamoeba histolytica disulphide oxidoreductase, putative 0.0043 0.0088 0.0059
Echinococcus multilocularis muscleblind protein 1 0.018 0.0885 0.1703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.018 0.0884 0.1701
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0088 0.0233
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0111 0.0481 0.1864
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0088 0.0433
Brugia malayi Cathepsin L-like precursor 0.0033 0.0028 0.0061
Mycobacterium leprae PROBABLE NAD(P) TRANSHYDROGENASE (SUBUNIT ALPHA) PNTAA [FIRST PART; CATALYTIC PART] (PYRIDINE NUCLEOTIDE TRANSHYDROGENASE SUBUNI 0.0057 0.017 0.0124
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.009 0.0062
Brugia malayi Bromodomain containing protein 0.0088 0.0348 0.075
Echinococcus granulosus inositol monophosphatase 1 0.0111 0.0481 0.092
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0261 0.1352 0.2611
Plasmodium falciparum pyridine nucleotide transhydrogenase, putative 0.0057 0.017 0.065
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0342 0.0649
Loa Loa (eye worm) thioredoxin reductase 0.047 0.2566 0.5535
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0043 0.0088 0.0433
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0088 0.0348 0.0402
Plasmodium vivax importin-beta 2, putative 0.0029 0.0007 0.0015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0056 0.0109
Schistosoma mansoni ap endonuclease 0.0038 0.0056 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0088 0.0348 0.1343
Brugia malayi Cathepsin L-like precursor 0.0033 0.0028 0.0061
Brugia malayi Cathepsin L-like precursor 0.0033 0.0028 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.018 0.0884 0.1029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0071 0.0122
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0028 0.004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.047 0.2566 0.3745
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0106 0.0452 0.1668
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0118 0.0525 0.2034
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0088 0.0328
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0056 0.0028
Echinococcus granulosus CREB binding protein 0.0086 0.0338 0.0642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0071 0.0152
Schistosoma mansoni hypothetical protein 0.0521 0.2862 0.3342
Toxoplasma gondii NADPH-glutathione reductase 0.0163 0.0782 0.3039
Leishmania major cathepsin L-like protease 0.0126 0.0567 0.2124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0826 0.4636 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0007 0.0015
Leishmania major cathepsin L-like protease 0.0126 0.0567 0.2124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Brugia malayi jmjC domain containing protein 0.0106 0.0452 0.0974
Trypanosoma cruzi trypanothione reductase, putative 0.0163 0.0782 0.2971
Plasmodium vivax ferrodoxin reductase, putative 0.0043 0.0088 0.0328
Trypanosoma brucei glucosidase, putative 0.0044 0.009 0.0338
Toxoplasma gondii thioredoxin reductase 0.047 0.2566 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0118 0.0525 0.1004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0056 0.0094
Entamoeba histolytica hypothetical protein 0.0035 0.0039 0.0011
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0088 0.0059
Giardia lamblia NADH oxidase lateral transfer candidate 0.0163 0.0782 0.073
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0056 0.0028
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0043 0.0088 0.0059
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.098 0.1888
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0088 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.0567 0.2124
Echinococcus granulosus neuropeptide receptor A26 0.0916 0.5159 1
Giardia lamblia Glutamate synthase 0.0043 0.0088 0.0032
Loa Loa (eye worm) glutathione reductase 0.047 0.2566 0.5535
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0071 0.0122
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0071 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0071 0.0152
Giardia lamblia Thioredoxin reductase 0.0043 0.0088 0.0032
Loa Loa (eye worm) programmed cell death 8 0.0043 0.0088 0.0189
Echinococcus multilocularis cysteine protease 0.0033 0.0028 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0088 0.0189
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0106 0.0452 0.0862
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0261 0.1352 0.2917
Entamoeba histolytica NAD(P) transhydrogenase subunit alpha, putative 0.0057 0.017 0.0142
Schistosoma mansoni alpha-glucosidase 0.0169 0.0821 0.0955
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0043 0.0088 0.0047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0039 0.0061
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0163 0.0782 0.1531
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.0189
Schistosoma mansoni lipoxygenase 0.0081 0.0309 0.0357
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.0567 0.2124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0071 0.0152
Trichomonas vaginalis nADP transhydrogenase, putative 0.0057 0.017 0.0142
Brugia malayi nuclear hormone receptor 0.004 0.0071 0.0152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0138 0.0297
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0163 0.0782 0.3039
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0163 0.0782 0.3039
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0071 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1749 1 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.009 0.0244
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0261 0.1352 0.5218
Mycobacterium ulcerans dehydrogenase 0.051 0.28 0.5783
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0106 0.0452 0.1748
Leishmania major hypothetical protein, conserved 0.0106 0.0452 0.1668
Schistosoma mansoni inositol monophosphatase 0.0111 0.0481 0.0558
Schistosoma mansoni jumonji domain containing protein 0.0106 0.0452 0.0524
Brugia malayi glutamate synthase 0.0043 0.0088 0.0189
Schistosoma mansoni jumonji domain containing protein 0.0519 0.2854 0.3333
Brugia malayi Inositol-1 0.0111 0.0481 0.1038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0363 0.1948 0.3987
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0261 0.1352 0.5218
Brugia malayi TAZ zinc finger family protein 0.0086 0.0338 0.0729
Echinococcus multilocularis cysteine protease 0.0033 0.0028 0.004
Mycobacterium tuberculosis Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43) 0.0057 0.017 0.017
Brugia malayi jmjC domain containing protein 0.0579 0.3199 0.69
Echinococcus granulosus FTZ F1 alpha 0.004 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.018 0.0885 0.1909
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0088 0.0066
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1191 0.6758 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.098 0.2114
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0028 0.004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0008
Onchocerca volvulus Alhambra homolog 0.0088 0.0348 0.0606
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0071 0.0122
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0088 0.0189
Brugia malayi MH2 domain containing protein 0.0118 0.052 0.1123
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.009 0.0244
Echinococcus granulosus JmjC domain containing protein 4 0.0106 0.0452 0.0862
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0163 0.0782 0.3039
Brugia malayi jmjC domain containing protein 0.0106 0.0452 0.0974
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Onchocerca volvulus 0.094 0.5299 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.0481 0.0454
Mycobacterium ulcerans dehydrogenase 0.0043 0.0088 0.0066
Schistosoma mansoni alpha glucosidase 0.0044 0.009 0.0101
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0086 0.0338 0.0391
Echinococcus multilocularis inositol monophosphatase 1 0.0111 0.0481 0.092
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.052 0.1123
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0152
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0163 0.0782 0.2971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.0567 0.22
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0039 0.0042
Leishmania major hypothetical protein, conserved 0.0043 0.0088 0.0233
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0028 0.0097
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.0512 0.098
Plasmodium falciparum glutathione reductase 0.047 0.2566 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0043 0.0088 0.0328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0071 0.0122

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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