Detailed information for compound 1257518

Basic information

Technical information
  • TDR Targets ID: 1257518
  • Name: 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)cycloh exan-1-ol
  • MW: 263.296 | Formula: C12H17N5O2
  • H donors: 3 H acceptors: 5 LogP: 0.03 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CCC(CC1O)n1cnc2c1ncnc2N
  • InChi: 1S/C12H17N5O2/c13-11-10-12(15-5-14-11)17(6-16-10)8-2-1-7(4-18)9(19)3-8/h5-9,18-19H,1-4H2,(H2,13,14,15)
  • InChiKey: QZEHMNCVKZWEHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(6-amino-9-purinyl)-2-(hydroxymethyl)-1-cyclohexanol
  • 5-(6-aminopurin-9-yl)-2-methylol-cyclohexan-1-ol
  • MLS000098008
  • SMR000065645
  • Oprea1_811355
  • TULIP001807

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA topoisomerase II, putative 0.0056 0.839 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.5304 0.5304
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.5304 0.5304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.5304 0.5304
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.6821 0.8131
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.5304 0.5304
Loa Loa (eye worm) DR-78 0.002 0.034 0.034
Schistosoma mansoni nuclear receptor 0.002 0.034 0.034
Schistosoma mansoni hypothetical protein 0.0041 0.5113 0.5113
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0019 0.0168 0.0168
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.034 0.034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Brugia malayi Probable DNA topoisomerase II 0.0062 0.9787 0.9787
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.034 0.034
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.034 0.034
Trichomonas vaginalis DNA topoisomerase II, putative 0.0062 0.9787 1
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.5304 0.8816
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.1515 0.1548
Brugia malayi nuclear receptor RXR 0.0022 0.0871 0.0871
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0474 0.0484
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Brugia malayi steroid hormone receptor 0.0042 0.5304 0.5304
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.5304 0.5304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.5304 0.5304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0871 0.0871
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.034 0.034
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.5304 0.5304
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.8264 0.8264
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.5304 0.5304
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.1515 0.1806
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0056 0.839 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.5304 0.5304
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.034 0.034
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.034 0.034
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.034 0.034
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.002 0.0474 1
Brugia malayi TAR-binding protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.5304 0.5304
Schistosoma mansoni thyroid hormone receptor 0.0042 0.5304 0.5304
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0062 0.9787 0.9787
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.5304 0.5304
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.6821 0.8131
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0168 0.0168
Schistosoma mansoni thyroid hormone receptor 0.0042 0.5304 0.5304
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Loa Loa (eye worm) TOPoisomerase family member 0.0062 0.9787 0.9787
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.8264 0.8264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.5304 0.5304
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.5304 0.5304
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.5304 0.5304
Brugia malayi Nuclear hormone receptor E75 0.002 0.034 0.034
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.034 0.034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0027 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0027 0.2042 0.2042
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0474 0.0484
Toxoplasma gondii DNA topoisomerase 2, putative 0.0062 0.9787 1
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.5304 0.5304
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.5304 0.5304
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Echinococcus multilocularis tar DNA binding protein 0.0063 1 1
Brugia malayi hypothetical protein 0.0025 0.1515 0.1515
Echinococcus multilocularis GPCR, family 2 0.0019 0.0168 0.0168
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.3439 1
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.5304 0.5304
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.5304 0.5304
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.5304 0.5304
Loa Loa (eye worm) TAR-binding protein 0.0063 1 1
Schistosoma mansoni nuclear receptor 0.002 0.034 0.034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Brugia malayi RNA recognition motif domain containing protein 0.0063 1 1
Schistosoma mansoni coup transcription factor 0.0042 0.5304 0.5304
Brugia malayi nuclear receptor NHR-88 0.002 0.034 0.034
Schistosoma mansoni DNA topoisomerase II 0.0062 0.9787 0.9787
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0022 0.0871 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.5304 0.5304
Brugia malayi Nuclear hormone receptor E75 0.002 0.034 0.034
Echinococcus granulosus GPCR family 2 0.0019 0.0168 0.0168
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0871 0.0871
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.034 0.034
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0062 0.9787 0.9787
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1515 0.1548
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.034 0.034
Brugia malayi hypothetical protein 0.002 0.034 0.034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.5304 0.5304
Schistosoma mansoni hypothetical protein 0.0019 0.0168 0.0168
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.034 0.034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.5304 0.5304
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0871 0.0871
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.034 0.034
Brugia malayi nuclear hormone receptor 0.002 0.034 0.034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.034 0.034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.5304 0.5304
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 1 1
Brugia malayi conserved hypotetical protein 0.002 0.034 0.034
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.034 0.034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.034 0.034
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0871 0.0871
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.8264 0.8264
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.9374 0.9374
Giardia lamblia DNA topoisomerase II 0.0059 0.9173 1
Mycobacterium ulcerans DNA gyrase subunit B 0.002 0.0474 1
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.5304 0.5304
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1515 0.1548
Schistosoma mansoni nuclear hormone receptor 0.002 0.034 0.034
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Brugia malayi hypothetical protein 0.0022 0.0871 0.0871
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.8264 0.8264
Brugia malayi hypothetical protein 0.0022 0.0871 0.0871
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.5304 0.5304
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.0168
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0045 0.5971 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.5304 0.8816
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Brugia malayi nuclear receptor RXR 0.002 0.034 0.034
Trypanosoma brucei DNA topoisomerase ii 0.0049 0.6821 0.8131
Loa Loa (eye worm) RNA binding protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.5304 0.5304
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.002 0.0474 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.034 0.034
Brugia malayi nuclear receptor NHR-67 0.002 0.034 0.034
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.034 0.034
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0871 0.0871
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.8264 0.8264
Brugia malayi hypothetical protein 0.002 0.034 0.034
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.5304 0.5304
Trypanosoma cruzi DNA topoisomerase II, putative 0.0056 0.839 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.034 0.034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0041 0.5113 0.5113
Plasmodium falciparum DNA topoisomerase 2 0.0062 0.9787 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0045 0.5971 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0022 0.0871 0.0871
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0022 0.0871 0.0871
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.034 0.034
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0062 0.9787 0.9787
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0168 0.0168
Brugia malayi ecdysteroid receptor 0.0042 0.5304 0.5304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.8264 0.8264
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0045 0.5971 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.5304 0.5304
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1515 0.1806
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.5304 0.5304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.5304 0.5304
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0871 0.0871
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.5113 0.5113
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.5304 0.5304
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.9374 0.9374
Brugia malayi nuclear hormone receptor 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Plasmodium vivax DNA topoisomerase II, putative 0.0062 0.9787 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.5304 0.5304
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.5304 0.8816
Schistosoma mansoni nuclear hormone receptor 0.002 0.034 0.034
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Loa Loa (eye worm) hypothetical protein 0.0025 0.1515 0.1515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.8264 0.8264
Brugia malayi nuclear receptor NHR-88 0.0042 0.5304 0.5304
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.1515 0.1548
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.5304 0.5304
Brugia malayi tailless protein 0.002 0.034 0.034
Leishmania major mitochondrial DNA topoisomerase II 0.0049 0.6821 0.8131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.8264 0.8264
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.5304 0.5304
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Onchocerca volvulus 0.0042 0.5304 0.8816
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0019 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0019 0.0168 0.0168
Echinococcus granulosus tar DNA binding protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0871 0.0871
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0168 0.0168
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0474 0.0484
Loa Loa (eye worm) hypothetical protein 0.0042 0.5304 0.5304
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0056 0.839 1
Loa Loa (eye worm) hypothetical protein 0.006 0.9374 0.9374
Loa Loa (eye worm) hypothetical protein 0.002 0.034 0.034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.5304 0.5304
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.002 0.0474 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.5304 0.5304
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1515 0.1806
Loa Loa (eye worm) hypothetical protein 0.0042 0.522 0.522
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.8264 0.8264
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Echinococcus granulosus FTZ F1 alpha 0.0042 0.5304 0.5304
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.9374 0.9374
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.5304 0.5304
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.5304 0.5304
Entamoeba histolytica DNA topoisomerase II, putative 0.0062 0.9787 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.5304 0.5304
Leishmania major hypothetical protein, conserved 0.0025 0.1515 0.1806
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0042 0.522 0.522
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.5304 0.5304
Brugia malayi ecdysone receptor 0.002 0.034 0.034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.5304 0.5304
Schistosoma mansoni zinc finger protein 0.002 0.034 0.034
Schistosoma mansoni nuclear hormone receptor 0.0042 0.5304 0.5304
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0062 0.9787 0.9787
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0871 0.0871
Leishmania major DNA topoisomerase ii 0.0056 0.839 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.034 0.034

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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