Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0815 | 0.1565 | 0.2627 | |
Brugia malayi | Trypsin family protein | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0275 | 0.0429 | 0.0429 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.053 | 0.0964 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0217 | 0.0306 | 0.0306 |
Trypanosoma brucei | prolyl endopeptidase | 0.026 | 0.0397 | 1 |
Onchocerca volvulus | 0.0275 | 0.0429 | 0.0666 | |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0092 | 0.0043 | 0.0043 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0193 | 0.0256 | 0.0256 |
Brugia malayi | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.053 | 0.0964 | 0.5 |
Brugia malayi | protein kinase C3,putative | 0.0147 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0237 | 0.0237 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.026 | 0.0397 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Echinococcus granulosus | acetylcholinesterase | 0.4824 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.4824 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4824 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4824 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.0567 | 0.0567 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0275 | 0.0429 | 0.0429 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0275 | 0.0429 | 0.0429 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Echinococcus multilocularis | neuroligin | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Toxoplasma gondii | prolyl endopeptidase | 0.026 | 0.0397 | 0.412 |
Brugia malayi | Trypsin family protein | 0.0275 | 0.0429 | 0.0429 |
Brugia malayi | Muscle positioning protein 4 | 0.0108 | 0.0077 | 0.0077 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0277 | 0.0433 | 0.0433 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.053 | 0.0964 | 0.0964 |
Echinococcus granulosus | Mastin | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | atypical protein kinase C | 0.0223 | 0.0319 | 0.0319 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0104 | 0.0067 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.053 | 0.0964 | 0.0964 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4824 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0116 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0277 | 0.0433 | 0.0433 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0186 | 0.0241 | 0.0241 |
Onchocerca volvulus | 0.0119 | 0.01 | 0.0098 | |
Brugia malayi | Protein kinase c protein 2 | 0.0189 | 0.0247 | 0.0247 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.053 | 0.0964 | 0.0964 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0815 | 0.1565 | 0.1565 |
Brugia malayi | Carboxylesterase family protein | 0.0815 | 0.1565 | 0.1565 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0277 | 0.0433 | 0.0433 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Onchocerca volvulus | 0.0108 | 0.0077 | 0.0059 | |
Onchocerca volvulus | 0.257 | 0.5256 | 0.9 | |
Loa Loa (eye worm) | carboxylesterase | 0.0815 | 0.1565 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Leishmania major | hypothetical protein, conserved | 0.053 | 0.0964 | 1 |
Onchocerca volvulus | 0.0275 | 0.0429 | 0.0666 | |
Trypanosoma brucei | oligopeptidase b | 0.0104 | 0.0067 | 0.1518 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0815 | 0.1565 | 1 |
Brugia malayi | Kringle domain containing protein | 0.053 | 0.0964 | 0.0964 |
Onchocerca volvulus | 0.0815 | 0.1565 | 0.2627 | |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0008 | 0.0578 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0141 | 0.0146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.023 | 0.023 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0275 | 0.0429 | 0.0429 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0233 | 0.034 | 0.1819 |
Brugia malayi | C1-like domain containing protein | 0.0186 | 0.0241 | 0.0241 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0815 | 0.1565 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.0417 | 0.0417 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0283 | 0.0445 | 0.0445 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.287 | 0.5887 | 0.5887 |
Onchocerca volvulus | 0.0188 | 0.0245 | 0.0348 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0815 | 0.1565 | 1 |
Echinococcus granulosus | neuroligin | 0.0815 | 0.1565 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | protein kinase C mu | 0.0186 | 0.0241 | 0.0241 |
Echinococcus granulosus | acetylcholinesterase | 0.4824 | 1 | 1 |
Onchocerca volvulus | 0.0815 | 0.1565 | 0.2627 | |
Brugia malayi | Carboxylesterase family protein | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Echinococcus granulosus | protein kinase c iota type | 0.0217 | 0.0306 | 0.0306 |
Echinococcus granulosus | carboxylesterase 5A | 0.4824 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4824 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.053 | 0.0964 | 0.0964 |
Schistosoma mansoni | gliotactin | 0.0815 | 0.1565 | 0.1565 |
Onchocerca volvulus | 0.0275 | 0.0429 | 0.0666 | |
Onchocerca volvulus | 0.2845 | 0.5836 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0258 | 0.0393 | 0.0393 |
Echinococcus granulosus | enteropeptidase | 0.0275 | 0.0429 | 0.0429 |
Toxoplasma gondii | kringle domain-containing protein | 0.053 | 0.0964 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.2845 | 0.5836 | 0.5836 |
Loa Loa (eye worm) | hypothetical protein | 0.4824 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.4824 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.0554 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.0417 | 0.0417 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0075 | 0.0008 | 0.0008 |
Onchocerca volvulus | 0.0275 | 0.0429 | 0.0666 | |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0258 | 0.0393 | 0.0393 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Onchocerca volvulus | 0.0815 | 0.1565 | 0.2627 | |
Onchocerca volvulus | 0.027 | 0.0417 | 0.0645 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2845 | 0.5836 | 0.5836 |
Onchocerca volvulus | 0.053 | 0.0964 | 0.159 | |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0116 | 0.0093 | 0.0093 |
Brugia malayi | Trypsin family protein | 0.2845 | 0.5836 | 0.5836 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.053 | 0.0964 | 1 |
Onchocerca volvulus | 0.0184 | 0.0237 | 0.0334 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0093 | 0.0093 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0275 | 0.0429 | 0.0429 |
Trypanosoma cruzi | prolyl endopeptidase | 0.026 | 0.0397 | 0.3677 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0275 | 0.0429 | 0.0429 |
Echinococcus granulosus | protein kinase C gamma type | 0.0193 | 0.0256 | 0.0256 |
Schistosoma mansoni | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Echinococcus multilocularis | acetylcholinesterase | 0.4824 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0153 | 0.0172 | 0.0172 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Brugia malayi | Carboxylesterase family protein | 0.0815 | 0.1565 | 0.1565 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0124 | 0.011 | 0.011 |
Brugia malayi | SEA domain containing protein | 0.0092 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0043 | 0.0043 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0206 | 0.0284 | 0.0284 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.01 | 0.01 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Onchocerca volvulus | 0.0275 | 0.0429 | 0.0666 | |
Echinococcus multilocularis | enteropeptidase | 0.0275 | 0.0429 | 0.0429 |
Brugia malayi | Protein kinase domain containing protein | 0.0075 | 0.0008 | 0.0008 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.026 | 0.0397 | 0.3677 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0815 | 0.1565 | 0.1565 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Brugia malayi | prolyl oligopeptidase family protein | 0.026 | 0.0397 | 0.0397 |
Loa Loa (eye worm) | trypsin family protein | 0.0275 | 0.0429 | 0.0429 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0815 | 0.1565 | 1 |
Brugia malayi | Trypsin family protein | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0121 | 0.0104 | 0.0104 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.026 | 0.0397 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.2845 | 0.5836 | 0.5836 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0008 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.0397 | 0.0397 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0815 | 0.1565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.0417 | 0.0417 |
Mycobacterium ulcerans | hypothetical protein | 0.0275 | 0.0429 | 0.2415 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.026 | 0.0397 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0245 | 0.0245 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Brugia malayi | Carboxylesterase family protein | 0.0815 | 0.1565 | 0.1565 |
Loa Loa (eye worm) | carboxylesterase | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Echinococcus multilocularis | Mastin | 0.0275 | 0.0429 | 0.0429 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0186 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0258 | 0.0393 | 0.0393 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0815 | 0.1565 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0137 | 0.0138 | 0.0138 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0258 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0008 | 0.0054 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0815 | 0.1565 | 0.1565 |
Echinococcus granulosus | prolyl endopeptidase | 0.026 | 0.0397 | 0.0397 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0104 | 0.0067 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.01 | 0.01 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.0964 | 0.0964 |
Onchocerca volvulus | 0.0815 | 0.1565 | 0.2627 | |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | carboxylesterase | 0.4824 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.0429 | 0.0429 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0104 | 0.0067 | 0.1518 |
Brugia malayi | Protein kinase domain containing protein | 0.053 | 0.0964 | 0.0964 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0275 | 0.0429 | 0.0429 |
Brugia malayi | hypothetical protein | 0.0815 | 0.1565 | 0.1565 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0275 | 0.0429 | 0.0429 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0815 | 0.1565 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0116 | 0.0093 | 0.0093 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0277 | 0.0433 | 0.0433 |
Echinococcus multilocularis | prolyl endopeptidase | 0.026 | 0.0397 | 0.0397 |
Brugia malayi | protein kinase C II. | 0.0277 | 0.0433 | 0.0433 |
Schistosoma mansoni | acetylcholinesterase | 0.0815 | 0.1565 | 0.1565 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | Antimicrobial activity against Escherichia coli W3110 after 16 to 20 hrs by broth microdilution assay | ChEMBL. | 20211885 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.