Detailed information for compound 1257878

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.881 | Formula: C19H17ClN4O4S
  • H donors: 1 H acceptors: 4 LogP: 3.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1N(c1ccnc(n1)Nc1cccc(c1)S(=O)(=O)C)C)OCO2
  • InChi: 1S/C19H17ClN4O4S/c1-24(17-14(20)6-7-15-18(17)28-11-27-15)16-8-9-21-19(23-16)22-12-4-3-5-13(10-12)29(2,25)26/h3-10H,11H2,1-2H3,(H,21,22,23)
  • InChiKey: VPLVGQXSWQPIQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens EPH receptor B4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Onchocerca volvulus Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum ko:K05109 Eph receptor A8, putative Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma mansoni ephrin receptor Get druggable targets OG5_126715 All targets in OG5_126715
Brugia malayi ephrin receptor 1 precursor Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) TK/EPH protein kinase Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus granulosus ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) runx1 0.0117 0.0116 0.0259
Chlamydia trachomatis cysteine--tRNA ligase 0.0132 0.0133 0.0905
Entamoeba histolytica protein kinase, putative 0.004 0.0032 0.0953
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0058 0.0051 0.0115
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.001 0.0075
Schistosoma mansoni ap endonuclease 0.0059 0.0053 0.0117
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0007 0.0065
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0053 0.0411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Echinococcus granulosus lysine specific demethylase 5A 0.0245 0.0258 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0007 0.0016
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.0039 0.0087
Schistosoma mansoni lozenge 0.0117 0.0116 0.0259
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.0015
Brugia malayi 6-phosphofructokinase 0.0116 0.0116 0.0258
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0022 0.1621
Leishmania major DNA polymerase eta, putative 0.0034 0.0024 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Leishmania major importin beta-1 subunit, putative 0.0025 0.0014 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0007 0.0016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0007 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0053 0.0117
Echinococcus granulosus bloom syndrome protein 0.0021 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0261 0.0275 0.0615
Onchocerca volvulus 0.0018 0.0007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0085 0.0081 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0068 0.0068
Schistosoma mansoni jumonji/arid domain-containing protein 0.0245 0.0258 0.0577
Loa Loa (eye worm) TK/CSK protein kinase 0.0044 0.0035 0.0078
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0264 0.059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Plasmodium vivax cysteine--tRNA ligase, putative 0.0132 0.0133 1
Brugia malayi jmjC domain containing protein 0.0245 0.0258 0.0577
Echinococcus multilocularis JmjC domain containing protein 4 0.0065 0.0059 0.0132
Plasmodium vivax importin-beta 2, putative 0.003 0.002 0.1541
Brugia malayi GCC2 and GCC3 family protein 0.0031 0.0021 0.0048
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0058 0.0051 0.0115
Onchocerca volvulus 0.0014 0.0003 0.0026
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0007 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0055
Schistosoma mansoni tyrosine kinase 0.0023 0.0012 0.0028
Onchocerca volvulus 0.0074 0.0068 0.0672
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.003 0.2235
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0007 0.0494
Plasmodium falciparum JmjC domain-containing protein, putative 0.0065 0.0059 0.4452
Schistosoma mansoni hypothetical protein 0.0541 0.0585 0.1308
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.0068
Schistosoma mansoni tyrosine kinase 0.0061 0.0055 0.0122
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.001 0.0137
Plasmodium falciparum cysteine--tRNA ligase 0.0132 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0044 0.0098
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.003 0.0171
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0014 0.011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.001 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.087
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0019 0.0043
Brugia malayi Importin beta-1 subunit 0.003 0.002 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0007 0.0016
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.003 0.0171
Echinococcus granulosus snurportin 1 0.0326 0.0347 0.0775
Mycobacterium ulcerans beta-lactamase 0.0074 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0007 0.0015
Mycobacterium tuberculosis Conserved protein 0.0074 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.004 0.003 0.0068
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0094
Loa Loa (eye worm) glutaminase 0.1168 0.1279 0.2859
Brugia malayi Protein kinase domain containing protein 0.0313 0.0333 0.0744
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0065 0.0059 0.4452
Schistosoma mansoni phosphatidylserine receptor 0.0065 0.0059 0.0132
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0007 0.0072
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0007 0.0016
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0132 0.0133 0.0765
Schistosoma mansoni adapter molecule crk 0.0018 0.0007 0.0015
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0014 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0233 0.0522
Plasmodium vivax vivapain-2 0.0018 0.0007 0.0494
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0621 0.0674 0.061
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0065 0.0059 0.034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0022 0.0049
Brugia malayi phosphofructokinase 0.0116 0.0116 0.0258
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0349
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0059 0.0132
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0116 0.0666
Brugia malayi hypothetical protein 0.0014 0.0003 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0053 0.3958
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0062 0.0359
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.003 0.0171
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0037 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0007 0.0051
Echinococcus multilocularis tyrosine protein kinase Abl 0.0023 0.0012 0.0028
Echinococcus multilocularis musashi 0.0085 0.0081 0.0181
Trypanosoma brucei Aph-1 protein, putative 0.1581 0.1735 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0059 0.034
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0007 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0116 0.3494
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0132 0.0133 0.0765
Brugia malayi Protein kinase domain containing protein 0.0014 0.0003 0.0006
Brugia malayi 6-phosphofructokinase 0.0116 0.0116 0.0258
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0132 0.0133 0.1038
Leishmania major GTP-binding protein, putative 0.0022 0.0012 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0022 0.0049
Echinococcus multilocularis protein tyrosine kinase 0.0309 0.0329 0.0735
Schistosoma mansoni DNA polymerase eta 0.0048 0.004 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0022 0.0049
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0067
Toxoplasma gondii exonuclease III APE 0.0059 0.0053 0.3958
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0042 0.0093
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0007 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0305 0.0324 0.1869
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0053 0.0053
Echinococcus granulosus cathepsin l1 0.0018 0.0007 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0007 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0645 0.07 0.4035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0007 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0053 0.0117
Giardia lamblia CEGP1 protein 0.0031 0.0021 0.0648
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0007 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0245 0.0258 0.0577
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0116 0.0116
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0074 0.0068 0.0153
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0031 0.0021 0.1616
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0007 0.0016
Echinococcus multilocularis cysteine protease 0.0018 0.0007 0.0015
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0044 0.0099
Echinococcus multilocularis gamma secretase subunit aph 1 0.4057 0.4475 1
Schistosoma mansoni gamma-secretase subunit aph-1 0.4057 0.4475 1
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0116 0.3494
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0341 0.0364 0.0298
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0068 0.0153
Echinococcus granulosus ephrin type A receptor 4 A 0.0168 0.0173 0.0387
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.004 0.0229
Giardia lamblia DINP protein human, muc B family 0.0021 0.001 0.029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0007 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0007 0.0016
Echinococcus granulosus growth factor receptor bound protein 2 0.0018 0.0007 0.0015
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.001 0.0769
Plasmodium falciparum conserved protein, unknown function 0.0031 0.0021 0.1616
Loa Loa (eye worm) hypothetical protein 0.0132 0.0133 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Echinococcus granulosus geminin 0.0541 0.0585 0.1308
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0116 0.0635
Echinococcus granulosus tyrosine protein kinase csk 0.0044 0.0035 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0044 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0044 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0053 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0116 0.0258
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0087 0.0502
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0007 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0014
Brugia malayi nuclear receptor NHR-88 0.0019 0.0007 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0068 0.0153
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0022 0.1621
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0002 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0007 0.0016
Toxoplasma gondii hypothetical protein 0.0104 0.0102 0.7669
Brugia malayi Pre-SET motif family protein 0.0032 0.0022 0.0049
Echinococcus granulosus dna polymerase kappa 0.0021 0.001 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0198
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0065 0.0059 0.0132
Schistosoma mansoni hypothetical protein 0.0541 0.0585 0.1308
Brugia malayi Pre-SET motif family protein 0.0223 0.0233 0.0522
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0059 0.0132
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.0168
Echinococcus multilocularis jumonji domain containing 1A 0.0065 0.0059 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0068 0.0153
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.001 0.0055
Loa Loa (eye worm) cysteine protease 0.0018 0.0007 0.0015
Onchocerca volvulus 0.0018 0.0007 0.0065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0068 0.0153
Leishmania major DNA polymerase eta, putative 0.0048 0.004 0.0568
Echinococcus granulosus intermediate filament protein 0.0085 0.0081 0.0181
Echinococcus granulosus c src tyrosine kinase 0.0061 0.0055 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.002 0.0118
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0132 0.0133 0.4013
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0037 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0007 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0177
Brugia malayi RNA, U transporter 1 0.0087 0.0083 0.0185
Schistosoma mansoni ephrin receptor 0.0137 0.0138 0.0309
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0032 0.0072
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0116 0.0258
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.0155 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0022 0.1665
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0132 0.0133 0.0296
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.0155 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0053 0.0411
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0053 0.1588
Onchocerca volvulus 0.0014 0.0003 0.0026
Echinococcus granulosus tyrosine protein kinase csk 0.0044 0.0035 0.0078
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0245 0.0258 0.0577
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.0035 0.0078
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0007 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0068 0.0068
Trichomonas vaginalis glutaminase, putative 0.1168 0.1279 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0051 0.0115
Giardia lamblia Cysteinyl-tRNA synthetase 0.0132 0.0133 0.4013
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.004 0.0089
Echinococcus granulosus tyrosine protein kinase ABL1 0.0014 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Brugia malayi SH2 domain containing protein 0.0053 0.0045 0.01
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0044 0.0347
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.003 0.0232
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0044 0.0099
Leishmania major hypothetical protein, conserved 0.0074 0.0068 0.0975
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.0032 0.007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0007 0.0016
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0044 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0012 0.087
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0995 0.1087 0.1081
Brugia malayi Sex muscle abnormal protein 5 0.0018 0.0007 0.0015
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0044 0.0256
Loa Loa (eye worm) hypothetical protein 0.0074 0.0068 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0068 0.0533
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0081 0.0181
Brugia malayi Protein kinase domain containing protein 0.0052 0.0044 0.0099
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0007 0.0065
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0087 0.0502
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0116 0.3494
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0023
Brugia malayi beta-lactamase family protein 0.0074 0.0068 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0645 0.07 0.4035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0007 0.0016
Echinococcus granulosus gamma secretase subunit aph 1 0.4057 0.4475 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0068 0.0068
Plasmodium vivax JmjC domain containing protein 0.0065 0.0059 0.4452
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0044 0.1341
Loa Loa (eye worm) glutaminase 2 0.1168 0.1279 0.2859
Brugia malayi GCC2 and GCC3 family protein 0.0031 0.0021 0.0048
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0022 0.0651
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Entamoeba histolytica Ran family GTPase 0.0022 0.0012 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0007 0.0016
Leishmania major hypothetical protein, conserved 0.0065 0.0059 0.0844
Echinococcus multilocularis Protein lozenge 0.0117 0.0116 0.0259
Trichomonas vaginalis set domain proteins, putative 0.0254 0.0268 0.2091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.001 0.0021
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0132 0.0133 0.0297
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.0036 0.008
Leishmania major cysteinyl-tRNA synthetase, putative 0.0132 0.0133 0.1896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Schistosoma mansoni survival motor neuron protein 0.0053 0.0046 0.0102
Schistosoma mansoni ap endonuclease 0.0059 0.0053 0.0117
Onchocerca volvulus 0.0074 0.0068 0.0672
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0988 0.108 0.108
Echinococcus multilocularis endonuclease reverse transcriptase 0.0031 0.0021 0.0048
Echinococcus multilocularis tyrosine kinase 0.0014 0.0003 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0007 0.0043
Loa Loa (eye worm) ctsf protein 0.0018 0.0007 0.0015
Onchocerca volvulus 0.0018 0.0007 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Loa Loa (eye worm) hypothetical protein 0.0074 0.0068 0.0153
Onchocerca volvulus 0.0032 0.0022 0.0218
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.001 0.008
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.001 0.0002
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0014 0.0081
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.0035 0.0078
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0081 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0068 0.0533
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0065 0.0059 0.4452
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0245 0.0258 0.0577
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0007 0.0016
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0007 0.0494
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0012 0.087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0023 0.0012 0.0028
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0056 0.0321
Onchocerca volvulus 0.0031 0.0021 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Schistosoma mansoni hypothetical protein 0.0053 0.0046 0.0102
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0007 0.0016
Brugia malayi jmjC domain containing protein 0.0065 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0049
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0988 0.108 0.1073
Loa Loa (eye worm) ICD-1 protein 0.0039 0.003 0.0066
Plasmodium falciparum cysteine repeat modular protein 2 0.0031 0.0021 0.1616
Onchocerca volvulus 0.0132 0.0133 0.1307
Onchocerca volvulus 0.0014 0.0003 0.0026
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0365 0.0391 0.0325
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.0331 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0044 0.0099
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.0347 0.0775
Echinococcus multilocularis tyrosine protein kinase shark 0.0014 0.0003 0.0006
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0511 0.0552 0.0552
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0051 0.0115
Loa Loa (eye worm) fibroinase 0.0018 0.0007 0.0015
Mycobacterium ulcerans hypothetical protein 0.0074 0.0068 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.0168
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0132 0.0133 0.0125
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0264 0.059
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0132 0.0133 0.0297
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0058 0.0051 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Echinococcus multilocularis bloom syndrome protein 0.0021 0.001 0.0023
Brugia malayi ephrin receptor 1 precursor 0.0067 0.0061 0.0137
Echinococcus granulosus tyrosine protein kinase shark 0.0014 0.0003 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.003 0.0232
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0007 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Brugia malayi beta-NAC-like protein 0.0039 0.003 0.0066
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.9051 1 1
Onchocerca volvulus 0.0254 0.0268 0.2634
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.001 0.0023
Brugia malayi jmjC domain containing protein 0.0245 0.0258 0.0577
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0044 0.0256
Echinococcus multilocularis phd:f box containing protein 0.0065 0.0059 0.0132
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0094
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.0155 0.0155
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0116 0.0258
Trichomonas vaginalis esterase, putative 0.0074 0.0068 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0044 0.1341
Schistosoma mansoni ran 0.0022 0.0012 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0068 0.5141
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0024 0.1809
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0116 0.165
Treponema pallidum hypothetical protein 0.0341 0.0364 0.1998
Loa Loa (eye worm) hypothetical protein 0.093 0.1016 0.227
Schistosoma mansoni tyrosine kinase 0.0309 0.0329 0.0735
Echinococcus granulosus tyrosine protein kinase Src42A 0.0058 0.0051 0.0115
Leishmania major cathepsin L-like protease 0.0068 0.0062 0.089
Brugia malayi GCC2 and GCC3 family protein 0.0031 0.0021 0.0048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0053 0.0303
Brugia malayi cell division control protein 2 homolog 0.0052 0.0044 0.0099
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0012 0.0026
Loa Loa (eye worm) TK protein kinase 0.004 0.0032 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.0168
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0062 0.0359
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0007 0.0016
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.001 0.0023
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0046 0.0266
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0022 0.0049
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0053 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0022 0.0049
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0007 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0068 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0068 0.0393
Echinococcus multilocularis lysine specific demethylase 5A 0.0245 0.0258 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.001 0.0055
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0094
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0365 0.0391 0.0391
Brugia malayi hypothetical protein 0.093 0.1016 0.227
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.002 0.0118
Brugia malayi hypothetical protein 0.0261 0.0275 0.0615
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0116 0.0903
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0068 0.0533
Mycobacterium ulcerans hypothetical protein 0.034 0.0363 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0007 0.0016
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.001 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0024 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Schistosoma mansoni transcription factor btf3 0.0039 0.003 0.0066
Brugia malayi Cytochrome P450 family protein 0.0019 0.0007 0.0017
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0053 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0007 0.0016
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0015
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0116 0.0108
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0007 0.0016
Brugia malayi Protein kinase domain containing protein 0.0014 0.0003 0.0006
Schistosoma mansoni tyrosine kinase 0.0058 0.0051 0.0115
Leishmania major basic transcription factor 3a, putative 0.0039 0.003 0.0424
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0007 0.0015
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0132 0.0133 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.002 0.0046
Schistosoma mansoni protein phosphatase 2C 0.0065 0.0059 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0023 0.0012 0.0028
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0044 0.0256
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0053 0.1588
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0341 0.0364 0.0357
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.0035 0.0078
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.0508 0.0508
Leishmania major cathepsin L-like protease 0.0068 0.0062 0.089
Echinococcus multilocularis geminin 0.0541 0.0585 0.1308
Echinococcus granulosus protein tyrosine kinase 0.0309 0.0329 0.0735
Mycobacterium ulcerans glutaminase 0.1168 0.1279 0.1273
Onchocerca volvulus 0.0018 0.0007 0.0065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0051 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0015
Chlamydia trachomatis transglycolase/transpeptidase 0.0685 0.0744 0.588
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0058 0.0051 0.0115
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0007 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0053 0.3958
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0132 0.0133 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0116 0.0903
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.001 0.008
Trypanosoma brucei unspecified product 0.0014 0.0002 0.0014
Echinococcus granulosus lamin 0.0085 0.0081 0.0181
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0007 0.0015
Echinococcus granulosus dna polymerase eta 0.0048 0.004 0.0089
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0044 0.0256
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.002 0.1541
Loa Loa (eye worm) beta-lactamase 0.0074 0.0068 0.0153
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0015
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0044 0.0633
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0132 0.0133 0.0669
Mycobacterium tuberculosis Conserved hypothetical protein 0.034 0.0363 0.0363
Echinococcus granulosus tyrosine kinase 0.005 0.0042 0.0093
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0007 0.0016
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0044 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0062 0.0359
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.0036 0.008
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0116 0.0258
Echinococcus granulosus phd:f box containing protein 0.0065 0.0059 0.0132
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.001 0.0021
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0995 0.1087 0.1026
Brugia malayi Protein kinase domain containing protein 0.0014 0.0003 0.0006
Echinococcus granulosus NCK adaptor protein 0.0018 0.0007 0.0015
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0059
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0044 0.0099
Plasmodium vivax protein kinase Crk2 0.0052 0.0044 0.3342
Echinococcus granulosus cysteinyl tRNA synthetase 0.0132 0.0133 0.0297
Plasmodium falciparum cysteine--tRNA ligase 0.0132 0.0133 1
Onchocerca volvulus 0.0018 0.0007 0.0065
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.005 0.0042 0.0093
Brugia malayi SRC-1 0.0058 0.0051 0.0115
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0116 0.0048
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Loa Loa (eye worm) TK protein kinase 0.005 0.0042 0.0093
Schistosoma mansoni lamin 0.0085 0.0081 0.0181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0068 0.0153
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0769
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0007 0.0017
Entamoeba histolytica hypothetical protein 0.0025 0.0014 0.0425
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0081 0.0181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0007 0.0016
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0007 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Loa Loa (eye worm) hypothetical protein 0.0074 0.0068 0.0153
Leishmania major DNA polymerase kappa, putative 0.0021 0.001 0.0137
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.0331 1
Echinococcus granulosus tyrosine protein kinase csk 0.0044 0.0035 0.0078
Onchocerca volvulus 0.0085 0.0081 0.0797
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0068 0.0061
Brugia malayi Protein kinase domain containing protein 0.0014 0.0003 0.0006
Echinococcus granulosus tyrosine protein kinase Lyn 0.0059 0.0052 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Plasmodium falciparum importin beta, putative 0.003 0.002 0.1541
Brugia malayi GCC2 and GCC3 family protein 0.0031 0.0021 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0055
Onchocerca volvulus 0.0018 0.0007 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Trypanosoma brucei unspecified product 0.0021 0.001 0.0055
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0059 0.034
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0015
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0132 0.0133 0.0297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0053 0.0303
Plasmodium falciparum protein kinase 5 0.0052 0.0044 0.3342
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0007 0.0016
Brugia malayi Cytochrome P450 family protein 0.0029 0.0019 0.0043
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0007 0.0016
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0132 0.0133 0.0297
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0032 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0021 0.1616
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0065 0.0059 0.0132
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0014 0.0003 0.0079
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0014 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Loa Loa (eye worm) RecQ helicase 0.0021 0.001 0.0023
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.0032 0.007
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0022 0.0168
Echinococcus granulosus JmjC domain containing protein 4 0.0065 0.0059 0.0132
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0059
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.9051 1 1
Toxoplasma gondii cathepsin CPL 0.0018 0.0007 0.0494
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0022 0.0049
Schistosoma mansoni lamin 0.0085 0.0081 0.0181
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.003 0.0897
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.0035 0.0078
Brugia malayi jmjC domain containing protein 0.0065 0.0059 0.0132
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0511 0.0552 0.0487
Brugia malayi beta-lactamase 0.0074 0.0068 0.0153
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.001 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.001 0.0055
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0116 0.0258
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0058 0.0051 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Echinococcus multilocularis transcription factor btf3 0.0039 0.003 0.0066
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0022 0.1621
Echinococcus multilocularis dna polymerase kappa 0.0021 0.001 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0007 0.0016
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.001 0.0023
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0044 0.0099
Giardia lamblia Hypothetical protein 0.0031 0.0021 0.0648
Brugia malayi jmjC domain containing protein 0.0065 0.0059 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0044 0.0099
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0044 0.0256
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0007 0.0016
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0012 0.0026
Onchocerca volvulus 0.0014 0.0003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0074 0.0068 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Echinococcus multilocularis lamin 0.0085 0.0081 0.0181
Leishmania major mitochondrial DNA polymerase beta 0.0645 0.07 1
Toxoplasma gondii NAC domain-containing protein 0.0039 0.003 0.2235
Schistosoma mansoni nck2/grb4 0.0018 0.0007 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0053 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0091 0.0087 0.0502
Toxoplasma gondii ABC1 family protein 0.0074 0.0068 0.5141
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0022 0.0118
Brugia malayi Cytochrome P450 family protein 0.0019 0.0007 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0007 0.0016
Echinococcus granulosus lamin dm0 0.0085 0.0081 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0014
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0223 0.0233 0.0522
Echinococcus granulosus jumonji domain containing 1A 0.0065 0.0059 0.0132
Entamoeba histolytica hypothetical protein 0.0031 0.0021 0.0648
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0007 0.0043
Onchocerca volvulus 0.0074 0.0068 0.0672
Schistosoma mansoni intermediate filament proteins 0.0085 0.0081 0.0181
Plasmodium falciparum cysteine repeat modular protein 4 0.0031 0.0021 0.1616
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0022 0.0049
Schistosoma mansoni tyrosine kinase 0.0014 0.0003 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0044 0.0099
Trypanosoma brucei unspecified product 0.0014 0.0002 0.0014
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0007 0.0016
Onchocerca volvulus 0.0053 0.0046 0.0448
Plasmodium falciparum cysteine repeat modular protein 3 0.0031 0.0021 0.1616
Echinococcus multilocularis NCK adaptor protein 0.0018 0.0007 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0014
Schistosoma mansoni importin beta-1 0.003 0.002 0.0046
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0645 0.07 0.4035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0048
Trichomonas vaginalis ran, putative 0.0022 0.0012 0.009
Echinococcus granulosus leucyl tRNA synthetase 0.0132 0.0133 0.0297
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0058 0.0051 0.0115
Echinococcus granulosus transcription factor btf3 0.0039 0.003 0.0066
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0044 0.3342
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0007 0.0072
Loa Loa (eye worm) TK/ABL protein kinase 0.0014 0.0003 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.001 0.0075
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.001 0.0309
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0048
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0053 0.0117
Schistosoma mansoni jumonji domain containing protein 0.0245 0.0258 0.0577
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0068 0.0153
Schistosoma mansoni ran 0.0022 0.0012 0.0026
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1316 0.1443 0.1437
Echinococcus multilocularis tyrosine protein kinase Blk 0.005 0.0042 0.0093
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0044 0.0633
Brugia malayi beta-lactamase family protein 0.0074 0.0068 0.0153
Echinococcus granulosus tyrosine kinase 0.0014 0.0003 0.0006
Schistosoma mansoni coup transcription factor 0.0019 0.0007 0.0016
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0007 0.0015
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0031 0.0021 0.1616
Echinococcus multilocularis c src tyrosine kinase 0.0061 0.0055 0.0122
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.0258 0.0577
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0198
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.001 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0021 0.1616
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0022 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.003 0.0232
Mycobacterium tuberculosis Conserved protein 0.0074 0.0068 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0068 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Schistosoma mansoni glutaminase 0.1168 0.1279 0.2859
Leishmania major cytochrome p450-like protein 0.0019 0.0007 0.0107
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0058 0.0051 0.0115
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0988 0.108 0.1019
Brugia malayi jmjC domain containing protein 0.0065 0.0059 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0995 0.1087 0.8499
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0018 0.0007 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0007 0.0016
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.0331 0.1818
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0062 0.0359
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0116 0.0258
Plasmodium vivax vivapain-2 0.0018 0.0007 0.0494
Loa Loa (eye worm) SRC-1 0.0058 0.0051 0.0115
Brugia malayi nuclear hormone receptor 0.0019 0.0007 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0059 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0068 0.0533
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0007 0.0016
Loa Loa (eye worm) TK/FAK protein kinase 0.0313 0.0333 0.0744
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0007 0.0016
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0068 0.0061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0051 0.0115
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0022 0.1621
Leishmania major cathepsin L-like protease 0.0068 0.0062 0.089
Echinococcus granulosus tyrosine protein kinase Blk 0.005 0.0042 0.0093
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.0168
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0068 0.0068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0007 0.0072
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0305 0.0324 0.1869
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0016
Echinococcus multilocularis cysteine protease 0.0018 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0132
Brugia malayi SH2 domain containing protein 0.0014 0.0003 0.0006
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0051 0.0115
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0021 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0007 0.0016
Brugia malayi intermediate filament protein 0.0085 0.0081 0.0181
Echinococcus multilocularis snurportin 1 0.0326 0.0347 0.0775
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0058 0.0051 0.0115
Onchocerca volvulus 0.0031 0.0021 0.0211
Mycobacterium ulcerans lipase LipD 0.0074 0.0068 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0007 0.0016
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0341 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Trypanosoma cruzi Aph-1 protein, putative 0.1581 0.1735 1
Onchocerca volvulus 0.0019 0.0007 0.0072
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.0331 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0003 0.0006
Echinococcus multilocularis lamin dm0 0.0085 0.0081 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0007 0.0016
Chlamydia trachomatis transglycolase/transpeptidase 0.1143 0.1251 1
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0059 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0007 0.0016
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0621 0.0674 0.0667
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.004 0.0229
Brugia malayi steroid hormone receptor 0.0019 0.0007 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0055
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0007 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0132 0.0133 0.0765
Echinococcus multilocularis growth factor receptor bound protein 2 0.0018 0.0007 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0007 0.0016
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.001 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0007 0.0016
Trypanosoma cruzi Aph-1 protein, putative 0.1581 0.1735 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0015
Onchocerca volvulus 0.0014 0.0003 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0022 0.0168
Schistosoma mansoni tyrosine kinase 0.0014 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Entamoeba histolytica recQ family helicase, putative 0.0021 0.001 0.0309
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0023 0.0012 0.0028
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0146
Loa Loa (eye worm) hypothetical protein 0.0048 0.004 0.0089
Treponema pallidum penicillin-binding protein (pbp-1) 0.1143 0.1251 0.6874
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0007 0.0017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0769
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0022 0.1621
Loa Loa (eye worm) TK/EPH protein kinase 0.0173 0.0178 0.0399
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0014 0.0003 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0007 0.0016
Onchocerca volvulus 0.0085 0.0081 0.0797
Onchocerca volvulus 0.0053 0.0045 0.0442
Schistosoma mansoni hypothetical protein 0.0326 0.0347 0.0775
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0021 0.0046
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0347 0.0371 0.0371
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0007 0.0016
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0044 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0007 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0007 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0044 0.0347
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0116 0.0903
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0305 0.0324 0.4633
Treponema pallidum penicillin-binding protein (pbp-2) 0.0995 0.1087 0.5975
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0007 0.0038
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0022 0.1621
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0065 0.0059 0.0132
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0094
Loa Loa (eye worm) hypothetical protein 0.093 0.1016 0.227
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0511 0.0552 0.0545
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.001 0.0769
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0275 0.0615
Brugia malayi protein-tyrosine kinase 0.005 0.0042 0.0093
Echinococcus multilocularis tyrosine protein kinase Srms 0.005 0.0042 0.0093
Echinococcus granulosus endonuclease reverse transcriptase 0.0031 0.0021 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0062 0.0359
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0007 0.0016
Entamoeba histolytica cysteine-rich surface protein, putative 0.0031 0.0021 0.0648
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0094
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0014 0.011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0046 0.0102
Plasmodium vivax protein kinase, putative 0.0016 0.0004 0.0302
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0007 0.0015
Treponema pallidum cysteinyl-tRNA synthetase 0.0132 0.0133 0.0729
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.001 0.0023
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0007 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0068 0.0393
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0003 0.0006
Mycobacterium tuberculosis Conserved protein 0.0074 0.0068 0.0068
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0116 0.0666
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0007 0.0016
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.001 0.029
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.4057 0.4475 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Entamoeba histolytica protein kinase, putative 0.0032 0.0022 0.0667
Echinococcus multilocularis lysine specific demethylase 6a 0.0065 0.0059 0.0132
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0068 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0068 0.0393
Toxoplasma gondii hypothetical protein 0.0031 0.0021 0.1616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Brugia malayi glutaminase DH11.1 0.1168 0.1279 0.2859
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0068 0.0068
Onchocerca volvulus 0.0132 0.0133 0.1305
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.0072
Echinococcus multilocularis ephrin type A receptor 4 A 0.0168 0.0173 0.0387
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0111 0.0109 0.0628
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0007 0.0016
Plasmodium vivax SET domain protein, putative 0.0032 0.0022 0.1665
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0031 0.0021 0.1616
Treponema pallidum penicillin-binding protein (pbp-3) 0.1657 0.182 1
Onchocerca volvulus 0.0018 0.0007 0.0065
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0012 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0067
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0044 0.1341
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0007 0.0094
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.003 0.2235
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0116 0.0903
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0051 0.0115
Brugia malayi ecdysteroid receptor 0.0019 0.0007 0.0016
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0044 0.0099
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0044 0.0099
Echinococcus multilocularis dna polymerase eta 0.0048 0.004 0.0089
Schistosoma mansoni DNA helicase recq1 0.0021 0.001 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0331 0.2585
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.001 0.008
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0014 0.011
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0007 0.0016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0053 0.075
Schistosoma mansoni DNA helicase recq5 0.0021 0.001 0.0023
Schistosoma mansoni phd/f-box containing protein 0.0065 0.0059 0.0132
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.001 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0007 0.0016
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0091 0.0087 0.0502
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.001 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0007 0.0494
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0007 0.0016
Echinococcus granulosus lysine specific demethylase 6a 0.0065 0.0059 0.0132
Echinococcus granulosus tyrosine protein kinase Srms 0.0014 0.0003 0.0006
Plasmodium falciparum cysteine repeat modular protein 1 0.0031 0.0021 0.1616
Brugia malayi gamma-secretase subunit aph-1 0.4057 0.4475 1
Onchocerca volvulus 0.093 0.1016 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0044 0.1341
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0116 0.0258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0275 0.0615
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1226 0.1343 0.3002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0055
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1143 0.1251 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0022 0.1621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0007 0.0016
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0044 0.0099
Schistosoma mansoni tyrosine kinase 0.0058 0.0051 0.0115
Entamoeba histolytica hypothetical protein 0.0031 0.0021 0.0648
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0015
Brugia malayi Tyrosine-protein kinase abl-1 0.0023 0.0012 0.0028
Echinococcus granulosus importin subunit beta 1 0.003 0.002 0.0046
Echinococcus granulosus tyrosine protein kinase Src64B 0.0058 0.0051 0.0115
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0621 0.0674 0.0674
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0031 0.0021 0.1616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0051
Toxoplasma gondii kringle domain-containing protein 0.0031 0.0021 0.1616

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.036 uM Inhibition of EphB4 by acoustic dispensing assay ChEMBL. 20850301
IC50 (binding) = 0.042 uM Inhibition of EphB4 autophosphorylation expressed in CHOK1 cells ChEMBL. 20850301

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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