Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | 0.0091 | 0.0998 | 0.0929 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0076 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.0998 | 0.0868 |
Echinococcus multilocularis | acetylcholinesterase | 0.0541 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0091 | 0.0998 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.0998 | 0.0868 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0091 | 0.0998 | 0.0929 |
Echinococcus granulosus | acetylcholinesterase | 0.0541 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0076 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.0998 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Brugia malayi | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Echinococcus multilocularis | neuroligin | 0.0091 | 0.0998 | 0.0868 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0541 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 1 | 1 |
Onchocerca volvulus | 0.0091 | 0.0998 | 0.5 | |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0154 | 0.2256 | 0.2144 |
Echinococcus multilocularis | acetylcholinesterase | 0.0541 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0154 | 0.2256 | 0.2144 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0142 | 0.0067 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0154 | 0.2256 | 0.2144 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Schistosoma mansoni | acetylcholinesterase | 0.0091 | 0.0998 | 0.0868 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.0998 | 0.0868 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0091 | 0.0998 | 0.0929 |
Onchocerca volvulus | 0.0091 | 0.0998 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0142 | 0.0067 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0091 | 0.0998 | 0.0868 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Loa Loa (eye worm) | acetyltransferase | 0.0154 | 0.2256 | 0.2144 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0091 | 0.0998 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0091 | 0.0998 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.0998 | 0.0868 |
Echinococcus granulosus | acetylcholinesterase | 0.0541 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0541 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0541 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0541 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 1 | 1 |
Onchocerca volvulus | 0.0091 | 0.0998 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0091 | 0.0998 | 1 |
Echinococcus granulosus | neuroligin | 0.0091 | 0.0998 | 0.0929 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0076 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0541 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0091 | 0.0998 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.0998 | 0.0868 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.0998 | 0.0868 |
Onchocerca volvulus | 0.0091 | 0.0998 | 0.5 | |
Schistosoma mansoni | gliotactin | 0.0091 | 0.0998 | 0.0868 |
Brugia malayi | Carboxylesterase family protein | 0.0541 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.015 | 0.2169 | 0.211 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0091 | 0.0998 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0998 | 0.0868 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0091 | 0.0998 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 41 % | Inhibition of human aurora A at 10 uM | ChEMBL. | 20833547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.