Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hexokinase, putative | 0.0824 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0824 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hexokinase | 0.0824 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0824 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0094 | 0.0094 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0094 | 0.0094 |
Onchocerca volvulus | Hexokinase homolog | 0.0517 | 0.6137 | 0.61 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0059 | 0.038 | 0.038 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0059 | 0.038 | 0.038 |
Echinococcus granulosus | hexokinase type 2 | 0.0824 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0824 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0824 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0059 | 0.038 | 0.038 |
Echinococcus multilocularis | NMDA receptor | 0.0039 | 0.0127 | 0.0127 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0.0094 | 0.0094 |
Trypanosoma brucei | hexokinase, putative | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0.0094 | 0.0094 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0059 | 0.038 | 0.038 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0039 | 0.0127 | 0.0127 |
Echinococcus granulosus | hexokinase | 0.0824 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0.0094 | 0.0094 |
Brugia malayi | hexokinase type II | 0.0262 | 0.2929 | 0.2861 |
Brugia malayi | Hexokinase family protein | 0.0517 | 0.6137 | 0.61 |
Onchocerca volvulus | 0.0824 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0517 | 0.6137 | 0.61 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0059 | 0.038 | 0.038 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0039 | 0.0127 | 0.0127 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0.0094 | 0.0094 |
Trypanosoma cruzi | hexokinase, putative | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0039 | 0.0127 | 0.0127 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0.0094 | 0.0094 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0.0094 | 0.0094 |
Brugia malayi | Hexokinase family protein | 0.0824 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0094 | 0.0094 |
Schistosoma mansoni | glutamate receptor kainate | 0.0055 | 0.0322 | 0.0322 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0351 | 0.4056 | 0.4056 |
Leishmania major | hexokinase, putative | 0.0824 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0094 | 0.0094 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0039 | 0.0127 | 0.0127 |
Plasmodium falciparum | hexokinase | 0.0824 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0.0094 | 0.0094 |
Brugia malayi | Hexokinase family protein | 0.0255 | 0.284 | 0.2772 |
Trypanosoma cruzi | hexokinase, putative | 0.0824 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0094 | 0.0094 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | hexokinase | 0.0824 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0.0094 | 0.0094 |
Onchocerca volvulus | 0.0517 | 0.6137 | 0.61 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0094 | 0.0094 |
Schistosoma mansoni | glutamate receptor kainate | 0.0055 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hexokinase type II | 0.0824 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0.0094 | 0.0094 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2929 | 0.2861 |
Trypanosoma brucei | hexokinase | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0094 | 0.0094 |
Entamoeba histolytica | hexokinase 1 | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0824 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0824 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0824 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0824 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.6704 | 0.6672 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0.0094 | 0.0094 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0.0094 | 0.0094 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0.0094 | 0.0094 |
Onchocerca volvulus | 0.0824 | 1 | 1 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0.0094 | 0.0094 |
Echinococcus multilocularis | hexokinase | 0.0824 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0824 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2929 | 0.2861 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0059 | 0.038 | 0.038 |
Loa Loa (eye worm) | hexokinase | 0.0255 | 0.284 | 0.2772 |
Toxoplasma gondii | hexokinase | 0.0824 | 1 | 0.5 |
Onchocerca volvulus | 0.0824 | 1 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0.0094 | 0.0094 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0094 | 0.0094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 40 % | Antagonist activity at PAR2 receptor in human HT-29 cells assessed as inhibition of intracellular calcium release at 5 uM relative to SLIGRLI-NH2 | ChEMBL. | 20873792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.